gene
stringlengths 2
15
| uniprot_id
stringlengths 6
10
| protein_name
stringlengths 5
112
⌀ | protein_function
stringlengths 9
12.5k
⌀ | protein_domains
stringlengths 2
119k
| protein_interactions
stringlengths 2
1.12k
| pathways
stringlengths 11
43.4k
| go_mf
stringlengths 2
1.83k
| go_bp
stringlengths 2
10.3k
| go_cc
stringlengths 2
1.57k
| subcellular_location
listlengths 0
21
|
|---|---|---|---|---|---|---|---|---|---|---|
A1BG
|
P04217
|
Alpha-1B-glycoprotein
| null |
['- IPR016332: Alpha-1B-glycoprotein/leukocyte immunoglobulin-like receptor (family) [1-495]', '- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [26-111]', '- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [28-111]', '- IPR003599: Immunoglobulin domain subtype (domain) [34-202]', '- IPR003598: Immunoglobulin subtype 2 (domain) [40-100]', '- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [115-202]', '- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [116-202]', '- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [205-305]', '- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [207-302]', '- IPR050412: Immunoglobulin-like Receptors in Immune Regulation (family) [208-401]', '- IPR007110: Immunoglobulin-like domain (domain) [209-280]', '- IPR003599: Immunoglobulin domain subtype (domain) [217-302]', '- IPR003598: Immunoglobulin subtype 2 (domain) [223-286]', '- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [306-398]', '- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [307-398]', '- IPR003599: Immunoglobulin domain subtype (domain) [310-397]', '- IPR003598: Immunoglobulin subtype 2 (domain) [316-381]', '- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [399-494]', '- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [400-493]', '- IPR003599: Immunoglobulin domain subtype (domain) [408-493]', '- IPR003598: Immunoglobulin subtype 2 (domain) [414-477]']
|
['Growth factor receptor-bound protein 2', 'Cysteine rich secretory protein 3', 'Tyrosine-protein phosphatase non-receptor type 11', 'GRB2-associated-binding protein 2', 'Alpha-2-HS-glycoprotein chain A', 'GRB2 associated binding protein 3.', 'Adapter molecule crk', 'Short peptide from AAT', 'Inter-alpha-trypsin inhibitor light chain']
|
['GOBP_IMMUNE_RESPONSE_REGULATING_SIGNALING_PATHWAY'
'GOBP_REGULATION_OF_IMMUNE_RESPONSE'
'GOBP_REGULATION_OF_IMMUNE_SYSTEM_PROCESS' 'GOCC_BLOOD_MICROPARTICLE'
'GOCC_COLLAGEN_CONTAINING_EXTRACELLULAR_MATRIX'
'GOCC_EXTERNAL_ENCAPSULATING_STRUCTURE' 'GOCC_FICOLIN_1_RICH_GRANULE'
'GOCC_FICOLIN_1_RICH_GRANULE_LUMEN' 'GOCC_PLATELET_ALPHA_GRANULE'
'GOCC_PLATELET_ALPHA_GRANULE_LUMEN' 'GOCC_SECRETORY_GRANULE'
'GOCC_SECRETORY_VESICLE' 'GOCC_VESICLE_LUMEN' 'REACTOME_HEMOSTASIS'
'REACTOME_INNATE_IMMUNE_SYSTEM' 'REACTOME_NEUTROPHIL_DEGRANULATION'
'REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION'
'REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2']
|
[]
|
['GO:0002764 immune response-regulating signaling pathway']
|
['GO:0072562 blood microparticle', 'GO:0070062 extracellular exosome', 'GO:0005576 extracellular region', 'GO:0005615 extracellular space', 'GO:1904813 ficolin-1-rich granule lumen', 'GO:0005886 plasma membrane', 'GO:0031093 platelet alpha granule lumen', 'GO:0034774 secretory granule lumen']
|
[
"Secreted"
] |
A1CF
|
Q9NQ94
|
APOBEC1 complementation factor
|
Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay
|
['- IPR006535: HnRNP R/Q splicing factor (family) [3-594]', '- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [25-135]', '- IPR035979: RNA-binding domain superfamily (homologous_superfamily) [26-130]', '- IPR034538: ACF, RNA recognition motif 1 (domain) [55-132]', '- IPR000504: RNA recognition motif domain (domain) [56-134]', '- IPR000504: RNA recognition motif domain (domain) [57-130]', '- IPR000504: RNA recognition motif domain (domain) [58-125]', '- IPR000504: RNA recognition motif domain (domain) [136-218]', '- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [136-217]', '- IPR035979: RNA-binding domain superfamily (homologous_superfamily) [136-223]', '- IPR000504: RNA recognition motif domain (domain) [137-214]', '- IPR000504: RNA recognition motif domain (domain) [138-199]', '- IPR035979: RNA-binding domain superfamily (homologous_superfamily) [223-326]', '- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [230-304]', '- IPR000504: RNA recognition motif domain (domain) [231-303]', '- IPR000504: RNA recognition motif domain (domain) [232-299]', '- IPR000504: RNA recognition motif domain (domain) [233-296]', '- IPR044461: A1CF, double-stranded RNA binding domain (domain) [445-525]']
|
['C->U-editing enzyme APOBEC-1', 'Apolipoprotein B-100', 'DNA dC->dU-editing enzyme APOBEC-3F', 'DNA dC->dU-editing enzyme APOBEC-3G', 'Heterogeneous nuclear ribonucleoprotein Q', 'Putative C->U-editing enzyme APOBEC-4', 'C->U-editing enzyme APOBEC-2', 'DNA dC->dU-editing enzyme APOBEC-3H', 'DNA dC->dU-editing enzyme APOBEC-3A', 'Cytidine deaminase']
|
['GOBP_BASE_CONVERSION_OR_SUBSTITUTION_EDITING'
'GOBP_CHROMOSOMAL_5_METHYLCYTOSINE_DNA_DEMETHYLATION_PATHWAY'
'GOBP_CYTIDINE_TO_URIDINE_EDITING' 'GOBP_DNA_METABOLIC_PROCESS'
'GOBP_EMBRYO_IMPLANTATION' 'GOBP_INTRACELLULAR_MRNA_LOCALIZATION'
'GOBP_MACROMOLECULE_CATABOLIC_PROCESS' 'GOBP_MRNA_CATABOLIC_PROCESS'
'GOBP_MRNA_METABOLIC_PROCESS' 'GOBP_MRNA_MODIFICATION'
'GOBP_MRNA_PROCESSING' 'GOBP_MULTI_MULTICELLULAR_ORGANISM_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_CATABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_GENE_EXPRESSION'
'GOBP_NEGATIVE_REGULATION_OF_MRNA_CATABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY'
'GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_RNA_CATABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_RNA_METABOLIC_PROCESS'
'GOBP_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS'
'GOBP_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY'
'GOBP_NUCLEIC_ACID_CATABOLIC_PROCESS'
'GOBP_NUCLEOBASE_CONTAINING_COMPOUND_CATABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_GENE_EXPRESSION'
'GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION'
'GOBP_PROTEIN_STABILIZATION' 'GOBP_REGULATION_OF_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_MRNA_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_MRNA_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY'
'GOBP_REGULATION_OF_PROTEIN_STABILITY' 'GOBP_REPRODUCTIVE_PROCESS'
'GOBP_RNA_LOCALIZATION' 'GOBP_RNA_MODIFICATION' 'GOBP_RNA_PROCESSING'
'GOCC_APOLIPOPROTEIN_B_MRNA_EDITING_ENZYME_COMPLEX'
'GOCC_CATALYTIC_COMPLEX' 'GOCC_MRNA_EDITING_COMPLEX'
'GOCC_NUCLEAR_PROTEIN_CONTAINING_COMPLEX'
'GOMF_DOUBLE_STRANDED_RNA_BINDING'
'GOMF_ENZYME_SUBSTRATE_ADAPTOR_ACTIVITY'
'GOMF_MOLECULAR_ADAPTOR_ACTIVITY' 'GOMF_MRNA_BINDING'
'GOMF_SINGLE_STRANDED_RNA_BINDING' 'IL21_UP.V1_DN' 'IL2_UP.V1_DN'
'REACTOME_METABOLISM_OF_RNA' 'REACTOME_MRNA_EDITING'
'REACTOME_MRNA_EDITING_C_TO_U_CONVERSION']
|
['GO:0140767 enzyme-substrate adaptor activity', 'GO:0003729 mRNA binding', 'GO:0003727 single-stranded RNA binding']
|
['GO:0141166 chromosomal 5-methylcytosine DNA demethylation pathway', 'GO:0016554 cytidine to uridine editing', 'GO:0007566 embryo implantation', 'GO:0010609 mRNA localization resulting in post-transcriptional regulation of gene expression', 'GO:0016556 mRNA modification', 'GO:0006397 mRNA processing', 'GO:2000623 negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay', 'GO:0050821 protein stabilization']
|
['GO:0030895 apolipoprotein B mRNA editing enzyme complex', 'GO:0005737 cytoplasm', 'GO:0005783 endoplasmic reticulum', 'GO:0045293 mRNA editing complex', 'GO:0005654 nucleoplasm', 'GO:0005634 nucleus']
|
[
"Nucleus",
"Endoplasmic reticulum",
"Cytoplasm"
] |
A2M
|
P01023
|
Alpha-2-macroglobulin
|
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase
|
['- IPR010916: TonB box, conserved site (conserved_site) [1-63]', '- IPR050473: Alpha-2-macroglobulin/Complement system (family) [11-1472]', '- IPR002890: Macroglobulin domain (domain) [129-221]', '- IPR041555: Macroglobulin domain MG3 (domain) [223-312]', '- IPR040839: Macroglobulin domain MG4 (domain) [350-445]', '- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [352-433]', '- IPR011625: Alpha-2-macroglobulin, bait region domain (domain) [459-607]', '- IPR001599: Alpha-2-macroglobulin (domain) [738-828]', '- IPR014756: Immunoglobulin E-set (homologous_superfamily) [786-906]', '- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [789-906]', '- IPR011626: Alpha-macroglobulin-like, TED domain (domain) [948-1264]', '- IPR008930: Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid (homologous_superfamily) [958-1267]', '- IPR041813: Alpha-2-macroglobulin, TED domain (domain) [958-1264]', '- IPR047565: Alpha-macroglobulin-like, thiol-ester bond-forming region (conserved_site) [961-990]', '- IPR019742: Alpha-2-macroglobulin, conserved site (conserved_site) [969-977]', '- IPR036595: Alpha-macroglobulin, receptor-binding domain superfamily (homologous_superfamily) [1337-1474]', '- IPR036595: Alpha-macroglobulin, receptor-binding domain superfamily (homologous_superfamily) [1339-1472]', '- IPR009048: Alpha-macroglobulin, receptor-binding (domain) [1375-1464]', '- IPR009048: Alpha-macroglobulin, receptor-binding (domain) [1376-1463]']
|
['Truncated apolipoprotein A-I', 'Low-density lipoprotein receptor-related protein 1 intracellular domain', 'Haptoglobin alpha chain', 'Kallikrein-4', 'Interleukin-1 beta', 'Serum albumin', 'Short peptide from AAT', 'Apolipoprotein E', 'Endoplasmic reticulum chaperone BiP', 'Alpha-2-antiplasmin']
|
['ATF2_S_UP.V1_DN' 'BMI1_DN_MEL18_DN.V1_DN' 'CYCLIN_D1_KE_.V1_DN'
'EGFR_UP.V1_UP' 'GOBP_ACTIVATION_OF_IMMUNE_RESPONSE'
'GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS'
'GOBP_COMPLEMENT_ACTIVATION' 'GOBP_COMPLEMENT_ACTIVATION_LECTIN_PATHWAY'
'GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM'
'GOBP_DEFENSE_RESPONSE_TO_SYMBIONT' 'GOBP_HUMORAL_IMMUNE_RESPONSE'
'GOBP_IMMUNE_EFFECTOR_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_COMPLEMENT_ACTIVATION'
'GOBP_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE'
'GOBP_NEGATIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE'
'GOBP_NEGATIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_IMMUNE_RESPONSE'
'GOBP_NEGATIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE'
'GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS'
'GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS'
'GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS'
'GOBP_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE'
'GOBP_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS'
'GOBP_REGULATION_OF_COMPLEMENT_ACTIVATION'
'GOBP_REGULATION_OF_DEFENSE_RESPONSE'
'GOBP_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE'
'GOBP_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS'
'GOBP_REGULATION_OF_IMMUNE_RESPONSE'
'GOBP_REGULATION_OF_IMMUNE_SYSTEM_PROCESS'
'GOBP_REGULATION_OF_INNATE_IMMUNE_RESPONSE'
'GOBP_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS'
'GOBP_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS'
'GOBP_REGULATION_OF_RESPONSE_TO_STRESS' 'GOBP_STEM_CELL_DIFFERENTIATION'
'GOCC_BLOOD_MICROPARTICLE'
'GOCC_COLLAGEN_CONTAINING_EXTRACELLULAR_MATRIX'
'GOCC_EXTERNAL_ENCAPSULATING_STRUCTURE' 'GOCC_PLATELET_ALPHA_GRANULE'
'GOCC_PLATELET_ALPHA_GRANULE_LUMEN' 'GOCC_SECRETORY_GRANULE'
'GOCC_SECRETORY_VESICLE' 'GOCC_VESICLE_LUMEN'
'GOMF_CALCIUM_DEPENDENT_PROTEIN_BINDING' 'GOMF_CHEMOKINE_BINDING'
'GOMF_CYTOKINE_BINDING' 'GOMF_C_X_C_CHEMOKINE_BINDING'
'GOMF_ENDOPEPTIDASE_ACTIVITY' 'GOMF_ENDOPEPTIDASE_REGULATOR_ACTIVITY'
'GOMF_ENZYME_INHIBITOR_ACTIVITY' 'GOMF_ENZYME_REGULATOR_ACTIVITY'
'GOMF_GROWTH_FACTOR_BINDING' 'GOMF_INTERLEUKIN_1_BINDING'
'GOMF_MOLECULAR_FUNCTION_INHIBITOR_ACTIVITY' 'GOMF_PEPTIDASE_ACTIVITY'
'GOMF_PEPTIDASE_INHIBITOR_ACTIVITY' 'GOMF_PEPTIDASE_REGULATOR_ACTIVITY'
'GOMF_PROTEASE_BINDING' 'GOMF_SERINE_HYDROLASE_ACTIVITY'
'GOMF_SERINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY'
'GOMF_SIGNALING_RECEPTOR_BINDING' 'GOMF_TUMOR_NECROSIS_FACTOR_BINDING'
'HALLMARK_COAGULATION' 'HALLMARK_IL6_JAK_STAT3_SIGNALING'
'KEGG_COMPLEMENT_AND_COAGULATION_CASCADES' 'KRAS.300_UP.V1_UP'
'KRAS.50_UP.V1_UP' 'KRAS.600.LUNG.BREAST_UP.V1_UP' 'KRAS.600_UP.V1_UP'
'KRAS.BREAST_UP.V1_UP' 'KRAS.KIDNEY_UP.V1_UP' 'KRAS.LUNG.BREAST_UP.V1_UP'
'MEL18_DN.V1_DN' 'PID_IL6_7_PATHWAY'
'REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX'
'REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION'
'REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE'
'REACTOME_HDL_ASSEMBLY' 'REACTOME_HEMOSTASIS'
'REACTOME_INTRINSIC_PATHWAY_OF_FIBRIN_CLOT_FORMATION'
'REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY'
'REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY_REMODELING_AND_CLEARANCE'
'REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION'
'REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES' 'STK33_NOMO_UP']
|
['GO:0048306 calcium-dependent protein binding', 'GO:0004866 endopeptidase inhibitor activity', 'GO:0019899 enzyme binding', 'GO:0019838 growth factor binding', 'GO:0019966 interleukin-1 binding', 'GO:0019959 interleukin-8 binding', 'GO:0002020 protease binding', 'GO:0004867 serine-type endopeptidase inhibitor activity', 'GO:0005102 signaling receptor binding', 'GO:0043120 tumor necrosis factor binding']
|
['GO:0001869 negative regulation of complement activation, lectin pathway', 'GO:0048863 stem cell differentiation']
|
['GO:0072562 blood microparticle', 'GO:0070062 extracellular exosome', 'GO:0031012 extracellular matrix', 'GO:0005576 extracellular region', 'GO:0005615 extracellular space', 'GO:0031093 platelet alpha granule lumen']
|
[
"Secreted"
] |
A2ML1
|
A8K2U0
|
Alpha-2-macroglobulin-like protein 1
|
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases
|
['- IPR050473: Alpha-2-macroglobulin/Complement system (family) [5-1454]', '- IPR002890: Macroglobulin domain (domain) [122-201]', '- IPR041555: Macroglobulin domain MG3 (domain) [213-302]', '- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [341-428]', '- IPR040839: Macroglobulin domain MG4 (domain) [342-439]', '- IPR011625: Alpha-2-macroglobulin, bait region domain (domain) [453-601]', '- IPR011625: Alpha-2-macroglobulin, bait region domain (domain) [459-601]', '- IPR001599: Alpha-2-macroglobulin (domain) [736-825]', '- IPR001599: Alpha-2-macroglobulin (domain) [736-826]', '- IPR014756: Immunoglobulin E-set (homologous_superfamily) [784-904]', '- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [787-904]', '- IPR011626: Alpha-macroglobulin-like, TED domain (domain) [946-1251]', '- IPR008930: Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid (homologous_superfamily) [955-1253]', '- IPR041813: Alpha-2-macroglobulin, TED domain (domain) [956-1251]', '- IPR047565: Alpha-macroglobulin-like, thiol-ester bond-forming region (conserved_site) [959-988]', '- IPR019742: Alpha-2-macroglobulin, conserved site (conserved_site) [967-975]', '- IPR036595: Alpha-macroglobulin, receptor-binding domain superfamily (homologous_superfamily) [1324-1454]', '- IPR036595: Alpha-macroglobulin, receptor-binding domain superfamily (homologous_superfamily) [1325-1453]', '- IPR009048: Alpha-macroglobulin, receptor-binding (domain) [1361-1450]', '- IPR009048: Alpha-macroglobulin, receptor-binding (domain) [1362-1449]']
|
['Kallikrein-7', 'Chymotrypsinogen B2', 'Chymotrypsinogen B1', 'Kallikrein-6', 'Periplakin', 'Envoplakin']
|
['GOBP_PROTEOLYSIS' 'GOBP_REGULATION_OF_CATALYTIC_ACTIVITY'
'GOBP_REGULATION_OF_ENDOPEPTIDASE_ACTIVITY'
'GOBP_REGULATION_OF_HYDROLASE_ACTIVITY'
'GOBP_REGULATION_OF_MOLECULAR_FUNCTION'
'GOBP_REGULATION_OF_PEPTIDASE_ACTIVITY'
'GOBP_REGULATION_OF_PROTEIN_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_PROTEOLYSIS' 'GOMF_ENDOPEPTIDASE_ACTIVITY'
'GOMF_ENDOPEPTIDASE_REGULATOR_ACTIVITY' 'GOMF_ENZYME_INHIBITOR_ACTIVITY'
'GOMF_ENZYME_REGULATOR_ACTIVITY'
'GOMF_MOLECULAR_FUNCTION_INHIBITOR_ACTIVITY' 'GOMF_PEPTIDASE_ACTIVITY'
'GOMF_PEPTIDASE_INHIBITOR_ACTIVITY' 'GOMF_PEPTIDASE_REGULATOR_ACTIVITY'
'GOMF_SERINE_HYDROLASE_ACTIVITY'
'GOMF_SERINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY']
|
['GO:0030414 peptidase inhibitor activity', 'GO:0004867 serine-type endopeptidase inhibitor activity']
|
['GO:0052548 regulation of endopeptidase activity']
|
['GO:0070062 extracellular exosome', 'GO:0005615 extracellular space']
|
[
"Secreted"
] |
A3GALT2
|
U3KPV4
|
Alpha-1,3-galactosyltransferase 2
|
Synthesizes the galactose-alpha(1,3)-galactose group on the glycosphingolipid isoglobotrihexosylceramide or isogloboside 3 (iGb3) by catalyzing the transfer of galactose from UDP-Galactose to its acceptor molecule Gal-beta-1,4-Glc-ceramide. Can also catalyze the addition of galactose to iGb3 itself to form polygalactose structures
|
['- IPR005076: Glycosyl transferase, family 6 (family) [14-340]', '- IPR029044: Nucleotide-diphospho-sugar transferases (homologous_superfamily) [49-340]', '- IPR029044: Nucleotide-diphospho-sugar transferases (homologous_superfamily) [59-331]', '- IPR005076: Glycosyl transferase, family 6 (family) [66-340]']
|
['UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1', 'Beta-1,4-galactosyltransferase 6', 'Beta-galactosidase']
|
['GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS'
'GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS'
'GOBP_CARBOHYDRATE_METABOLIC_PROCESS'
'GOBP_GLYCOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_GLYCOSPHINGOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_GLYCOSPHINGOLIPID_METABOLIC_PROCESS' 'GOBP_GLYCOSYLATION'
'GOBP_LIPID_BIOSYNTHETIC_PROCESS' 'GOBP_LIPID_GLYCOSYLATION'
'GOBP_LIPID_METABOLIC_PROCESS' 'GOBP_LIPID_MODIFICATION'
'GOBP_LIPOSACCHARIDE_METABOLIC_PROCESS'
'GOBP_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_MEMBRANE_LIPID_METABOLIC_PROCESS'
'GOBP_SPHINGOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_SPHINGOLIPID_METABOLIC_PROCESS' 'GOCC_GOLGI_APPARATUS'
'GOCC_GOLGI_APPARATUS_SUBCOMPARTMENT' 'GOCC_GOLGI_CISTERNA'
'GOCC_GOLGI_CISTERNA_MEMBRANE' 'GOCC_GOLGI_STACK'
'GOCC_ORGANELLE_SUBCOMPARTMENT' 'GOMF_GALACTOSYLTRANSFERASE_ACTIVITY'
'GOMF_GLYCOSYLTRANSFERASE_ACTIVITY' 'GOMF_HEXOSYLTRANSFERASE_ACTIVITY'
'GOMF_UDP_GLYCOSYLTRANSFERASE_ACTIVITY'
'WP_GANGLIO_SPHINGOLIPID_METABOLISM' 'WP_GLYCOSPHINGOLIPID_METABOLISM'
'WP_SYNTHESIS_OF_CERAMIDES_AND_1DEOXYCERAMIDES']
|
['GO:0016757 glycosyltransferase activity', 'GO:0046872 metal ion binding', 'GO:0047276 N-acetyllactosaminide 3-alpha-galactosyltransferase activity']
|
['GO:0005975 carbohydrate metabolic process', 'GO:0006688 glycosphingolipid biosynthetic process']
|
['GO:0005794 Golgi apparatus', 'GO:0032580 Golgi cisterna membrane', 'GO:0031982 vesicle']
|
[
"Golgi apparatus, Golgi stack membrane"
] |
A4GALT
|
Q9NPC4
|
Lactosylceramide 4-alpha-galactosyltransferase
|
Glycosyltransferase involved in biosynthesis of P1, P(k) and the rare NOR antigens of P1PK histo-blood group system (PubMed:10747952, PubMed:10748143, PubMed:22965229, PubMed:26773500, PubMed:29572228, PubMed:33460651). Catalyzes the transfer of galactose from UDP-alpha-D-galactose in an alpha1,4 linkage to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)), also known as P(k) antigen or CD77 (PubMed:10748143, PubMed:10747952, PubMed:26773500, PubMed:29572228, PubMed:22965229). Globoside Gb3Cer/P(k)/CD77 is a root structure in biosynthesis pathway of neutral glycosphingolipids of the globo-series. Broadly expressed in cell membranes of immune cells and other tissues, Gb3Cer/P(k)/CD77 antigen may participate in mechanisms that regulate cell-cell interactions and cell differentiation. In germinal center B cells, Gb3Cer/CD77 interacts with CD19 to drive centroblast-to-centrocyte transition, B cell receptor complex assembly and T follicular helper cell differentiation. In epithelium, Gb3Cer regulates CDH1/E-cadherin-dependent cell-cell adhesion counteracting epithelial-to-mesenchymal transition (By similarity) (PubMed:29572228). Synthesizes P1 glycan epitope (alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-GlcNAc-R) by transferring a galactose moiety to paragloboside nLc4 or to complex-type N-glycans (PubMed:26773500, PubMed:29572228, PubMed:33460651). Generates the rare NOR1 and NOR2 antigens which carry a Gal(alpha1->4)GalNAc terminal moiety and are both derived from Gb4Cer precursor (PubMed:22965229, PubMed:26773500, PubMed:33460651). Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer (PubMed:10748143)
|
['- IPR029044: Nucleotide-diphospho-sugar transferases (homologous_superfamily) [25-351]', '- IPR051981: Alpha-1,4-N-acetylglucosaminyltransferase (family) [68-351]', '- IPR007577: Glycosyltransferase, DXD sugar-binding motif (conserved_site) [94-212]', '- IPR007652: Alpha 1,4-glycosyltransferase domain (domain) [222-348]']
|
['UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1', 'Galactosidase alpha', 'Processed beta-1,4-galactosyltransferase 1', 'Beta-1,4-galactosyltransferase 6', 'Beta-1,4-galactosyltransferase 4', 'Beta-1,4-galactosyltransferase 2', 'Beta-1,4-galactosyltransferase 3', 'Beta-hexosaminidase subunit alpha', 'Beta-hexosaminidase subunit beta chain A', 'Beta-1,3-galactosyltransferase 4']
|
['AKT_UP_MTOR_DN.V1_UP' 'E2F1_UP.V1_DN' 'ESC_J1_UP_EARLY.V1_UP'
'GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS'
'GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS'
'GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION'
'GOBP_GLYCOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_GLYCOSPHINGOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_GLYCOSPHINGOLIPID_METABOLIC_PROCESS'
'GOBP_LIPID_BIOSYNTHETIC_PROCESS' 'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_LIPOSACCHARIDE_METABOLIC_PROCESS'
'GOBP_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_MEMBRANE_LIPID_METABOLIC_PROCESS' 'GOBP_MEMBRANE_ORGANIZATION'
'GOBP_PLASMA_MEMBRANE_ORGANIZATION'
'GOBP_SPHINGOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_SPHINGOLIPID_METABOLIC_PROCESS' 'GOCC_GOLGI_APPARATUS'
'GOCC_GOLGI_MEMBRANE' 'GOMF_GALACTOSYLTRANSFERASE_ACTIVITY'
'GOMF_GLYCOSYLTRANSFERASE_ACTIVITY' 'GOMF_HEXOSYLTRANSFERASE_ACTIVITY'
'GOMF_TOXIC_SUBSTANCE_BINDING' 'GOMF_UDP_GLYCOSYLTRANSFERASE_ACTIVITY'
'KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES'
'REACTOME_GLYCOSPHINGOLIPID_BIOSYNTHESIS'
'REACTOME_GLYCOSPHINGOLIPID_METABOLISM' 'REACTOME_METABOLISM_OF_LIPIDS'
'REACTOME_SPHINGOLIPID_METABOLISM' 'WNT_UP.V1_UP'
'WP_GLYCOSPHINGOLIPID_METABOLISM'
'WP_SYNTHESIS_OF_CERAMIDES_AND_1DEOXYCERAMIDES']
|
['GO:0008378 galactosyltransferase activity', 'GO:0050512 lactosylceramide 4-alpha-galactosyltransferase activity', 'GO:0015643 toxic substance binding']
|
['GO:0001576 globoside biosynthetic process', 'GO:0006688 glycosphingolipid biosynthetic process', 'GO:0007009 plasma membrane organization']
|
['GO:0000139 Golgi membrane', 'GO:0016020 membrane']
|
[
"Golgi apparatus membrane"
] |
A4GNT
|
Q9UNA3
|
Alpha-1,4-N-acetylglucosaminyltransferase
|
Catalyzes the transfer of N-acetylglucosamine (GlcNAc) residues from UDP-N-acetyl-alpha-D-glucosamine donnors to beta (1->4)-linked or beta-(1->3)-linked galactose residues on O-glycans like core 2 branched O-glycans (PubMed:10430883). Necessary for the synthesis of type III mucin which is specifically produced in the stomach, duodenum, and pancreatic duct (PubMed:10430883). May protect against inflammation-associated gastric adenocarcinomas (By similarity)
|
['- IPR051981: Alpha-1,4-N-acetylglucosaminyltransferase (family) [1-325]', '- IPR029044: Nucleotide-diphospho-sugar transferases (homologous_superfamily) [38-321]', '- IPR007577: Glycosyltransferase, DXD sugar-binding motif (conserved_site) [64-179]', '- IPR007652: Alpha 1,4-glycosyltransferase domain (domain) [197-321]']
|
['Mucin-6', 'Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4']
|
['GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS'
'GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS'
'GOBP_CARBOHYDRATE_METABOLIC_PROCESS'
'GOBP_EPITHELIAL_CELL_PROLIFERATION'
'GOBP_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS'
'GOBP_GLYCOPROTEIN_METABOLIC_PROCESS' 'GOBP_GLYCOSYLATION'
'GOBP_NEGATIVE_REGULATION_OF_CELL_POPULATION_PROLIFERATION'
'GOBP_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION'
'GOBP_O_GLYCAN_PROCESSING' 'GOBP_PROTEIN_O_LINKED_GLYCOSYLATION'
'GOBP_REGULATION_OF_CELL_POPULATION_PROLIFERATION'
'GOBP_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION' 'GOCC_GOLGI_APPARATUS'
'GOCC_GOLGI_MEMBRANE' 'GOMF_ACETYLGLUCOSAMINYLTRANSFERASE_ACTIVITY'
'GOMF_GLYCOSYLTRANSFERASE_ACTIVITY' 'GOMF_HEXOSYLTRANSFERASE_ACTIVITY'
'GOMF_UDP_GLYCOSYLTRANSFERASE_ACTIVITY' 'IL21_UP.V1_DN' 'IL2_UP.V1_DN'
'REACTOME_O_LINKED_GLYCOSYLATION'
'REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS'
'REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION']
|
['GO:0008375 acetylglucosaminyltransferase activity']
|
['GO:0005975 carbohydrate metabolic process', 'GO:0050673 epithelial cell proliferation', 'GO:0009101 glycoprotein biosynthetic process', 'GO:0050680 negative regulation of epithelial cell proliferation', 'GO:0006493 protein O-linked glycosylation', 'GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine']
|
['GO:0000139 Golgi membrane', 'GO:0016020 membrane']
|
[
"Golgi apparatus membrane"
] |
AAAS
|
Q9NRG9
|
Aladin
|
Plays a role in the normal development of the peripheral and central nervous system (PubMed:11062474, PubMed:11159947, PubMed:16022285). Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment (PubMed:26246606)
|
['- IPR045139: Aladin (family) [1-545]', '- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [99-281]', '- IPR001680: WD40 repeat (repeat) [136-179]', '- IPR057403: Aladin, seven-bladed propeller (domain) [136-485]', '- IPR001680: WD40 repeat (repeat) [181-221]', '- IPR001680: WD40 repeat (repeat) [232-273]', '- IPR001680: WD40 repeat (repeat) [247-282]', '- IPR019775: WD40 repeat, conserved site (conserved_site) [260-274]', '- IPR001680: WD40 repeat (repeat) [278-315]', '- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [285-491]']
|
['E3 SUMO-protein ligase RanBP2', 'Nuclear pore complex protein Nup88', 'Nucleoporin NDC1', 'Nucleoporin SEH1', 'Nuclear pore complex protein Nup214', 'Nuclear pore complex protein Nup155', 'Nucleoporin NUP35', 'Nuclear pore complex protein Nup205', 'Nuclear pore complex protein Nup85', 'Nuclear pore complex protein Nup93']
|
['CAMP_UP.V1_UP' 'GOBP_AMIDE_METABOLIC_PROCESS' 'GOBP_BEHAVIOR'
'GOBP_CELL_CYCLE' 'GOBP_CELL_CYCLE_PROCESS'
'GOBP_CHROMOSOME_ORGANIZATION' 'GOBP_CHROMOSOME_SEGREGATION'
'GOBP_COGNITION' 'GOBP_CYTOSKELETON_ORGANIZATION'
'GOBP_DEVELOPMENTAL_GROWTH' 'GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION'
'GOBP_ESTABLISHMENT_OF_RNA_LOCALIZATION' 'GOBP_FERTILIZATION'
'GOBP_GLUTATHIONE_METABOLIC_PROCESS' 'GOBP_GROWTH'
'GOBP_INTRACELLULAR_TRANSPORT' 'GOBP_LEARNING'
'GOBP_MEMBRANELESS_ORGANELLE_ASSEMBLY' 'GOBP_MICROTUBULE_BASED_PROCESS'
'GOBP_MICROTUBULE_BUNDLE_FORMATION'
'GOBP_MICROTUBULE_CYTOSKELETON_ORGANIZATION'
'GOBP_MICROTUBULE_CYTOSKELETON_ORGANIZATION_INVOLVED_IN_MITOSIS'
'GOBP_MITOTIC_CELL_CYCLE' 'GOBP_MITOTIC_CELL_CYCLE_PROCESS'
'GOBP_MITOTIC_NUCLEAR_DIVISION'
'GOBP_MITOTIC_SISTER_CHROMATID_SEGREGATION'
'GOBP_MITOTIC_SPINDLE_ASSEMBLY' 'GOBP_MITOTIC_SPINDLE_ORGANIZATION'
'GOBP_MODIFIED_AMINO_ACID_METABOLIC_PROCESS' 'GOBP_MRNA_TRANSPORT'
'GOBP_MULTICELLULAR_ORGANISM_GROWTH' 'GOBP_NERVOUS_SYSTEM_PROCESS'
'GOBP_NITROGEN_COMPOUND_TRANSPORT' 'GOBP_NUCLEAR_CHROMOSOME_SEGREGATION'
'GOBP_NUCLEAR_TRANSPORT' 'GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT'
'GOBP_ORGANELLE_ASSEMBLY' 'GOBP_ORGANELLE_FISSION'
'GOBP_PROTEIN_TRANSPORT' 'GOBP_REGULATION_OF_CELLULAR_LOCALIZATION'
'GOBP_REGULATION_OF_INTRACELLULAR_TRANSPORT'
'GOBP_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT'
'GOBP_REGULATION_OF_TRANSPORT' 'GOBP_REPRODUCTIVE_PROCESS'
'GOBP_RESPONSE_TO_OXIDATIVE_STRESS' 'GOBP_RNA_LOCALIZATION'
'GOBP_SEXUAL_REPRODUCTION' 'GOBP_SISTER_CHROMATID_SEGREGATION'
'GOBP_SPINDLE_ASSEMBLY' 'GOBP_SPINDLE_ORGANIZATION'
'GOBP_SULFUR_COMPOUND_METABOLIC_PROCESS' 'GOCC_CENTROSOME'
'GOCC_MICROTUBULE_CYTOSKELETON' 'GOCC_MICROTUBULE_ORGANIZING_CENTER'
'GOCC_MITOTIC_SPINDLE' 'GOCC_NUCLEAR_ENVELOPE' 'GOCC_NUCLEAR_MEMBRANE'
'GOCC_NUCLEAR_PORE' 'GOCC_NUCLEAR_PROTEIN_CONTAINING_COMPLEX'
'GOCC_ORGANELLE_ENVELOPE' 'GOCC_SPINDLE' 'GOCC_SPINDLE_POLE'
'HALLMARK_DNA_REPAIR' 'KRAS.600.LUNG.BREAST_UP.V1_DN' 'RB_DN.V1_UP'
'REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES'
'REACTOME_CELLULAR_RESPONSES_TO_STIMULI'
'REACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS' 'REACTOME_CELL_CYCLE'
'REACTOME_CELL_CYCLE_MITOTIC'
'REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM'
'REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS'
'REACTOME_EXPORT_OF_VIRAL_RIBONUCLEOPROTEINS_FROM_NUCLEUS'
'REACTOME_GENE_SILENCING_BY_RNA' 'REACTOME_GLUCOSE_METABOLISM'
'REACTOME_HCMV_EARLY_EVENTS' 'REACTOME_HCMV_INFECTION'
'REACTOME_HCMV_LATE_EVENTS' 'REACTOME_HIV_INFECTION'
'REACTOME_HIV_LIFE_CYCLE' 'REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS'
'REACTOME_INFECTIOUS_DISEASE' 'REACTOME_INFLUENZA_INFECTION'
'REACTOME_INTERACTIONS_OF_REV_WITH_HOST_CELLULAR_PROTEINS'
'REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS'
'REACTOME_INTERFERON_SIGNALING' 'REACTOME_ISG15_ANTIVIRAL_MECHANISM'
'REACTOME_METABOLISM_OF_CARBOHYDRATES_AND_CARBOHYDRATE_DERIVATIVES'
'REACTOME_METABOLISM_OF_RNA' 'REACTOME_MITOTIC_PROPHASE'
'REACTOME_M_PHASE' 'REACTOME_NS1_MEDIATED_EFFECTS_ON_HOST_PATHWAYS'
'REACTOME_NUCLEAR_ENVELOPE_BREAKDOWN'
'REACTOME_NUCLEAR_IMPORT_OF_REV_PROTEIN'
'REACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY'
'REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION'
'REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA'
'REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN'
'REACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE'
'REACTOME_RHOA_GTPASE_CYCLE' 'REACTOME_RHO_GTPASE_CYCLE'
'REACTOME_SARS_COV_2_ACTIVATES_MODULATES_INNATE_AND_ADAPTIVE_IMMUNE_RESPONSES'
'REACTOME_SARS_COV_2_HOST_INTERACTIONS' 'REACTOME_SARS_COV_2_INFECTION'
'REACTOME_SARS_COV_INFECTIONS'
'REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3'
'REACTOME_SLC_TRANSPORTER_DISORDERS' 'REACTOME_SNRNP_ASSEMBLY'
'REACTOME_SUMOYLATION'
'REACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS'
'REACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS'
'REACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS'
'REACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS'
'REACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS'
'REACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS'
'REACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS'
'REACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS'
'REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM'
'REACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA'
'REACTOME_TRNA_PROCESSING' 'REACTOME_TRNA_PROCESSING_IN_THE_NUCLEUS'
'REACTOME_VIRAL_INFECTION_PATHWAYS'
'REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS' 'SRC_UP.V1_UP'
'WP_PRADERWILLI_AND_ANGELMAN_SYNDROME']
|
[]
|
['GO:0009566 fertilization', 'GO:0006749 glutathione metabolic process', 'GO:0007612 learning', 'GO:0001578 microtubule bundle formation', 'GO:0090307 mitotic spindle assembly', 'GO:0051028 mRNA transport', 'GO:0035264 multicellular organism growth', 'GO:0006913 nucleocytoplasmic transport', 'GO:0015031 protein transport', 'GO:0046822 regulation of nucleocytoplasmic transport', 'GO:0006979 response to oxidative stress']
|
['GO:0005813 centrosome', 'GO:0005829 cytosol', 'GO:0016020 membrane', 'GO:0072686 mitotic spindle', 'GO:0005635 nuclear envelope', 'GO:0031965 nuclear membrane', 'GO:0005643 nuclear pore', 'GO:0005654 nucleoplasm', 'GO:0005634 nucleus', 'GO:0097229 sperm end piece', 'GO:0000922 spindle pole']
|
[
"Nucleus, nuclear pore complex",
"Cytoplasm, cytoskeleton, spindle pole",
"Nucleus envelope"
] |
AACS
|
Q86V21
|
Acetoacetyl-CoA synthetase
|
Converts acetoacetate to acetoacetyl-CoA in the cytosol (By similarity). Ketone body-utilizing enzyme, responsible for the synthesis of cholesterol and fatty acids (By similarity)
|
['- IPR005914: Acetoacetyl-CoA synthase (family) [16-670]', '- IPR042099: ANL, N-terminal domain (homologous_superfamily) [25-541]', '- IPR032387: Acetyl-coenzyme A synthetase, N-terminal domain (domain) [47-104]', '- IPR000873: AMP-dependent synthetase/ligase domain (domain) [110-488]', '- IPR020845: AMP-binding, conserved site (conserved_site) [287-298]', '- IPR045851: AMP-binding enzyme domain superfamily (homologous_superfamily) [543-664]']
|
['Hydroxymethylglutaryl-CoA lyase, mitochondrial', 'Acetyl-CoA acetyltransferase, mitochondrial', 'Hydroxymethylglutaryl-CoA synthase, cytoplasmic', 'Acetyl-CoA acetyltransferase, cytosolic', 'Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial', 'Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase', 'Hydroxymethylglutaryl-CoA synthase, mitochondrial', '3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic', 'Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial', '3-hydroxybutyrate dehydrogenase type 2']
|
['GOBP_AMIDE_TRANSPORT' 'GOBP_CELL_CELL_SIGNALING'
'GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION' 'GOBP_EXPORT_FROM_CELL'
'GOBP_FATTY_ACID_DERIVATIVE_BIOSYNTHETIC_PROCESS'
'GOBP_FATTY_ACID_DERIVATIVE_METABOLIC_PROCESS'
'GOBP_FATTY_ACID_METABOLIC_PROCESS'
'GOBP_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY'
'GOBP_HORMONE_TRANSPORT' 'GOBP_INSULIN_SECRETION'
'GOBP_KETONE_BODY_BIOSYNTHETIC_PROCESS'
'GOBP_KETONE_BODY_METABOLIC_PROCESS' 'GOBP_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS'
'GOBP_NITROGEN_COMPOUND_TRANSPORT' 'GOBP_ORGANIC_ACID_METABOLIC_PROCESS'
'GOBP_PEPTIDE_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_HORMONE_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_INSULIN_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_PEPTIDE_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_SIGNALING'
'GOBP_POSITIVE_REGULATION_OF_TRANSPORT'
'GOBP_PROTEIN_LOCALIZATION_TO_EXTRACELLULAR_REGION'
'GOBP_PROTEIN_TRANSPORT' 'GOBP_REGULATION_OF_CELLULAR_LOCALIZATION'
'GOBP_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION'
'GOBP_REGULATION_OF_HORMONE_LEVELS'
'GOBP_REGULATION_OF_HORMONE_SECRETION'
'GOBP_REGULATION_OF_INSULIN_SECRETION'
'GOBP_REGULATION_OF_PEPTIDE_TRANSPORT'
'GOBP_REGULATION_OF_PROTEIN_SECRETION'
'GOBP_REGULATION_OF_PROTEIN_TRANSPORT' 'GOBP_REGULATION_OF_SECRETION'
'GOBP_REGULATION_OF_TRANSPORT' 'GOBP_SECRETION' 'GOBP_SIGNAL_RELEASE'
'GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS' 'GOMF_ACID_THIOL_LIGASE_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING' 'GOMF_COA_LIGASE_ACTIVITY'
'GOMF_LIGASE_ACTIVITY' 'GOMF_LIGASE_ACTIVITY_FORMING_CARBON_SULFUR_BONDS'
'KEGG_BUTANOATE_METABOLISM' 'REACTOME_KETONE_BODY_METABOLISM'
'REACTOME_METABOLISM_OF_LIPIDS' 'REACTOME_SYNTHESIS_OF_KETONE_BODIES']
|
['GO:0030729 acetoacetate-CoA ligase activity', 'GO:0005524 ATP binding']
|
['GO:0006631 fatty acid metabolic process', 'GO:0046951 ketone body biosynthetic process', 'GO:0032024 positive regulation of insulin secretion']
|
['GO:0005829 cytosol']
|
[
"Cytoplasm, cytosol"
] |
AADAC
|
P22760
|
Arylacetamide deacetylase
|
Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity
|
['- IPR017157: Arylacetamide deacetylase (family) [4-399]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [63-399]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [69-399]', '- IPR050300: GDXG lipolytic enzyme (family) [71-397]', '- IPR013094: Alpha/beta hydrolase fold-3 (domain) [107-265]', '- IPR033140: Lipase, GDXG, putative serine active site (active_site) [183-195]', '- IPR013094: Alpha/beta hydrolase fold-3 (domain) [315-376]']
|
['Arylamine N-acetyltransferase 2', 'Arylamine N-acetyltransferase 1']
|
['ATF2_S_UP.V1_DN' 'ATF2_UP.V1_DN'
'GOBP_CELLULAR_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_GLYCEROLIPID_CATABOLIC_PROCESS'
'GOBP_GLYCEROLIPID_METABOLIC_PROCESS' 'GOBP_LIPID_CATABOLIC_PROCESS'
'GOBP_LIPID_METABOLIC_PROCESS' 'GOBP_NEUTRAL_LIPID_CATABOLIC_PROCESS'
'GOBP_NEUTRAL_LIPID_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_TRIGLYCERIDE_CATABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_TRIGLYCERIDE_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS'
'GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_TRIGLYCERIDE_CATABOLIC_PROCESS'
'GOBP_TRIGLYCERIDE_METABOLIC_PROCESS' 'GOBP_XENOBIOTIC_METABOLIC_PROCESS'
'GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK'
'GOCC_ORGANELLE_SUBCOMPARTMENT'
'GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY' 'GOMF_DEACETYLASE_ACTIVITY'
'GOMF_DEACYLASE_ACTIVITY' 'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS'
'GOMF_LIPASE_ACTIVITY' 'GOMF_SERINE_HYDROLASE_ACTIVITY'
'GOMF_TRIACYLGLYCEROL_LIPASE_ACTIVITY' 'KRAS.KIDNEY_UP.V1_DN'
'REACTOME_BIOLOGICAL_OXIDATIONS'
'REACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS' 'SRC_UP.V1_UP']
|
['GO:0003824 catalytic activity', 'GO:0019213 deacetylase activity', 'GO:0016298 lipase activity', 'GO:0017171 serine hydrolase activity', 'GO:0004806 triacylglycerol lipase activity']
|
['GO:0006629 lipid metabolic process', 'GO:0010898 positive regulation of triglyceride catabolic process', 'GO:0006805 xenobiotic metabolic process']
|
['GO:0005789 endoplasmic reticulum membrane']
|
[
"Endoplasmic reticulum membrane",
"Microsome membrane"
] |
AADACL2
|
Q6P093
|
Arylacetamide deacetylase-like 2
| null |
['- IPR017157: Arylacetamide deacetylase (family) [3-401]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [58-398]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [71-401]', '- IPR050300: GDXG lipolytic enzyme (family) [73-400]', '- IPR013094: Alpha/beta hydrolase fold-3 (domain) [107-258]', '- IPR033140: Lipase, GDXG, putative serine active site (active_site) [183-195]', '- IPR013094: Alpha/beta hydrolase fold-3 (domain) [311-373]']
|
[]
|
['GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS']
|
['GO:0052689 carboxylic ester hydrolase activity']
|
[]
|
['GO:0005576 extracellular region', 'GO:0016020 membrane']
|
[
"Secreted"
] |
AADACL3
|
Q5VUY0
|
Arylacetamide deacetylase-like 3
| null |
['- IPR017157: Arylacetamide deacetylase (family) [19-403]', '- IPR050300: GDXG lipolytic enzyme (family) [74-385]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [75-405]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [78-406]', '- IPR013094: Alpha/beta hydrolase fold-3 (domain) [115-245]', '- IPR013094: Alpha/beta hydrolase fold-3 (domain) [310-380]']
|
['Hypothetical protein.']
|
['GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS']
|
['GO:0052689 carboxylic ester hydrolase activity']
|
[]
|
['GO:0016020 membrane']
|
[] |
AADACL4
|
Q5VUY2
|
Arylacetamide deacetylase-like 4
| null |
['- IPR017157: Arylacetamide deacetylase (family) [21-404]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [75-394]', '- IPR050300: GDXG lipolytic enzyme (family) [79-402]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [89-404]', '- IPR013094: Alpha/beta hydrolase fold-3 (domain) [115-268]', '- IPR013094: Alpha/beta hydrolase fold-3 (domain) [310-378]']
|
[]
|
['GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS']
|
['GO:0052689 carboxylic ester hydrolase activity']
|
[]
|
['GO:0016020 membrane']
|
[
"Membrane"
] |
AADAT
|
Q8N5Z0
|
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
|
Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro)
|
['- IPR015421: Pyridoxal phosphate-dependent transferase, major domain (homologous_superfamily) [1-425]', '- IPR050859: Class-I pyridoxal-phosphate-dependent aminotransferase-like (family) [1-424]', '- IPR015424: Pyridoxal phosphate-dependent transferase (homologous_superfamily) [6-423]', '- IPR004839: Aminotransferase, class I/classII, large domain (domain) [65-416]']
|
['Kynurenine--oxoglutarate transaminase 1', 'Kynurenine 3-monooxygenase', 'Kynureninase', 'Kynurenine--oxoglutarate transaminase 3', 'Kynurenine formamidase', 'Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial', 'Alpha-aminoadipic semialdehyde dehydrogenase', 'Dihydrolipoyl dehydrogenase, mitochondrial', '2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase)', 'Branched-chain-amino-acid aminotransferase, mitochondrial']
|
['GOBP_2_OXOGLUTARATE_METABOLIC_PROCESS'
'GOBP_ACETYL_COA_METABOLIC_PROCESS' 'GOBP_ACYL_COA_METABOLIC_PROCESS'
'GOBP_ALPHA_AMINO_ACID_METABOLIC_PROCESS' 'GOBP_AMIDE_CATABOLIC_PROCESS'
'GOBP_AMIDE_METABOLIC_PROCESS' 'GOBP_AMINO_ACID_CATABOLIC_PROCESS'
'GOBP_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_ASPARTATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS'
'GOBP_ASPARTATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_BENZENE_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_DICARBOXYLIC_ACID_METABOLIC_PROCESS'
'GOBP_GLUTAMATE_METABOLIC_PROCESS'
'GOBP_GLUTAMINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_KETONE_METABOLIC_PROCESS' 'GOBP_KYNURENINE_METABOLIC_PROCESS'
'GOBP_LYSINE_METABOLIC_PROCESS' 'GOBP_L_AMINO_ACID_CATABOLIC_PROCESS'
'GOBP_NON_PROTEINOGENIC_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_CATABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_METABOLIC_PROCESS'
'GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS'
'GOBP_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_PROTEINOGENIC_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_SULFUR_COMPOUND_METABOLIC_PROCESS' 'GOCC_MITOCHONDRIAL_MATRIX'
'GOCC_MITOCHONDRION' 'GOMF_PROTEIN_DIMERIZATION_ACTIVITY'
'GOMF_PROTEIN_HOMODIMERIZATION_ACTIVITY' 'GOMF_TRANSAMINASE_ACTIVITY'
'GOMF_TRANSFERASE_ACTIVITY_TRANSFERRING_NITROGENOUS_GROUPS'
'GOMF_VITAMIN_B6_BINDING' 'GOMF_VITAMIN_BINDING'
'HALLMARK_FATTY_ACID_METABOLISM' 'KEGG_LYSINE_DEGRADATION'
'KEGG_TRYPTOPHAN_METABOLISM' 'REACTOME_LYSINE_CATABOLISM'
'REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES'
'REACTOME_TRYPTOPHAN_CATABOLISM' 'WP_ADHD_AND_AUTISM_ASD_PATHWAYS'
'WP_IDO_METABOLIC_PATHWAY'
'WP_KYNURENINE_PATHWAY_AND_LINKS_TO_CELL_SENESCENCE'
'WP_METABOLIC_EPILEPTIC_DISORDERS'
'WP_TRYPTOPHAN_CATABOLISM_LEADING_TO_NAD_PRODUCTION'
'WP_TRYPTOPHAN_METABOLISM']
|
['GO:0047536 2-aminoadipate transaminase activity', 'GO:0047958 glycine:2-oxoglutarate aminotransferase activity', 'GO:0047315 kynurenine-glyoxylate transaminase activity', 'GO:0016212 kynurenine-oxoglutarate transaminase activity', 'GO:0050094 methionine-glyoxylate transaminase activity', 'GO:0042803 protein homodimerization activity', 'GO:0030170 pyridoxal phosphate binding']
|
['GO:0006103 2-oxoglutarate metabolic process', 'GO:1901605 alpha-amino acid metabolic process', 'GO:0006536 glutamate metabolic process', 'GO:0070189 kynurenine metabolic process', 'GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine']
|
['GO:0005759 mitochondrial matrix', 'GO:0005739 mitochondrion']
|
[
"Mitochondrion"
] |
AAGAB
|
Q6PD74
|
Alpha- and gamma-adaptin-binding protein p34
|
May be involved in endocytic recycling of growth factor receptors such as EGFR
|
['- IPR019341: Alpha/gamma-adaptin-binding protein p34 (family) [1-308]']
|
['AP-2 complex subunit sigma', 'AP-1 complex subunit sigma-3', 'AP-1 complex subunit gamma-1', 'AP-2 complex subunit alpha-2', 'Coiled-coil domain containing 32.', 'Keratin, type I cytoskeletal 9']
|
['GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION'
'GOBP_NITROGEN_COMPOUND_TRANSPORT' 'GOBP_PROTEIN_TRANSPORT'
'GOCC_NUCLEAR_BODY' 'GOCC_NUCLEAR_SPECK' 'PDGF_ERK_DN.V1_UP']
|
[]
|
['GO:0015031 protein transport']
|
['GO:0005737 cytoplasm', 'GO:0005829 cytosol', 'GO:0016607 nuclear speck']
|
[
"Cytoplasm, cytosol"
] |
AAK1
|
Q2M2I8
|
AP2-associated protein kinase 1
|
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:17494869, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124)
|
['- IPR051744: AP2-associated Ser/Thr protein kinase (family) [1-941]', '- IPR000719: Protein kinase domain (domain) [46-313]', '- IPR000719: Protein kinase domain (domain) [46-315]', '- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [46-309]', '- IPR000719: Protein kinase domain (domain) [48-307]', '- IPR008271: Serine/threonine-protein kinase, active site (active_site) [172-184]']
|
['AP-2 complex subunit mu', 'RalBP1-associated Eps domain-containing protein 1', 'Epidermal growth factor receptor substrate 15', 'AP-2 complex subunit beta', 'AP-2 complex subunit sigma', 'SH3-containing GRB2-like protein 3-interacting protein 1', 'RalA-binding protein 1', 'Adaptin ear-binding coat-associated protein 2', 'Clathrin coat assembly protein AP180', 'Clathrin light chain B']
|
['GOBP_CLATHRIN_DEPENDENT_ENDOCYTOSIS' 'GOBP_ENDOCYTOSIS'
'GOBP_IMPORT_INTO_CELL' 'GOBP_MEMBRANE_ORGANIZATION'
'GOBP_NOTCH_SIGNALING_PATHWAY' 'GOBP_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_PHOSPHORYLATION'
'GOBP_POSITIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY'
'GOBP_POSITIVE_REGULATION_OF_SIGNALING' 'GOBP_PRESYNAPTIC_ENDOCYTOSIS'
'GOBP_PROTEIN_STABILIZATION' 'GOBP_RECEPTOR_MEDIATED_ENDOCYTOSIS'
'GOBP_REGULATION_OF_CELLULAR_LOCALIZATION'
'GOBP_REGULATION_OF_CLATHRIN_DEPENDENT_ENDOCYTOSIS'
'GOBP_REGULATION_OF_ENDOCYTOSIS'
'GOBP_REGULATION_OF_NOTCH_SIGNALING_PATHWAY'
'GOBP_REGULATION_OF_PROTEIN_STABILITY'
'GOBP_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS'
'GOBP_REGULATION_OF_TRANSPORT'
'GOBP_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT'
'GOBP_VESICLE_MEDIATED_TRANSPORT'
'GOBP_VESICLE_MEDIATED_TRANSPORT_IN_SYNAPSE' 'GOCC_AXON'
'GOCC_CELL_LEADING_EDGE' 'GOCC_CLATHRIN_COATED_PIT'
'GOCC_CLATHRIN_COATED_VESICLE' 'GOCC_COATED_VESICLE' 'GOCC_DISTAL_AXON'
'GOCC_NEURON_PROJECTION' 'GOCC_NEURON_PROJECTION_TERMINUS'
'GOCC_PRESYNAPSE' 'GOCC_SYNAPSE' 'GOCC_TERMINAL_BOUTON'
'GOMF_ADENYL_NUCLEOTIDE_BINDING' 'GOMF_AP_2_ADAPTOR_COMPLEX_BINDING'
'GOMF_KINASE_ACTIVITY' 'GOMF_NOTCH_BINDING'
'GOMF_PROTEIN_CONTAINING_COMPLEX_BINDING' 'GOMF_PROTEIN_KINASE_ACTIVITY'
'GOMF_PROTEIN_SERINE_KINASE_ACTIVITY'
'GOMF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY'
'GOMF_SIGNALING_RECEPTOR_BINDING'
'GOMF_TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS'
'RAF_UP.V1_UP'
'REACTOME_CARGO_RECOGNITION_FOR_CLATHRIN_MEDIATED_ENDOCYTOSIS'
'REACTOME_CLATHRIN_MEDIATED_ENDOCYTOSIS' 'REACTOME_MEMBRANE_TRAFFICKING'
'REACTOME_VESICLE_MEDIATED_TRANSPORT'
'WP_FATTY_ACID_AND_LIPOPROTEIN_TRANSPORT_IN_HEPATOCYTES']
|
['GO:0035612 AP-2 adaptor complex binding', 'GO:0005524 ATP binding', 'GO:0005112 Notch binding', 'GO:0106310 protein serine kinase activity', 'GO:0004674 protein serine/threonine kinase activity']
|
['GO:0061024 membrane organization', 'GO:0045747 positive regulation of Notch signaling pathway', 'GO:0140238 presynaptic endocytosis', 'GO:0006468 protein phosphorylation', 'GO:0050821 protein stabilization', 'GO:2000369 regulation of clathrin-dependent endocytosis', 'GO:0032880 regulation of protein localization']
|
['GO:0031252 cell leading edge', 'GO:0005905 clathrin-coated pit', 'GO:0030136 clathrin-coated vesicle', 'GO:0005829 cytosol', 'GO:0005886 plasma membrane', 'GO:0098793 presynapse', 'GO:0043195 terminal bouton']
|
[
"Cell membrane",
"Membrane, clathrin-coated pit",
"Presynapse"
] |
AAMDC
|
Q9H7C9
|
Mth938 domain-containing protein
|
May play a role in preadipocyte differentiation and adipogenesis
|
['- IPR036748: MTH938-like superfamily (homologous_superfamily) [1-122]', '- IPR036748: MTH938-like superfamily (homologous_superfamily) [3-122]', '- IPR034096: Mth938 domain-containing protein (family) [5-120]', '- IPR007523: NDUFAF3/Mth938 domain-containing protein (family) [6-119]']
|
[]
|
['GOBP_APOPTOTIC_PROCESS' 'GOBP_FAT_CELL_DIFFERENTIATION'
'GOBP_NEGATIVE_REGULATION_OF_PROGRAMMED_CELL_DEATH'
'GOBP_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION'
'GOBP_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION'
'GOBP_POSITIVE_REGULATION_OF_RNA_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II'
'GOBP_REGULATION_OF_CELL_DIFFERENTIATION'
'GOBP_REGULATION_OF_FAT_CELL_DIFFERENTIATION'
'GOBP_REGULATION_OF_PROGRAMMED_CELL_DEATH']
|
[]
|
['GO:0043066 negative regulation of apoptotic process', 'GO:0045600 positive regulation of fat cell differentiation', 'GO:0045944 positive regulation of transcription by RNA polymerase II', 'GO:0006366 transcription by RNA polymerase II']
|
['GO:0005737 cytoplasm']
|
[
"Cytoplasm"
] |
AAMP
|
Q13685
|
Angio-associated migratory cell protein
|
Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway
|
['- IPR051179: Multifunctional WD repeat-containing protein (family) [21-430]', '- IPR001680: WD40 repeat (repeat) [80-120]', '- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [80-431]', '- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [85-429]', '- IPR001680: WD40 repeat (repeat) [86-119]', '- IPR001680: WD40 repeat (repeat) [87-129]', '- IPR001680: WD40 repeat (repeat) [123-162]', '- IPR001680: WD40 repeat (repeat) [125-161]', '- IPR001680: WD40 repeat (repeat) [130-171]', '- IPR001680: WD40 repeat (repeat) [165-202]', '- IPR001680: WD40 repeat (repeat) [204-243]', '- IPR001680: WD40 repeat (repeat) [209-243]', '- IPR001680: WD40 repeat (repeat) [225-252]', '- IPR001680: WD40 repeat (repeat) [246-288]', '- IPR001680: WD40 repeat (repeat) [256-297]', '- IPR056551: Nucleolar protein 10-like, N-terminal domain (domain) [263-428]', '- IPR001680: WD40 repeat (repeat) [291-345]', '- IPR001680: WD40 repeat (repeat) [348-386]', '- IPR001680: WD40 repeat (repeat) [354-395]', '- IPR019775: WD40 repeat, conserved site (conserved_site) [373-387]', '- IPR001680: WD40 repeat (repeat) [389-428]', '- IPR001680: WD40 repeat (repeat) [396-434]']
|
['60S ribosomal protein L10', 'Nucleotide-binding oligomerization domain-containing protein 2', 'Epidermal growth factor receptor', 'Thromboxane A2 receptor', '60S ribosomal protein L10-like', 'Glutamate-rich WD repeat-containing protein 1', 'Apoptosis-enhancing nuclease', 'mRNA turnover protein 4 homolog', '60S ribosomal export protein NMD3', 'Transducin beta like 3.']
|
['GOBP_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS'
'GOBP_BLOOD_VESSEL_MORPHOGENESIS' 'GOBP_CELL_MOTILITY'
'GOBP_CIRCULATORY_SYSTEM_DEVELOPMENT' 'GOBP_ENDOTHELIAL_CELL_MIGRATION'
'GOBP_LOCOMOTION' 'GOBP_MUSCLE_CELL_MIGRATION'
'GOBP_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION'
'GOBP_POSITIVE_REGULATION_OF_LOCOMOTION'
'GOBP_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION'
'GOBP_REGULATION_OF_LOCOMOTION' 'GOBP_SMOOTH_MUSCLE_CELL_MIGRATION'
'GOBP_TUBE_DEVELOPMENT' 'GOBP_TUBE_MORPHOGENESIS'
'GOBP_VASCULATURE_DEVELOPMENT' 'GOCC_CELL_SURFACE'
'GOCC_INTERCELLULAR_BRIDGE' 'GOCC_MICROTUBULE_CYTOSKELETON'
'GOMF_GLYCOSAMINOGLYCAN_BINDING' 'GOMF_HEPARIN_BINDING'
'GOMF_SULFUR_COMPOUND_BINDING' 'REACTOME_HEMOSTASIS'
'REACTOME_INNATE_IMMUNE_SYSTEM' 'REACTOME_NOD1_2_SIGNALING_PATHWAY'
'REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS'
'REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION'
'REACTOME_SIGNALING_BY_EGFR'
'REACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES'
'REACTOME_SIGNALING_BY_VEGF' 'REACTOME_SIGNAL_AMPLIFICATION'
'REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR'
'WP_NUCLEOTIDEBINDING_OLIGOMERIZATION_DOMAIN_NOD_PATHWAY']
|
['GO:0008201 heparin binding']
|
['GO:0001525 angiogenesis', 'GO:0030154 cell differentiation', 'GO:0010595 positive regulation of endothelial cell migration', 'GO:0014909 smooth muscle cell migration']
|
['GO:0009986 cell surface', 'GO:0005829 cytosol', 'GO:0045171 intercellular bridge', 'GO:0015630 microtubule cytoskeleton', 'GO:0005886 plasma membrane']
|
[
"Cell membrane",
"Cytoplasm"
] |
AANAT
|
Q16613
|
Serotonin N-acetyltransferase
|
Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin
|
['- IPR051635: Serotonin N-acetyltransferase-like (family) [1-207]', '- IPR016181: Acyl-CoA N-acyltransferase (homologous_superfamily) [32-179]', '- IPR000182: GNAT domain (domain) [35-194]', '- IPR000182: GNAT domain (domain) [49-173]']
|
['Acetylserotonin O-methyltransferase', '14-3-3 protein zeta/delta', 'Aromatic-L-amino-acid decarboxylase', 'Amine oxidase [flavin-containing] A', 'Amine oxidase [flavin-containing] B', 'Indoleamine 2,3-dioxygenase 2', 'Indoleamine 2,3-dioxygenase 1', 'Indolethylamine N-methyltransferase', 'Melanopsin', 'Glycine N-acyltransferase-like protein 1']
|
['GOBP_AMIDE_BIOSYNTHETIC_PROCESS' 'GOBP_AMIDE_METABOLIC_PROCESS'
'GOBP_AMINE_BIOSYNTHETIC_PROCESS' 'GOBP_AMINE_METABOLIC_PROCESS'
'GOBP_CELLULAR_RESPONSE_TO_CAMP'
'GOBP_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND'
'GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND'
'GOBP_CIRCADIAN_RHYTHM' 'GOBP_HORMONE_BIOSYNTHETIC_PROCESS'
'GOBP_HORMONE_METABOLIC_PROCESS' 'GOBP_INDOLALKYLAMINE_METABOLIC_PROCESS'
'GOBP_INDOLE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS'
'GOBP_INDOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_N_TERMINAL_PROTEIN_AMINO_ACID_ACETYLATION'
'GOBP_N_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION' 'GOBP_PHOTOPERIODISM'
'GOBP_PROTEIN_ACETYLATION' 'GOBP_PROTEIN_ACYLATION'
'GOBP_PROTEIN_MATURATION' 'GOBP_REGULATION_OF_HORMONE_LEVELS'
'GOBP_RESPONSE_TO_ABIOTIC_STIMULUS' 'GOBP_RESPONSE_TO_ALCOHOL'
'GOBP_RESPONSE_TO_CALCIUM_ION' 'GOBP_RESPONSE_TO_CAMP'
'GOBP_RESPONSE_TO_COPPER_ION' 'GOBP_RESPONSE_TO_CORTICOSTEROID'
'GOBP_RESPONSE_TO_CORTICOSTERONE' 'GOBP_RESPONSE_TO_ENDOGENOUS_STIMULUS'
'GOBP_RESPONSE_TO_HORMONE' 'GOBP_RESPONSE_TO_INSULIN'
'GOBP_RESPONSE_TO_KETONE' 'GOBP_RESPONSE_TO_LIGHT_STIMULUS'
'GOBP_RESPONSE_TO_LIPID' 'GOBP_RESPONSE_TO_METAL_ION'
'GOBP_RESPONSE_TO_MINERALOCORTICOID' 'GOBP_RESPONSE_TO_NITROGEN_COMPOUND'
'GOBP_RESPONSE_TO_ORGANOPHOSPHORUS'
'GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND' 'GOBP_RESPONSE_TO_PEPTIDE'
'GOBP_RESPONSE_TO_PEPTIDE_HORMONE' 'GOBP_RESPONSE_TO_PROSTAGLANDIN'
'GOBP_RESPONSE_TO_PROSTAGLANDIN_E'
'GOBP_RESPONSE_TO_PURINE_CONTAINING_COMPOUND'
'GOBP_RESPONSE_TO_RADIATION' 'GOBP_RESPONSE_TO_STEROID_HORMONE'
'GOBP_RESPONSE_TO_ZINC_ION' 'GOBP_RHYTHMIC_PROCESS'
'GOCC_PERINUCLEAR_REGION_OF_CYTOPLASM' 'GOMF_14_3_3_PROTEIN_BINDING'
'GOMF_ACETYLTRANSFERASE_ACTIVITY' 'GOMF_ACYLTRANSFERASE_ACTIVITY'
'GOMF_ACYLTRANSFERASE_ACTIVITY_TRANSFERRING_GROUPS_OTHER_THAN_AMINO_ACYL_GROUPS'
'GOMF_N_ACETYLTRANSFERASE_ACTIVITY' 'GOMF_N_ACYLTRANSFERASE_ACTIVITY'
'KEGG_TRYPTOPHAN_METABOLISM' 'PRC1_BMI_UP.V1_DN'
'REACTOME_METABOLISM_OF_AMINE_DERIVED_HORMONES'
'REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES'
'REACTOME_SEROTONIN_AND_MELATONIN_BIOSYNTHESIS'
'WP_ADHD_AND_AUTISM_ASD_PATHWAYS' 'WP_BIOGENIC_AMINE_SYNTHESIS'
'WP_BIOSYNTHESIS_AND_REGENERATION_OF_TETRAHYDROBIOPTERIN_AND_CATABOLISM_OF_PHENYLALANINE'
'WP_CIRCADIAN_RHYTHM_GENES' 'WP_MELATONIN_METABOLISM_AND_EFFECTS'
'WP_TRYPTOPHAN_METABOLISM']
|
['GO:0071889 14-3-3 protein binding', 'GO:0004059 aralkylamine N-acetyltransferase activity', 'GO:0004060 arylamine N-acetyltransferase activity']
|
['GO:0071320 cellular response to cAMP', 'GO:0007623 circadian rhythm', 'GO:0046219 indolalkylamine biosynthetic process', 'GO:0030187 melatonin biosynthetic process', 'GO:0006474 N-terminal protein amino acid acetylation', 'GO:0009648 photoperiodism', 'GO:0051592 response to calcium ion', 'GO:0046688 response to copper ion', 'GO:0051412 response to corticosterone', 'GO:0034097 response to cytokine', 'GO:0032868 response to insulin', 'GO:0009416 response to light stimulus', 'GO:0034695 response to prostaglandin E', 'GO:0010043 response to zinc ion']
|
['GO:0005737 cytoplasm', 'GO:0005829 cytosol', 'GO:0048471 perinuclear region of cytoplasm']
|
[
"Cytoplasm"
] |
AAR2
|
Q9Y312
|
Protein AAR2 homolog
|
Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing
|
['- IPR007946: A1 cistron-splicing factor, AAR2 (family) [4-380]', '- IPR033647: AAR2, N-terminal (domain) [17-150]', '- IPR033647: AAR2, N-terminal (domain) [19-148]', '- IPR038516: AAR2, N-terminal domain superfamily (homologous_superfamily) [19-161]', '- IPR038514: AAR2, C-terminal domain superfamily (homologous_superfamily) [192-377]', '- IPR033648: AAR2, C-terminal domain (domain) [205-359]', '- IPR033648: AAR2, C-terminal domain (domain) [208-363]']
|
['Pre-mRNA-processing-splicing factor 8', 'U5 small nuclear ribonucleoprotein 200 kDa helicase', '116 kDa U5 small nuclear ribonucleoprotein component', 'Probable ATP-dependent RNA helicase DDX23', 'U5 small nuclear ribonucleoprotein 40 kDa protein', 'CD2 antigen cytoplasmic tail-binding protein 2', 'Protein ecdysoneless homolog', 'Pre-mRNA-processing factor 6', 'Zinc finger HIT domain-containing protein 2', 'Protein TSSC4']
|
['GOBP_MRNA_METABOLIC_PROCESS' 'GOBP_MRNA_PROCESSING'
'GOBP_PROTEIN_CONTAINING_COMPLEX_ORGANIZATION'
'GOBP_PROTEIN_RNA_COMPLEX_ORGANIZATION'
'GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS' 'GOBP_RNA_PROCESSING'
'GOBP_RNA_SPLICING' 'GOBP_RNA_SPLICING_VIA_TRANSESTERIFICATION_REACTIONS'
'GOBP_SPLICEOSOMAL_SNRNP_ASSEMBLY'
'GOBP_SPLICEOSOMAL_TRI_SNRNP_COMPLEX_ASSEMBLY'
'GOCC_NUCLEAR_PROTEIN_CONTAINING_COMPLEX'
'GOCC_RIBONUCLEOPROTEIN_COMPLEX'
'GOCC_SMALL_NUCLEAR_RIBONUCLEOPROTEIN_COMPLEX'
'GOCC_SM_LIKE_PROTEIN_FAMILY_COMPLEX' 'GOCC_SPLICEOSOMAL_COMPLEX'
'GOCC_U5_SNRNP' 'WP_CILIARY_LANDSCAPE']
|
[]
|
['GO:0000244 spliceosomal tri-snRNP complex assembly']
|
['GO:0005681 spliceosomal complex', 'GO:0005682 U5 snRNP']
|
[] |
AARD
|
Q4LEZ3
|
Alanine- and arginine-rich domain-containing protein
| null |
['- IPR051771: FAM167 domain-containing protein (family) [85-151]']
|
[]
|
['GCNP_SHH_UP_LATE.V1_UP' 'GOBP_RESPONSE_TO_KETONE'
'GOBP_RESPONSE_TO_LIPID' 'GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND'
'GOBP_RESPONSE_TO_TESTOSTERONE' 'WNT_UP.V1_DN']
|
[]
|
['GO:0033574 response to testosterone']
|
[]
|
[] |
AARS1
|
P49588
|
Alanine--tRNA ligase, cytoplasmic
|
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:27622773, PubMed:27911835, PubMed:28493438, PubMed:33909043). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:27622773, PubMed:27911835, PubMed:28493438, PubMed:29273753). In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as TEAD1, TP53/p53 and YAP1 (PubMed:38512451, PubMed:38653238). Protein lactylation takes place in a two-step reaction: lactate is first activated by ATP to form lactate-AMP and then transferred to lysine residues of target proteins (PubMed:38512451, PubMed:38653238, PubMed:39322678). Acts as an inhibitor of TP53/p53 activity by catalyzing lactylation of TP53/p53 (PubMed:38653238). Acts as a positive regulator of the Hippo pathway by mediating lactylation of TEAD1 and YAP1 (PubMed:38512451)
|
['- IPR023033: Alanine-tRNA ligase, eukaryota/bacteria (family) [1-963]', '- IPR045864: Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) (homologous_superfamily) [4-255]', '- IPR050058: Alanine--tRNA ligase (family) [4-960]', '- IPR018165: Alanyl-tRNA synthetase, class IIc, core domain (domain) [5-766]', '- IPR045864: Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) (homologous_superfamily) [6-258]', '- IPR002318: Alanine-tRNA ligase, class IIc (family) [9-941]', '- IPR018164: Alanyl-tRNA synthetase, class IIc, N-terminal (domain) [9-596]', '- IPR002318: Alanine-tRNA ligase, class IIc (family) [83-94]', '- IPR002318: Alanine-tRNA ligase, class IIc (family) [212-223]', '- IPR002318: Alanine-tRNA ligase, class IIc (family) [239-252]', '- IPR018162: Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily (homologous_superfamily) [259-458]', '- IPR002318: Alanine-tRNA ligase, class IIc (family) [296-312]', '- IPR002318: Alanine-tRNA ligase, class IIc (family) [320-333]', '- IPR009000: Translation protein, beta-barrel domain superfamily (homologous_superfamily) [515-593]', '- IPR018163: Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily (homologous_superfamily) [597-760]', '- IPR012947: Threonyl/alanyl tRNA synthetase, SAD (domain) [694-752]', '- IPR012947: Threonyl/alanyl tRNA synthetase, SAD (domain) [694-753]', '- IPR003156: DHHA1 domain (domain) [855-959]']
|
['Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed', 'Lysine--tRNA ligase', 'Glycine--tRNA ligase', 'Isoleucine--tRNA ligase, cytoplasmic', 'Bifunctional glutamate/proline--tRNA ligase', 'Leucine--tRNA ligase, cytoplasmic', 'Glutamine--tRNA ligase', 'Threonine--tRNA ligase 2, cytoplasmic', 'Asparagine--tRNA ligase, cytoplasmic', 'Isoleucine--tRNA ligase, mitochondrial']
|
['CAMP_UP.V1_UP'
'GOBP_AMINOACYL_TRNA_METABOLISM_INVOLVED_IN_TRANSLATIONAL_FIDELITY'
'GOBP_AMINO_ACID_ACTIVATION' 'GOBP_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_APOPTOTIC_PROCESS' 'GOBP_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT'
'GOBP_CEREBELLAR_CORTEX_DEVELOPMENT'
'GOBP_CEREBELLAR_PURKINJE_CELL_LAYER_DEVELOPMENT'
'GOBP_CYTOPLASMIC_TRANSLATION'
'GOBP_CYTOPLASMIC_TRANSLATIONAL_ELONGATION' 'GOBP_HEAD_DEVELOPMENT'
'GOBP_HINDBRAIN_DEVELOPMENT' 'GOBP_HIPPO_SIGNALING'
'GOBP_METENCEPHALON_DEVELOPMENT'
'GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION'
'GOBP_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_PROGRAMMED_CELL_DEATH'
'GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS'
'GOBP_NEGATIVE_REGULATION_OF_SIGNALING'
'GOBP_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR'
'GOBP_NERVOUS_SYSTEM_PROCESS' 'GOBP_NEUROMUSCULAR_PROCESS'
'GOBP_NEUROMUSCULAR_PROCESS_CONTROLLING_BALANCE'
'GOBP_NEURON_APOPTOTIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_HIPPO_SIGNALING'
'GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION'
'GOBP_POSITIVE_REGULATION_OF_SIGNALING'
'GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION'
'GOBP_REGULATION_OF_HIPPO_SIGNALING'
'GOBP_REGULATION_OF_NEURON_APOPTOTIC_PROCESS'
'GOBP_REGULATION_OF_PROGRAMMED_CELL_DEATH'
'GOBP_REGULATION_OF_PROTEIN_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR'
'GOBP_REGULATION_OF_TRANSLATION'
'GOBP_REGULATION_OF_TRANSLATIONAL_ELONGATION'
'GOBP_REGULATION_OF_TRANSLATIONAL_FIDELITY' 'GOBP_RNA_MODIFICATION'
'GOBP_RNA_PROCESSING' 'GOBP_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR'
'GOBP_TRANSLATION' 'GOBP_TRANSLATIONAL_ELONGATION'
'GOBP_TRNA_METABOLIC_PROCESS' 'GOBP_TRNA_MODIFICATION'
'GOBP_TRNA_PROCESSING' 'GOCC_MITOCHONDRION'
'GOMF_ADENYL_NUCLEOTIDE_BINDING' 'GOMF_AMINOACYL_TRNA_DEACYLASE_ACTIVITY'
'GOMF_AMINO_ACID_BINDING'
'GOMF_CATALYTIC_ACTIVITY_ACTING_ON_A_NUCLEIC_ACID'
'GOMF_CATALYTIC_ACTIVITY_ACTING_ON_A_TRNA'
'GOMF_CATALYTIC_ACTIVITY_ACTING_ON_RNA' 'GOMF_LIGASE_ACTIVITY'
'GOMF_LIGASE_ACTIVITY_FORMING_CARBON_OXYGEN_BONDS'
'GOMF_LIGASE_ACTIVITY_FORMING_PHOSPHORIC_ESTER_BONDS' 'GOMF_TRNA_BINDING'
'HALLMARK_ALLOGRAFT_REJECTION' 'KEGG_AMINOACYL_TRNA_BIOSYNTHESIS'
'RB_P107_DN.V1_DN' 'REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION'
'REACTOME_TRANSLATION' 'REACTOME_TRNA_AMINOACYLATION' 'WP_IL18_SIGNALING']
|
['GO:0004813 alanine-tRNA ligase activity', 'GO:0016597 amino acid binding', 'GO:0002161 aminoacyl-tRNA deacylase activity', 'GO:0005524 ATP binding', 'GO:0141207 peptide lactyltransferase (ATP-dependent) activity', 'GO:0002196 Ser-tRNA(Ala) deacylase activity', 'GO:0000049 tRNA binding', 'GO:0008270 zinc ion binding']
|
['GO:0006419 alanyl-tRNA aminoacylation', 'GO:0021680 cerebellar Purkinje cell layer development', 'GO:0043524 negative regulation of neuron apoptotic process', 'GO:1901797 negative regulation of signal transduction by p53 class mediator', 'GO:0050885 neuromuscular process controlling balance', 'GO:0051402 neuron apoptotic process', 'GO:0035332 positive regulation of hippo signaling', 'GO:0140018 regulation of cytoplasmic translational fidelity', 'GO:0006418 tRNA aminoacylation for protein translation', 'GO:0006400 tRNA modification', 'GO:0008033 tRNA processing']
|
['GO:0005737 cytoplasm', 'GO:0005829 cytosol', 'GO:0070062 extracellular exosome', 'GO:0016020 membrane', 'GO:0005634 nucleus']
|
[
"Cytoplasm",
"Nucleus"
] |
AARS2
|
Q5JTZ9
|
Alanine--tRNA ligase, mitochondrial
|
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:21549344). In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as CGAS (PubMed:39322678). Acts as an inhibitor of cGAS/STING signaling by catalyzing lactylation of CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:39322678)
|
['- IPR050058: Alanine--tRNA ligase (family) [34-981]', '- IPR018165: Alanyl-tRNA synthetase, class IIc, core domain (domain) [37-792]', '- IPR045864: Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) (homologous_superfamily) [37-281]', '- IPR023033: Alanine-tRNA ligase, eukaryota/bacteria (family) [38-985]', '- IPR045864: Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) (homologous_superfamily) [39-284]', '- IPR002318: Alanine-tRNA ligase, class IIc (family) [42-965]', '- IPR018164: Alanyl-tRNA synthetase, class IIc, N-terminal (domain) [42-623]', '- IPR002318: Alanine-tRNA ligase, class IIc (family) [116-127]', '- IPR002318: Alanine-tRNA ligase, class IIc (family) [238-249]', '- IPR002318: Alanine-tRNA ligase, class IIc (family) [265-278]', '- IPR018162: Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily (homologous_superfamily) [285-493]', '- IPR002318: Alanine-tRNA ligase, class IIc (family) [322-338]', '- IPR002318: Alanine-tRNA ligase, class IIc (family) [346-359]', '- IPR009000: Translation protein, beta-barrel domain superfamily (homologous_superfamily) [545-620]', '- IPR018163: Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily (homologous_superfamily) [620-796]', '- IPR012947: Threonyl/alanyl tRNA synthetase, SAD (domain) [721-778]', '- IPR012947: Threonyl/alanyl tRNA synthetase, SAD (domain) [721-779]']
|
['Aspartate--tRNA ligase, mitochondrial', 'Valine--tRNA ligase, mitochondrial', 'Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed', 'Probable glutamate--tRNA ligase, mitochondrial', 'Probable leucine--tRNA ligase, mitochondrial', 'Isoleucine--tRNA ligase, mitochondrial', 'Valine--tRNA ligase', 'Threonine--tRNA ligase, mitochondrial', 'Alanine--tRNA ligase, cytoplasmic', 'Probable arginine--tRNA ligase, mitochondrial']
|
['GOBP_ACTIVATION_OF_IMMUNE_RESPONSE'
'GOBP_ACTIVATION_OF_INNATE_IMMUNE_RESPONSE'
'GOBP_AMINOACYL_TRNA_METABOLISM_INVOLVED_IN_TRANSLATIONAL_FIDELITY'
'GOBP_AMINO_ACID_ACTIVATION' 'GOBP_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS'
'GOBP_CGAS_STING_SIGNALING_PATHWAY'
'GOBP_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM'
'GOBP_DEFENSE_RESPONSE_TO_SYMBIONT'
'GOBP_IMMUNE_RESPONSE_REGULATING_SIGNALING_PATHWAY'
'GOBP_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_MITOCHONDRIAL_GENE_EXPRESSION'
'GOBP_MITOCHONDRIAL_RNA_METABOLIC_PROCESS'
'GOBP_MITOCHONDRIAL_TRANSLATION'
'GOBP_NEGATIVE_REGULATION_OF_CGAS_STING_SIGNALING_PATHWAY'
'GOBP_NEGATIVE_REGULATION_OF_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_NEGATIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION'
'GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS'
'GOBP_NEGATIVE_REGULATION_OF_SIGNALING'
'GOBP_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE'
'GOBP_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE'
'GOBP_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS'
'GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS'
'GOBP_REGULATION_OF_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_REGULATION_OF_DEFENSE_RESPONSE'
'GOBP_REGULATION_OF_IMMUNE_RESPONSE'
'GOBP_REGULATION_OF_IMMUNE_SYSTEM_PROCESS'
'GOBP_REGULATION_OF_INNATE_IMMUNE_RESPONSE'
'GOBP_REGULATION_OF_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS'
'GOBP_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS'
'GOBP_REGULATION_OF_RESPONSE_TO_STRESS'
'GOBP_REGULATION_OF_TRANSLATIONAL_FIDELITY' 'GOBP_TRANSLATION'
'GOBP_TRNA_AMINOACYLATION_FOR_MITOCHONDRIAL_PROTEIN_TRANSLATION'
'GOBP_TRNA_METABOLIC_PROCESS' 'GOCC_MITOCHONDRION'
'GOMF_ADENYL_NUCLEOTIDE_BINDING' 'GOMF_AMINOACYL_TRNA_DEACYLASE_ACTIVITY'
'GOMF_CATALYTIC_ACTIVITY_ACTING_ON_A_NUCLEIC_ACID'
'GOMF_CATALYTIC_ACTIVITY_ACTING_ON_A_TRNA'
'GOMF_CATALYTIC_ACTIVITY_ACTING_ON_RNA' 'GOMF_LIGASE_ACTIVITY'
'GOMF_LIGASE_ACTIVITY_FORMING_CARBON_OXYGEN_BONDS'
'GOMF_LIGASE_ACTIVITY_FORMING_PHOSPHORIC_ESTER_BONDS' 'GOMF_TRNA_BINDING'
'KEGG_AMINOACYL_TRNA_BIOSYNTHESIS'
'REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION' 'REACTOME_TRANSLATION'
'REACTOME_TRNA_AMINOACYLATION' 'WP_PRIMARY_OVARIAN_INSUFFICIENCY']
|
['GO:0004813 alanine-tRNA ligase activity', 'GO:0002161 aminoacyl-tRNA deacylase activity', 'GO:0005524 ATP binding', 'GO:0141207 peptide lactyltransferase (ATP-dependent) activity', 'GO:0000049 tRNA binding', 'GO:0008270 zinc ion binding']
|
['GO:0070143 mitochondrial alanyl-tRNA aminoacylation', 'GO:0160049 negative regulation of cGAS/STING signaling pathway']
|
['GO:0005739 mitochondrion']
|
[
"Mitochondrion"
] |
AARSD1
|
Q9BTE6
|
Alanyl-tRNA editing protein Aarsd1
|
Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala)
|
['- IPR009000: Translation protein, beta-barrel domain superfamily (homologous_superfamily) [2-95]', '- IPR051335: Alanyl-tRNA Editing Enzymes (family) [2-242]', '- IPR018165: Alanyl-tRNA synthetase, class IIc, core domain (domain) [43-252]', '- IPR018163: Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily (homologous_superfamily) [98-242]', '- IPR012947: Threonyl/alanyl tRNA synthetase, SAD (domain) [196-238]', '- IPR012947: Threonyl/alanyl tRNA synthetase, SAD (domain) [196-239]']
|
['Alanine--tRNA ligase, cytoplasmic', 'Putative protein PTGES3L', 'Lysine--tRNA ligase']
|
['GOBP_AMINOACYL_TRNA_METABOLISM_INVOLVED_IN_TRANSLATIONAL_FIDELITY'
'GOBP_AMINO_ACID_ACTIVATION' 'GOBP_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_TRANSLATIONAL_FIDELITY' 'GOBP_TRANSLATION'
'GOBP_TRNA_METABOLIC_PROCESS' 'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_AMINOACYL_TRNA_DEACYLASE_ACTIVITY'
'GOMF_CATALYTIC_ACTIVITY_ACTING_ON_A_NUCLEIC_ACID'
'GOMF_CATALYTIC_ACTIVITY_ACTING_ON_A_TRNA'
'GOMF_CATALYTIC_ACTIVITY_ACTING_ON_RNA' 'GOMF_LIGASE_ACTIVITY'
'GOMF_LIGASE_ACTIVITY_FORMING_CARBON_OXYGEN_BONDS']
|
['GO:0004813 alanine-tRNA ligase activity', 'GO:0005524 ATP binding', 'GO:0046872 metal ion binding', 'GO:0003676 nucleic acid binding', 'GO:0002196 Ser-tRNA(Ala) deacylase activity']
|
['GO:0006419 alanyl-tRNA aminoacylation', 'GO:0006450 regulation of translational fidelity']
|
['GO:0005737 cytoplasm', 'GO:0005634 nucleus']
|
[
"Cytoplasm"
] |
AASDH
|
Q4L235
|
Beta-alanine-activating enzyme
|
Covalently binds beta-alanine in an ATP-dependent manner to form a thioester bond with its phosphopantetheine group and transfers it to an, as yet, unknown acceptor. May be required for a post-translational protein modification or for post-transcriptional modification of an RNA
|
['- IPR052091: Beta-alanine Activation and Resistance (family) [3-1092]', '- IPR042099: ANL, N-terminal domain (homologous_superfamily) [7-444]', '- IPR000873: AMP-dependent synthetase/ligase domain (domain) [9-406]', '- IPR048005: Beta-alanine-activating enzyme, AMP-binding domain (domain) [15-533]', '- IPR020845: AMP-binding, conserved site (conserved_site) [195-206]', '- IPR045851: AMP-binding enzyme domain superfamily (homologous_superfamily) [445-540]', '- IPR009081: Phosphopantetheine binding ACP domain (domain) [553-630]', '- IPR036736: ACP-like superfamily (homologous_superfamily) [553-608]', '- IPR009081: Phosphopantetheine binding ACP domain (domain) [558-610]', '- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [729-965]', '- IPR011047: Quinoprotein alcohol dehydrogenase-like superfamily (homologous_superfamily) [754-1095]', '- IPR002372: Pyrrolo-quinoline quinone repeat domain (domain) [763-1092]', '- IPR018391: Pyrrolo-quinoline quinone beta-propeller repeat (repeat) [776-809]', '- IPR018391: Pyrrolo-quinoline quinone beta-propeller repeat (repeat) [819-851]', '- IPR018391: Pyrrolo-quinoline quinone beta-propeller repeat (repeat) [861-893]', '- IPR018391: Pyrrolo-quinoline quinone beta-propeller repeat (repeat) [905-935]', '- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [966-1098]', '- IPR018391: Pyrrolo-quinoline quinone beta-propeller repeat (repeat) [983-1015]', '- IPR018391: Pyrrolo-quinoline quinone beta-propeller repeat (repeat) [1030-1062]']
|
['Partner and localizer of BRCA2', 'Acyl carrier protein, mitochondrial', 'L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase', '3-hydroxyacyl-[acyl-carrier-protein] dehydratase', 'Long-chain fatty acid transport protein 1', 'Long-chain-fatty-acid--CoA ligase 1', 'Carnitine O-palmitoyltransferase 2, mitochondrial', 'Mitochondrial carnitine/acylcarnitine carrier protein', 'Long-chain-fatty-acid--CoA ligase 5', 'Long-chain-fatty-acid--CoA ligase 3']
|
['GOBP_AMINO_ACID_ACTIVATION' 'GOBP_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_FATTY_ACID_METABOLIC_PROCESS' 'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS'
'GOBP_NONRIBOSOMAL_PEPTIDE_BIOSYNTHETIC_PROCESS'
'GOBP_NON_PROTEINOGENIC_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_METABOLIC_PROCESS' 'GOBP_PEPTIDE_BIOSYNTHETIC_PROCESS'
'GOBP_PEPTIDE_METABOLIC_PROCESS' 'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOMF_ACID_THIOL_LIGASE_ACTIVITY' 'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_LIGASE_ACTIVITY' 'GOMF_LIGASE_ACTIVITY_FORMING_CARBON_SULFUR_BONDS'
'KEGG_LYSINE_DEGRADATION']
|
['GO:0005524 ATP binding', 'GO:0016874 ligase activity']
|
['GO:0043041 amino acid activation for nonribosomal peptide biosynthetic process', 'GO:0019482 beta-alanine metabolic process', 'GO:0006631 fatty acid metabolic process']
|
[]
|
[] |
AASDHPPT
|
Q9NRN7
|
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
|
Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A, regardless of whether the CoA is presented in the free thiol form or as an acetyl thioester, to a serine residue of a broad range of acceptors including the acyl carrier domain of FASN
|
['- IPR050559: Phosphopantetheinyl Transferase Superfamily (family) [14-282]', "- IPR037143: 4'-phosphopantetheinyl transferase domain superfamily (homologous_superfamily) [17-290]", "- IPR037143: 4'-phosphopantetheinyl transferase domain superfamily (homologous_superfamily) [18-117]", "- IPR055066: 4'-phosphopantetheinyl transferase, N-terminal (domain) [25-122]", "- IPR037143: 4'-phosphopantetheinyl transferase domain superfamily (homologous_superfamily) [124-248]", "- IPR008278: 4'-phosphopantetheinyl transferase domain (domain) [125-241]", "- IPR037143: 4'-phosphopantetheinyl transferase domain superfamily (homologous_superfamily) [125-250]"]
|
['3-hydroxyacyl-[acyl-carrier-protein] dehydratase', 'Beta-alanine-activating enzyme', 'Phosphopantetheine adenylyltransferase', 'Histone acetyltransferase type B catalytic subunit', 'Malonyl-CoA-acyl carrier protein transacylase, mitochondrial', 'Complex I assembly factor TMEM126B, mitochondrial', 'Dihydrolipoyl dehydrogenase, mitochondrial', 'Transmembrane protein 126A', 'Histone H4', 'Histone H4-like protein type G']
|
['ERBB2_UP.V1_DN' 'GOBP_10_FORMYLTETRAHYDROFOLATE_METABOLIC_PROCESS'
'GOBP_AMIDE_METABOLIC_PROCESS' 'GOBP_DICARBOXYLIC_ACID_CATABOLIC_PROCESS'
'GOBP_DICARBOXYLIC_ACID_METABOLIC_PROCESS'
'GOBP_FOLIC_ACID_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_MODIFIED_AMINO_ACID_CATABOLIC_PROCESS'
'GOBP_MODIFIED_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_CATABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_METABOLIC_PROCESS'
'GOBP_PANTOTHENATE_METABOLIC_PROCESS' 'GOBP_PROTEIN_MATURATION'
'GOBP_PTERIDINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS'
'GOBP_PTERIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_TETRAHYDROFOLATE_METABOLIC_PROCESS'
'GOBP_VITAMIN_METABOLIC_PROCESS'
'GOBP_WATER_SOLUBLE_VITAMIN_METABOLIC_PROCESS'
'GOMF_MAGNESIUM_ION_BINDING'
'GOMF_PHOSPHOTRANSFERASE_ACTIVITY_FOR_OTHER_SUBSTITUTED_PHOSPHATE_GROUPS'
'GOMF_TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS'
'KEGG_LYSINE_DEGRADATION' 'REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS'
'REACTOME_METABOLISM_OF_WATER_SOLUBLE_VITAMINS_AND_COFACTORS'
'REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM']
|
['GO:0008897 holo-[acyl-carrier-protein] synthase activity', 'GO:0000287 magnesium ion binding']
|
['GO:0009258 10-formyltetrahydrofolate catabolic process', 'GO:0019878 lysine biosynthetic process via aminoadipic acid', 'GO:0015939 pantothenate metabolic process', 'GO:0051604 protein maturation']
|
['GO:0005829 cytosol', 'GO:0070062 extracellular exosome']
|
[
"Cytoplasm, cytosol"
] |
AASS
|
Q9UDR5
|
Alpha-aminoadipic semialdehyde synthase, mitochondrial
|
Bifunctional enzyme that catalyzes the first two steps in lysine degradation
|
['- IPR007886: Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal (domain) [27-157]', '- IPR007886: Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal (domain) [28-157]', '- IPR051168: Alpha-aminoadipic semialdehyde synthase (family) [28-919]', '- IPR007698: Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain (domain) [197-399]', '- IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [481-656]', '- IPR005097: Saccharopine dehydrogenase, NADP binding domain (domain) [483-598]', '- IPR032095: Saccharopine dehydrogenase-like, C-terminal (domain) [602-916]']
|
['Alpha-aminoadipic semialdehyde dehydrogenase', '5-phosphohydroxy-L-lysine phospho-lyase', 'Spermidine synthase', 'Biotinidase', 'Ornithine decarboxylase', 'Superoxide dismutase', 'Antizyme inhibitor 1', 'Superoxide dismutase [Mn], mitochondrial', 'Antizyme inhibitor 2', 'Argininosuccinate synthase']
|
['GOBP_ACETYL_COA_METABOLIC_PROCESS' 'GOBP_ACYL_COA_METABOLIC_PROCESS'
'GOBP_ALPHA_AMINO_ACID_METABOLIC_PROCESS' 'GOBP_AMIDE_CATABOLIC_PROCESS'
'GOBP_AMIDE_METABOLIC_PROCESS' 'GOBP_AMINO_ACID_CATABOLIC_PROCESS'
'GOBP_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_ASPARTATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS'
'GOBP_ASPARTATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_LYSINE_METABOLIC_PROCESS' 'GOBP_L_AMINO_ACID_CATABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_RNA_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II'
'GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_CATABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_METABOLIC_PROCESS'
'GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS'
'GOBP_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_PROTEINOGENIC_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_SULFUR_COMPOUND_METABOLIC_PROCESS' 'GOCC_MITOCHONDRIAL_MATRIX'
'GOCC_MITOCHONDRION' 'GOMF_HISTONE_BINDING'
'GOMF_MOLECULAR_ADAPTOR_ACTIVITY' 'GOMF_OXIDOREDUCTASE_ACTIVITY'
'GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS'
'GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR'
'GOMF_TRANSCRIPTION_COREGULATOR_ACTIVITY'
'GOMF_TRANSCRIPTION_COREPRESSOR_ACTIVITY'
'GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY' 'KEGG_LYSINE_DEGRADATION'
'REACTOME_LYSINE_CATABOLISM'
'REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES' 'VEGF_A_UP.V1_DN'
'WP_METABOLIC_EPILEPTIC_DISORDERS']
|
['GO:0042393 histone binding', 'GO:0047131 saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity', 'GO:0004754 saccharopine dehydrogenase (NAD+, L-lysine-forming) activity', 'GO:0047130 saccharopine dehydrogenase (NADP+, L-lysine-forming) activity', 'GO:0004753 saccharopine dehydrogenase activity', 'GO:0003714 transcription corepressor activity']
|
['GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine', 'GO:0019878 lysine biosynthetic process via aminoadipic acid', 'GO:0006554 lysine catabolic process', 'GO:0000122 negative regulation of transcription by RNA polymerase II']
|
['GO:0005737 cytoplasm', 'GO:0005829 cytosol', 'GO:0005759 mitochondrial matrix', 'GO:0005739 mitochondrion', 'GO:0005634 nucleus']
|
[
"Mitochondrion"
] |
AATF
|
Q9NY61
|
Protein AATF
|
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date
|
['- IPR039223: Protein AATF/Bfr2 (family) [1-553]', '- IPR025160: AATF leucine zipper-containing domain (domain) [220-373]', '- IPR012617: Apoptosis-antagonizing transcription factor, C-terminal (domain) [464-548]']
|
['Nucleolar protein 10', 'RNA cytidine acetyltransferase', 'Neuroguidin', 'Probable U3 small nucleolar RNA-associated protein 11', 'WD repeat-containing protein 36', 'Transducin beta like 3.', 'Ribosome biogenesis protein BMS1 homolog', 'Nucleolar protein 6', 'WD repeat-containing protein 43', 'WD repeat domain 3']
|
['CAMP_UP.V1_UP' 'GOBP_AMYLOID_PRECURSOR_PROTEIN_BIOSYNTHETIC_PROCESS'
'GOBP_AMYLOID_PRECURSOR_PROTEIN_METABOLIC_PROCESS'
'GOBP_APOPTOTIC_PROCESS' 'GOBP_APOPTOTIC_SIGNALING_PATHWAY'
'GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS'
'GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS' 'GOBP_CELL_ADHESION'
'GOBP_CELL_CYCLE' 'GOBP_CELL_DIVISION' 'GOBP_EMBRYONIC_CLEAVAGE'
'GOBP_EMBRYO_DEVELOPMENT' 'GOBP_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS'
'GOBP_GLYCOPROTEIN_METABOLIC_PROCESS' 'GOBP_MITOTIC_CELL_CYCLE'
'GOBP_NEGATIVE_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_BIOSYNTHETIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY'
'GOBP_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_PROGRAMMED_CELL_DEATH'
'GOBP_NEGATIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS'
'GOBP_NEGATIVE_REGULATION_OF_SIGNALING'
'GOBP_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY'
'GOBP_REGULATION_OF_CELL_CYCLE'
'GOBP_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_MITOTIC_CELL_CYCLE'
'GOBP_REGULATION_OF_PROGRAMMED_CELL_DEATH'
'GOBP_REGULATION_OF_PROTEIN_METABOLIC_PROCESS'
'GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS'
'GOBP_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS' 'GOBP_RIBOSOME_BIOGENESIS'
'GOCC_NUCLEOLUS' 'GOCC_PRERIBOSOME' 'GOCC_RIBONUCLEOPROTEIN_COMPLEX'
'GOCC_SMALL_SUBUNIT_PROCESSOME' 'GOCC_TRANSCRIPTION_REGULATOR_COMPLEX'
'GOMF_LEUCINE_ZIPPER_DOMAIN_BINDING' 'GOMF_LRR_DOMAIN_BINDING'
'GOMF_PROTEIN_DOMAIN_SPECIFIC_BINDING' 'PID_RB_1PATHWAY'
'REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE'
'REACTOME_DEATH_RECEPTOR_SIGNALING'
'REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK'
'REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING'
'WP_17Q12_COPY_NUMBER_VARIATION_SYNDROME']
|
['GO:0043522 leucine zipper domain binding', 'GO:0003723 RNA binding']
|
['GO:0007155 cell adhesion', 'GO:0040016 embryonic cleavage', 'GO:0042985 negative regulation of amyloid precursor protein biosynthetic process', 'GO:2001234 negative regulation of apoptotic signaling pathway', 'GO:0007346 regulation of mitotic cell cycle', 'GO:0042274 ribosomal small subunit biogenesis']
|
['GO:0005737 cytoplasm', 'GO:0005730 nucleolus', 'GO:0005654 nucleoplasm', 'GO:0005634 nucleus', 'GO:0032040 small-subunit processome', 'GO:0005667 transcription regulator complex']
|
[
"Nucleus, nucleolus"
] |
AATK
|
Q6ZMQ8
|
Serine/threonine-protein kinase LMTK1
|
May be involved in neuronal differentiation
|
['- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [98-392]', '- IPR000719: Protein kinase domain (domain) [125-395]', '- IPR042817: Serine/threonine-protein kinase LMTK1, catalytic domain (domain) [127-397]', '- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [128-392]', '- IPR017441: Protein kinase, ATP binding site (binding_site) [131-156]', '- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [202-215]', '- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [243-261]', '- IPR008266: Tyrosine-protein kinase, active site (active_site) [249-261]', '- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [318-340]']
|
['Cyclin-dependent-like kinase 5', 'Cyclin-dependent kinase 5 activator 1, p25']
|
['GOBP_APOPTOTIC_PROCESS' 'GOBP_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT'
'GOBP_HEAD_DEVELOPMENT' 'GOBP_NEURON_APOPTOTIC_PROCESS'
'GOCC_PERINUCLEAR_REGION_OF_CYTOPLASM' 'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_KINASE_ACTIVITY' 'GOMF_PROTEIN_KINASE_ACTIVITY'
'GOMF_PROTEIN_SERINE_KINASE_ACTIVITY'
'GOMF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY'
'GOMF_PROTEIN_TYROSINE_KINASE_ACTIVITY'
'GOMF_TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS'
'IL21_UP.V1_UP' 'IL2_UP.V1_UP' 'KRAS.AMP.LUNG_UP.V1_DN'
'KRAS.PROSTATE_UP.V1_DN' 'PRC1_BMI_UP.V1_UP' 'PRC2_EED_DN.V1_UP'
'PRC2_EZH2_UP.V1_UP' 'PRC2_SUZ12_UP.V1_UP']
|
['GO:0005524 ATP binding', 'GO:0106310 protein serine kinase activity', 'GO:0004674 protein serine/threonine kinase activity', 'GO:0004713 protein tyrosine kinase activity']
|
['GO:0007420 brain development', 'GO:0051402 neuron apoptotic process']
|
['GO:0012505 endomembrane system', 'GO:0016020 membrane', 'GO:0048471 perinuclear region of cytoplasm']
|
[
"Membrane",
"Cytoplasm",
"Cytoplasm, perinuclear region"
] |
ABAT
|
P80404
|
4-aminobutyrate aminotransferase, mitochondrial
|
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively (PubMed:10407778, PubMed:15528998). Can also convert delta-aminovalerate and beta-alanine (By similarity)
|
['- IPR005814: Aminotransferase class-III (family) [27-498]', '- IPR004631: 4-aminobutyrate aminotransferase, eukaryotic (family) [37-496]', '- IPR015424: Pyridoxal phosphate-dependent transferase (homologous_superfamily) [40-498]', '- IPR015422: Pyridoxal phosphate-dependent transferase, small domain (homologous_superfamily) [48-489]', '- IPR005814: Aminotransferase class-III (family) [67-496]', '- IPR005814: Aminotransferase class-III (family) [78-496]', '- IPR015421: Pyridoxal phosphate-dependent transferase, major domain (homologous_superfamily) [109-409]', '- IPR049704: Aminotransferases class-III pyridoxal-phosphate attachment site (conserved_site) [323-362]']
|
['Succinate-semialdehyde dehydrogenase, mitochondrial', 'Glutamate decarboxylase 2', 'Glutamate decarboxylase 1', 'Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial', 'Beta-ureidopropionase', 'Alpha-aminoadipic semialdehyde dehydrogenase', 'Acidic amino acid decarboxylase GADL1', 'Aldehyde dehydrogenase X, mitochondrial', 'Aldehyde dehydrogenase family 3 member A2', 'Carnosine dipeptidase 1']
|
['GOBP_ACIDIC_AMINO_ACID_TRANSPORT' 'GOBP_ACID_SECRETION'
'GOBP_AMIDE_TRANSPORT' 'GOBP_AMINE_METABOLIC_PROCESS'
'GOBP_AMINE_TRANSPORT' 'GOBP_AMINO_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_AMINO_ACID_CATABOLIC_PROCESS' 'GOBP_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_AMINO_ACID_TRANSPORT' 'GOBP_BEHAVIOR'
'GOBP_C4_DICARBOXYLATE_TRANSPORT' 'GOBP_CATECHOLAMINE_SECRETION'
'GOBP_CATECHOLAMINE_TRANSPORT'
'GOBP_CATECHOL_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_CELL_CELL_SIGNALING' 'GOBP_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT'
'GOBP_CHEMICAL_SYNAPTIC_TRANSMISSION_POSTSYNAPTIC'
'GOBP_CIRCULATORY_SYSTEM_PROCESS' 'GOBP_COPULATION'
'GOBP_DICARBOXYLIC_ACID_TRANSPORT' 'GOBP_DOPAMINE_METABOLIC_PROCESS'
'GOBP_DOPAMINE_SECRETION' 'GOBP_DOPAMINE_TRANSPORT'
'GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION' 'GOBP_EXPLORATION_BEHAVIOR'
'GOBP_EXPORT_FROM_CELL'
'GOBP_GAMMA_AMINOBUTYRIC_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_GAMMA_AMINOBUTYRIC_ACID_METABOLIC_PROCESS'
'GOBP_GAMMA_AMINOBUTYRIC_ACID_SECRETION'
'GOBP_GAMMA_AMINOBUTYRIC_ACID_TRANSPORT' 'GOBP_HEAD_DEVELOPMENT'
'GOBP_HEAT_GENERATION' 'GOBP_HINDBRAIN_DEVELOPMENT'
'GOBP_HOMEOSTATIC_PROCESS' 'GOBP_HORMONE_TRANSPORT'
'GOBP_INHIBITORY_POSTSYNAPTIC_POTENTIAL' 'GOBP_INSULIN_SECRETION'
'GOBP_LOCOMOTORY_BEHAVIOR' 'GOBP_MATING_BEHAVIOR'
'GOBP_METENCEPHALON_DEVELOPMENT'
'GOBP_MODULATION_OF_INHIBITORY_POSTSYNAPTIC_POTENTIAL'
'GOBP_MONOAMINE_TRANSPORT' 'GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS'
'GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS'
'GOBP_MULTICELLULAR_ORGANISMAL_REPRODUCTIVE_PROCESS'
'GOBP_MUSCLE_CONTRACTION' 'GOBP_MUSCLE_SYSTEM_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_AMINE_TRANSPORT'
'GOBP_NEGATIVE_REGULATION_OF_AMINO_ACID_TRANSPORT'
'GOBP_NEGATIVE_REGULATION_OF_BLOOD_PRESSURE'
'GOBP_NEGATIVE_REGULATION_OF_CATECHOLAMINE_SECRETION'
'GOBP_NEGATIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT'
'GOBP_NEGATIVE_REGULATION_OF_SECRETION'
'GOBP_NEGATIVE_REGULATION_OF_TRANSPORT' 'GOBP_NERVOUS_SYSTEM_PROCESS'
'GOBP_NITROGEN_COMPOUND_TRANSPORT'
'GOBP_NON_PROTEINOGENIC_AMINO_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_NON_PROTEINOGENIC_AMINO_ACID_CATABOLIC_PROCESS'
'GOBP_NON_PROTEINOGENIC_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_ORGANIC_ACID_CATABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_METABOLIC_PROCESS' 'GOBP_ORGANIC_ACID_TRANSPORT'
'GOBP_ORGANIC_ANION_TRANSPORT' 'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_PEPTIDE_TRANSPORT'
'GOBP_PHENOL_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_AMINE_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_AMINE_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_AMINO_ACID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_HEAT_GENERATION'
'GOBP_POSITIVE_REGULATION_OF_HORMONE_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_INSULIN_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_MUSCLE_CONTRACTION'
'GOBP_POSITIVE_REGULATION_OF_NERVOUS_SYSTEM_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_PEPTIDE_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_SIGNALING'
'GOBP_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION'
'GOBP_POSITIVE_REGULATION_OF_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_UTERINE_SMOOTH_MUSCLE_CONTRACTION'
'GOBP_PROLACTIN_SECRETION'
'GOBP_PROTEIN_LOCALIZATION_TO_EXTRACELLULAR_REGION'
'GOBP_PROTEIN_TRANSPORT' 'GOBP_REGULATION_OF_AMINE_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_AMINO_ACID_TRANSPORT'
'GOBP_REGULATION_OF_BLOOD_PRESSURE'
'GOBP_REGULATION_OF_CATECHOLAMINE_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_CATECHOLAMINE_SECRETION'
'GOBP_REGULATION_OF_CELLULAR_LOCALIZATION'
'GOBP_REGULATION_OF_DOPAMINE_SECRETION'
'GOBP_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION'
'GOBP_REGULATION_OF_GAMMA_AMINOBUTYRIC_ACID_SECRETION'
'GOBP_REGULATION_OF_HEAT_GENERATION' 'GOBP_REGULATION_OF_HORMONE_LEVELS'
'GOBP_REGULATION_OF_HORMONE_SECRETION'
'GOBP_REGULATION_OF_INSULIN_SECRETION'
'GOBP_REGULATION_OF_MEMBRANE_POTENTIAL'
'GOBP_REGULATION_OF_MUSCLE_CONTRACTION'
'GOBP_REGULATION_OF_MUSCLE_SYSTEM_PROCESS'
'GOBP_REGULATION_OF_NERVOUS_SYSTEM_PROCESS'
'GOBP_REGULATION_OF_ORGANIC_ACID_TRANSPORT'
'GOBP_REGULATION_OF_PEPTIDE_TRANSPORT'
'GOBP_REGULATION_OF_POSTSYNAPTIC_MEMBRANE_POTENTIAL'
'GOBP_REGULATION_OF_PROTEIN_SECRETION'
'GOBP_REGULATION_OF_PROTEIN_TRANSPORT' 'GOBP_REGULATION_OF_SECRETION'
'GOBP_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION'
'GOBP_REGULATION_OF_SYSTEM_PROCESS' 'GOBP_REGULATION_OF_TRANSPORT'
'GOBP_REPRODUCTIVE_BEHAVIOR' 'GOBP_REPRODUCTIVE_PROCESS'
'GOBP_RESPONSE_TO_ABIOTIC_STIMULUS' 'GOBP_RESPONSE_TO_ALCOHOL'
'GOBP_RESPONSE_TO_ALKALOID' 'GOBP_RESPONSE_TO_COCAINE'
'GOBP_RESPONSE_TO_ETHANOL' 'GOBP_RESPONSE_TO_IRON_ION'
'GOBP_RESPONSE_TO_METAL_ION' 'GOBP_RESPONSE_TO_NICOTINE'
'GOBP_RESPONSE_TO_NITROGEN_COMPOUND'
'GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND'
'GOBP_RESPONSE_TO_OXYGEN_LEVELS' 'GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_SECRETION' 'GOBP_SIGNAL_RELEASE'
'GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS'
'GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS' 'GOBP_SMOOTH_MUSCLE_CONTRACTION'
'GOBP_SYNAPTIC_SIGNALING' 'GOBP_TEMPERATURE_HOMEOSTASIS'
'GOBP_UTERINE_SMOOTH_MUSCLE_CONTRACTION' 'GOCC_CATALYTIC_COMPLEX'
'GOCC_INTRACELLULAR_PROTEIN_CONTAINING_COMPLEX'
'GOCC_MITOCHONDRIAL_MATRIX' 'GOCC_MITOCHONDRION'
'GOCC_TRANSFERASE_COMPLEX' 'GOMF_METAL_CLUSTER_BINDING'
'GOMF_TRANSAMINASE_ACTIVITY'
'GOMF_TRANSFERASE_ACTIVITY_TRANSFERRING_NITROGENOUS_GROUPS'
'GOMF_VITAMIN_B6_BINDING' 'GOMF_VITAMIN_BINDING'
'HALLMARK_ESTROGEN_RESPONSE_EARLY' 'HALLMARK_P53_PATHWAY'
'KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM'
'KEGG_BETA_ALANINE_METABOLISM' 'KEGG_BUTANOATE_METABOLISM'
'KEGG_PROPANOATE_METABOLISM'
'KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION' 'RAF_UP.V1_DN'
'RB_P107_DN.V1_UP'
'REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION'
'REACTOME_NEURONAL_SYSTEM' 'REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE'
'REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES'
'WP_ADHD_AND_AUTISM_ASD_PATHWAYS' 'WP_ALANINE_AND_ASPARTATE_METABOLISM'
'WP_FRAGILE_X_SYNDROME' 'WP_GABA_METABOLISM_AKA_GHB'
'WP_GABA_RECEPTOR_SIGNALING'
'WP_PYRIMIDINE_METABOLISM_AND_RELATED_DISEASES'
'WP_VALPROIC_ACID_PATHWAY']
|
['GO:0047298 (S)-3-amino-2-methylpropionate transaminase activity', 'GO:0034386 4-aminobutyrate:2-oxoglutarate transaminase activity', 'GO:0042802 identical protein binding', 'GO:0051536 iron-sulfur cluster binding', 'GO:0046872 metal ion binding', 'GO:0030170 pyridoxal phosphate binding', 'GO:0032145 succinate-semialdehyde dehydrogenase binding']
|
['GO:0021549 cerebellum development', 'GO:0007620 copulation', 'GO:0035640 exploration behavior', 'GO:0009449 gamma-aminobutyric acid biosynthetic process', 'GO:0009450 gamma-aminobutyric acid catabolic process', 'GO:0009448 gamma-aminobutyric acid metabolic process', 'GO:0007626 locomotory behavior', 'GO:0045776 negative regulation of blood pressure', 'GO:0033602 negative regulation of dopamine secretion', 'GO:0014053 negative regulation of gamma-aminobutyric acid secretion', 'GO:0050877 nervous system process', 'GO:1904450 positive regulation of aspartate secretion', 'GO:0045964 positive regulation of dopamine metabolic process', 'GO:0031652 positive regulation of heat generation', 'GO:0097151 positive regulation of inhibitory postsynaptic potential', 'GO:0032024 positive regulation of insulin secretion', 'GO:1902722 positive regulation of prolactin secretion', 'GO:0070474 positive regulation of uterine smooth muscle contraction', 'GO:0042220 response to cocaine', 'GO:0045471 response to ethanol', 'GO:0001666 response to hypoxia', 'GO:0010039 response to iron ion', 'GO:0035094 response to nicotine', 'GO:0009410 response to xenobiotic stimulus']
|
['GO:0032144 4-aminobutyrate transaminase complex', 'GO:0005759 mitochondrial matrix', 'GO:0005739 mitochondrion']
|
[
"Mitochondrion matrix"
] |
ABCA1
|
O95477
|
Phospholipid-transporting ATPase ABCA1
|
Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981, PubMed:35974019). Thereby, participates in phospholipid transfer to apolipoproteins to form nascent high density lipoproteins/HDLs (PubMed:14754908). Transports preferentially phosphatidylcholine over phosphatidylserine (PubMed:24097981). May play a similar role in the efflux of intracellular cholesterol to apolipoproteins and the formation of nascent high density lipoproteins/HDLs (PubMed:10533863, PubMed:14754908, PubMed:24097981, PubMed:35974019). Translocates phospholipids from the outer face of the plasma membrane and forces it through its gateway and annulus into an elongated hydrophobic tunnel in its extracellular domain (PubMed:35974019)
|
['- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [640-841]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [889-1162]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [899-1131]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [907-1113]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [917-1061]', '- IPR003593: AAA+ ATPase domain (domain) [925-1122]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [1033-1047]', '- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [1543-1869]', '- IPR026082: ABC transporter A (family) [1891-2229]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1903-2147]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1909-2142]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1912-2144]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1932-2073]', '- IPR003593: AAA+ ATPase domain (domain) [1938-2123]', '- IPR056264: ABCA1-4-like, C-terminal R2 regulatory domain (domain) [2136-2210]']
|
['Truncated apolipoprotein A-I', 'Oxysterols receptor LXR-beta', 'Apolipoprotein E', 'Oxysterols receptor LXR-alpha', 'Xenotropic and polytropic retrovirus receptor 1', 'Processed sterol regulatory element-binding protein 2', 'Scavenger receptor class B member 1', 'Retinoic acid receptor RXR-alpha', 'Phosphatidylcholine-sterol acyltransferase', 'Processed sterol regulatory element-binding protein 1']
|
['BIOCARTA_FXR_PATHWAY' 'BIOCARTA_NUCLEARRS_PATHWAY' 'BMI1_DN.V1_UP'
'BMI1_DN_MEL18_DN.V1_UP'
'GOBP_ADENYLATE_CYCLASE_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_ADENYLATE_CYCLASE_MODULATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_ALCOHOL_METABOLIC_PROCESS' 'GOBP_AMIDE_TRANSPORT'
'GOBP_APOLIPOPROTEIN_A_I_MEDIATED_SIGNALING_PATHWAY'
'GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS'
'GOBP_CDC42_PROTEIN_SIGNAL_TRANSDUCTION'
'GOBP_CELLULAR_RESPONSE_TO_ALCOHOL'
'GOBP_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_CHOLESTEROL' 'GOBP_CELLULAR_RESPONSE_TO_LIPID'
'GOBP_CELLULAR_RESPONSE_TO_LIPOPROTEIN_PARTICLE_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN'
'GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND'
'GOBP_CELLULAR_RESPONSE_TO_RETINOIC_ACID'
'GOBP_CELLULAR_RESPONSE_TO_STEROL'
'GOBP_CELLULAR_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_CELL_CELL_SIGNALING' 'GOBP_CHEMICAL_HOMEOSTASIS'
'GOBP_CHOLESTEROL_EFFLUX' 'GOBP_CHOLESTEROL_STORAGE' 'GOBP_ENDOCYTOSIS'
'GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION' 'GOBP_ENDOSOMAL_TRANSPORT'
'GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION'
'GOBP_EXPORT_ACROSS_PLASMA_MEMBRANE' 'GOBP_EXPORT_FROM_CELL'
'GOBP_FOAM_CELL_DIFFERENTIATION'
'GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_ASSEMBLY'
'GOBP_HOMEOSTATIC_PROCESS' 'GOBP_IMPORT_INTO_CELL'
'GOBP_INTRACELLULAR_LIPID_TRANSPORT'
'GOBP_INTRACELLULAR_STEROL_TRANSPORT' 'GOBP_INTRACELLULAR_TRANSPORT'
'GOBP_LIPID_HOMEOSTASIS' 'GOBP_LIPID_LOCALIZATION'
'GOBP_LIPID_METABOLIC_PROCESS' 'GOBP_LIPOPROTEIN_BIOSYNTHETIC_PROCESS'
'GOBP_LIPOPROTEIN_METABOLIC_PROCESS' 'GOBP_LYTIC_VACUOLE_ORGANIZATION'
'GOBP_MEMBRANE_INVAGINATION' 'GOBP_MEMBRANE_ORGANIZATION'
'GOBP_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION'
'GOBP_NEGATIVE_REGULATION_OF_CHOLESTEROL_STORAGE'
'GOBP_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_NEGATIVE_REGULATION_OF_LIPID_STORAGE'
'GOBP_NEGATIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION'
'GOBP_NITROGEN_COMPOUND_TRANSPORT' 'GOBP_NUTRIENT_STORAGE'
'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT' 'GOBP_PEPTIDE_TRANSPORT'
'GOBP_PHAGOCYTOSIS' 'GOBP_PHAGOCYTOSIS_ENGULFMENT'
'GOBP_PHOSPHOLIPID_EFFLUX' 'GOBP_PHOSPHOLIPID_HOMEOSTASIS'
'GOBP_PHOSPHOLIPID_TRANSLOCATION' 'GOBP_PHOSPHOLIPID_TRANSPORT'
'GOBP_PLATELET_DENSE_GRANULE_ORGANIZATION'
'GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS'
'GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION'
'GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX'
'GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY'
'GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_TRANSPORT'
'GOBP_PROTEIN_CONTAINING_COMPLEX_ORGANIZATION'
'GOBP_PROTEIN_LIPID_COMPLEX_ASSEMBLY'
'GOBP_PROTEIN_LIPID_COMPLEX_ORGANIZATION'
'GOBP_PROTEIN_LOCALIZATION_TO_EXTRACELLULAR_REGION'
'GOBP_PROTEIN_TRANSMEMBRANE_TRANSPORT' 'GOBP_PROTEIN_TRANSPORT'
'GOBP_REGULATION_OF_CDC42_PROTEIN_SIGNAL_TRANSDUCTION'
'GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS'
'GOBP_REGULATION_OF_CELL_DIFFERENTIATION'
'GOBP_REGULATION_OF_CHOLESTEROL_EFFLUX'
'GOBP_REGULATION_OF_CHOLESTEROL_STORAGE'
'GOBP_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_REGULATION_OF_LIPID_STORAGE' 'GOBP_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION'
'GOBP_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS'
'GOBP_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY'
'GOBP_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION'
'GOBP_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION'
'GOBP_REGULATION_OF_STEROL_TRANSPORT' 'GOBP_REGULATION_OF_TRANSPORT'
'GOBP_RESPONSE_TO_ALCOHOL' 'GOBP_RESPONSE_TO_BACTERIUM'
'GOBP_RESPONSE_TO_ENDOGENOUS_STIMULUS'
'GOBP_RESPONSE_TO_FLUID_SHEAR_STRESS'
'GOBP_RESPONSE_TO_LAMINAR_FLUID_SHEAR_STRESS' 'GOBP_RESPONSE_TO_LIPID'
'GOBP_RESPONSE_TO_LIPOPROTEIN_PARTICLE'
'GOBP_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN'
'GOBP_RESPONSE_TO_NITROGEN_COMPOUND' 'GOBP_RESPONSE_TO_NUTRIENT'
'GOBP_RESPONSE_TO_NUTRIENT_LEVELS'
'GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND' 'GOBP_RESPONSE_TO_PEPTIDE'
'GOBP_RESPONSE_TO_RETINOIC_ACID' 'GOBP_RESPONSE_TO_STEROL'
'GOBP_RESPONSE_TO_VITAMIN' 'GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_REVERSE_CHOLESTEROL_TRANSPORT'
'GOBP_RHO_PROTEIN_SIGNAL_TRANSDUCTION'
'GOBP_SECONDARY_ALCOHOL_METABOLIC_PROCESS' 'GOBP_SECRETION'
'GOBP_SECRETORY_GRANULE_ORGANIZATION' 'GOBP_SIGNAL_RELEASE'
'GOBP_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS' 'GOBP_SPHINGOLIPID_TRANSLOCATION'
'GOBP_STEROID_METABOLIC_PROCESS' 'GOBP_STEROL_HOMEOSTASIS'
'GOBP_STEROL_TRANSPORT' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_VACUOLE_ORGANIZATION' 'GOBP_VESICLE_MEDIATED_TRANSPORT'
'GOBP_VESICLE_ORGANIZATION' 'GOCC_BASAL_PART_OF_CELL'
'GOCC_BASOLATERAL_PLASMA_MEMBRANE' 'GOCC_CELL_SURFACE'
'GOCC_ENDOCYTIC_VESICLE' 'GOCC_ENDOSOME'
'GOCC_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE' 'GOCC_GOLGI_APPARATUS'
'GOCC_MEMBRANE_MICRODOMAIN'
'GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK'
'GOCC_ORGANELLE_SUBCOMPARTMENT' 'GOCC_PERINUCLEAR_REGION_OF_CYTOPLASM'
'GOCC_PHAGOCYTIC_VESICLE' 'GOCC_PLASMA_MEMBRANE_REGION'
'GOCC_SIDE_OF_MEMBRANE' 'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING' 'GOMF_ALCOHOL_BINDING'
'GOMF_APOLIPOPROTEIN_A_I_BINDING' 'GOMF_APOLIPOPROTEIN_BINDING'
'GOMF_ATPASE_BINDING'
'GOMF_ATPASE_COUPLED_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_CARGO_RECEPTOR_ACTIVITY' 'GOMF_CHOLESTEROL_BINDING'
'GOMF_CHOLESTEROL_TRANSFER_ACTIVITY' 'GOMF_FLOPPASE_ACTIVITY'
'GOMF_GTPASE_BINDING' 'GOMF_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_BINDING'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY' 'GOMF_LIPID_BINDING'
'GOMF_LIPID_TRANSFER_ACTIVITY' 'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_MACROMOLECULE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PHOSPHATIDYLCHOLINE_BINDING'
'GOMF_PHOSPHATIDYLCHOLINE_FLOPPASE_ACTIVITY'
'GOMF_PHOSPHATIDYLCHOLINE_TRANSPORTER_ACTIVITY'
'GOMF_PHOSPHATIDYLSERINE_FLOPPASE_ACTIVITY' 'GOMF_PHOSPHOLIPID_BINDING'
'GOMF_PHOSPHOLIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PROTEIN_CONTAINING_COMPLEX_BINDING'
'GOMF_PROTEIN_LIPID_COMPLEX_BINDING'
'GOMF_PROTEIN_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PROTEIN_TRANSPORTER_ACTIVITY'
'GOMF_QUATERNARY_AMMONIUM_GROUP_BINDING'
'GOMF_SIGNALING_RECEPTOR_BINDING' 'GOMF_SNARE_BINDING'
'GOMF_SPHINGOLIPID_TRANSPORTER_ACTIVITY' 'GOMF_STEROID_BINDING'
'GOMF_STEROL_BINDING' 'GOMF_STEROL_TRANSFER_ACTIVITY'
'GOMF_SYNTAXIN_BINDING' 'GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY' 'HALLMARK_ADIPOGENESIS'
'HALLMARK_BILE_ACID_METABOLISM' 'HALLMARK_INFLAMMATORY_RESPONSE'
'HALLMARK_PROTEIN_SECRETION' 'HALLMARK_TNFA_SIGNALING_VIA_NFKB'
'KEGG_ABC_TRANSPORTERS' 'MTOR_UP.V1_DN' 'NOTCH_DN.V1_DN'
'PID_RXR_VDR_PATHWAY' 'REACTOME_ABC_TRANSPORTER_DISORDERS'
'REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS'
'REACTOME_HDL_ASSEMBLY' 'REACTOME_METABOLISM_OF_LIPIDS'
'REACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING'
'REACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX'
'REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY'
'REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY_REMODELING_AND_CLEARANCE'
'REACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA'
'REACTOME_SIGNALING_BY_NUCLEAR_RECEPTORS'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES' 'STK33_NOMO_UP' 'STK33_UP'
'WNT_UP.V1_DN' 'WP_2Q37_COPY_NUMBER_VARIATION_SYNDROME'
'WP_CAMKK2_PATHWAY' 'WP_CHOLESTEROL_BIOSYNTHESIS_PATHWAY_IN_HEPATOCYTES'
'WP_CHOLESTEROL_METABOLISM'
'WP_CHOLESTEROL_METABOLISM_WITH_BLOCH_AND_KANDUTSCHRUSSELL_PATHWAYS'
'WP_EFFECT_OF_OMEGA3_PUFA_ON_HUNTINGTONS_DISEASE_PATHWAYS'
'WP_ENTEROCYTE_CHOLESTEROL_METABOLISM'
'WP_FATTY_ACID_AND_LIPOPROTEIN_TRANSPORT_IN_HEPATOCYTES'
'WP_FOLATE_METABOLISM'
'WP_METABOLIC_PATHWAY_OF_LDL_HDL_AND_TG_INCLUDING_DISEASES'
'WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY'
'WP_SELENIUM_MICRONUTRIENT_NETWORK'
'WP_SREBF_AND_MIR33_IN_CHOLESTEROL_AND_LIPID_HOMEOSTASIS'
'WP_STATIN_INHIBITION_OF_CHOLESTEROL_PRODUCTION'
'WP_UROTENSINIIMEDIATED_SIGNALING' 'WP_VITAMIN_B12_METABOLISM']
|
['GO:0140359 ABC-type transporter activity', 'GO:0034186 apolipoprotein A-I binding', 'GO:0034188 apolipoprotein A-I receptor activity', 'GO:0034185 apolipoprotein binding', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0051117 ATPase binding', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0015485 cholesterol binding', 'GO:0120020 cholesterol transfer activity', 'GO:0140328 floppase activity', 'GO:0008035 high-density lipoprotein particle binding', 'GO:0031210 phosphatidylcholine binding', 'GO:0090554 phosphatidylcholine floppase activity', 'GO:0090556 phosphatidylserine floppase activity', 'GO:0005548 phospholipid transporter activity', 'GO:0008320 protein transmembrane transporter activity', 'GO:0005102 signaling receptor binding', 'GO:0031267 small GTPase binding', 'GO:0046623 sphingolipid floppase activity', 'GO:0019905 syntaxin binding']
|
['GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'GO:0071397 cellular response to cholesterol', 'GO:0071345 cellular response to cytokine stimulus', 'GO:0071222 cellular response to lipopolysaccharide', 'GO:0071404 cellular response to low-density lipoprotein particle stimulus', 'GO:0071300 cellular response to retinoic acid', 'GO:0071466 cellular response to xenobiotic stimulus', 'GO:0033344 cholesterol efflux', 'GO:0042632 cholesterol homeostasis', 'GO:0008203 cholesterol metabolic process', 'GO:0016197 endosomal transport', 'GO:0140115 export across plasma membrane', 'GO:0007186 G protein-coupled receptor signaling pathway', 'GO:0034380 high-density lipoprotein particle assembly', 'GO:0032367 intracellular cholesterol transport', 'GO:0042158 lipoprotein biosynthetic process', 'GO:0007040 lysosome organization', 'GO:0010887 negative regulation of cholesterol storage', 'GO:0010745 negative regulation of macrophage derived foam cell differentiation', 'GO:0002790 peptide secretion', 'GO:0006911 phagocytosis, engulfment', 'GO:0033700 phospholipid efflux', 'GO:0055091 phospholipid homeostasis', 'GO:0045332 phospholipid translocation', 'GO:0060155 platelet dense granule organization', 'GO:0010875 positive regulation of cholesterol efflux', 'GO:0090108 positive regulation of high-density lipoprotein particle assembly', 'GO:0009306 protein secretion', 'GO:0071806 protein transmembrane transport', 'GO:0032489 regulation of Cdc42 protein signal transduction', 'GO:0090107 regulation of high-density lipoprotein particle assembly', 'GO:0034616 response to laminar fluid shear stress', 'GO:0033552 response to vitamin B3', 'GO:0043691 reverse cholesterol transport', 'GO:0023061 signal release']
|
['GO:0016323 basolateral plasma membrane', 'GO:0030139 endocytic vesicle', 'GO:0005789 endoplasmic reticulum membrane', 'GO:0005768 endosome', 'GO:0009897 external side of plasma membrane', 'GO:0005794 Golgi apparatus', 'GO:0097708 intracellular vesicle', 'GO:0045121 membrane raft', 'GO:0048471 perinuclear region of cytoplasm', 'GO:0045335 phagocytic vesicle', 'GO:0005886 plasma membrane']
|
[
"Cell membrane",
"Endosome"
] |
ABCA10
|
Q8WWZ4
|
ATP-binding cassette sub-family A member 10
|
Probable transporter which may play a role in macrophage lipid transport and homeostasis
|
['- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [91-329]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [382-658]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [390-610]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [391-626]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [410-556]', '- IPR003593: AAA+ ATPase domain (domain) [419-603]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [528-542]', '- IPR026082: ABC transporter A (family) [1169-1528]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1189-1461]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1206-1440]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1215-1435]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1223-1367]', '- IPR003593: AAA+ ATPase domain (domain) [1231-1417]', '- IPR056264: ABCA1-4-like, C-terminal R2 regulatory domain (domain) [1432-1506]']
|
[]
|
['GOBP_LIPID_LOCALIZATION' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY' 'KEGG_ABC_TRANSPORTERS'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES']
|
['GO:0140359 ABC-type transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0005319 lipid transporter activity']
|
['GO:0006869 lipid transport']
|
['GO:0005886 plasma membrane']
|
[
"Membrane"
] |
ABCA12
|
Q86UK0
|
Glucosylceramide transporter ABCA12
|
Transports lipids such as glucosylceramides from the outer to the inner leaflet of lamellar granules (LGs) membrane, whereby the lipids are finally transported to the keratinocyte periphery via the trans-Golgi network and LGs and released to the apical surface of the granular keratinocytes to form lipid lamellae in the stratum corneum of the epidermis, which is essential for skin barrier function (PubMed:16007253, PubMed:20869849). In the meantime, participates in the transport of the lamellar granules-associated proteolytic enzymes, in turn regulates desquamation and keratinocyte differentiation (PubMed:19179616). Furthermore, is essential for the regulation of cellular cholesterol homeostasis by regulating ABCA1-dependent cholesterol efflux from macrophages through interaction with NR1H2 and ABCA1 (By similarity). Plays pleiotropic roles in regulating glucose stimulated insulin secretion from beta cells, regulating the morphology and fusion of insulin granules, lipid raft abundance and the actin cytoskeleton (By similarity). Also involved in lung surfactant biogenesis (By similarity)
|
['- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [937-1270]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1335-1578]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1339-1581]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1346-1577]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1362-1506]', '- IPR003593: AAA+ ATPase domain (domain) [1370-1554]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [1479-1493]', '- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [1745-2168]', '- IPR026082: ABC transporter A (family) [2227-2581]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [2245-2509]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [2254-2489]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [2267-2471]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [2273-2417]', '- IPR003593: AAA+ ATPase domain (domain) [2282-2467]', '- IPR056264: ABCA1-4-like, C-terminal R2 regulatory domain (domain) [2481-2555]']
|
['Cytochrome P450 4F22', 'Protein-glutamine gamma-glutamyltransferase K', 'Magnesium transporter NIPA4', 'Lipase member N', 'Cystatin-M', 'Hydroperoxide isomerase ALOXE3', 'Arachidonate 12-lipoxygenase, 12R-type', 'Patatin-like phospholipase domain-containing protein 1', 'Ceramide synthase 3']
|
['GOBP_AMIDE_METABOLIC_PROCESS' 'GOBP_AMIDE_TRANSPORT'
'GOBP_ANIMAL_ORGAN_MORPHOGENESIS' 'GOBP_CARBOHYDRATE_HOMEOSTASIS'
'GOBP_CELLULAR_HOMEOSTASIS'
'GOBP_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND'
'GOBP_CELL_ADHESION' 'GOBP_CELL_CELL_ADHESION' 'GOBP_CELL_CELL_SIGNALING'
'GOBP_CERAMIDE_METABOLIC_PROCESS' 'GOBP_CERAMIDE_TRANSPORT'
'GOBP_CHEMICAL_HOMEOSTASIS' 'GOBP_CHOLESTEROL_EFFLUX' 'GOBP_DELAMINATION'
'GOBP_EPIDERMAL_CELL_DIFFERENTIATION' 'GOBP_EPIDERMIS_DEVELOPMENT'
'GOBP_EPITHELIAL_CELL_DEVELOPMENT' 'GOBP_EPITHELIAL_CELL_DIFFERENTIATION'
'GOBP_EPITHELIUM_DEVELOPMENT'
'GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION'
'GOBP_ESTABLISHMENT_OF_SKIN_BARRIER' 'GOBP_EXOCYTOSIS'
'GOBP_EXPORT_FROM_CELL' 'GOBP_HOMEOSTATIC_PROCESS'
'GOBP_HORMONE_TRANSPORT' 'GOBP_INSULIN_SECRETION'
'GOBP_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS'
'GOBP_INTRACELLULAR_GLUCOSE_HOMEOSTASIS'
'GOBP_INTRACELLULAR_LIPID_TRANSPORT'
'GOBP_INTRACELLULAR_PROTEIN_TRANSPORT' 'GOBP_INTRACELLULAR_TRANSPORT'
'GOBP_KERATINIZATION' 'GOBP_KERATINOCYTE_DEVELOPMENT'
'GOBP_KERATINOCYTE_DIFFERENTIATION' 'GOBP_LIPID_HOMEOSTASIS'
'GOBP_LIPID_LOCALIZATION' 'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_LOCALIZATION_WITHIN_MEMBRANE' 'GOBP_LUNG_ALVEOLUS_DEVELOPMENT'
'GOBP_MEMBRANE_LIPID_METABOLIC_PROCESS' 'GOBP_MEMBRANE_ORGANIZATION'
'GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_CHEMICAL_HOMEOSTASIS'
'GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS'
'GOBP_NEGATIVE_REGULATION_OF_CELL_ADHESION'
'GOBP_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION'
'GOBP_NITROGEN_COMPOUND_TRANSPORT'
'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT' 'GOBP_PEPTIDE_TRANSPORT'
'GOBP_PHOSPHOLIPID_EFFLUX' 'GOBP_PHOSPHOLIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX'
'GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_LIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE'
'GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_TRANSPORT'
'GOBP_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY'
'GOBP_PROTEIN_LOCALIZATION_TO_CELL_SURFACE'
'GOBP_PROTEIN_LOCALIZATION_TO_EXTRACELLULAR_REGION'
'GOBP_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE' 'GOBP_PROTEIN_TRANSPORT'
'GOBP_REGULATED_EXOCYTOSIS' 'GOBP_REGULATION_OF_CELLULAR_LOCALIZATION'
'GOBP_REGULATION_OF_CELL_ADHESION'
'GOBP_REGULATION_OF_CELL_CELL_ADHESION'
'GOBP_REGULATION_OF_CELL_DIFFERENTIATION'
'GOBP_REGULATION_OF_CHOLESTEROL_EFFLUX'
'GOBP_REGULATION_OF_EPIDERMIS_DEVELOPMENT'
'GOBP_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION'
'GOBP_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION'
'GOBP_REGULATION_OF_HORMONE_LEVELS'
'GOBP_REGULATION_OF_HORMONE_SECRETION'
'GOBP_REGULATION_OF_INSULIN_SECRETION'
'GOBP_REGULATION_OF_INTRACELLULAR_LIPID_TRANSPORT'
'GOBP_REGULATION_OF_INTRACELLULAR_TRANSPORT'
'GOBP_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION'
'GOBP_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION'
'GOBP_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT'
'GOBP_REGULATION_OF_PEPTIDE_TRANSPORT'
'GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE'
'GOBP_REGULATION_OF_PROTEIN_SECRETION'
'GOBP_REGULATION_OF_PROTEIN_TRANSPORT' 'GOBP_REGULATION_OF_SECRETION'
'GOBP_REGULATION_OF_STEROL_TRANSPORT' 'GOBP_REGULATION_OF_TRANSPORT'
'GOBP_RESPIRATORY_SYSTEM_DEVELOPMENT' 'GOBP_RESPONSE_TO_CARBOHYDRATE'
'GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND' 'GOBP_SECRETION'
'GOBP_SIGNAL_RELEASE' 'GOBP_SKIN_DEVELOPMENT'
'GOBP_SKIN_EPIDERMIS_DEVELOPMENT' 'GOBP_SKIN_MORPHOGENESIS'
'GOBP_SPHINGOLIPID_METABOLIC_PROCESS' 'GOBP_STEROL_TRANSPORT'
'GOBP_SURFACTANT_HOMEOSTASIS' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_TUBE_DEVELOPMENT' 'GOBP_VESICLE_MEDIATED_TRANSPORT'
'GOCC_GOLGI_APPARATUS' 'GOCC_GOLGI_MEMBRANE' 'GOCC_LAMELLAR_BODY'
'GOCC_SECRETORY_GRANULE' 'GOCC_SECRETORY_GRANULE_MEMBRANE'
'GOCC_SECRETORY_VESICLE' 'GOCC_TRANSPORT_VESICLE'
'GOCC_TRANSPORT_VESICLE_MEMBRANE' 'GOCC_VESICLE_MEMBRANE'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING' 'GOMF_APOLIPOPROTEIN_RECEPTOR_BINDING'
'GOMF_ATPASE_COUPLED_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_SIGNALING_RECEPTOR_BINDING' 'GOMF_TRANSPORTER_ACTIVITY'
'KEGG_ABC_TRANSPORTERS' 'MEK_UP.V1_DN' 'RAF_UP.V1_DN'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS'
'REACTOME_ABC_TRANSPORTER_DISORDERS'
'REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES']
|
['GO:0140359 ABC-type transporter activity', 'GO:0034191 apolipoprotein A-I receptor binding', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0140326 ATPase-coupled intramembrane lipid transporter activity', 'GO:0034040 ATPase-coupled lipid transmembrane transporter activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0005319 lipid transporter activity', 'GO:0005102 signaling receptor binding']
|
['GO:0019725 cellular homeostasis', 'GO:0006672 ceramide metabolic process', 'GO:0035627 ceramide transport', 'GO:0033344 cholesterol efflux', 'GO:0003336 corneocyte desquamation', 'GO:0061436 establishment of skin barrier', 'GO:0006886 intracellular protein transport', 'GO:0031424 keratinization', 'GO:0055088 lipid homeostasis', 'GO:0006869 lipid transport', 'GO:0048286 lung alveolus development', 'GO:0033700 phospholipid efflux', 'GO:0010875 positive regulation of cholesterol efflux', 'GO:0032379 positive regulation of intracellular lipid transport', 'GO:2000010 positive regulation of protein localization to cell surface', 'GO:0072659 protein localization to plasma membrane', 'GO:0045055 regulated exocytosis', 'GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus', 'GO:0045616 regulation of keratinocyte differentiation', 'GO:0032940 secretion by cell', 'GO:0043129 surfactant homeostasis']
|
['GO:0005737 cytoplasm', 'GO:0005829 cytosol', 'GO:0097209 epidermal lamellar body', 'GO:0097234 epidermal lamellar body membrane', 'GO:0000139 Golgi membrane', 'GO:0016020 membrane', 'GO:0005886 plasma membrane', 'GO:0030658 transport vesicle membrane']
|
[
"Cytoplasmic vesicle, secretory vesicle membrane",
"Golgi apparatus membrane"
] |
ABCA13
|
Q86UQ4
|
ATP-binding cassette sub-family A member 13
|
May mediate the cholesterol and gangliosides transport from the plasma membrane to intracellular vesicles in an ATP hydrolysis dependent manner, thus playing a role in their internalization by endocytic retrograde transport and may also participate in the endocytosis of synaptic vesicle in cortical neurons
|
['- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [3548-3768]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [3829-4094]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [3842-4074]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [3842-4075]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [3859-4004]', '- IPR003593: AAA+ ATPase domain (domain) [3867-4051]', '- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [4392-4631]', '- IPR026082: ABC transporter A (family) [4698-5043]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [4706-4969]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [4718-4956]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [4718-4947]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [4738-4884]', '- IPR003593: AAA+ ATPase domain (domain) [4746-4934]', '- IPR056264: ABCA1-4-like, C-terminal R2 regulatory domain (domain) [4948-5022]']
|
[]
|
['GOBP_AMIDE_TRANSPORT' 'GOBP_CERAMIDE_TRANSPORT' 'GOBP_ENDOCYTOSIS'
'GOBP_IMPORT_INTO_CELL' 'GOBP_LIPID_LOCALIZATION'
'GOBP_NITROGEN_COMPOUND_TRANSPORT'
'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION'
'GOBP_POSITIVE_REGULATION_OF_ENDOCYTOSIS'
'GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_SYNAPTIC_VESICLE_RECYCLING'
'GOBP_POSITIVE_REGULATION_OF_TRANSPORT' 'GOBP_PRESYNAPTIC_ENDOCYTOSIS'
'GOBP_REGULATION_OF_ENDOCYTOSIS' 'GOBP_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_REGULATION_OF_STEROL_TRANSPORT'
'GOBP_REGULATION_OF_SYNAPTIC_VESICLE_ENDOCYTOSIS'
'GOBP_REGULATION_OF_SYNAPTIC_VESICLE_RECYCLING'
'GOBP_REGULATION_OF_TRANSPORT'
'GOBP_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT' 'GOBP_STEROL_TRANSPORT'
'GOBP_SYNAPTIC_VESICLE_RECYCLING' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_VESICLE_MEDIATED_TRANSPORT'
'GOBP_VESICLE_MEDIATED_TRANSPORT_IN_SYNAPSE' 'GOCC_AZUROPHIL_GRANULE'
'GOCC_AZUROPHIL_GRANULE_MEMBRANE' 'GOCC_SECRETORY_GRANULE'
'GOCC_SECRETORY_GRANULE_MEMBRANE' 'GOCC_SECRETORY_VESICLE'
'GOCC_VACUOLAR_MEMBRANE' 'GOCC_VACUOLE' 'GOCC_VESICLE_MEMBRANE'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY' 'KEGG_ABC_TRANSPORTERS'
'REACTOME_INNATE_IMMUNE_SYSTEM' 'REACTOME_NEUTROPHIL_DEGRANULATION']
|
['GO:0140359 ABC-type transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0005319 lipid transporter activity']
|
['GO:0035627 ceramide transport', 'GO:0006869 lipid transport', 'GO:0032376 positive regulation of cholesterol transport', 'GO:1900244 positive regulation of synaptic vesicle endocytosis']
|
['GO:0035577 azurophil granule membrane', 'GO:0097708 intracellular vesicle', 'GO:0005886 plasma membrane', 'GO:0030667 secretory granule membrane']
|
[
"Cytoplasmic vesicle membrane"
] |
ABCA2
|
Q9BZC7
|
ATP-binding cassette sub-family A member 2
|
Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable) (PubMed:15238223, PubMed:21810484, PubMed:24201375). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed:24201375). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926, PubMed:26510981). May play a role in myelin formation (By similarity)
|
['- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [706-912]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [980-1226]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [983-1205]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [990-1221]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1007-1151]', '- IPR003593: AAA+ ATPase domain (domain) [1016-1198]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [1123-1137]', '- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [1725-2007]', '- IPR026082: ABC transporter A (family) [2023-2371]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [2038-2294]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [2047-2283]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [2050-2285]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [2072-2214]', '- IPR003593: AAA+ ATPase domain (domain) [2079-2264]', '- IPR056264: ABCA1-4-like, C-terminal R2 regulatory domain (domain) [2277-2350]']
|
['ATP-binding cassette sub-family D member 4', 'ATP-binding cassette sub-family B member 6, mitochondrial', 'ATP-binding cassette sub-family G member 5', 'ATP-binding cassette sub-family G member 8', 'Mitochondrial potassium channel ATP-binding subunit', 'Sodium/potassium-transporting ATPase subunit alpha-3', 'Potassium-transporting ATPase alpha chain 2', 'Sodium/potassium-transporting ATPase subunit alpha-1', 'Sodium/hydrogen exchanger 1', 'Sarcoplasmic/endoplasmic reticulum calcium ATPase 2']
|
['CYCLIN_D1_UP.V1_UP' 'ESC_V6.5_UP_EARLY.V1_DN' 'ESC_V6.5_UP_LATE.V1_DN'
'GOBP_ALCOHOL_BIOSYNTHETIC_PROCESS' 'GOBP_ALCOHOL_METABOLIC_PROCESS'
'GOBP_AMIDE_METABOLIC_PROCESS' 'GOBP_AMIDE_TRANSPORT'
'GOBP_AMYLOID_BETA_FORMATION' 'GOBP_AMYLOID_BETA_METABOLIC_PROCESS'
'GOBP_AMYLOID_PRECURSOR_PROTEIN_BIOSYNTHETIC_PROCESS'
'GOBP_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS'
'GOBP_AMYLOID_PRECURSOR_PROTEIN_METABOLIC_PROCESS'
'GOBP_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS'
'GOBP_AXON_ENSHEATHMENT_IN_CENTRAL_NERVOUS_SYSTEM' 'GOBP_BEHAVIOR'
'GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS'
'GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS'
'GOBP_CELLULAR_COMPONENT_ASSEMBLY_INVOLVED_IN_MORPHOGENESIS'
'GOBP_CELLULAR_HOMEOSTASIS' 'GOBP_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT'
'GOBP_CENTRAL_NERVOUS_SYSTEM_MYELIN_FORMATION'
'GOBP_CERAMIDE_METABOLIC_PROCESS' 'GOBP_CERAMIDE_TRANSPORT'
'GOBP_CHEMICAL_HOMEOSTASIS' 'GOBP_CHOLESTEROL_EFFLUX'
'GOBP_CIRCULATORY_SYSTEM_PROCESS' 'GOBP_DIOL_BIOSYNTHETIC_PROCESS'
'GOBP_DIOL_METABOLIC_PROCESS' 'GOBP_ENDOCYTOSIS'
'GOBP_ENSHEATHMENT_OF_NEURONS' 'GOBP_GANGLIOSIDE_METABOLIC_PROCESS'
'GOBP_GLIAL_CELL_DEVELOPMENT' 'GOBP_GLIAL_CELL_DIFFERENTIATION'
'GOBP_GLIOGENESIS' 'GOBP_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS'
'GOBP_GLYCOPROTEIN_METABOLIC_PROCESS'
'GOBP_GLYCOSPHINGOLIPID_METABOLIC_PROCESS' 'GOBP_GLYCOSYLATION'
'GOBP_HOMEOSTATIC_PROCESS' 'GOBP_IMPORT_INTO_CELL'
'GOBP_INTRACELLULAR_LIPID_TRANSPORT'
'GOBP_INTRACELLULAR_SPHINGOLIPID_HOMEOSTASIS'
'GOBP_INTRACELLULAR_STEROL_TRANSPORT' 'GOBP_INTRACELLULAR_TRANSPORT'
'GOBP_LIPID_BIOSYNTHETIC_PROCESS' 'GOBP_LIPID_HOMEOSTASIS'
'GOBP_LIPID_LOCALIZATION' 'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_LIPOSACCHARIDE_METABOLIC_PROCESS' 'GOBP_LOCOMOTORY_BEHAVIOR'
'GOBP_LOW_DENSITY_LIPOPROTEIN_RECEPTOR_PARTICLE_METABOLIC_PROCESS'
'GOBP_MACROMOLECULE_CATABOLIC_PROCESS'
'GOBP_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_MEMBRANE_LIPID_METABOLIC_PROCESS' 'GOBP_MEMBRANE_ORGANIZATION'
'GOBP_MYELIN_ASSEMBLY'
'GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION'
'GOBP_NEGATIVE_REGULATION_OF_CHOLESTEROL_EFFLUX'
'GOBP_NEGATIVE_REGULATION_OF_ENDOCYTOSIS'
'GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_LIPID_TRANSPORT'
'GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT'
'GOBP_NEGATIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_NEGATIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_NEGATIVE_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS'
'GOBP_NEGATIVE_REGULATION_OF_SPHINGOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_STEROL_TRANSPORT'
'GOBP_NEGATIVE_REGULATION_OF_TRANSPORT' 'GOBP_NEUROGENESIS'
'GOBP_NITROGEN_COMPOUND_TRANSPORT' 'GOBP_OLIGODENDROCYTE_DEVELOPMENT'
'GOBP_OLIGODENDROCYTE_DIFFERENTIATION'
'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS'
'GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS'
'GOBP_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_PHOSPHOLIPID_METABOLIC_PROCESS' 'GOBP_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_POLYOL_BIOSYNTHETIC_PROCESS' 'GOBP_POLYOL_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_AMIDE_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_AMYLOID_BETA_FORMATION'
'GOBP_POSITIVE_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_RECEPTOR_CATABOLIC_PROCESS'
'GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION'
'GOBP_PROTEIN_CATABOLIC_PROCESS'
'GOBP_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY'
'GOBP_PROTEIN_LOCALIZATION_TO_CELL_SURFACE'
'GOBP_RECEPTOR_CATABOLIC_PROCESS' 'GOBP_RECEPTOR_MEDIATED_ENDOCYTOSIS'
'GOBP_RECEPTOR_MEDIATED_ENDOCYTOSIS_INVOLVED_IN_CHOLESTEROL_TRANSPORT'
'GOBP_RECEPTOR_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_AMIDE_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS'
'GOBP_REGULATION_OF_CELLULAR_LOCALIZATION'
'GOBP_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_CHOLESTEROL_EFFLUX'
'GOBP_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_ENDOCYTOSIS'
'GOBP_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_INTRACELLULAR_LIPID_TRANSPORT'
'GOBP_REGULATION_OF_INTRACELLULAR_TRANSPORT'
'GOBP_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION'
'GOBP_REGULATION_OF_MEMBRANE_LIPID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_POST_TRANSLATIONAL_PROTEIN_MODIFICATION'
'GOBP_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_PROTEIN_GLYCOSYLATION'
'GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY'
'GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE'
'GOBP_REGULATION_OF_PROTEIN_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS'
'GOBP_REGULATION_OF_RECEPTOR_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS'
'GOBP_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_SPHINGOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_STEROID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_STEROL_TRANSPORT' 'GOBP_REGULATION_OF_TRANSPORT'
'GOBP_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT'
'GOBP_RESPONSE_TO_ALCOHOL' 'GOBP_RESPONSE_TO_ENDOGENOUS_STIMULUS'
'GOBP_RESPONSE_TO_HORMONE' 'GOBP_RESPONSE_TO_LIPID'
'GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND'
'GOBP_RESPONSE_TO_STEROID_HORMONE' 'GOBP_RESPONSE_TO_STEROL'
'GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_SECONDARY_ALCOHOL_METABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_SPHINGOID_BIOSYNTHETIC_PROCESS' 'GOBP_SPHINGOID_METABOLIC_PROCESS'
'GOBP_SPHINGOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_SPHINGOLIPID_METABOLIC_PROCESS' 'GOBP_SPHINGOLIPID_TRANSLOCATION'
'GOBP_SPHINGOMYELIN_METABOLIC_PROCESS'
'GOBP_STEROID_BIOSYNTHETIC_PROCESS' 'GOBP_STEROID_METABOLIC_PROCESS'
'GOBP_STEROL_BIOSYNTHETIC_PROCESS' 'GOBP_STEROL_HOMEOSTASIS'
'GOBP_STEROL_TRANSPORT' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM' 'GOBP_VASCULAR_TRANSPORT'
'GOBP_VESICLE_MEDIATED_TRANSPORT'
'GOCC_ATPASE_DEPENDENT_TRANSMEMBRANE_TRANSPORT_COMPLEX'
'GOCC_ATP_BINDING_CASSETTE_ABC_TRANSPORTER_COMPLEX' 'GOCC_ENDOSOME'
'GOCC_ENDOSOME_MEMBRANE' 'GOCC_MEMBRANE_PROTEIN_COMPLEX'
'GOCC_MICROTUBULE_CYTOSKELETON' 'GOCC_MICROTUBULE_ORGANIZING_CENTER'
'GOCC_PLASMA_MEMBRANE_PROTEIN_COMPLEX' 'GOCC_TRANSPORTER_COMPLEX'
'GOCC_VACUOLAR_MEMBRANE' 'GOCC_VACUOLE' 'GOCC_VESICLE_MEMBRANE'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_ENDOPEPTIDASE_ACTIVITY' 'GOMF_ENDOPEPTIDASE_REGULATOR_ACTIVITY'
'GOMF_ENZYME_REGULATOR_ACTIVITY' 'GOMF_FLOPPASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSPORTER_ACTIVITY' 'GOMF_PEPTIDASE_ACTIVITY'
'GOMF_PEPTIDASE_REGULATOR_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_SPHINGOLIPID_TRANSPORTER_ACTIVITY' 'GOMF_TRANSPORTER_ACTIVITY'
'HALLMARK_BILE_ACID_METABOLISM' 'HALLMARK_CHOLESTEROL_HOMEOSTASIS'
'KEGG_ABC_TRANSPORTERS' 'KEGG_LYSOSOME' 'MTOR_UP.V1_UP'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES']
|
['GO:0140359 ABC-type transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0099038 ceramide floppase activity', 'GO:0061135 endopeptidase regulator activity', 'GO:0005319 lipid transporter activity', 'GO:0000166 nucleotide binding']
|
['GO:0032289 central nervous system myelin formation', 'GO:0099040 ceramide translocation', 'GO:0042632 cholesterol homeostasis', 'GO:0001573 ganglioside metabolic process', 'GO:0006687 glycosphingolipid metabolic process', 'GO:0090156 intracellular sphingolipid homeostasis', 'GO:0006629 lipid metabolic process', 'GO:0006869 lipid transport', 'GO:0007626 locomotory behavior', 'GO:0090370 negative regulation of cholesterol efflux', 'GO:0032384 negative regulation of intracellular cholesterol transport', 'GO:0071072 negative regulation of phospholipid biosynthetic process', 'GO:1905601 negative regulation of receptor-mediated endocytosis involved in cholesterol transport', 'GO:0090155 negative regulation of sphingolipid biosynthetic process', 'GO:0045939 negative regulation of steroid metabolic process', 'GO:0042986 positive regulation of amyloid precursor protein biosynthetic process', 'GO:1902993 positive regulation of amyloid precursor protein catabolic process', 'GO:1902004 positive regulation of amyloid-beta formation', 'GO:0032805 positive regulation of low-density lipoprotein particle receptor catabolic process', 'GO:0032383 regulation of intracellular cholesterol transport', 'GO:1901873 regulation of post-translational protein modification', 'GO:1904375 regulation of protein localization to cell periphery', 'GO:2000008 regulation of protein localization to cell surface', 'GO:0019218 regulation of steroid metabolic process', 'GO:0070723 response to cholesterol', 'GO:0048545 response to steroid hormone', 'GO:0009410 response to xenobiotic stimulus', 'GO:0006684 sphingomyelin metabolic process', 'GO:0046512 sphingosine biosynthetic process', 'GO:0055085 transmembrane transport', 'GO:0150104 transport across blood-brain barrier']
|
['GO:0043190 ATP-binding cassette (ABC) transporter complex', 'GO:0031410 cytoplasmic vesicle', 'GO:0005768 endosome', 'GO:0010008 endosome membrane', 'GO:0005765 lysosomal membrane', 'GO:0005764 lysosome', 'GO:0016020 membrane', 'GO:0005815 microtubule organizing center', 'GO:0005886 plasma membrane']
|
[
"Endosome membrane",
"Lysosome membrane"
] |
ABCA3
|
Q99758
|
Phospholipid-transporting ATPase ABCA3
|
Catalyzes the ATP-dependent transport of phospholipids such as phosphatidylcholine and phosphoglycerol from the cytoplasm into the lumen side of lamellar bodies, in turn participates in the lamellar bodies biogenesis and homeostasis of pulmonary surfactant (PubMed:16959783, PubMed:17574245, PubMed:27177387, PubMed:28887056, PubMed:31473345). Transports preferentially phosphatidylcholine containing short acyl chains (PubMed:27177387). In addition plays a role as an efflux transporter of miltefosine across macrophage membranes and free cholesterol (FC) through intralumenal vesicles by removing FC from the cell as a component of surfactant and protects cells from free cholesterol toxicity (PubMed:25817392, PubMed:26903515, PubMed:27177387)
|
['- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [259-469]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [523-767]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [529-766]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [530-763]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [550-693]', '- IPR003593: AAA+ ATPase domain (domain) [558-740]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [665-679]', '- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [923-1321]', '- IPR026082: ABC transporter A (family) [1355-1696]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1378-1634]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1381-1614]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1395-1609]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1400-1542]', '- IPR003593: AAA+ ATPase domain (domain) [1408-1592]', '- IPR056264: ABCA1-4-like, C-terminal R2 regulatory domain (domain) [1606-1682]']
|
['Pulmonary surfactant-associated protein B', 'Pulmonary surfactant-associated protein C', 'Granulocyte-macrophage colony-stimulating factor receptor subunit alpha', 'Pulmonary surfactant-associated protein A1']
|
['GOBP_CHEMICAL_HOMEOSTASIS' 'GOBP_CHOLESTEROL_EFFLUX'
'GOBP_EXPORT_FROM_CELL' 'GOBP_GLYCEROLIPID_METABOLIC_PROCESS'
'GOBP_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS' 'GOBP_HOMEOSTATIC_PROCESS'
'GOBP_INTERMEMBRANE_LIPID_TRANSFER' 'GOBP_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_LIPID_HOMEOSTASIS' 'GOBP_LIPID_LOCALIZATION'
'GOBP_LIPID_METABOLIC_PROCESS' 'GOBP_MEMBRANE_ORGANIZATION'
'GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_CHEMICAL_HOMEOSTASIS'
'GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS'
'GOBP_ORGANELLE_ASSEMBLY' 'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT'
'GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS'
'GOBP_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS'
'GOBP_PHOSPHATIDYLGLYCEROL_METABOLIC_PROCESS' 'GOBP_PHOSPHOLIPID_EFFLUX'
'GOBP_PHOSPHOLIPID_HOMEOSTASIS' 'GOBP_PHOSPHOLIPID_METABOLIC_PROCESS'
'GOBP_PHOSPHOLIPID_TRANSPORT' 'GOBP_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS'
'GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION'
'GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX'
'GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_PHOSPHOLIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY'
'GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_TRANSPORT'
'GOBP_PROTEIN_COMPLEX_OLIGOMERIZATION'
'GOBP_PROTEIN_CONTAINING_COMPLEX_ORGANIZATION'
'GOBP_PROTEIN_HOMOOLIGOMERIZATION'
'GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS'
'GOBP_REGULATION_OF_CHOLESTEROL_EFFLUX'
'GOBP_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION'
'GOBP_REGULATION_OF_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY'
'GOBP_REGULATION_OF_PROTEIN_OLIGOMERIZATION'
'GOBP_REGULATION_OF_STEROL_TRANSPORT' 'GOBP_REGULATION_OF_TRANSPORT'
'GOBP_RESPIRATORY_SYSTEM_DEVELOPMENT' 'GOBP_RESPONSE_TO_CORTICOSTEROID'
'GOBP_RESPONSE_TO_ENDOGENOUS_STIMULUS' 'GOBP_RESPONSE_TO_HORMONE'
'GOBP_RESPONSE_TO_LIPID' 'GOBP_RESPONSE_TO_STEROID_HORMONE'
'GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS' 'GOBP_STEROL_TRANSPORT'
'GOBP_SURFACTANT_HOMEOSTASIS' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_TUBE_DEVELOPMENT' 'GOBP_XENOBIOTIC_EXPORT_FROM_CELL'
'GOBP_XENOBIOTIC_TRANSMEMBRANE_TRANSPORT' 'GOBP_XENOBIOTIC_TRANSPORT'
'GOCC_ALVEOLAR_LAMELLAR_BODY' 'GOCC_ENDOSOME' 'GOCC_ENDOSOME_MEMBRANE'
'GOCC_LAMELLAR_BODY' 'GOCC_LATE_ENDOSOME' 'GOCC_LATE_ENDOSOME_MEMBRANE'
'GOCC_MULTIVESICULAR_BODY' 'GOCC_MULTIVESICULAR_BODY_MEMBRANE'
'GOCC_SECRETORY_GRANULE' 'GOCC_SECRETORY_GRANULE_MEMBRANE'
'GOCC_SECRETORY_VESICLE' 'GOCC_VACUOLAR_MEMBRANE' 'GOCC_VACUOLE'
'GOCC_VESICLE_MEMBRANE' 'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_FLIPPASE_ACTIVITY' 'GOMF_GLYCEROPHOSPHOLIPID_FLIPPASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSFER_ACTIVITY' 'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_PHOSPHATIDYLCHOLINE_FLIPPASE_ACTIVITY'
'GOMF_PHOSPHATIDYLCHOLINE_TRANSFER_ACTIVITY'
'GOMF_PHOSPHATIDYLCHOLINE_TRANSPORTER_ACTIVITY'
'GOMF_PHOSPHOLIPID_TRANSFER_ACTIVITY'
'GOMF_PHOSPHOLIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY'
'GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'HALLMARK_BILE_ACID_METABOLISM' 'HALLMARK_ESTROGEN_RESPONSE_EARLY'
'HALLMARK_ESTROGEN_RESPONSE_LATE' 'KEGG_ABC_TRANSPORTERS'
'KRAS.KIDNEY_UP.V1_DN' 'PID_ERA_GENOMIC_PATHWAY'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS'
'REACTOME_ABC_TRANSPORTER_DISORDERS'
'REACTOME_DISEASES_ASSOCIATED_WITH_SURFACTANT_METABOLISM'
'REACTOME_DISEASES_OF_METABOLISM'
'REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS'
'REACTOME_SURFACTANT_METABOLISM' 'REACTOME_TRANSPORT_OF_SMALL_MOLECULES']
|
['GO:0008559 ABC-type xenobiotic transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0005319 lipid transporter activity', 'GO:0140345 phosphatidylcholine flippase activity', 'GO:0120019 phosphatidylcholine transfer activity']
|
['GO:0006869 lipid transport', 'GO:0030324 lung development', 'GO:0070925 organelle assembly', 'GO:0046470 phosphatidylcholine metabolic process', 'GO:0046471 phosphatidylglycerol metabolic process', 'GO:0055091 phospholipid homeostasis', 'GO:0015914 phospholipid transport', 'GO:0010875 positive regulation of cholesterol efflux', 'GO:1902995 positive regulation of phospholipid efflux', 'GO:2001140 positive regulation of phospholipid transport', 'GO:0032464 positive regulation of protein homooligomerization', 'GO:0046890 regulation of lipid biosynthetic process', 'GO:0150172 regulation of phosphatidylcholine metabolic process', 'GO:0051384 response to glucocorticoid', 'GO:0009410 response to xenobiotic stimulus', 'GO:0043129 surfactant homeostasis', 'GO:0046618 xenobiotic export from cell', 'GO:0006855 xenobiotic transmembrane transport', 'GO:0042908 xenobiotic transport']
|
['GO:0097208 alveolar lamellar body', 'GO:0097233 alveolar lamellar body membrane', 'GO:0030659 cytoplasmic vesicle membrane', 'GO:0005615 extracellular space', 'GO:0042599 lamellar body', 'GO:0097232 lamellar body membrane', 'GO:0005770 late endosome', 'GO:0005765 lysosomal membrane', 'GO:0032585 multivesicular body membrane', 'GO:0005886 plasma membrane']
|
[
"Endosome, multivesicular body membrane",
"Cytoplasmic vesicle membrane",
"Late endosome membrane",
"Lysosome membrane"
] |
ABCA4
|
P78363
|
Retinal-specific phospholipid-transporting ATPase ABCA4
|
Flippase that catalyzes in an ATP-dependent manner the transport of retinal-phosphatidylethanolamine conjugates like 11-cis and all-trans isomers of N-retinylidene-phosphatidylethanolamine (N-Ret-PE) from the lumen to the cytoplasmic leaflet of photoreceptor outer segment disk membranes, where 11-cis-retinylidene-phosphatidylethanolamine is then isomerized to its all-trans isomer and reduced by RDH8 to produce all-trans-retinol. This transport activity ensures that all-trans-retinal generated from photoexcitation and 11-cis-retinal not needed for the regeneration of rhodopsin and cone opsins are effectively cleared from the photoreceptors, therefore preventing their accumulation and the formation of toxic bisretinoid (PubMed:10075733, PubMed:20404325, PubMed:22735453, PubMed:23144455, PubMed:24097981, PubMed:29847635, PubMed:33375396). Displays ATPase activity in vitro in absence of retinal substrate (PubMed:33605212, PubMed:39128720, PubMed:29847635, PubMed:33375396). May display GTPase activity that is strongly influenced by the lipid environment and the presence of retinoid compounds (PubMed:22735453). Binds the unprotonated form of N-retinylidene-phosphatidylethanolamine with high affinity in the absence of ATP, and ATP binding and hydrolysis induce a protein conformational change that causes N-retinylidene-phosphatidylethanolamine release (By similarity)
|
['- IPR005951: Retinal-specific ATP-binding cassette transporter (family) [1-2272]', '- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [626-856]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [927-1163]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [927-1165]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [929-1160]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [947-1090]', '- IPR003593: AAA+ ATPase domain (domain) [955-1145]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [1062-1076]', '- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [1604-1895]', '- IPR026082: ABC transporter A (family) [1917-2255]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1926-2175]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1937-2160]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1938-2170]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1959-2099]', '- IPR003593: AAA+ ATPase domain (domain) [1964-2148]', '- IPR056264: ABCA1-4-like, C-terminal R2 regulatory domain (domain) [2162-2238]']
|
['X-linked retinitis pigmentosa GTPase regulator', 'Elongation of very long chain fatty acids protein 4', 'Peripherin-2', 'Retinoid isomerohydrolase', 'Cyclic nucleotide-gated cation channel beta-1', 'Cyclic nucleotide-gated cation channel beta-3', 'Protein eyes shut homolog', 'Retinol dehydrogenase 12', 'Retinal guanylyl cyclase 1', 'Ceramide kinase-like protein']
|
['BMI1_DN_MEL18_DN.V1_DN' 'CRX_DN.V1_UP' 'GOBP_ALDEHYDE_METABOLIC_PROCESS'
'GOBP_DETECTION_OF_ABIOTIC_STIMULUS' 'GOBP_DETECTION_OF_LIGHT_STIMULUS'
'GOBP_DETECTION_OF_STIMULUS' 'GOBP_DETECTION_OF_VISIBLE_LIGHT'
'GOBP_HOMEOSTATIC_PROCESS' 'GOBP_ISOPRENOID_METABOLIC_PROCESS'
'GOBP_LIPID_LOCALIZATION' 'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_MEMBRANE_ORGANIZATION'
'GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS'
'GOBP_NERVOUS_SYSTEM_PROCESS' 'GOBP_OLEFINIC_COMPOUND_METABOLIC_PROCESS'
'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT' 'GOBP_PHOSPHOLIPID_TRANSLOCATION'
'GOBP_PHOSPHOLIPID_TRANSPORT' 'GOBP_PHOTORECEPTOR_CELL_MAINTENANCE'
'GOBP_PHOTOTRANSDUCTION' 'GOBP_PHOTOTRANSDUCTION_VISIBLE_LIGHT'
'GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION'
'GOBP_RESPONSE_TO_ABIOTIC_STIMULUS' 'GOBP_RESPONSE_TO_LIGHT_STIMULUS'
'GOBP_RESPONSE_TO_RADIATION' 'GOBP_RETINAL_METABOLIC_PROCESS'
'GOBP_RETINA_HOMEOSTASIS' 'GOBP_SENSORY_PERCEPTION'
'GOBP_SENSORY_PERCEPTION_OF_LIGHT_STIMULUS'
'GOBP_TERPENOID_METABOLIC_PROCESS' 'GOBP_TISSUE_HOMEOSTASIS'
'GOBP_TRANSMEMBRANE_TRANSPORT' 'GOCC_9PLUS0_NON_MOTILE_CILIUM'
'GOCC_CILIUM' 'GOCC_NEURON_PROJECTION' 'GOCC_NON_MOTILE_CILIUM'
'GOCC_PHOTORECEPTOR_DISC_MEMBRANE' 'GOCC_PHOTORECEPTOR_OUTER_SEGMENT'
'GOCC_VESICLE_MEMBRANE' 'GOMF_11_CIS_RETINAL_BINDING'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ALCOHOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ALL_TRANS_RETINAL_BINDING'
'GOMF_ATPASE_COUPLED_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_FLIPPASE_ACTIVITY' 'GOMF_GLYCEROPHOSPHOLIPID_FLIPPASE_ACTIVITY'
'GOMF_GTPASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY' 'GOMF_ISOPRENOID_BINDING'
'GOMF_LIPID_BINDING' 'GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_PHOSPHATIDYLETHANOLAMINE_FLIPPASE_ACTIVITY'
'GOMF_PHOSPHOLIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_RETINAL_BINDING' 'GOMF_TRANSPORTER_ACTIVITY' 'GOMF_VITAMIN_BINDING'
'GOMF_VITAMIN_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'HALLMARK_BILE_ACID_METABOLISM' 'JNK_DN.V1_DN' 'KEGG_ABC_TRANSPORTERS'
'P53_DN.V1_DN' 'PKCA_DN.V1_DN'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_RETINOID_CYCLE_DISEASE_EVENTS' 'REACTOME_SENSORY_PERCEPTION'
'REACTOME_THE_CANONICAL_RETINOID_CYCLE_IN_RODS_TWILIGHT_VISION'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES'
'REACTOME_VISUAL_PHOTOTRANSDUCTION' 'SNF5_DN.V1_DN' 'VEGF_A_UP.V1_UP'
'WP_VISUAL_CYCLE']
|
['GO:0005502 11-cis retinal binding', 'GO:0140359 ABC-type transporter activity', 'GO:0005503 all-trans retinal binding', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0140326 ATPase-coupled intramembrane lipid transporter activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0140327 flippase activity', 'GO:0003924 GTPase activity', 'GO:0140347 N-retinylidene-phosphatidylethanolamine flippase activity', 'GO:0090555 phosphatidylethanolamine flippase activity', 'GO:0005548 phospholipid transporter activity', 'GO:0005501 retinoid binding', 'GO:0034632 retinol transmembrane transporter activity']
|
['GO:0006869 lipid transport', 'GO:0006649 phospholipid transfer to membrane', 'GO:0045332 phospholipid translocation', 'GO:0045494 photoreceptor cell maintenance', 'GO:0007603 phototransduction, visible light', 'GO:0042574 retinal metabolic process', 'GO:0001523 retinoid metabolic process', 'GO:0055085 transmembrane transport', 'GO:0007601 visual perception']
|
['GO:0031410 cytoplasmic vesicle', 'GO:0005783 endoplasmic reticulum', 'GO:0016020 membrane', 'GO:0097381 photoreceptor disc membrane', 'GO:0001750 photoreceptor outer segment', 'GO:0005886 plasma membrane', 'GO:0120202 rod photoreceptor disc membrane']
|
[
"Membrane",
"Endoplasmic reticulum",
"Cytoplasmic vesicle",
"Cell projection, cilium, photoreceptor outer segment"
] |
ABCA5
|
Q8WWZ7
|
Cholesterol transporter ABCA5
|
Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport (PubMed:25125465). May play a role in the processing of autolysosomes (By similarity)
|
['- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [35-416]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [468-707]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [477-697]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [478-713]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [497-643]', '- IPR003593: AAA+ ATPase domain (domain) [506-691]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [615-629]', '- IPR026082: ABC transporter A (family) [1264-1622]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1281-1538]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1286-1530]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1290-1533]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1318-1460]', '- IPR003593: AAA+ ATPase domain (domain) [1325-1512]', '- IPR056264: ABCA1-4-like, C-terminal R2 regulatory domain (domain) [1525-1602]']
|
['Elongator complex protein 6']
|
['DCA_UP.V1_DN' 'GOBP_ALCOHOL_METABOLIC_PROCESS'
'GOBP_CHEMICAL_HOMEOSTASIS' 'GOBP_CHOLESTEROL_EFFLUX'
'GOBP_FOAM_CELL_DIFFERENTIATION'
'GOBP_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING'
'GOBP_HOMEOSTATIC_PROCESS' 'GOBP_LIPID_HOMEOSTASIS'
'GOBP_LIPID_LOCALIZATION' 'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION'
'GOBP_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION'
'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_TRANSPORT'
'GOBP_PROTEIN_CONTAINING_COMPLEX_ORGANIZATION'
'GOBP_PROTEIN_CONTAINING_COMPLEX_REMODELING'
'GOBP_PROTEIN_LIPID_COMPLEX_ORGANIZATION'
'GOBP_REGULATION_OF_CELL_DIFFERENTIATION'
'GOBP_REGULATION_OF_CHOLESTEROL_EFFLUX'
'GOBP_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS'
'GOBP_REGULATION_OF_REVERSE_CHOLESTEROL_TRANSPORT'
'GOBP_REGULATION_OF_STEROL_TRANSPORT' 'GOBP_REGULATION_OF_TRANSPORT'
'GOBP_REVERSE_CHOLESTEROL_TRANSPORT'
'GOBP_SECONDARY_ALCOHOL_METABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS' 'GOBP_STEROID_METABOLIC_PROCESS'
'GOBP_STEROL_HOMEOSTASIS' 'GOBP_STEROL_TRANSPORT'
'GOBP_TRANSMEMBRANE_TRANSPORT' 'GOCC_ENDOSOME' 'GOCC_ENDOSOME_MEMBRANE'
'GOCC_GOLGI_APPARATUS' 'GOCC_GOLGI_MEMBRANE' 'GOCC_LATE_ENDOSOME'
'GOCC_LATE_ENDOSOME_MEMBRANE' 'GOCC_VACUOLAR_MEMBRANE' 'GOCC_VACUOLE'
'GOCC_VESICLE_MEMBRANE' 'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY' 'HALLMARK_BILE_ACID_METABOLISM'
'KEGG_ABC_TRANSPORTERS' 'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES']
|
['GO:0140359 ABC-type transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0005319 lipid transporter activity']
|
['GO:0033344 cholesterol efflux', 'GO:0042632 cholesterol homeostasis', 'GO:0008203 cholesterol metabolic process', 'GO:0034375 high-density lipoprotein particle remodeling', 'GO:0006869 lipid transport', 'GO:0010745 negative regulation of macrophage derived foam cell differentiation', 'GO:1903064 positive regulation of reverse cholesterol transport', 'GO:0010874 regulation of cholesterol efflux', 'GO:0043691 reverse cholesterol transport']
|
['GO:0000139 Golgi membrane', 'GO:0005770 late endosome', 'GO:0031902 late endosome membrane', 'GO:0005765 lysosomal membrane', 'GO:0005764 lysosome', 'GO:0005886 plasma membrane']
|
[
"Golgi apparatus membrane",
"Lysosome membrane",
"Late endosome membrane",
"Cell membrane"
] |
ABCA6
|
Q8N139
|
ATP-binding cassette sub-family A member 6
|
Probable transporter which may play a role in macrophage lipid transport and homeostasis
|
['- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [36-416]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [464-713]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [469-740]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [478-713]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [497-643]', '- IPR003593: AAA+ ATPase domain (domain) [506-690]', '- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [918-1166]', '- IPR026082: ABC transporter A (family) [1250-1600]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1269-1530]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1288-1513]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1296-1509]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1304-1440]', '- IPR003593: AAA+ ATPase domain (domain) [1312-1490]', '- IPR056264: ABCA1-4-like, C-terminal R2 regulatory domain (domain) [1505-1579]']
|
['ATP-binding cassette sub-family A member 9', 'Forkhead box protein O1', 'Forkhead box protein O3']
|
['CSR_LATE_UP.V1_DN' 'GOBP_LIPID_LOCALIZATION'
'GOBP_TRANSMEMBRANE_TRANSPORT' 'GOCC_GOLGI_APPARATUS'
'GOCC_GOLGI_MEMBRANE' 'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY' 'HALLMARK_BILE_ACID_METABOLISM'
'IL21_UP.V1_UP' 'KEGG_ABC_TRANSPORTERS' 'PTEN_DN.V1_DN'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS'
'REACTOME_FOXO_MEDIATED_TRANSCRIPTION'
'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES'
'REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES']
|
['GO:0140359 ABC-type transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0005319 lipid transporter activity']
|
['GO:0006869 lipid transport']
|
['GO:0000139 Golgi membrane', 'GO:0005654 nucleoplasm', 'GO:0005886 plasma membrane']
|
[
"Golgi apparatus membrane"
] |
ABCA7
|
Q8IZY2
|
Phospholipid-transporting ATPase ABCA7
|
Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Transports preferentially phosphatidylserine over phosphatidylcholine (PubMed:24097981). Plays a role in lipid homeostasis and macrophage-mediated phagocytosis (PubMed:12917409, PubMed:12925201, PubMed:14570867, PubMed:14592415). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (PubMed:12917409, PubMed:14570867, PubMed:14592415). May also mediate cholesterol efflux (PubMed:14570867). May regulate cellular ceramide homeostasis during keratinocyte differentiation (PubMed:12925201). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (By similarity). Plays a role in phagocytosis of apoptotic cells by macrophages (By similarity). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (By similarity). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (By similarity). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (PubMed:26260791). Amyloid-beta is the main component of amyloid plaques found in the brains of Alzheimer patients (PubMed:26260791)
|
['- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [551-750]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [802-1071]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [807-1038]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [812-1020]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [824-968]', '- IPR003593: AAA+ ATPase domain (domain) [833-1014]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [940-954]', '- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [1466-1750]', '- IPR026082: ABC transporter A (family) [1771-2114]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1780-2037]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1792-2014]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1793-2025]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1812-1954]', '- IPR003593: AAA+ ATPase domain (domain) [1819-2004]', '- IPR056264: ABCA1-4-like, C-terminal R2 regulatory domain (domain) [2019-2090]']
|
['Truncated apolipoprotein A-I', 'Minor histocompatibility antigen HA-1', 'CD2-associated protein', 'Phosphatidylinositol-binding clathrin assembly protein', 'Sortilin-related receptor', 'Myc box-dependent-interacting protein 1', 'Putative membrane-spanning 4-domains subfamily A member 4E', 'Membrane-spanning 4-domains subfamily A member 6A', 'Clusterin alpha chain', 'Presenilin-2 CTF subunit']
|
['AKT_UP.V1_UP' 'AKT_UP_MTOR_DN.V1_UP' 'ESC_V6.5_UP_EARLY.V1_DN'
'GOBP_AMIDE_METABOLIC_PROCESS' 'GOBP_AMYLOID_BETA_CLEARANCE'
'GOBP_AMYLOID_BETA_CLEARANCE_BY_CELLULAR_CATABOLIC_PROCESS'
'GOBP_AMYLOID_BETA_FORMATION' 'GOBP_AMYLOID_BETA_METABOLIC_PROCESS'
'GOBP_AMYLOID_PRECURSOR_PROTEIN_BIOSYNTHETIC_PROCESS'
'GOBP_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS'
'GOBP_AMYLOID_PRECURSOR_PROTEIN_METABOLIC_PROCESS'
'GOBP_APOLIPOPROTEIN_A_I_MEDIATED_SIGNALING_PATHWAY'
'GOBP_APOPTOTIC_CELL_CLEARANCE' 'GOBP_ASSOCIATIVE_LEARNING'
'GOBP_BEHAVIOR' 'GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS'
'GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS'
'GOBP_CELLULAR_RESPONSE_TO_STRESS'
'GOBP_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN'
'GOBP_CELLULAR_RESPONSE_TO_UNFOLDED_PROTEIN' 'GOBP_CHOLESTEROL_EFFLUX'
'GOBP_COGNITION' 'GOBP_ENDOCYTOSIS'
'GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION'
'GOBP_ENGULFMENT_OF_APOPTOTIC_CELL' 'GOBP_ERK1_AND_ERK2_CASCADE'
'GOBP_ER_NUCLEUS_SIGNALING_PATHWAY'
'GOBP_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS'
'GOBP_GLYCOPROTEIN_METABOLIC_PROCESS'
'GOBP_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_ASSEMBLY' 'GOBP_IMPORT_INTO_CELL'
'GOBP_INTEGRATED_STRESS_RESPONSE_SIGNALING' 'GOBP_LEARNING'
'GOBP_LIPID_LOCALIZATION' 'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_MAPK_CASCADE' 'GOBP_MEMBRANE_INVAGINATION'
'GOBP_MEMBRANE_ORGANIZATION' 'GOBP_MEMBRANE_RAFT_ORGANIZATION'
'GOBP_MEMORY' 'GOBP_NEGATIVE_REGULATION_OF_AMIDE_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_BIOSYNTHETIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION'
'GOBP_NEGATIVE_REGULATION_OF_ENDOCYTOSIS'
'GOBP_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE'
'GOBP_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION'
'GOBP_NEGATIVE_REGULATION_OF_MAPK_CASCADE'
'GOBP_NEGATIVE_REGULATION_OF_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE'
'GOBP_NEGATIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS'
'GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS'
'GOBP_NEGATIVE_REGULATION_OF_SIGNALING'
'GOBP_NEGATIVE_REGULATION_OF_TRANSPORT' 'GOBP_NERVOUS_SYSTEM_PROCESS'
'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT'
'GOBP_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE' 'GOBP_PHAGOCYTOSIS'
'GOBP_PHAGOCYTOSIS_ENGULFMENT' 'GOBP_PHOSPHOLIPID_EFFLUX'
'GOBP_PHOSPHOLIPID_TRANSLOCATION' 'GOBP_PHOSPHOLIPID_TRANSPORT'
'GOBP_PLASMA_MEMBRANE_ORGANIZATION'
'GOBP_PLASMA_MEMBRANE_RAFT_ORGANIZATION'
'GOBP_POSITIVE_REGULATION_OF_AMYLOID_BETA_CLEARANCE'
'GOBP_POSITIVE_REGULATION_OF_APOPTOTIC_CELL_CLEARANCE'
'GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION'
'GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX'
'GOBP_POSITIVE_REGULATION_OF_ENDOCYTOSIS'
'GOBP_POSITIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE'
'GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION'
'GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_MAPK_CASCADE'
'GOBP_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_PHAGOCYTOSIS'
'GOBP_POSITIVE_REGULATION_OF_PHOSPHOLIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE'
'GOBP_POSITIVE_REGULATION_OF_SIGNALING'
'GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_TRANSPORT'
'GOBP_PROTEIN_CONTAINING_COMPLEX_ORGANIZATION'
'GOBP_PROTEIN_LIPID_COMPLEX_ASSEMBLY'
'GOBP_PROTEIN_LIPID_COMPLEX_ORGANIZATION'
'GOBP_PROTEIN_LOCALIZATION_TO_CELL_SURFACE'
'GOBP_PROTEIN_LOCALIZATION_TO_NUCLEUS'
'GOBP_PROTEIN_LOCALIZATION_TO_ORGANELLE'
'GOBP_REGULATION_OF_AMIDE_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_AMYLOID_BETA_CLEARANCE'
'GOBP_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_APOPTOTIC_CELL_CLEARANCE'
'GOBP_REGULATION_OF_CELLULAR_LOCALIZATION'
'GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_STRESS'
'GOBP_REGULATION_OF_CHOLESTEROL_EFFLUX' 'GOBP_REGULATION_OF_ENDOCYTOSIS'
'GOBP_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE'
'GOBP_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_REGULATION_OF_MEMBRANE_INVAGINATION'
'GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION'
'GOBP_REGULATION_OF_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE'
'GOBP_REGULATION_OF_PHAGOCYTOSIS'
'GOBP_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS'
'GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE'
'GOBP_REGULATION_OF_PROTEIN_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS'
'GOBP_REGULATION_OF_RESPONSE_TO_STRESS'
'GOBP_REGULATION_OF_STEROL_TRANSPORT' 'GOBP_REGULATION_OF_TRANSPORT'
'GOBP_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT'
'GOBP_RESPONSE_TO_ABIOTIC_STIMULUS'
'GOBP_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS'
'GOBP_RESPONSE_TO_LIGHT_STIMULUS' 'GOBP_RESPONSE_TO_RADIATION'
'GOBP_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN'
'GOBP_STEROL_TRANSPORT' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_VESICLE_MEDIATED_TRANSPORT' 'GOBP_VISUAL_BEHAVIOR'
'GOCC_CELL_LEADING_EDGE' 'GOCC_CELL_PROJECTION_MEMBRANE'
'GOCC_CELL_SURFACE' 'GOCC_EARLY_ENDOSOME' 'GOCC_EARLY_ENDOSOME_MEMBRANE'
'GOCC_ENDOSOME' 'GOCC_ENDOSOME_MEMBRANE' 'GOCC_GLIAL_CELL_PROJECTION'
'GOCC_GOLGI_APPARATUS' 'GOCC_GOLGI_MEMBRANE' 'GOCC_LEADING_EDGE_MEMBRANE'
'GOCC_PHAGOCYTIC_CUP' 'GOCC_PLASMA_MEMBRANE_REGION' 'GOCC_RUFFLE'
'GOCC_RUFFLE_MEMBRANE' 'GOCC_VESICLE_MEMBRANE'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_CARGO_RECEPTOR_ACTIVITY' 'GOMF_FLOPPASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_PHOSPHATIDYLCHOLINE_FLOPPASE_ACTIVITY'
'GOMF_PHOSPHATIDYLCHOLINE_TRANSPORTER_ACTIVITY'
'GOMF_PHOSPHATIDYLSERINE_FLOPPASE_ACTIVITY'
'GOMF_PHOSPHOLIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY' 'KEGG_ABC_TRANSPORTERS'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES']
|
['GO:0140359 ABC-type transporter activity', 'GO:0034188 apolipoprotein A-I receptor activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0140328 floppase activity', 'GO:0090554 phosphatidylcholine floppase activity', 'GO:0090556 phosphatidylserine floppase activity', 'GO:0005548 phospholipid transporter activity']
|
['GO:0150094 amyloid-beta clearance by cellular catabolic process', 'GO:0034205 amyloid-beta formation', 'GO:0038027 apolipoprotein A-I-mediated signaling pathway', 'GO:0033344 cholesterol efflux', 'GO:0034380 high-density lipoprotein particle assembly', 'GO:0007613 memory', 'GO:0042985 negative regulation of amyloid precursor protein biosynthetic process', 'GO:1902430 negative regulation of amyloid-beta formation', 'GO:0045806 negative regulation of endocytosis', 'GO:0043409 negative regulation of MAPK cascade', 'GO:1903898 negative regulation of PERK-mediated unfolded protein response', 'GO:0006909 phagocytosis', 'GO:0033700 phospholipid efflux', 'GO:0045332 phospholipid translocation', 'GO:0044857 plasma membrane raft organization', 'GO:1900223 positive regulation of amyloid-beta clearance', 'GO:0010875 positive regulation of cholesterol efflux', 'GO:1901076 positive regulation of engulfment of apoptotic cell', 'GO:0070374 positive regulation of ERK1 and ERK2 cascade', 'GO:0050766 positive regulation of phagocytosis', 'GO:1902995 positive regulation of phospholipid efflux', 'GO:2000010 positive regulation of protein localization to cell surface', 'GO:0034504 protein localization to nucleus', 'GO:1902991 regulation of amyloid precursor protein catabolic process', 'GO:0019216 regulation of lipid metabolic process', 'GO:0008542 visual learning']
|
['GO:0030054 cell junction', 'GO:0009986 cell surface', 'GO:0031901 early endosome membrane', 'GO:0005783 endoplasmic reticulum', 'GO:0097386 glial cell projection', 'GO:0005794 Golgi apparatus', 'GO:0000139 Golgi membrane', 'GO:0001891 phagocytic cup', 'GO:0005886 plasma membrane', 'GO:0032587 ruffle membrane']
|
[
"Cell membrane",
"Golgi apparatus membrane",
"Early endosome membrane",
"Cytoplasm",
"Cell projection, ruffle membrane",
"Cell projection, phagocytic cup",
"Endoplasmic reticulum"
] |
ABCA8
|
O94911
|
ABC-type organic anion transporter ABCA8
|
Catalyzes ATP-dependent import of organic anions such as taurocholate and estrone sulfate (PubMed:12379217). In vitro, also imports ochratoxin A (PubMed:12379217). Also mediates cholesterol efflux independent of apolipoprotein, and plays a role in sphingomyelin production in oligodendrocytes (PubMed:23560799)
|
['- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [73-418]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [469-732]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [479-699]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [480-715]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [499-645]', '- IPR003593: AAA+ ATPase domain (domain) [508-692]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [617-631]', '- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [924-1186]', '- IPR026082: ABC transporter A (family) [1254-1602]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1270-1534]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1285-1518]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1298-1513]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1307-1445]', '- IPR003593: AAA+ ATPase domain (domain) [1315-1495]', '- IPR056264: ABCA1-4-like, C-terminal R2 regulatory domain (domain) [1510-1584]']
|
['Solute carrier family 22 member 8']
|
['ATF2_S_UP.V1_DN' 'ATF2_UP.V1_DN' 'ATM_DN.V1_UP'
'GOBP_AMIDE_BIOSYNTHETIC_PROCESS' 'GOBP_AMIDE_METABOLIC_PROCESS'
'GOBP_CHOLESTEROL_EFFLUX' 'GOBP_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_LIPID_LOCALIZATION' 'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_MEMBRANE_LIPID_METABOLIC_PROCESS'
'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS'
'GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS'
'GOBP_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_PHOSPHOLIPID_METABOLIC_PROCESS' 'GOBP_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX'
'GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_TRANSPORT'
'GOBP_REGULATION_OF_CHOLESTEROL_EFFLUX'
'GOBP_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_REGULATION_OF_STEROL_TRANSPORT' 'GOBP_REGULATION_OF_TRANSPORT'
'GOBP_SPHINGOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_SPHINGOLIPID_METABOLIC_PROCESS'
'GOBP_SPHINGOMYELIN_BIOSYNTHETIC_PROCESS'
'GOBP_SPHINGOMYELIN_METABOLIC_PROCESS' 'GOBP_STEROL_TRANSPORT'
'GOBP_TRANSMEMBRANE_TRANSPORT' 'GOBP_XENOBIOTIC_TRANSMEMBRANE_TRANSPORT'
'GOBP_XENOBIOTIC_TRANSPORT' 'GOCC_BASAL_PART_OF_CELL'
'GOCC_BASOLATERAL_PLASMA_MEMBRANE' 'GOCC_PLASMA_MEMBRANE_REGION'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY'
'GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'HALLMARK_BILE_ACID_METABOLISM' 'KEGG_ABC_TRANSPORTERS' 'PGF_UP.V1_UP'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES']
|
['GO:0140359 ABC-type transporter activity', 'GO:0008559 ABC-type xenobiotic transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0005319 lipid transporter activity']
|
['GO:0033344 cholesterol efflux', 'GO:0030301 cholesterol transport', 'GO:0006869 lipid transport', 'GO:0010875 positive regulation of cholesterol efflux', 'GO:0010874 regulation of cholesterol efflux', 'GO:0006686 sphingomyelin biosynthetic process', 'GO:0055085 transmembrane transport', 'GO:0006855 xenobiotic transmembrane transport', 'GO:0042908 xenobiotic transport']
|
['GO:0016323 basolateral plasma membrane', 'GO:0005783 endoplasmic reticulum', 'GO:0005886 plasma membrane']
|
[
"Cell membrane",
"Basolateral cell membrane"
] |
ABCA9
|
Q8IUA7
|
ATP-binding cassette sub-family A member 9
|
Transporter that may play a role in monocyte differentiation and lipid transport and homeostasis
|
['- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [33-419]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [474-745]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [480-700]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [481-716]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [500-646]', '- IPR003593: AAA+ ATPase domain (domain) [509-693]', '- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [974-1219]', '- IPR026082: ABC transporter A (family) [1257-1604]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1275-1540]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1288-1521]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1298-1516]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1310-1448]', '- IPR003593: AAA+ ATPase domain (domain) [1318-1498]']
|
['ATP-binding cassette sub-family A member 6']
|
['GOBP_LIPID_LOCALIZATION' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY' 'HALLMARK_BILE_ACID_METABOLISM'
'KEGG_ABC_TRANSPORTERS' 'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES']
|
['GO:0140359 ABC-type transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0005319 lipid transporter activity']
|
['GO:0006869 lipid transport']
|
['GO:0005886 plasma membrane']
|
[
"Membrane"
] |
ABCB1
|
P08183
|
ATP-dependent translocase ABCB1
|
Translocates drugs and phospholipids across the membrane (PubMed:2897240, PubMed:35970996, PubMed:8898203, PubMed:9038218, PubMed:35507548). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:35970996, PubMed:9038218)
|
['- IPR039421: Type 1 protein exporter (family) [17-631]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [39-376]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [52-343]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [52-357]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [116-1008]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [383-629]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [390-647]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [392-628]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [410-559]', '- IPR003593: AAA+ ATPase domain (domain) [419-611]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [531-545]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [699-1008]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [712-1000]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [712-986]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1025-1280]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1026-1274]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1035-1273]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1053-1204]', '- IPR003593: AAA+ ATPase domain (domain) [1062-1250]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [1176-1190]']
|
['Cytochrome P450 3A5', 'Immunoglobulin kappa variable 2D-29', 'Cytochrome P450 3A4', 'Solute carrier organic anion transporter family member 1B1', 'Cytochrome P450 2C19', 'Solute carrier organic anion transporter family member 1B3', 'Nuclear receptor subfamily 1 group I member 2', 'ATP binding cassette subfamily F member 2.', 'ATP binding cassette subfamily F member 2.', 'Peptidyl-prolyl cis-trans isomerase G']
|
['BCAT.100_UP.V1_UP' 'BCAT_GDS748_UP' 'BIOCARTA_MRP_PATHWAY'
'BIOCARTA_NUCLEARRS_PATHWAY' 'BIOCARTA_P53HYPOXIA_PATHWAY'
'GOBP_AMIDE_TRANSPORT'
'GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS'
'GOBP_BODY_FLUID_SECRETION' 'GOBP_CARBOHYDRATE_DERIVATIVE_TRANSPORT'
'GOBP_CELLULAR_HYPEROSMOTIC_RESPONSE'
'GOBP_CELLULAR_RESPONSE_TO_ABIOTIC_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_ACID_CHEMICAL'
'GOBP_CELLULAR_RESPONSE_TO_ALKALOID'
'GOBP_CELLULAR_RESPONSE_TO_ANTIBIOTIC'
'GOBP_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS'
'GOBP_CELLULAR_RESPONSE_TO_CORTICOSTEROID_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_DEXAMETHASONE_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_ENDOGENOUS_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_ESTRADIOL_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_EXTERNAL_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_GLUCOCORTICOID_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_KETONE' 'GOBP_CELLULAR_RESPONSE_TO_LIPID'
'GOBP_CELLULAR_RESPONSE_TO_L_GLUTAMATE'
'GOBP_CELLULAR_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN'
'GOBP_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND'
'GOBP_CELLULAR_RESPONSE_TO_OSMOTIC_STRESS'
'GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND'
'GOBP_CELLULAR_RESPONSE_TO_SALT_STRESS'
'GOBP_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_STRESS'
'GOBP_CELLULAR_RESPONSE_TO_TOXIC_SUBSTANCE'
'GOBP_CELLULAR_RESPONSE_TO_XENOBIOTIC_STIMULUS' 'GOBP_CELL_CYCLE'
'GOBP_CELL_CYCLE_G2_M_PHASE_TRANSITION'
'GOBP_CELL_CYCLE_PHASE_TRANSITION' 'GOBP_CELL_CYCLE_PROCESS'
'GOBP_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT' 'GOBP_CERAMIDE_TRANSPORT'
'GOBP_CHLORIDE_TRANSPORT' 'GOBP_CIRCADIAN_RHYTHM'
'GOBP_CIRCULATORY_SYSTEM_PROCESS' 'GOBP_DETOXIFICATION'
'GOBP_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION'
'GOBP_DEVELOPMENT_OF_PRIMARY_SEXUAL_CHARACTERISTICS' 'GOBP_DIGESTION'
'GOBP_DIGESTIVE_SYSTEM_PROCESS' 'GOBP_EPITHELIAL_CELL_DEVELOPMENT'
'GOBP_EPITHELIAL_CELL_DIFFERENTIATION' 'GOBP_EPITHELIUM_DEVELOPMENT'
'GOBP_ESTABLISHMENT_OF_BLOOD_BRAIN_BARRIER'
'GOBP_ESTABLISHMENT_OF_BLOOD_RETINAL_BARRIER'
'GOBP_ESTABLISHMENT_OF_SERTOLI_CELL_BARRIER'
'GOBP_EXPORT_ACROSS_PLASMA_MEMBRANE' 'GOBP_EXPORT_FROM_CELL'
'GOBP_GLAND_DEVELOPMENT' 'GOBP_GLYCOSIDE_TRANSPORT'
'GOBP_HOMEOSTATIC_PROCESS' 'GOBP_HORMONE_TRANSPORT'
'GOBP_HYPEROSMOTIC_RESPONSE' 'GOBP_HYPEROSMOTIC_SALINITY_RESPONSE'
'GOBP_INORGANIC_ANION_TRANSPORT' 'GOBP_INTESTINAL_ABSORPTION'
'GOBP_LACTATION' 'GOBP_LIPID_LOCALIZATION'
'GOBP_MAINTENANCE_OF_BLOOD_BRAIN_BARRIER' 'GOBP_MALE_SEX_DIFFERENTIATION'
'GOBP_MAMMARY_GLAND_DEVELOPMENT' 'GOBP_MEMBRANE_ORGANIZATION'
'GOBP_MITOTIC_CELL_CYCLE' 'GOBP_MITOTIC_CELL_CYCLE_PHASE_TRANSITION'
'GOBP_MITOTIC_CELL_CYCLE_PROCESS' 'GOBP_MONOATOMIC_ANION_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSPORT'
'GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS'
'GOBP_MULTI_MULTICELLULAR_ORGANISM_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_NERVOUS_SYSTEM_PROCESS'
'GOBP_NERVOUS_SYSTEM_PROCESS' 'GOBP_NITROGEN_COMPOUND_TRANSPORT'
'GOBP_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT' 'GOBP_ORGANIC_ACID_TRANSPORT'
'GOBP_ORGANIC_ANION_TRANSPORT' 'GOBP_ORGANIC_CATION_TRANSPORT'
'GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT' 'GOBP_PHOSPHOLIPID_TRANSLOCATION'
'GOBP_PHOSPHOLIPID_TRANSPORT' 'GOBP_PLACENTA_DEVELOPMENT'
'GOBP_POSITIVE_REGULATION_OF_CELL_DEVELOPMENT'
'GOBP_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION'
'GOBP_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_REPRODUCTIVE_PROCESS'
'GOBP_PROTEIN_LOCALIZATION_TO_BICELLULAR_TIGHT_JUNCTION'
'GOBP_PROTEIN_LOCALIZATION_TO_CELL_CELL_JUNCTION'
'GOBP_PROTEIN_LOCALIZATION_TO_CELL_JUNCTION'
'GOBP_REGULATION_OF_BODY_FLUID_LEVELS'
'GOBP_REGULATION_OF_CELL_DEVELOPMENT'
'GOBP_REGULATION_OF_CELL_DIFFERENTIATION'
'GOBP_REGULATION_OF_CHLORIDE_TRANSPORT'
'GOBP_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS'
'GOBP_REGULATION_OF_HORMONE_LEVELS'
'GOBP_REGULATION_OF_INTESTINAL_ABSORPTION'
'GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION'
'GOBP_REGULATION_OF_MONOATOMIC_ANION_TRANSPORT'
'GOBP_REGULATION_OF_MONOATOMIC_ION_TRANSPORT'
'GOBP_REGULATION_OF_NERVOUS_SYSTEM_PROCESS'
'GOBP_REGULATION_OF_REPRODUCTIVE_PROCESS'
'GOBP_REGULATION_OF_RESPONSE_TO_DRUG'
'GOBP_REGULATION_OF_SENSORY_PERCEPTION'
'GOBP_REGULATION_OF_SYSTEM_PROCESS' 'GOBP_REGULATION_OF_TRANSPORT'
'GOBP_REPRODUCTIVE_PROCESS' 'GOBP_REPRODUCTIVE_SYSTEM_DEVELOPMENT'
'GOBP_RESPONSE_TO_ABIOTIC_STIMULUS' 'GOBP_RESPONSE_TO_ACID_CHEMICAL'
'GOBP_RESPONSE_TO_ALCOHOL' 'GOBP_RESPONSE_TO_ALKALOID'
'GOBP_RESPONSE_TO_ANTIBIOTIC' 'GOBP_RESPONSE_TO_BACTERIUM'
'GOBP_RESPONSE_TO_CADMIUM_ION' 'GOBP_RESPONSE_TO_CORTICOSTEROID'
'GOBP_RESPONSE_TO_DEXAMETHASONE' 'GOBP_RESPONSE_TO_ENDOGENOUS_STIMULUS'
'GOBP_RESPONSE_TO_ESTRADIOL' 'GOBP_RESPONSE_TO_GLUCAGON'
'GOBP_RESPONSE_TO_GLYCOSIDE' 'GOBP_RESPONSE_TO_HORMONE'
'GOBP_RESPONSE_TO_ISOQUINOLINE_ALKALOID' 'GOBP_RESPONSE_TO_KETONE'
'GOBP_RESPONSE_TO_LIPID' 'GOBP_RESPONSE_TO_L_GLUTAMATE'
'GOBP_RESPONSE_TO_L_PHENYLALANINE_DERIVATIVE'
'GOBP_RESPONSE_TO_METAL_ION'
'GOBP_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN'
'GOBP_RESPONSE_TO_MYCOTOXIN' 'GOBP_RESPONSE_TO_NITROGEN_COMPOUND'
'GOBP_RESPONSE_TO_NUTRIENT' 'GOBP_RESPONSE_TO_NUTRIENT_LEVELS'
'GOBP_RESPONSE_TO_OSMOTIC_STRESS'
'GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND'
'GOBP_RESPONSE_TO_OXYGEN_LEVELS' 'GOBP_RESPONSE_TO_PEPTIDE'
'GOBP_RESPONSE_TO_PEPTIDE_HORMONE' 'GOBP_RESPONSE_TO_PROGESTERONE'
'GOBP_RESPONSE_TO_SALT_STRESS' 'GOBP_RESPONSE_TO_STEROID_HORMONE'
'GOBP_RESPONSE_TO_THYROID_HORMONE' 'GOBP_RESPONSE_TO_THYROXINE'
'GOBP_RESPONSE_TO_TOXIC_SUBSTANCE'
'GOBP_RESPONSE_TO_TUMOR_NECROSIS_FACTOR' 'GOBP_RESPONSE_TO_VITAMIN'
'GOBP_RESPONSE_TO_VITAMIN_A' 'GOBP_RESPONSE_TO_VITAMIN_D'
'GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS' 'GOBP_RHYTHMIC_PROCESS'
'GOBP_SECRETION' 'GOBP_SENSORY_PERCEPTION'
'GOBP_SENSORY_PERCEPTION_OF_PAIN' 'GOBP_SERTOLI_CELL_DEVELOPMENT'
'GOBP_SERTOLI_CELL_DIFFERENTIATION' 'GOBP_SEX_DIFFERENTIATION'
'GOBP_SPHINGOLIPID_TRANSLOCATION' 'GOBP_STEM_CELL_PROLIFERATION'
'GOBP_TISSUE_HOMEOSTASIS' 'GOBP_TRANSEPITHELIAL_TRANSPORT'
'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM' 'GOBP_VASCULAR_TRANSPORT'
'GOBP_XENOBIOTIC_EXPORT_FROM_CELL' 'GOBP_XENOBIOTIC_METABOLIC_PROCESS'
'GOBP_XENOBIOTIC_TRANSPORT'
'GOBP_XENOBIOTIC_TRANSPORT_ACROSS_BLOOD_BRAIN_BARRIER'
'GOCC_APICAL_PART_OF_CELL' 'GOCC_BRUSH_BORDER'
'GOCC_BRUSH_BORDER_MEMBRANE' 'GOCC_CELL_PROJECTION_MEMBRANE'
'GOCC_CELL_SURFACE' 'GOCC_CLUSTER_OF_ACTIN_BASED_CELL_PROJECTIONS'
'GOCC_EXTERNAL_SIDE_OF_APICAL_PLASMA_MEMBRANE'
'GOCC_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE' 'GOCC_PLASMA_MEMBRANE_REGION'
'GOCC_SIDE_OF_MEMBRANE' 'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_EFFLUX_TRANSMEMBRANE_TRANSPORTER_ACTIVITY' 'GOMF_FLIPPASE_ACTIVITY'
'GOMF_FLOPPASE_ACTIVITY' 'GOMF_GLYCEROPHOSPHOLIPID_FLIPPASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PHOSPHATIDYLCHOLINE_FLOPPASE_ACTIVITY'
'GOMF_PHOSPHATIDYLCHOLINE_TRANSPORTER_ACTIVITY'
'GOMF_PHOSPHATIDYLETHANOLAMINE_FLIPPASE_ACTIVITY'
'GOMF_PHOSPHOLIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_SPHINGOLIPID_TRANSPORTER_ACTIVITY' 'GOMF_TRANSPORTER_ACTIVITY'
'GOMF_UBIQUITIN_LIKE_PROTEIN_LIGASE_BINDING'
'GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'HALLMARK_IL2_STAT5_SIGNALING' 'HALLMARK_KRAS_SIGNALING_UP'
'HALLMARK_PEROXISOME' 'HALLMARK_UV_RESPONSE_UP' 'KEGG_ABC_TRANSPORTERS'
'KEGG_MEDICUS_VARIANT_CDX2_OVEREXPRESSION_TO_TRANSCRIPTIONAL_ACTIVATION'
'KRAS.300_UP.V1_DN' 'KRAS.50_UP.V1_DN' 'KRAS.600_UP.V1_DN'
'KRAS.BREAST_UP.V1_DN' 'KRAS.LUNG_UP.V1_UP' 'KRAS.PROSTATE_UP.V1_DN'
'PID_HIF1_TFPATHWAY' 'REACTOME_ABACAVIR_ADME'
'REACTOME_ABACAVIR_TRANSMEMBRANE_TRANSPORT'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ATORVASTATIN_ADME' 'REACTOME_DRUG_ADME'
'REACTOME_PREDNISONE_ADME' 'REACTOME_TRANSPORT_OF_SMALL_MOLECULES'
'WP_ALLOGRAFT_REJECTION' 'WP_CODEINE_AND_MORPHINE_METABOLISM'
'WP_CONSTITUTIVE_ANDROSTANE_RECEPTOR_PATHWAY'
'WP_DISORDERS_OF_BILE_ACID_SYNTHESIS_AND_BILIARY_TRANSPORT'
'WP_DRUG_INDUCTION_OF_BILE_ACID_PATHWAY'
'WP_ENTEROHEPATIC_CIRCULATION_OF_BILE_ACIDS'
'WP_IMATINIB_AND_CHRONIC_MYELOID_LEUKEMIA'
'WP_LNCRNAMEDIATED_MECHANISMS_OF_THERAPEUTIC_RESISTANCE'
'WP_MALE_INFERTILITY'
'WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY'
'WP_NUCLEAR_RECEPTORS_METAPATHWAY' 'WP_PREGNANE_X_RECEPTOR_PATHWAY'
'WP_PROXIMAL_TUBULE_TRANSPORT' 'WP_VITAMIN_D_RECEPTOR_PATHWAY']
|
['GO:0008559 ABC-type xenobiotic transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0046943 carboxylic acid transmembrane transporter activity', 'GO:0099038 ceramide floppase activity', 'GO:0015562 efflux transmembrane transporter activity', 'GO:0140328 floppase activity', 'GO:0090554 phosphatidylcholine floppase activity', 'GO:0090555 phosphatidylethanolamine flippase activity', 'GO:0140341 phosphatidylethanolamine floppase activity', 'GO:0022857 transmembrane transporter activity', 'GO:0031625 ubiquitin protein ligase binding', 'GO:0042910 xenobiotic transmembrane transporter activity']
|
['GO:1905039 carboxylic acid transmembrane transport', 'GO:0071475 cellular hyperosmotic salinity response', 'GO:0071312 cellular response to alkaloid', 'GO:0071236 cellular response to antibiotic', 'GO:1905231 cellular response to borneol', 'GO:0071549 cellular response to dexamethasone stimulus', 'GO:0071392 cellular response to estradiol stimulus', 'GO:0071217 cellular response to external biotic stimulus', 'GO:1905232 cellular response to L-glutamate', 'GO:0071222 cellular response to lipopolysaccharide', 'GO:0036146 cellular response to mycotoxin', 'GO:1904148 cellular response to nonylphenol', 'GO:0071356 cellular response to tumor necrosis factor', 'GO:0099040 ceramide translocation', 'GO:0007623 circadian rhythm', 'GO:0043215 daunorubicin transport', 'GO:0060856 establishment of blood-brain barrier', 'GO:1990963 establishment of blood-retinal barrier', 'GO:0140115 export across plasma membrane', 'GO:0007565 female pregnancy', 'GO:0000086 G2/M transition of mitotic cell cycle', 'GO:0009914 hormone transport', 'GO:0050892 intestinal absorption', 'GO:0007595 lactation', 'GO:0035633 maintenance of blood-brain barrier', 'GO:1904057 negative regulation of sensory perception of pain', 'GO:0045332 phospholipid translocation', 'GO:0001890 placenta development', 'GO:1904446 positive regulation of establishment of Sertoli cell barrier', 'GO:2001025 positive regulation of response to drug', 'GO:1902396 protein localization to bicellular tight junction', 'GO:2001225 regulation of chloride transport', 'GO:1904478 regulation of intestinal absorption', 'GO:0097305 response to alcohol', 'GO:0097327 response to antineoplastic agent', 'GO:0046686 response to cadmium ion', 'GO:1905233 response to codeine', 'GO:1905237 response to cyclosporin A', 'GO:0033762 response to glucagon', 'GO:1903416 response to glycoside', 'GO:0001666 response to hypoxia', 'GO:0032570 response to progesterone', 'GO:1905235 response to quercetin', 'GO:0097068 response to thyroxine', 'GO:0033189 response to vitamin A', 'GO:0033280 response to vitamin D', 'GO:0009410 response to xenobiotic stimulus', 'GO:0072089 stem cell proliferation', 'GO:0046865 terpenoid transport', 'GO:0070633 transepithelial transport', 'GO:0055085 transmembrane transport', 'GO:0150104 transport across blood-brain barrier', 'GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane', 'GO:0006805 xenobiotic metabolic process', 'GO:1990962 xenobiotic transport across blood-brain barrier']
|
['GO:0016324 apical plasma membrane', 'GO:0031526 brush border membrane', 'GO:0009986 cell surface', 'GO:0005737 cytoplasm', 'GO:0098591 external side of apical plasma membrane', 'GO:0070062 extracellular exosome', 'GO:0016020 membrane', 'GO:0005886 plasma membrane']
|
[
"Cell membrane",
"Apical cell membrane",
"Cytoplasm"
] |
ABCB10
|
Q9NRK6
|
ATP-binding cassette sub-family B member 10, mitochondrial
|
ATP-dependent transporter located in the mitochondrial inner membrane that catalyzes the export of biliverdin from the mitochondrial matrix, and plays a crucial role in hemoglobin synthesis and antioxidative stress (PubMed:22085049, PubMed:28315685, PubMed:28808058, PubMed:34011630, PubMed:37041204). Participates in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX) (PubMed:22085049, PubMed:28808058). Involved in the stabilization of the iron transporter mitoferrin-1/SLC25A37 (By similarity). In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria (PubMed:28315685)
|
['- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [151-483]', '- IPR039421: Type 1 protein exporter (family) [155-734]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [158-473]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [172-457]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [174-438]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [484-736]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [487-733]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [492-731]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [511-662]', '- IPR003593: AAA+ ATPase domain (domain) [519-714]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [634-648]']
|
['Mitoferrin-1', 'Ferrochelatase, mitochondrial', 'Mitoferrin-2', 'ATP-binding cassette sub-family B member 7, mitochondrial', 'Protoheme IX farnesyltransferase, mitochondrial', 'Transmembrane protein 14C', '5-aminolevulinate synthase, erythroid-specific, mitochondrial', 'Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial', 'Protoporphyrinogen oxidase']
|
['GCNP_SHH_UP_EARLY.V1_UP' 'GOBP_CELLULAR_RESPONSE_TO_STRESS'
'GOBP_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN'
'GOBP_CELLULAR_RESPONSE_TO_UNFOLDED_PROTEIN'
'GOBP_ERYTHROCYTE_DEVELOPMENT' 'GOBP_ERYTHROCYTE_HOMEOSTASIS'
'GOBP_HEMOGLOBIN_BIOSYNTHETIC_PROCESS'
'GOBP_HEMOGLOBIN_METABOLIC_PROCESS' 'GOBP_HEMOPOIESIS'
'GOBP_HOMEOSTASIS_OF_NUMBER_OF_CELLS' 'GOBP_HOMEOSTATIC_PROCESS'
'GOBP_MITOCHONDRIAL_TRANSMEMBRANE_TRANSPORT'
'GOBP_MITOCHONDRIAL_TRANSPORT'
'GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS'
'GOBP_MYELOID_CELL_DEVELOPMENT' 'GOBP_MYELOID_CELL_DIFFERENTIATION'
'GOBP_MYELOID_CELL_HOMEOSTASIS' 'GOBP_PIGMENT_BIOSYNTHETIC_PROCESS'
'GOBP_PIGMENT_METABOLIC_PROCESS'
'GOBP_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION'
'GOBP_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION'
'GOBP_POSITIVE_REGULATION_OF_HEMOGLOBIN_BIOSYNTHETIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_CELL_DEVELOPMENT'
'GOBP_REGULATION_OF_CELL_DIFFERENTIATION'
'GOBP_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION'
'GOBP_REGULATION_OF_HEMOGLOBIN_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_HEMOPOIESIS'
'GOBP_REGULATION_OF_IMMUNE_SYSTEM_PROCESS'
'GOBP_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT'
'GOBP_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION'
'GOBP_REGULATION_OF_PROTEIN_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_TETRAPYRROLE_METABOLIC_PROCESS'
'GOBP_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN'
'GOBP_TETRAPYRROLE_BIOSYNTHETIC_PROCESS'
'GOBP_TETRAPYRROLE_METABOLIC_PROCESS' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOCC_MITOCHONDRIAL_ENVELOPE' 'GOCC_MITOCHONDRION'
'GOCC_ORGANELLE_ENVELOPE' 'GOCC_ORGANELLE_INNER_MEMBRANE'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PROTEIN_DIMERIZATION_ACTIVITY'
'GOMF_PROTEIN_HOMODIMERIZATION_ACTIVITY' 'GOMF_TRANSPORTER_ACTIVITY'
'KEGG_ABC_TRANSPORTERS' 'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES' 'VEGF_A_UP.V1_UP']
|
['GO:0140359 ABC-type transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0046872 metal ion binding', 'GO:0042803 protein homodimerization activity']
|
['GO:0048821 erythrocyte development', 'GO:0170037 export from the mitochondrion', 'GO:0006783 heme biosynthetic process', 'GO:0006839 mitochondrial transport', 'GO:0034514 mitochondrial unfolded protein response', 'GO:0045648 positive regulation of erythrocyte differentiation', 'GO:0070455 positive regulation of heme biosynthetic process', 'GO:0046985 positive regulation of hemoglobin biosynthetic process']
|
['GO:0005743 mitochondrial inner membrane', 'GO:0031966 mitochondrial membrane', 'GO:0005739 mitochondrion']
|
[
"Mitochondrion inner membrane"
] |
ABCB11
|
O95342
|
Bile salt export pump
|
Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner (PubMed:15791618, PubMed:16332456, PubMed:18985798, PubMed:19228692, PubMed:20010382, PubMed:20398791, PubMed:22262466, PubMed:24711118, PubMed:29507376, PubMed:32203132). Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts (PubMed:16332456). Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion (PubMed:15901796, PubMed:18245269)
|
['- IPR039421: Type 1 protein exporter (family) [21-660]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [50-404]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [63-370]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [63-385]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [144-1052]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [409-657]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [418-688]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [420-656]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [438-586]', '- IPR003593: AAA+ ATPase domain (domain) [447-633]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [559-573]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [738-1059]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [756-1043]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [757-1026]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1068-1318]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1071-1315]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1078-1316]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1096-1247]', '- IPR003593: AAA+ ATPase domain (domain) [1105-1299]']
|
['Phospholipid-transporting ATPase IC', 'Bile acid receptor', 'Nuclear receptor subfamily 0 group B member 2', 'Cytochrome P450 7A1', 'Sodium/bile acid cotransporter', 'Gastrotropin', 'Solute carrier organic anion transporter family member 1B1', 'Solute carrier organic anion transporter family member 1B3', 'Nuclear receptor subfamily 1 group I member 2', '7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase']
|
['BIOCARTA_MRP_PATHWAY' 'BIOCARTA_NUCLEARRS_PATHWAY' 'GOBP_ACID_SECRETION'
'GOBP_BILE_ACID_AND_BILE_SALT_TRANSPORT'
'GOBP_BILE_ACID_BIOSYNTHETIC_PROCESS' 'GOBP_BILE_ACID_METABOLIC_PROCESS'
'GOBP_BILE_ACID_SECRETION'
'GOBP_CELLULAR_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_CHEMICAL_HOMEOSTASIS' 'GOBP_EXPORT_FROM_CELL'
'GOBP_FATTY_ACID_BETA_OXIDATION' 'GOBP_FATTY_ACID_CATABOLIC_PROCESS'
'GOBP_FATTY_ACID_METABOLIC_PROCESS' 'GOBP_HOMEOSTATIC_PROCESS'
'GOBP_KETONE_METABOLIC_PROCESS' 'GOBP_LIPID_CATABOLIC_PROCESS'
'GOBP_LIPID_HOMEOSTASIS' 'GOBP_LIPID_LOCALIZATION'
'GOBP_LIPID_METABOLIC_PROCESS' 'GOBP_LIPID_MODIFICATION'
'GOBP_LIPID_OXIDATION' 'GOBP_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_TRANSPORT'
'GOBP_ORGANIC_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_ORGANIC_ACID_CATABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_METABOLIC_PROCESS' 'GOBP_ORGANIC_ACID_TRANSPORT'
'GOBP_ORGANIC_ANION_TRANSPORT' 'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_PHOSPHOLIPID_HOMEOSTASIS'
'GOBP_POSITIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_TRANSPORT'
'GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION'
'GOBP_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION'
'GOBP_REGULATION_OF_BILE_ACID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_BILE_ACID_SECRETION'
'GOBP_REGULATION_OF_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_FATTY_ACID_BETA_OXIDATION'
'GOBP_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_FATTY_ACID_OXIDATION'
'GOBP_REGULATION_OF_KETONE_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_ORGANIC_ACID_TRANSPORT'
'GOBP_REGULATION_OF_SECRETION'
'GOBP_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_STEROID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_TRANSPORT' 'GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_SECRETION' 'GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS'
'GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS' 'GOBP_STEROID_METABOLIC_PROCESS'
'GOBP_STEROL_HOMEOSTASIS' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_XENOBIOTIC_EXPORT_FROM_CELL' 'GOBP_XENOBIOTIC_METABOLIC_PROCESS'
'GOBP_XENOBIOTIC_TRANSMEMBRANE_TRANSPORT' 'GOBP_XENOBIOTIC_TRANSPORT'
'GOCC_ANCHORING_JUNCTION' 'GOCC_APICAL_PART_OF_CELL'
'GOCC_BASAL_PART_OF_CELL' 'GOCC_BASOLATERAL_PLASMA_MEMBRANE'
'GOCC_CELL_CELL_JUNCTION' 'GOCC_CELL_SURFACE' 'GOCC_ENDOSOME'
'GOCC_ENDOSOME_MEMBRANE' 'GOCC_INTERCELLULAR_CANALICULUS'
'GOCC_PLASMA_MEMBRANE_REGION' 'GOCC_RECYCLING_ENDOSOME'
'GOCC_RECYCLING_ENDOSOME_MEMBRANE' 'GOCC_VESICLE_MEMBRANE'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_BILE_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY'
'GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'HALLMARK_KRAS_SIGNALING_DN' 'IL21_UP.V1_UP' 'KEGG_ABC_TRANSPORTERS'
'KRAS.600_UP.V1_DN' 'KRAS.KIDNEY_UP.V1_DN'
'REACTOME_ABC_TRANSPORTER_DISORDERS'
'REACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM'
'REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS'
'REACTOME_METABOLISM_OF_LIPIDS' 'REACTOME_METABOLISM_OF_STEROIDS'
'REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS'
'REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS'
'REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL'
'WP_BILE_ACID_SYNTHESIS_AND_ENTEROHEPATIC_CIRCULATION' 'WP_CHOLESTASIS'
'WP_CHOLESTEROL_BIOSYNTHESIS_PATHWAY_IN_HEPATOCYTES'
'WP_CHOLESTEROL_METABOLISM'
'WP_DISORDERS_OF_BILE_ACID_SYNTHESIS_AND_BILIARY_TRANSPORT'
'WP_DRUG_INDUCTION_OF_BILE_ACID_PATHWAY'
'WP_ENTEROHEPATIC_CIRCULATION_OF_BILE_ACIDS'
'WP_FARNESOID_X_RECEPTOR_PATHWAY'
'WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY'
'WP_NUCLEAR_RECEPTORS_METAPATHWAY']
|
['GO:0015432 ABC-type bile acid transporter activity', 'GO:0008559 ABC-type xenobiotic transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0015125 bile acid transmembrane transporter activity', 'GO:0015126 canalicular bile acid transmembrane transporter activity']
|
['GO:0015721 bile acid and bile salt transport', 'GO:0006699 bile acid biosynthetic process', 'GO:0008206 bile acid metabolic process', 'GO:0015722 canalicular bile acid transport', 'GO:0042632 cholesterol homeostasis', 'GO:0006631 fatty acid metabolic process', 'GO:0055088 lipid homeostasis', 'GO:0055091 phospholipid homeostasis', 'GO:0120189 positive regulation of bile acid secretion', 'GO:0016567 protein ubiquitination', 'GO:1904251 regulation of bile acid metabolic process', 'GO:0031998 regulation of fatty acid beta-oxidation', 'GO:0055085 transmembrane transport', 'GO:0046618 xenobiotic export from cell', 'GO:0006805 xenobiotic metabolic process', 'GO:0006855 xenobiotic transmembrane transport']
|
['GO:0016324 apical plasma membrane', 'GO:0009986 cell surface', 'GO:0005768 endosome', 'GO:0070062 extracellular exosome', 'GO:0046581 intercellular canaliculus', 'GO:0046691 intracellular canaliculus', 'GO:0005886 plasma membrane', 'GO:0055037 recycling endosome', 'GO:0055038 recycling endosome membrane']
|
[
"Apical cell membrane",
"Recycling endosome membrane",
"Endosome",
"Cell membrane"
] |
ABCB4
|
P21439
|
Phosphatidylcholine translocator ABCB4
|
Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:17523162, PubMed:21820390, PubMed:23468132, PubMed:24594635, PubMed:24723470, PubMed:24806754, PubMed:31873305, PubMed:7957936, PubMed:8898203, PubMed:9366571). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes (PubMed:23468132). Required for proper phospholipid bile formation (By similarity). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:24045840). Promotes biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:28012258, PubMed:9366571). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance (By similarity)
|
['- IPR039421: Type 1 protein exporter (family) [28-634]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [44-1004]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [45-378]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [58-345]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [59-359]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [384-632]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [386-631]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [394-630]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [412-561]', '- IPR003593: AAA+ ATPase domain (domain) [421-613]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [533-547]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [699-1018]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [712-985]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [712-999]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1024-1285]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1025-1280]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1034-1279]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1052-1210]', '- IPR003593: AAA+ ATPase domain (domain) [1061-1256]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [1182-1196]']
|
['Phospholipid-transporting ATPase IC', 'Probable non-functional immunoglobulin heavy variable 3-16', 'Ileal sodium/bile acid cotransporter', 'Sodium/bile acid cotransporter', 'Gamma-glutamyltransferase 1.', 'Cytochrome P450 7A1', 'Bile acid receptor', 'Peroxisome proliferator-activated receptor alpha', 'Canalicular multispecific organic anion transporter 1', 'Nuclear receptor subfamily 1 group I member 2']
|
['BIOCARTA_MRP_PATHWAY' 'BIOCARTA_NUCLEARRS_PATHWAY' 'CTIP_DN.V1_DN'
'GOBP_ACID_SECRETION' 'GOBP_AMIDE_TRANSPORT' 'GOBP_BILE_ACID_SECRETION'
'GOBP_CELLULAR_RESPONSE_TO_LIPID'
'GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND'
'GOBP_CERAMIDE_TRANSPORT' 'GOBP_CHEMICAL_HOMEOSTASIS'
'GOBP_HOMEOSTATIC_PROCESS' 'GOBP_LIPID_HOMEOSTASIS'
'GOBP_LIPID_LOCALIZATION' 'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_MEMBRANE_ORGANIZATION' 'GOBP_MONOCARBOXYLIC_ACID_TRANSPORT'
'GOBP_NITROGEN_COMPOUND_TRANSPORT' 'GOBP_ORGANIC_ACID_TRANSPORT'
'GOBP_ORGANIC_ANION_TRANSPORT' 'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT' 'GOBP_PHOSPHOLIPID_TRANSLOCATION'
'GOBP_PHOSPHOLIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION'
'GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_PHOSPHOLIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_TRANSPORT'
'GOBP_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION'
'GOBP_REGULATION_OF_PHOSPHOLIPID_TRANSLOCATION'
'GOBP_REGULATION_OF_STEROL_TRANSPORT' 'GOBP_REGULATION_OF_TRANSPORT'
'GOBP_RESPONSE_TO_BILE_ACID' 'GOBP_RESPONSE_TO_ETHER'
'GOBP_RESPONSE_TO_KETONE' 'GOBP_RESPONSE_TO_LIPID'
'GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND' 'GOBP_SECRETION'
'GOBP_SPHINGOLIPID_TRANSLOCATION' 'GOBP_STEROL_TRANSPORT'
'GOBP_TRANSMEMBRANE_TRANSPORT' 'GOCC_ANCHORING_JUNCTION'
'GOCC_APICAL_PART_OF_CELL' 'GOCC_CELL_CELL_JUNCTION'
'GOCC_CELL_SUBSTRATE_JUNCTION' 'GOCC_CLATHRIN_COATED_VESICLE'
'GOCC_COATED_VESICLE' 'GOCC_INTERCELLULAR_CANALICULUS'
'GOCC_MEMBRANE_MICRODOMAIN' 'GOCC_PLASMA_MEMBRANE_REGION'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_FLOPPASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_PHOSPHATIDYLCHOLINE_FLOPPASE_ACTIVITY'
'GOMF_PHOSPHATIDYLCHOLINE_TRANSPORTER_ACTIVITY'
'GOMF_PHOSPHOLIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_SPHINGOLIPID_TRANSPORTER_ACTIVITY' 'GOMF_TRANSPORTER_ACTIVITY'
'HALLMARK_PEROXISOME' 'JAK2_DN.V1_UP' 'KEGG_ABC_TRANSPORTERS'
'NRL_DN.V1_DN' 'PRC1_BMI_UP.V1_UP'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTER_DISORDERS'
'REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS'
'REACTOME_METABOLISM_OF_LIPIDS'
'REACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES' 'WP_CHOLESTASIS'
'WP_DISORDERS_OF_BILE_ACID_SYNTHESIS_AND_BILIARY_TRANSPORT'
'WP_FARNESOID_X_RECEPTOR_PATHWAY'
'WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY'
'WP_NUCLEAR_RECEPTORS_METAPATHWAY']
|
['GO:0140359 ABC-type transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0090554 phosphatidylcholine floppase activity', 'GO:0005548 phospholipid transporter activity']
|
['GO:0032782 bile acid secretion', 'GO:1903413 cellular response to bile acid', 'GO:0055088 lipid homeostasis', 'GO:0006629 lipid metabolic process', 'GO:0045332 phospholipid translocation', 'GO:0032376 positive regulation of cholesterol transport', 'GO:0061092 positive regulation of phospholipid translocation', 'GO:2001140 positive regulation of phospholipid transport', 'GO:1901557 response to fenofibrate', 'GO:0055085 transmembrane transport']
|
['GO:0016324 apical plasma membrane', 'GO:0030136 clathrin-coated vesicle', 'GO:0005737 cytoplasm', 'GO:0005829 cytosol', 'GO:0070062 extracellular exosome', 'GO:0005925 focal adhesion', 'GO:0046581 intercellular canaliculus', 'GO:0016020 membrane', 'GO:0045121 membrane raft', 'GO:0005654 nucleoplasm', 'GO:0005886 plasma membrane']
|
[
"Cell membrane",
"Apical cell membrane",
"Membrane raft",
"Cytoplasm",
"Cytoplasmic vesicle, clathrin-coated vesicle"
] |
ABCB5
|
Q2M3G0
|
ATP-binding cassette sub-family B member 5
|
Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:12960149, PubMed:15205344, PubMed:15899824, PubMed:22306008). Specifically present in limbal stem cells, where it plays a key role in corneal development and repair (By similarity)
|
['- IPR039421: Type 1 protein exporter (family) [4-625]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [35-984]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [36-367]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [48-333]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [49-350]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [376-633]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [378-623]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [386-622]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [404-553]', '- IPR003593: AAA+ ATPase domain (domain) [413-598]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [525-539]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [680-999]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [693-965]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [693-980]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1005-1257]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1007-1254]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1015-1253]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1033-1184]', '- IPR003593: AAA+ ATPase domain (domain) [1042-1252]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [1156-1170]']
|
['ATP-sensitive inward rectifier potassium channel 11', 'Prominin-1']
|
['GOBP_REGULATION_OF_MEMBRANE_POTENTIAL' 'GOBP_SENSORY_ORGAN_DEVELOPMENT'
'GOBP_SENSORY_SYSTEM_DEVELOPMENT' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_XENOBIOTIC_TRANSPORT' 'GOCC_APICAL_PART_OF_CELL'
'GOCC_PLASMA_MEMBRANE_REGION' 'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_EFFLUX_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY'
'GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'KEGG_ABC_TRANSPORTERS' 'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES']
|
['GO:0008559 ABC-type xenobiotic transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0015562 efflux transmembrane transporter activity']
|
['GO:0030154 cell differentiation', 'GO:0001654 eye development', 'GO:0042391 regulation of membrane potential', 'GO:0055085 transmembrane transport']
|
['GO:0016324 apical plasma membrane', 'GO:0005886 plasma membrane']
|
[
"Cell membrane"
] |
ABCB6
|
Q9NP58
|
ATP-binding cassette sub-family B member 6
|
ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen (PubMed:17661442, PubMed:23792964, PubMed:27507172, PubMed:33007128). May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress (PubMed:10837493, PubMed:17006453, PubMed:23792964, PubMed:33007128). May also play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils (PubMed:29940187). In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin (PubMed:21266531, PubMed:25202056, PubMed:31053883). In addition may play a role in the transition metal homeostasis (By similarity)
|
['- IPR032410: ATP-binding cassette sub-family B member 6, N-terminal five TM domain (domain) [6-255]', '- IPR039421: Type 1 protein exporter (family) [155-821]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [252-577]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [265-578]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [266-556]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [274-544]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [581-841]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [583-825]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [590-824]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [606-755]', '- IPR003593: AAA+ ATPase domain (domain) [615-816]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [727-741]']
|
['ATP-binding cassette sub-family D member 4', 'ATP-binding cassette sub-family A member 2', 'ATP-binding cassette sub-family G member 5', 'ATP-binding cassette sub-family G member 8', 'Mitochondrial potassium channel ATP-binding subunit', 'Ferrochelatase, mitochondrial', 'Sarcoplasmic/endoplasmic reticulum calcium ATPase 2', 'Sodium/potassium-transporting ATPase subunit alpha-1', 'Sodium/potassium-transporting ATPase subunit alpha-3', 'Sodium/potassium-transporting ATPase subunit alpha-2']
|
['GOBP_CELLULAR_HOMEOSTASIS' 'GOBP_CELLULAR_PIGMENTATION'
'GOBP_CELLULAR_RESPONSE_TO_CADMIUM_ION'
'GOBP_CELLULAR_RESPONSE_TO_METAL_ION'
'GOBP_CELLULAR_RESPONSE_TO_TOXIC_SUBSTANCE'
'GOBP_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT' 'GOBP_CHEMICAL_HOMEOSTASIS'
'GOBP_COPPER_ION_HOMEOSTASIS' 'GOBP_DETOXIFICATION'
'GOBP_DETOXIFICATION_OF_CADMIUM_ION'
'GOBP_DETOXIFICATION_OF_INORGANIC_COMPOUND' 'GOBP_HEAD_DEVELOPMENT'
'GOBP_HEME_B_METABOLIC_PROCESS' 'GOBP_HEME_TRANSPORT'
'GOBP_HOMEOSTATIC_PROCESS' 'GOBP_INORGANIC_ION_HOMEOSTASIS'
'GOBP_INTRACELLULAR_COPPER_ION_HOMEOSTASIS'
'GOBP_INTRACELLULAR_IRON_ION_HOMEOSTASIS'
'GOBP_INTRACELLULAR_MONOATOMIC_ION_HOMEOSTASIS'
'GOBP_IRON_COORDINATION_ENTITY_TRANSPORT'
'GOBP_IRON_ION_TRANSMEMBRANE_TRANSPORT' 'GOBP_IRON_ION_TRANSPORT'
'GOBP_MELANOSOME_ASSEMBLY' 'GOBP_METAL_ION_TRANSPORT'
'GOBP_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORT'
'GOBP_MONOATOMIC_CATION_TRANSPORT' 'GOBP_MONOATOMIC_ION_HOMEOSTASIS'
'GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSPORT' 'GOBP_NITROGEN_COMPOUND_TRANSPORT'
'GOBP_ORGANELLE_ASSEMBLY' 'GOBP_PIGMENTATION'
'GOBP_PIGMENT_BIOSYNTHETIC_PROCESS' 'GOBP_PIGMENT_GRANULE_ORGANIZATION'
'GOBP_PIGMENT_METABOLIC_PROCESS'
'GOBP_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_RESPONSE_TO_CADMIUM_ION' 'GOBP_RESPONSE_TO_METAL_ION'
'GOBP_RESPONSE_TO_TOXIC_SUBSTANCE' 'GOBP_SKIN_DEVELOPMENT'
'GOBP_TETRAPYRROLE_BIOSYNTHETIC_PROCESS'
'GOBP_TETRAPYRROLE_METABOLIC_PROCESS'
'GOBP_TRANSITION_METAL_ION_TRANSPORT' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_VESICLE_ORGANIZATION'
'GOCC_ATPASE_DEPENDENT_TRANSMEMBRANE_TRANSPORT_COMPLEX'
'GOCC_ATP_BINDING_CASSETTE_ABC_TRANSPORTER_COMPLEX' 'GOCC_CHITOSOME'
'GOCC_EARLY_ENDOSOME' 'GOCC_EARLY_ENDOSOME_MEMBRANE' 'GOCC_ENDOLYSOSOME'
'GOCC_ENDOLYSOSOME_MEMBRANE' 'GOCC_ENDOSOME' 'GOCC_ENDOSOME_MEMBRANE'
'GOCC_GOLGI_APPARATUS' 'GOCC_GOLGI_MEMBRANE' 'GOCC_LATE_ENDOSOME'
'GOCC_LATE_ENDOSOME_MEMBRANE' 'GOCC_MEMBRANE_PROTEIN_COMPLEX'
'GOCC_MITOCHONDRIAL_ENVELOPE' 'GOCC_MITOCHONDRION'
'GOCC_MULTIVESICULAR_BODY' 'GOCC_MULTIVESICULAR_BODY_MEMBRANE'
'GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK'
'GOCC_ORGANELLE_ENVELOPE' 'GOCC_ORGANELLE_SUBCOMPARTMENT'
'GOCC_OUTER_MEMBRANE' 'GOCC_PIGMENT_GRANULE'
'GOCC_PLASMA_MEMBRANE_PROTEIN_COMPLEX' 'GOCC_TRANSPORTER_COMPLEX'
'GOCC_VACUOLAR_MEMBRANE' 'GOCC_VACUOLE' 'GOCC_VESICLE_MEMBRANE'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_EFFLUX_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_HEME_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TETRAPYRROLE_BINDING' 'GOMF_TRANSPORTER_ACTIVITY'
'HALLMARK_GLYCOLYSIS' 'HALLMARK_HEME_METABOLISM' 'KEGG_ABC_TRANSPORTERS'
'NFE2L2.V2' 'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTER_DISORDERS'
'REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES']
|
['GO:0015439 ABC-type heme transporter activity', 'GO:0140359 ABC-type transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0015562 efflux transmembrane transporter activity', 'GO:0020037 heme binding', 'GO:0046906 tetrapyrrole binding']
|
['GO:0007420 brain development', 'GO:0098849 cellular detoxification of cadmium ion', 'GO:0042168 heme metabolic process', 'GO:0035351 heme transmembrane transport', 'GO:0015886 heme transport', 'GO:0006878 intracellular copper ion homeostasis', 'GO:0006879 intracellular iron ion homeostasis', 'GO:1903232 melanosome assembly', 'GO:0006779 porphyrin-containing compound biosynthetic process', 'GO:0006778 porphyrin-containing compound metabolic process', 'GO:0043588 skin development', 'GO:0033013 tetrapyrrole metabolic process', 'GO:0055085 transmembrane transport']
|
['GO:0043190 ATP-binding cassette (ABC) transporter complex', 'GO:0005829 cytosol', 'GO:0031901 early endosome membrane', 'GO:0036020 endolysosome membrane', 'GO:0005783 endoplasmic reticulum', 'GO:0005789 endoplasmic reticulum membrane', 'GO:0005768 endosome', 'GO:0070062 extracellular exosome', 'GO:0005794 Golgi apparatus', 'GO:0000139 Golgi membrane', 'GO:0005765 lysosomal membrane', 'GO:0033162 melanosome membrane', 'GO:0005740 mitochondrial envelope', 'GO:0005741 mitochondrial outer membrane', 'GO:0005739 mitochondrion', 'GO:0032585 multivesicular body membrane', 'GO:0005654 nucleoplasm', 'GO:0005886 plasma membrane', 'GO:0097225 sperm midpiece', 'GO:0097228 sperm principal piece', 'GO:0005774 vacuolar membrane']
|
[
"Cell membrane",
"Mitochondrion outer membrane",
"Endoplasmic reticulum membrane",
"Golgi apparatus membrane",
"Endosome membrane",
"Lysosome membrane",
"Late endosome membrane",
"Early endosome membrane",
"Secreted, extracellular exosome",
"Mitochondrion",
"Endosome, multivesicular body membrane",
"Melanosome membrane"
] |
ABCB7
|
O75027
|
Iron-sulfur clusters transporter ABCB7, mitochondrial
|
Exports glutathione-coordinated iron-sulfur clusters such as [2Fe-2S]-(GS)4 cluster from the mitochondria to the cytosol in an ATP-dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins and participates in iron homeostasis (PubMed:10196363, PubMed:17192393, PubMed:33157103). Moreover, through a functional complex formed of ABCB7, FECH and ABCB10, also plays a role in the cellular iron homeostasis, mitochondrial function and heme biosynthesis (PubMed:30765471). In cardiomyocytes, regulates cellular iron homeostasis and cellular reactive oxygen species (ROS) levels through its interaction with COX4I1 (By similarity). May also play a role in hematopoiesis (By similarity)
|
['- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [109-457]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [119-442]', '- IPR039421: Type 1 protein exporter (family) [119-704]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [141-436]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [148-423]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [464-708]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [466-728]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [472-706]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [488-637]', '- IPR003593: AAA+ ATPase domain (domain) [497-683]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [609-623]']
|
['Cytosolic Fe-S cluster assembly factor NUBP1', '5-aminolevulinate synthase, erythroid-specific, mitochondrial', 'Ferrochelatase, mitochondrial', 'Mitoferrin-1', 'Cytoplasmic aconitate hydratase', 'Cytosolic Fe-S cluster assembly factor NUBP2', 'Glutaredoxin-related protein 5, mitochondrial', 'Transmembrane protein 14C', 'ATP-binding cassette sub-family B member 10, mitochondrial', 'Mitochondrial glycine transporter']
|
['GOBP_CELLULAR_HOMEOSTASIS' 'GOBP_CHEMICAL_HOMEOSTASIS'
'GOBP_HEME_TRANSPORT' 'GOBP_HOMEOSTATIC_PROCESS'
'GOBP_INORGANIC_ION_HOMEOSTASIS'
'GOBP_INTRACELLULAR_IRON_ION_HOMEOSTASIS'
'GOBP_INTRACELLULAR_MONOATOMIC_ION_HOMEOSTASIS'
'GOBP_IRON_COORDINATION_ENTITY_TRANSPORT'
'GOBP_IRON_ION_TRANSMEMBRANE_TRANSPORT' 'GOBP_IRON_ION_TRANSPORT'
'GOBP_METALLO_SULFUR_CLUSTER_ASSEMBLY' 'GOBP_METAL_ION_TRANSPORT'
'GOBP_MITOCHONDRIAL_TRANSMEMBRANE_TRANSPORT'
'GOBP_MITOCHONDRIAL_TRANSPORT'
'GOBP_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORT'
'GOBP_MONOATOMIC_CATION_TRANSPORT' 'GOBP_MONOATOMIC_ION_HOMEOSTASIS'
'GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSPORT'
'GOBP_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS'
'GOBP_NITROGEN_COMPOUND_TRANSPORT' 'GOBP_PIGMENT_BIOSYNTHETIC_PROCESS'
'GOBP_PIGMENT_METABOLIC_PROCESS'
'GOBP_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION'
'GOBP_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS'
'GOBP_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS'
'GOBP_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_TETRAPYRROLE_METABOLIC_PROCESS'
'GOBP_TETRAPYRROLE_BIOSYNTHETIC_PROCESS'
'GOBP_TETRAPYRROLE_METABOLIC_PROCESS'
'GOBP_TRANSITION_METAL_ION_TRANSPORT' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOCC_MITOCHONDRIAL_ENVELOPE' 'GOCC_MITOCHONDRION'
'GOCC_ORGANELLE_ENVELOPE' 'GOCC_ORGANELLE_INNER_MEMBRANE'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_HEME_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PROTEIN_DIMERIZATION_ACTIVITY'
'GOMF_PROTEIN_HOMODIMERIZATION_ACTIVITY' 'GOMF_TRANSPORTER_ACTIVITY'
'HALLMARK_OXIDATIVE_PHOSPHORYLATION' 'KEGG_ABC_TRANSPORTERS'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_CYTOSOLIC_IRON_SULFUR_CLUSTER_ASSEMBLY'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES'
'WP_IRONSULFUR_CLUSTER_BIOGENESIS']
|
['GO:0140481 ABC-type iron-sulfur cluster transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0015232 heme transmembrane transporter activity', 'GO:0042802 identical protein binding', 'GO:0042803 protein homodimerization activity']
|
['GO:0006879 intracellular iron ion homeostasis', 'GO:0034755 iron ion transmembrane transport', 'GO:0016226 iron-sulfur cluster assembly', 'GO:0140466 iron-sulfur cluster export from the mitochondrion', 'GO:1903427 negative regulation of reactive oxygen species biosynthetic process', 'GO:0070455 positive regulation of heme biosynthetic process', 'GO:1903331 positive regulation of iron-sulfur cluster assembly', 'GO:0055085 transmembrane transport']
|
['GO:0005743 mitochondrial inner membrane', 'GO:0005739 mitochondrion']
|
[
"Mitochondrion inner membrane"
] |
ABCB8
|
Q9NUT2
|
Mitochondrial potassium channel ATP-binding subunit
|
ATP-binding subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)) (PubMed:31435016). Together with pore-forming subunit CCDC51/MITOK of the mitoK(ATP) channel, mediates ATP-dependent potassium currents across the mitochondrial inner membrane (PubMed:31435016). An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix (PubMed:31435016). Plays a role in mitochondrial iron transport (PubMed:30623799). Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (By similarity)
|
['- IPR039421: Type 1 protein exporter (family) [129-711]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [134-453]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [149-425]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [150-437]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [203-469]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [466-710]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [470-715]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [472-709]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [490-640]', '- IPR003593: AAA+ ATPase domain (domain) [499-686]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [612-626]']
|
['Mitochondrial potassium channel', 'Mitoferrin-2', 'ATP-binding cassette sub-family B member 6, mitochondrial', 'ATP-binding cassette sub-family A member 2', 'ATP-binding cassette sub-family D member 4', 'ATP-binding cassette sub-family G member 5', 'ATP-binding cassette sub-family G member 8', 'Mitoferrin-1', 'Potassium-transporting ATPase alpha chain 2', 'Sodium/potassium-transporting ATPase subunit alpha-3']
|
['GOBP_CELLULAR_HOMEOSTASIS' 'GOBP_CELL_VOLUME_HOMEOSTASIS'
'GOBP_HOMEOSTATIC_PROCESS' 'GOBP_METAL_ION_TRANSPORT'
'GOBP_MITOCHONDRIAL_TRANSMEMBRANE_TRANSPORT'
'GOBP_MITOCHONDRIAL_TRANSPORT'
'GOBP_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORT'
'GOBP_MONOATOMIC_CATION_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSPORT' 'GOBP_POTASSIUM_ION_TRANSPORT'
'GOBP_REGULATION_OF_ANATOMICAL_STRUCTURE_SIZE'
'GOBP_REGULATION_OF_CELLULAR_COMPONENT_SIZE'
'GOBP_REGULATION_OF_CELL_SIZE' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOCC_ATPASE_DEPENDENT_TRANSMEMBRANE_TRANSPORT_COMPLEX'
'GOCC_ATP_BINDING_CASSETTE_ABC_TRANSPORTER_COMPLEX'
'GOCC_CATION_CHANNEL_COMPLEX' 'GOCC_MEMBRANE_PROTEIN_COMPLEX'
'GOCC_MITOCHONDRIAL_ENVELOPE' 'GOCC_MITOCHONDRION'
'GOCC_MONOATOMIC_ION_CHANNEL_COMPLEX' 'GOCC_NUCLEOLUS'
'GOCC_ORGANELLE_ENVELOPE' 'GOCC_ORGANELLE_INNER_MEMBRANE'
'GOCC_PLASMA_MEMBRANE_PROTEIN_COMPLEX' 'GOCC_POTASSIUM_CHANNEL_COMPLEX'
'GOCC_TRANSPORTER_COMPLEX' 'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY' 'HALLMARK_ADIPOGENESIS'
'KEGG_ABC_TRANSPORTERS' 'KRAS.AMP.LUNG_UP.V1_DN' 'PRC2_EED_DN.V1_DN'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES']
|
['GO:0140359 ABC-type transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity']
|
['GO:0006884 cell volume homeostasis', 'GO:0140141 mitochondrial potassium ion transmembrane transport', 'GO:0071805 potassium ion transmembrane transport', 'GO:0055085 transmembrane transport']
|
['GO:0043190 ATP-binding cassette (ABC) transporter complex', 'GO:0016020 membrane', 'GO:0062157 mitochondrial ATP-gated potassium channel complex', 'GO:0005743 mitochondrial inner membrane', 'GO:0031966 mitochondrial membrane', 'GO:0005739 mitochondrion', 'GO:0005730 nucleolus', 'GO:0005654 nucleoplasm']
|
[
"Mitochondrion inner membrane"
] |
ABCB9
|
Q9NP78
|
ABC-type oligopeptide transporter ABCB9
|
ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen for degradation (PubMed:15863492, PubMed:17977821, PubMed:18434309, PubMed:22641697, PubMed:25646430, PubMed:30353140, PubMed:30877195, PubMed:31417173). Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers (PubMed:15863492, PubMed:25646430). Binds and transports smaller and larger peptides with the same affinity (PubMed:31417173). Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored (PubMed:15863492, PubMed:17977821, PubMed:18434309)
|
['- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [163-488]', '- IPR039421: Type 1 protein exporter (family) [167-742]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [176-487]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [189-471]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [190-454]', '- IPR030254: ATP-binding cassette subfamily B member 9, six-transmembrane helical domain (domain) [191-479]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [494-742]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [494-745]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [504-740]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [522-671]', '- IPR003593: AAA+ ATPase domain (domain) [531-717]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [643-657]']
|
['Lysosome-associated membrane glycoprotein 2', 'Lysosome-associated membrane glycoprotein 1', 'Antigen peptide transporter 2', 'Tapasin', 'Uncharacterized protein.']
|
['ATF2_UP.V1_UP' 'CAHOY_ASTROCYTIC' 'GOBP_AMIDE_TRANSPORT'
'GOBP_ANTIGEN_PROCESSING_AND_PRESENTATION'
'GOBP_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN'
'GOBP_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I'
'GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION'
'GOBP_NITROGEN_COMPOUND_TRANSPORT' 'GOBP_OLIGOPEPTIDE_TRANSPORT'
'GOBP_PEPTIDE_METABOLIC_PROCESS' 'GOBP_PEPTIDE_TRANSPORT'
'GOBP_PROTEIN_TRANSPORT' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOCC_EARLY_ENDOSOME' 'GOCC_ENDOSOME'
'GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK'
'GOCC_ORGANELLE_SUBCOMPARTMENT' 'GOCC_VACUOLAR_MEMBRANE' 'GOCC_VACUOLE'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_AMIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_OLIGOPEPTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PEPTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PROTEIN_DIMERIZATION_ACTIVITY'
'GOMF_PROTEIN_HOMODIMERIZATION_ACTIVITY' 'GOMF_TRANSPORTER_ACTIVITY'
'HALLMARK_PEROXISOME' 'KEGG_ABC_TRANSPORTERS' 'KEGG_LYSOSOME'
'NOTCH_DN.V1_DN' 'PRC2_EED_DN.V1_DN'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES']
|
['GO:0015421 ABC-type oligopeptide transporter activity', 'GO:0015440 ABC-type peptide transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042803 protein homodimerization activity', 'GO:0022857 transmembrane transporter activity']
|
['GO:0006518 peptide metabolic process', 'GO:0015833 peptide transport', 'GO:0015031 protein transport', 'GO:0055085 transmembrane transport']
|
['GO:0005789 endoplasmic reticulum membrane', 'GO:0005765 lysosomal membrane', 'GO:0005764 lysosome', 'GO:0016020 membrane']
|
[
"Lysosome membrane"
] |
ABCC1
|
P33527
|
Multidrug resistance-associated protein 1
|
Mediates export of organic anions and drugs from the cytoplasm (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595). Hydrolyzes ATP with low efficiency (PubMed:16230346). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthesizing cells (By similarity). Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export (PubMed:36070769). Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway (PubMed:36070769). Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 (via extracellular transport) with GGT5 (via GGG catabolism) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma (By similarity). Mediates basolateral export of GSH-conjugated R- and S-prostaglandin A2 diastereomers in polarized epithelial cells (PubMed:9426231)
|
['- IPR005292: Multi drug resistance-associated protein (family) [7-1530]', '- IPR056227: ABC transporter, TMD0 domain (domain) [25-160]', '- IPR050173: ATP-binding cassette transporter C-like (family) [211-1526]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [291-627]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [313-616]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [326-596]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [326-608]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [641-867]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [641-877]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [644-868]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [661-795]', '- IPR003593: AAA+ ATPase domain (domain) [670-861]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [768-782]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [937-1274]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [974-1275]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [976-1242]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [976-1256]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1276-1524]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1285-1525]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1293-1527]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1310-1458]', '- IPR003593: AAA+ ATPase domain (domain) [1319-1504]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [1430-1444]']
|
['Broad substrate specificity ATP-binding cassette transporter ABCG2', 'Mitochondrial ribosomal protein S7.', 'Major vault protein', 'Leukotriene B4 receptor 2']
|
['BIOCARTA_MRP_PATHWAY' 'GOBP_AMIDE_TRANSPORT'
'GOBP_CELLULAR_RESPONSE_TO_AMYLOID_BETA'
'GOBP_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS'
'GOBP_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND'
'GOBP_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS'
'GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND'
'GOBP_CELLULAR_RESPONSE_TO_STRESS'
'GOBP_CELLULAR_RESPONSE_TO_XENOBIOTIC_STIMULUS' 'GOBP_CELL_CHEMOTAXIS'
'GOBP_CELL_MOTILITY' 'GOBP_CIRCULATORY_SYSTEM_PROCESS'
'GOBP_COBALAMIN_TRANSPORT' 'GOBP_CYCLIC_NUCLEOTIDE_TRANSPORT'
'GOBP_EXPORT_ACROSS_PLASMA_MEMBRANE' 'GOBP_EXPORT_FROM_CELL'
'GOBP_GLUTATHIONE_TRANSMEMBRANE_TRANSPORT' 'GOBP_GLUTATHIONE_TRANSPORT'
'GOBP_ICOSANOID_METABOLIC_PROCESS' 'GOBP_ICOSANOID_TRANSPORT'
'GOBP_INFLAMMATORY_RESPONSE' 'GOBP_LEUKOTRIENE_METABOLIC_PROCESS'
'GOBP_LEUKOTRIENE_TRANSPORT' 'GOBP_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_LIPID_LOCALIZATION' 'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_LOCOMOTION' 'GOBP_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_MEMBRANE_LIPID_METABOLIC_PROCESS' 'GOBP_MEMBRANE_ORGANIZATION'
'GOBP_MODIFIED_AMINO_ACID_TRANSPORT' 'GOBP_MONOATOMIC_ANION_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSPORT' 'GOBP_NITROGEN_COMPOUND_TRANSPORT'
'GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT'
'GOBP_NUCLEOTIDE_TRANSPORT' 'GOBP_OLIGOPEPTIDE_TRANSPORT'
'GOBP_ORGANIC_ACID_METABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT' 'GOBP_ORGANIC_ACID_TRANSPORT'
'GOBP_ORGANIC_ANION_TRANSPORT' 'GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT'
'GOBP_PEPTIDE_TRANSPORT' 'GOBP_PHOSPHOLIPID_TRANSLOCATION'
'GOBP_PHOSPHOLIPID_TRANSPORT' 'GOBP_PIGMENT_CATABOLIC_PROCESS'
'GOBP_PIGMENT_METABOLIC_PROCESS'
'GOBP_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE'
'GOBP_POSITIVE_REGULATION_OF_INFLAMMATORY_RESPONSE'
'GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS'
'GOBP_REGULATION_OF_DEFENSE_RESPONSE'
'GOBP_REGULATION_OF_INFLAMMATORY_RESPONSE'
'GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION'
'GOBP_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS'
'GOBP_REGULATION_OF_RESPONSE_TO_STRESS' 'GOBP_RESPONSE_TO_AMYLOID_BETA'
'GOBP_RESPONSE_TO_NITROGEN_COMPOUND' 'GOBP_RESPONSE_TO_OXIDATIVE_STRESS'
'GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND'
'GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_SPHINGOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_SPHINGOLIPID_METABOLIC_PROCESS' 'GOBP_SPHINGOLIPID_TRANSLOCATION'
'GOBP_SULFUR_COMPOUND_TRANSPORT' 'GOBP_TAXIS'
'GOBP_TETRAPYRROLE_CATABOLIC_PROCESS'
'GOBP_TETRAPYRROLE_METABOLIC_PROCESS' 'GOBP_TRANSEPITHELIAL_TRANSPORT'
'GOBP_TRANSMEMBRANE_TRANSPORT' 'GOBP_TRIPEPTIDE_TRANSMEMBRANE_TRANSPORT'
'GOBP_TRIPEPTIDE_TRANSPORT' 'GOBP_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM'
'GOBP_VASCULAR_TRANSPORT' 'GOBP_VITAMIN_TRANSPORT'
'GOBP_XENOBIOTIC_METABOLIC_PROCESS' 'GOBP_XENOBIOTIC_TRANSPORT'
'GOBP_XENOBIOTIC_TRANSPORT_ACROSS_BLOOD_BRAIN_BARRIER'
'GOCC_APICAL_PART_OF_CELL' 'GOCC_BASAL_PART_OF_CELL'
'GOCC_BASOLATERAL_PLASMA_MEMBRANE' 'GOCC_LATERAL_PLASMA_MEMBRANE'
'GOCC_PLASMA_MEMBRANE_REGION'
'GOMF_ABC_TYPE_GLUTATHIONE_S_CONJUGATE_TRANSPORTER_ACTIVITY'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_AMIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_EFFLUX_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_GLUTATHIONE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_MODIFIED_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_OLIGOPEPTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_SPHINGOLIPID_TRANSPORTER_ACTIVITY'
'GOMF_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY'
'GOMF_TRIPEPTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_VITAMIN_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY' 'HALLMARK_UV_RESPONSE_DN'
'KEGG_ABC_TRANSPORTERS' 'PID_S1P_META_PATHWAY' 'PID_S1P_S1P1_PATHWAY'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ARACHIDONATE_METABOLISM'
'REACTOME_CELLULAR_RESPONSES_TO_STIMULI'
'REACTOME_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS'
'REACTOME_COBALAMIN_CBL_VITAMIN_B12_TRANSPORT_AND_METABOLISM'
'REACTOME_CYTOPROTECTION_BY_HMOX1' 'REACTOME_DRUG_ADME'
'REACTOME_FATTY_ACID_METABOLISM' 'REACTOME_HEME_DEGRADATION'
'REACTOME_KEAP1_NFE2L2_PATHWAY' 'REACTOME_METABOLISM_OF_LIPIDS'
'REACTOME_METABOLISM_OF_PORPHYRINS'
'REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS'
'REACTOME_METABOLISM_OF_WATER_SOLUBLE_VITAMINS_AND_COFACTORS'
'REACTOME_NFE2L2_REGULATING_MDR_ASSOCIATED_ENZYMES'
'REACTOME_NUCLEAR_EVENTS_MEDIATED_BY_NFE2L2' 'REACTOME_PARACETAMOL_ADME'
'REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS'
'REACTOME_SPHINGOLIPID_METABOLISM'
'REACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX'
'REACTOME_TRANSPORT_OF_RCBL_WITHIN_THE_BODY'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES'
'WP_16P1311_COPY_NUMBER_VARIATION_SYNDROME' 'WP_IRINOTECAN_PATHWAY'
'WP_LEUKOTRIENE_METABOLIC_PATHWAY' 'WP_TROP2_REGULATORY_SIGNALING']
|
['GO:0015431 ABC-type glutathione S-conjugate transporter activity', 'GO:0140359 ABC-type transporter activity', 'GO:0015420 ABC-type vitamin B12 transporter activity', 'GO:0008559 ABC-type xenobiotic transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0033284 ATPase-coupled carboxylic acid transmembrane transporter activity', 'GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity', 'GO:0034040 ATPase-coupled lipid transmembrane transporter activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0015127 bilirubin transmembrane transporter activity', 'GO:0046943 carboxylic acid transmembrane transporter activity', 'GO:0015562 efflux transmembrane transporter activity', 'GO:0034634 glutathione transmembrane transporter activity', 'GO:0046624 sphingolipid transporter activity', 'GO:0042910 xenobiotic transmembrane transporter activity']
|
['GO:0021764 amygdala development', 'GO:0097242 amyloid-beta clearance', 'GO:0050435 amyloid-beta metabolic process', 'GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib', 'GO:0097746 blood vessel diameter maintenance', 'GO:1905039 carboxylic acid transmembrane transport', 'GO:0060326 cell chemotaxis', 'GO:0045454 cell redox homeostasis', 'GO:1904646 cellular response to amyloid-beta', 'GO:0034599 cellular response to oxidative stress', 'GO:0071346 cellular response to type II interferon', 'GO:0015889 cobalamin transport', 'GO:0070729 cyclic nucleotide transport', 'GO:0050830 defense response to Gram-positive bacterium', 'GO:0072577 endothelial cell apoptotic process', 'GO:0003158 endothelium development', 'GO:0051649 establishment of localization in cell', 'GO:0035640 exploration behavior', 'GO:0140115 export across plasma membrane', 'GO:0010467 gene expression', 'GO:0008211 glucocorticoid metabolic process', 'GO:0006749 glutathione metabolic process', 'GO:0034775 glutathione transmembrane transport', 'GO:0002432 granuloma formation', 'GO:0042167 heme catabolic process', 'GO:0021766 hippocampus development', 'GO:0050665 hydrogen peroxide biosynthetic process', 'GO:0002437 inflammatory response to antigenic stimulus', 'GO:0141067 intracellular nitrogen homeostasis', 'GO:0019370 leukotriene biosynthetic process', 'GO:0006691 leukotriene metabolic process', 'GO:0071716 leukotriene transport', 'GO:0072676 lymphocyte migration', 'GO:0042116 macrophage activation', 'GO:0007613 memory', 'GO:0035264 multicellular organism growth', 'GO:0097719 neural tissue regeneration', 'GO:0022008 neurogenesis', 'GO:0051132 NK T cell activation', 'GO:0045332 phospholipid translocation', 'GO:0043476 pigment accumulation', 'GO:0050729 positive regulation of inflammatory response', 'GO:0034394 protein localization to cell surface', 'GO:0042391 regulation of membrane potential', 'GO:0034405 response to fluid shear stress', 'GO:0051384 response to glucocorticoid', 'GO:0009636 response to toxic substance', 'GO:0009410 response to xenobiotic stimulus', 'GO:0030148 sphingolipid biosynthetic process', 'GO:0099039 sphingolipid translocation', 'GO:0042554 superoxide anion generation', 'GO:0001894 tissue homeostasis', 'GO:0070633 transepithelial transport', 'GO:0055085 transmembrane transport', 'GO:0150104 transport across blood-brain barrier', 'GO:0006805 xenobiotic metabolic process', 'GO:0042908 xenobiotic transport', 'GO:1990962 xenobiotic transport across blood-brain barrier']
|
['GO:0016324 apical plasma membrane', 'GO:0009925 basal plasma membrane', 'GO:0016323 basolateral plasma membrane', 'GO:0070062 extracellular exosome', 'GO:0016328 lateral plasma membrane', 'GO:0016020 membrane', 'GO:0005886 plasma membrane']
|
[
"Cell membrane",
"Basolateral cell membrane"
] |
ABCC10
|
Q5T3U5
|
ATP-binding cassette sub-family C member 10
|
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:12527806, PubMed:15256465). May regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Mediates intercellular propagation of antiviral immune signaling in early stages of infection (By similarity). In RNA virus-infected cells, oligoadenylate synthase senses viral dsRNA and generates 2',5'-oligoadenylates (2-5A) which act as second messengers to activate RNASEL and type I interferon signaling to inhibit viral replication (By similarity). This innate signaling pathway is locally extended and amplified by ABCC10, which exports 2-5A from virus-infected cells to cross-activates RNASEL in uninfected neighboring cells and confers protection against viral infection (By similarity). Mediates multidrug resistance (MDR) in cancer cells by preventing the intracellular accumulation of certain antitumor drugs, such as, docetaxel and paclitaxel (PubMed:15256465, PubMed:23087055). Does not transport glycocholic acid, taurocholic acid, MTX, folic acid, cAMP, or cGMP (PubMed:12527806)
|
['- IPR050173: ATP-binding cassette transporter C-like (family) [219-1482]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [264-580]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [272-578]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [286-563]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [287-550]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [598-824]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [618-848]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [620-753]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [620-812]', '- IPR003593: AAA+ ATPase domain (domain) [625-809]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [726-740]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [849-1228]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [886-1210]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [887-1196]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [959-1229]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1233-1482]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1240-1478]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1246-1479]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1263-1410]', '- IPR003593: AAA+ ATPase domain (domain) [1272-1456]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [1382-1396]']
|
[]
|
['CSR_EARLY_UP.V1_DN' 'GOBP_ICOSANOID_METABOLIC_PROCESS'
'GOBP_ICOSANOID_TRANSPORT' 'GOBP_LEUKOTRIENE_METABOLIC_PROCESS'
'GOBP_LEUKOTRIENE_TRANSPORT' 'GOBP_LIPID_LOCALIZATION'
'GOBP_MONOATOMIC_ANION_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSPORT' 'GOBP_ORGANIC_ACID_METABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_TRANSPORT' 'GOBP_ORGANIC_ANION_TRANSPORT'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_XENOBIOTIC_TRANSPORT' 'GOCC_BASAL_PART_OF_CELL'
'GOCC_BASOLATERAL_PLASMA_MEMBRANE' 'GOCC_PLASMA_MEMBRANE_REGION'
'GOCC_VACUOLAR_MEMBRANE' 'GOCC_VACUOLE'
'GOMF_ABC_TYPE_GLUTATHIONE_S_CONJUGATE_TRANSPORTER_ACTIVITY'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY'
'GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'KEGG_ABC_TRANSPORTERS' 'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES']
|
['GO:0015431 ABC-type glutathione S-conjugate transporter activity', 'GO:0140359 ABC-type transporter activity', 'GO:0008559 ABC-type xenobiotic transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity']
|
['GO:0006691 leukotriene metabolic process', 'GO:0071716 leukotriene transport', 'GO:0006869 lipid transport', 'GO:0015711 organic anion transport', 'GO:0055085 transmembrane transport']
|
['GO:0009925 basal plasma membrane', 'GO:0016323 basolateral plasma membrane', 'GO:0005765 lysosomal membrane', 'GO:0005886 plasma membrane']
|
[
"Cell membrane",
"Basolateral cell membrane",
"Basal cell membrane"
] |
ABCC11
|
Q96J66
|
ATP-binding cassette sub-family C member 11
|
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Plays a role in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides, including cAMP and cGMP (PubMed:12764137, PubMed:15537867). Mediates the ATP-dependent efflux of a range of physiological lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates, such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate (PubMed:15537867, PubMed:16359813, PubMed:25896536). Plays a role in the transport of earwax components (PubMed:16444273, PubMed:19383836). Participates in the secretion of odorants and their precursors from the apocrine sweat glands, including the secretion of glutamine conjugates, as well as the Cys-Gly-(S) conjugates of 3-methyl-3-sulfanyl-hexanol (PubMed:19710689). Involved in the cellular extrusion of nucleotide analogs, hence confering resistance to various drugs, including clinically relevant drugs such as 5-fluorouracil (5-FU) and methotrexate (PubMed:12764137, PubMed:15537867, PubMed:25896536)
|
['- IPR050173: ATP-binding cassette transporter C-like (family) [87-1374]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [131-460]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [152-430]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [164-443]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [204-428]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [508-732]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [517-756]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [524-731]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [527-661]', '- IPR003593: AAA+ ATPase domain (domain) [536-709]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [634-648]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [770-1117]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [807-1086]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [808-1071]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [808-1115]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1125-1377]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1133-1368]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1141-1375]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1158-1306]', '- IPR003593: AAA+ ATPase domain (domain) [1167-1360]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [1278-1292]']
|
[]
|
['GOBP_BILE_ACID_AND_BILE_SALT_TRANSPORT' 'GOBP_ICOSANOID_TRANSPORT'
'GOBP_LEUKOTRIENE_TRANSPORT' 'GOBP_LIPID_LOCALIZATION'
'GOBP_MONOATOMIC_ANION_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSPORT' 'GOBP_MONOCARBOXYLIC_ACID_TRANSPORT'
'GOBP_NITROGEN_COMPOUND_TRANSPORT'
'GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT'
'GOBP_NUCLEOTIDE_TRANSPORT' 'GOBP_ORGANIC_ACID_TRANSPORT'
'GOBP_ORGANIC_ANION_TRANSPORT' 'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT' 'GOBP_PURINE_NUCLEOTIDE_TRANSPORT'
'GOBP_TRANSMEMBRANE_TRANSPORT' 'GOBP_XENOBIOTIC_TRANSPORT'
'GOCC_APICAL_PART_OF_CELL' 'GOCC_PLASMA_MEMBRANE_REGION'
'GOCC_VACUOLAR_MEMBRANE' 'GOCC_VACUOLE' 'GOCC_VESICLE_MEMBRANE'
'GOMF_ABC_TYPE_GLUTATHIONE_S_CONJUGATE_TRANSPORTER_ACTIVITY'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_BILE_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANOPHOSPHATE_ESTER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PURINE_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY'
'GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'KEGG_ABC_TRANSPORTERS' 'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES']
|
['GO:0015432 ABC-type bile acid transporter activity', 'GO:0015431 ABC-type glutathione S-conjugate transporter activity', 'GO:0140359 ABC-type transporter activity', 'GO:0008559 ABC-type xenobiotic transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity', 'GO:0008514 organic anion transmembrane transporter activity', 'GO:0015216 purine nucleotide transmembrane transporter activity']
|
['GO:0015721 bile acid and bile salt transport', 'GO:0071716 leukotriene transport', 'GO:0015711 organic anion transport', 'GO:0015865 purine nucleotide transport', 'GO:0055085 transmembrane transport', 'GO:0042908 xenobiotic transport']
|
['GO:0016324 apical plasma membrane', 'GO:0030659 cytoplasmic vesicle membrane', 'GO:0070062 extracellular exosome', 'GO:0005886 plasma membrane', 'GO:0005774 vacuolar membrane']
|
[
"Cell membrane",
"Vacuole membrane",
"Cytoplasmic vesicle membrane",
"Apical cell membrane"
] |
ABCC12
|
Q96J65
|
ATP-binding cassette sub-family C member 12
|
Probable transporter, its substrate specificity is unknown
|
['- IPR050173: ATP-binding cassette transporter C-like (family) [48-1353]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [80-421]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [111-417]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [127-387]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [127-403]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [444-712]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [467-701]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [492-700]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [496-630]', '- IPR003593: AAA+ ATPase domain (domain) [505-678]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [603-617]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [758-1096]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [785-1087]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [796-1082]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [798-1014]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1106-1356]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1113-1346]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1120-1354]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1137-1285]', '- IPR003593: AAA+ ATPase domain (domain) [1146-1339]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [1257-1271]']
|
[]
|
['GOBP_TRANSMEMBRANE_TRANSPORT'
'GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK'
'GOCC_ORGANELLE_SUBCOMPARTMENT' 'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY' 'KEGG_ABC_TRANSPORTERS']
|
['GO:0140359 ABC-type transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity']
|
['GO:0055085 transmembrane transport']
|
['GO:0005783 endoplasmic reticulum', 'GO:0005789 endoplasmic reticulum membrane', 'GO:0016020 membrane']
|
[
"Endoplasmic reticulum membrane"
] |
ABCC2
|
Q92887
|
ATP-binding cassette sub-family C member 2
|
ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates (PubMed:10220572, PubMed:10421658, PubMed:11500505, PubMed:16332456). Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification (PubMed:10421658). Also mediates hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4 (PubMed:11500505). Transports sulfated bile salt such as taurolithocholate sulfate (PubMed:16332456). Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (PubMed:10220572, PubMed:11500505, PubMed:12441801). Confers resistance to several anti-cancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine (PubMed:10220572, PubMed:11500505)
|
['- IPR005292: Multi drug resistance-associated protein (family) [9-1537]', '- IPR056227: ABC transporter, TMD0 domain (domain) [15-153]', '- IPR050173: ATP-binding cassette transporter C-like (family) [198-1532]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [288-618]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [306-617]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [323-593]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [325-605]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [620-881]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [632-859]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [637-861]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [655-788]', '- IPR003593: AAA+ ATPase domain (domain) [663-838]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [761-775]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [944-1282]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [979-1228]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [979-1281]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [980-1264]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1284-1530]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1290-1532]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1300-1534]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1317-1465]', '- IPR003593: AAA+ ATPase domain (domain) [1326-1511]']
|
['Broad substrate specificity ATP-binding cassette transporter ABCG2', 'Solute carrier family 22 member 8', 'UDP-glucuronosyltransferase 1-6', 'Solute carrier organic anion transporter family member 1B1', 'Solute carrier organic anion transporter family member 1B3', 'Radixin', 'Cryptochrome-1', 'Na(+)/H(+) exchange regulatory cofactor NHE-RF3', 'UDP-glucuronosyltransferase 2B7', 'Sodium/bile acid cotransporter']
|
['BIOCARTA_NUCLEARRS_PATHWAY' 'GOBP_BILE_ACID_AND_BILE_SALT_TRANSPORT'
'GOBP_CELLULAR_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_CIRCULATORY_SYSTEM_PROCESS' 'GOBP_DICARBOXYLIC_ACID_TRANSPORT'
'GOBP_EXPORT_FROM_CELL' 'GOBP_ICOSANOID_TRANSPORT'
'GOBP_LEUKOTRIENE_TRANSPORT' 'GOBP_LIPID_LOCALIZATION'
'GOBP_MONOATOMIC_ANION_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSPORT' 'GOBP_MONOCARBOXYLIC_ACID_TRANSPORT'
'GOBP_NEGATIVE_REGULATION_OF_GENE_EXPRESSION'
'GOBP_NITROGEN_COMPOUND_TRANSPORT' 'GOBP_ORGANIC_ACID_TRANSPORT'
'GOBP_ORGANIC_ANION_TRANSPORT' 'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_PIGMENT_CATABOLIC_PROCESS' 'GOBP_PIGMENT_METABOLIC_PROCESS'
'GOBP_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_TETRAPYRROLE_CATABOLIC_PROCESS'
'GOBP_TETRAPYRROLE_METABOLIC_PROCESS' 'GOBP_TRANSEPITHELIAL_TRANSPORT'
'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM' 'GOBP_VASCULAR_TRANSPORT'
'GOBP_XENOBIOTIC_EXPORT_FROM_CELL' 'GOBP_XENOBIOTIC_METABOLIC_PROCESS'
'GOBP_XENOBIOTIC_TRANSMEMBRANE_TRANSPORT' 'GOBP_XENOBIOTIC_TRANSPORT'
'GOBP_XENOBIOTIC_TRANSPORT_ACROSS_BLOOD_BRAIN_BARRIER'
'GOCC_ANCHORING_JUNCTION' 'GOCC_APICAL_PART_OF_CELL'
'GOCC_CELL_CELL_JUNCTION' 'GOCC_CELL_SURFACE'
'GOCC_INTERCELLULAR_CANALICULUS' 'GOCC_PLASMA_MEMBRANE_REGION'
'GOMF_ABC_TYPE_GLUTATHIONE_S_CONJUGATE_TRANSPORTER_ACTIVITY'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_DICARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY'
'GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'HALLMARK_XENOBIOTIC_METABOLISM' 'KEGG_ABC_TRANSPORTERS' 'NFE2L2.V2'
'P53_DN.V1_DN' 'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTER_DISORDERS' 'REACTOME_ASPIRIN_ADME'
'REACTOME_ATORVASTATIN_ADME'
'REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS' 'REACTOME_DRUG_ADME'
'REACTOME_HEME_DEGRADATION' 'REACTOME_METABOLISM_OF_PORPHYRINS'
'REACTOME_PARACETAMOL_ADME' 'REACTOME_TRANSPORT_OF_SMALL_MOLECULES'
'WP_CHOLESTASIS' 'WP_CODEINE_AND_MORPHINE_METABOLISM'
'WP_CONSTITUTIVE_ANDROSTANE_RECEPTOR_PATHWAY'
'WP_DISORDERS_OF_BILE_ACID_SYNTHESIS_AND_BILIARY_TRANSPORT'
'WP_DRUG_INDUCTION_OF_BILE_ACID_PATHWAY'
'WP_ENTEROHEPATIC_CIRCULATION_OF_BILE_ACIDS' 'WP_FOXA2_PATHWAY'
'WP_IRINOTECAN_PATHWAY' 'WP_NRF2_PATHWAY'
'WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY'
'WP_NUCLEAR_RECEPTORS_METAPATHWAY'
'WP_PHOTODYNAMIC_THERAPYINDUCED_NFE2L2_NRF2_SURVIVAL_SIGNALING'
'WP_PREGNANE_X_RECEPTOR_PATHWAY' 'WP_PROXIMAL_TUBULE_TRANSPORT']
|
['GO:0015431 ABC-type glutathione S-conjugate transporter activity', 'GO:0140359 ABC-type transporter activity', 'GO:0008559 ABC-type xenobiotic transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0015127 bilirubin transmembrane transporter activity', 'GO:0008514 organic anion transmembrane transporter activity', 'GO:0019534 toxin transmembrane transporter activity', 'GO:0042910 xenobiotic transmembrane transporter activity']
|
['GO:0015721 bile acid and bile salt transport', 'GO:0015723 bilirubin transport', 'GO:0055007 cardiac muscle cell differentiation', 'GO:0010467 gene expression', 'GO:0015779 glucuronoside transport', 'GO:0006749 glutathione metabolic process', 'GO:0034635 glutathione transport', 'GO:0042167 heme catabolic process', 'GO:0071716 leukotriene transport', 'GO:0015694 mercury ion transport', 'GO:0016071 mRNA metabolic process', 'GO:0010629 negative regulation of gene expression', 'GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction', 'GO:0072014 proximal tubule development', 'GO:0072718 response to cisplatin', 'GO:0060416 response to growth hormone', 'GO:0032868 response to insulin', 'GO:1901652 response to peptide', 'GO:1904567 response to wortmannin', 'GO:0070633 transepithelial transport', 'GO:0055085 transmembrane transport', 'GO:0150104 transport across blood-brain barrier', 'GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane', 'GO:0046618 xenobiotic export from cell', 'GO:0006805 xenobiotic metabolic process', 'GO:0006855 xenobiotic transmembrane transport', 'GO:1990962 xenobiotic transport across blood-brain barrier']
|
['GO:0016324 apical plasma membrane', 'GO:0009986 cell surface', 'GO:0046581 intercellular canaliculus', 'GO:0005886 plasma membrane', 'GO:0031982 vesicle']
|
[
"Apical cell membrane"
] |
ABCC3
|
O15438
|
ATP-binding cassette sub-family C member 3
|
ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:10359813, PubMed:11581266, PubMed:15083066). Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:11581266, PubMed:15083066). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can confer resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells (PubMed:10359813, PubMed:11581266)
|
['- IPR005292: Multi drug resistance-associated protein (family) [5-1526]', '- IPR056227: ABC transporter, TMD0 domain (domain) [25-157]', '- IPR050173: ATP-binding cassette transporter C-like (family) [210-1521]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [290-614]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [295-610]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [312-581]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [312-594]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [623-849]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [624-853]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [629-851]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [644-778]', '- IPR003593: AAA+ ATPase domain (domain) [653-828]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [751-765]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [935-1270]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [972-1239]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [972-1252]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [972-1269]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1273-1517]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1281-1521]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1291-1523]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1306-1454]', '- IPR003593: AAA+ ATPase domain (domain) [1315-1500]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [1426-1440]']
|
['Organic solute transporter subunit alpha', 'Organic solute transporter subunit beta', 'Cytochrome P450 7A1', 'Mitochondrial ribosomal protein S7.', 'Solute carrier organic anion transporter family member 1B1', 'Sodium/bile acid cotransporter', 'Solute carrier organic anion transporter family member 1B3', 'Solute carrier organic anion transporter family member 2B1', 'Solute carrier organic anion transporter family member 1A2', 'Nuclear receptor subfamily 1 group I member 2']
|
['ATF2_S_UP.V1_DN' 'ATF2_UP.V1_DN' 'BIOCARTA_MRP_PATHWAY'
'BIOCARTA_NUCLEARRS_PATHWAY' 'EGFR_UP.V1_UP' 'ERBB2_UP.V1_UP'
'GOBP_BILE_ACID_AND_BILE_SALT_TRANSPORT'
'GOBP_CARBOHYDRATE_DERIVATIVE_TRANSPORT'
'GOBP_CELLULAR_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_CIRCULATORY_SYSTEM_PROCESS' 'GOBP_GLYCOSIDE_TRANSPORT'
'GOBP_ICOSANOID_TRANSPORT' 'GOBP_LEUKOTRIENE_TRANSPORT'
'GOBP_LIPID_LOCALIZATION' 'GOBP_MONOATOMIC_ANION_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSPORT' 'GOBP_MONOCARBOXYLIC_ACID_TRANSPORT'
'GOBP_ORGANIC_ACID_TRANSPORT' 'GOBP_ORGANIC_ANION_TRANSPORT'
'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM' 'GOBP_VASCULAR_TRANSPORT'
'GOBP_XENOBIOTIC_METABOLIC_PROCESS'
'GOBP_XENOBIOTIC_TRANSMEMBRANE_TRANSPORT' 'GOBP_XENOBIOTIC_TRANSPORT'
'GOCC_BASAL_PART_OF_CELL' 'GOCC_BASOLATERAL_PLASMA_MEMBRANE'
'GOCC_CILIARY_BASAL_BODY' 'GOCC_CILIUM' 'GOCC_MICROTUBULE_CYTOSKELETON'
'GOCC_MICROTUBULE_ORGANIZING_CENTER' 'GOCC_PLASMA_MEMBRANE_REGION'
'GOMF_ABC_TYPE_GLUTATHIONE_S_CONJUGATE_TRANSPORTER_ACTIVITY'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_BILE_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_CARBOHYDRATE_DERIVATIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_ICOSANOID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY'
'GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'HALLMARK_XENOBIOTIC_METABOLISM' 'KEGG_ABC_TRANSPORTERS' 'LTE2_UP.V1_UP'
'MEK_UP.V1_UP' 'RAF_UP.V1_UP'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT' 'REACTOME_ASPIRIN_ADME'
'REACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM'
'REACTOME_CELLULAR_RESPONSES_TO_STIMULI'
'REACTOME_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS' 'REACTOME_DRUG_ADME'
'REACTOME_KEAP1_NFE2L2_PATHWAY' 'REACTOME_METABOLISM_OF_LIPIDS'
'REACTOME_METABOLISM_OF_STEROIDS'
'REACTOME_NFE2L2_REGULATING_MDR_ASSOCIATED_ENZYMES'
'REACTOME_NUCLEAR_EVENTS_MEDIATED_BY_NFE2L2' 'REACTOME_PARACETAMOL_ADME'
'REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES' 'WNT_UP.V1_DN' 'WP_CHOLESTASIS'
'WP_CODEINE_AND_MORPHINE_METABOLISM'
'WP_CONSTITUTIVE_ANDROSTANE_RECEPTOR_PATHWAY'
'WP_DISORDERS_OF_BILE_ACID_SYNTHESIS_AND_BILIARY_TRANSPORT'
'WP_DRUG_INDUCTION_OF_BILE_ACID_PATHWAY'
'WP_ENTEROHEPATIC_CIRCULATION_OF_BILE_ACIDS'
'WP_FLUOROPYRIMIDINE_ACTIVITY' 'WP_FOXA2_PATHWAY' 'WP_NRF2_PATHWAY'
'WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY'
'WP_NUCLEAR_RECEPTORS_METAPATHWAY'
'WP_PHOTODYNAMIC_THERAPYINDUCED_NFE2L2_NRF2_SURVIVAL_SIGNALING'
'WP_PREGNANE_X_RECEPTOR_PATHWAY']
|
['GO:0015432 ABC-type bile acid transporter activity', 'GO:0015431 ABC-type glutathione S-conjugate transporter activity', 'GO:0140359 ABC-type transporter activity', 'GO:0008559 ABC-type xenobiotic transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0015164 glucuronoside transmembrane transporter activity', 'GO:0071714 icosanoid transmembrane transporter activity', 'GO:0042910 xenobiotic transmembrane transporter activity']
|
['GO:0015721 bile acid and bile salt transport', 'GO:0071716 leukotriene transport', 'GO:0055085 transmembrane transport', 'GO:0150104 transport across blood-brain barrier', 'GO:0006805 xenobiotic metabolic process', 'GO:0006855 xenobiotic transmembrane transport', 'GO:0042908 xenobiotic transport']
|
['GO:0009925 basal plasma membrane', 'GO:0016323 basolateral plasma membrane', 'GO:0036064 ciliary basal body', 'GO:0005886 plasma membrane']
|
[
"Basolateral cell membrane",
"Basal cell membrane"
] |
ABCC4
|
O15439
|
ATP-binding cassette sub-family C member 4
|
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells (PubMed:11856762, PubMed:12523936, PubMed:15364914, PubMed:38886124, PubMed:40138312). Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12523936, PubMed:12835412, PubMed:12883481, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430, PubMed:38886124, PubMed:40138312). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12523936, PubMed:12883481, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotic molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:17344354, PubMed:18300232). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685)
|
['- IPR050173: ATP-binding cassette transporter C-like (family) [15-1275]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [82-386]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [83-387]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [93-377]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [94-359]', '- IPR030240: ATP-binding cassette sub-family C member 4, six-transmembrane helical domain 1 (domain) [94-386]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [388-643]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [407-629]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [410-633]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [428-562]', '- IPR003593: AAA+ ATPase domain (domain) [437-601]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [535-549]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [683-1023]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [708-1022]', '- IPR047083: ATP-binding cassette sub-family C member 4, six-transmembrane helical domain 2 (domain) [710-1017]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [714-991]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [715-1005]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1025-1276]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1031-1274]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1041-1274]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1058-1205]', '- IPR003593: AAA+ ATPase domain (domain) [1067-1251]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [1177-1191]']
|
['Mitochondrial ribosomal protein S7.', 'Solute carrier family 22 member 11', 'Solute carrier family 22 member 7', 'Solute carrier family 22 member 8', 'Na(+)/H(+) exchange regulatory cofactor NHE-RF3', 'Sorting nexin-27', 'Na(+)/H(+) exchange regulatory cofactor NHE-RF1', 'Solute carrier family 22 member 12', 'Solute carrier family 22 member 6', 'Gastrotropin']
|
['GOBP_AMIDE_TRANSPORT' 'GOBP_BILE_ACID_AND_BILE_SALT_TRANSPORT'
'GOBP_CARBOHYDRATE_DERIVATIVE_TRANSPORT'
'GOBP_CELLULAR_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_CELL_CELL_SIGNALING' 'GOBP_CELL_PROJECTION_ASSEMBLY'
'GOBP_CELL_PROJECTION_ORGANIZATION' 'GOBP_CILIUM_ORGANIZATION'
'GOBP_CIRCULATORY_SYSTEM_PROCESS' 'GOBP_CYCLIC_NUCLEOTIDE_TRANSPORT'
'GOBP_EXOCYTOSIS' 'GOBP_EXPORT_ACROSS_PLASMA_MEMBRANE'
'GOBP_EXPORT_FROM_CELL' 'GOBP_FATTY_ACID_TRANSPORT'
'GOBP_GLUTATHIONE_TRANSMEMBRANE_TRANSPORT' 'GOBP_GLUTATHIONE_TRANSPORT'
'GOBP_GUANINE_NUCLEOTIDE_TRANSPORT' 'GOBP_ICOSANOID_SECRETION'
'GOBP_ICOSANOID_TRANSPORT' 'GOBP_LEUKOTRIENE_TRANSPORT'
'GOBP_LIPID_EXPORT_FROM_CELL' 'GOBP_LIPID_LOCALIZATION'
'GOBP_MODIFIED_AMINO_ACID_TRANSPORT' 'GOBP_MONOATOMIC_ANION_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSPORT' 'GOBP_MONOCARBOXYLIC_ACID_TRANSPORT'
'GOBP_NITROGEN_COMPOUND_TRANSPORT'
'GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT'
'GOBP_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORT' 'GOBP_NUCLEOTIDE_TRANSPORT'
'GOBP_OLIGOPEPTIDE_TRANSPORT' 'GOBP_ORGANELLE_ASSEMBLY'
'GOBP_ORGANIC_ACID_TRANSPORT' 'GOBP_ORGANIC_ANION_TRANSPORT'
'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT' 'GOBP_PEPTIDE_TRANSPORT'
'GOBP_PLATELET_DEGRANULATION' 'GOBP_PROSTAGLANDIN_SECRETION'
'GOBP_PROSTAGLANDIN_TRANSPORT'
'GOBP_PURINE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORT'
'GOBP_PURINE_NUCLEOTIDE_TRANSPORT' 'GOBP_REGULATED_EXOCYTOSIS'
'GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS' 'GOBP_SECRETION'
'GOBP_SIGNAL_RELEASE' 'GOBP_SULFUR_COMPOUND_TRANSPORT'
'GOBP_TRANSMEMBRANE_TRANSPORT' 'GOBP_TRIPEPTIDE_TRANSMEMBRANE_TRANSPORT'
'GOBP_TRIPEPTIDE_TRANSPORT' 'GOBP_URATE_TRANSPORT'
'GOBP_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM' 'GOBP_VASCULAR_TRANSPORT'
'GOBP_VESICLE_MEDIATED_TRANSPORT' 'GOBP_XENOBIOTIC_METABOLIC_PROCESS'
'GOBP_XENOBIOTIC_TRANSMEMBRANE_TRANSPORT' 'GOBP_XENOBIOTIC_TRANSPORT'
'GOCC_APICAL_PART_OF_CELL' 'GOCC_BASAL_PART_OF_CELL'
'GOCC_BASOLATERAL_PLASMA_MEMBRANE' 'GOCC_CELL_SURFACE'
'GOCC_EXTERNAL_SIDE_OF_APICAL_PLASMA_MEMBRANE'
'GOCC_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE' 'GOCC_GOLGI_APPARATUS'
'GOCC_NUCLEOLUS' 'GOCC_PLASMA_MEMBRANE_REGION'
'GOCC_PLATELET_DENSE_GRANULE' 'GOCC_PLATELET_DENSE_GRANULE_MEMBRANE'
'GOCC_SECRETORY_GRANULE' 'GOCC_SECRETORY_GRANULE_MEMBRANE'
'GOCC_SECRETORY_VESICLE' 'GOCC_SIDE_OF_MEMBRANE' 'GOCC_VESICLE_MEMBRANE'
'GOMF_ABC_TYPE_GLUTATHIONE_S_CONJUGATE_TRANSPORTER_ACTIVITY'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_AMIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_BILE_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_EFFLUX_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_GLUTATHIONE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_GUANINE_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_ICOSANOID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_MODIFIED_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_OLIGOPEPTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANOPHOSPHATE_ESTER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_OXIDOREDUCTASE_ACTIVITY'
'GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_CH_OH_GROUP_OF_DONORS'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PURINE_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_SALT_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY'
'GOMF_TRIPEPTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'HALLMARK_ANDROGEN_RESPONSE' 'KEGG_ABC_TRANSPORTERS' 'MEK_UP.V1_UP'
'MYC_UP.V1_UP' 'RAF_UP.V1_UP'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_AZATHIOPRINE_ADME' 'REACTOME_DRUG_ADME' 'REACTOME_HEMOSTASIS'
'REACTOME_PARACETAMOL_ADME'
'REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION'
'REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES'
'WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER' 'WP_ASPIRIN_AND_MIRNAS'
'WP_CHOLESTASIS'
'WP_DISORDERS_OF_BILE_ACID_SYNTHESIS_AND_BILIARY_TRANSPORT'
'WP_DRUG_INDUCTION_OF_BILE_ACID_PATHWAY' 'WP_ECTODERM_DIFFERENTIATION'
'WP_ENTEROHEPATIC_CIRCULATION_OF_BILE_ACIDS'
'WP_FLUOROPYRIMIDINE_ACTIVITY' 'WP_FOXA2_PATHWAY' 'WP_NRF2_PATHWAY'
'WP_NUCLEAR_RECEPTORS_METAPATHWAY' 'WP_OMEGA6FATTY_ACIDS_IN_SENESCENCE'
'WP_PHOTODYNAMIC_THERAPYINDUCED_NFE2L2_NRF2_SURVIVAL_SIGNALING'
'WP_PREGNANE_X_RECEPTOR_PATHWAY'
'WP_PROSTAGLANDIN_SYNTHESIS_AND_REGULATION'
'WP_PROXIMAL_TUBULE_TRANSPORT' 'WP_TYROBP_CAUSAL_NETWORK_IN_MICROGLIA']
|
['GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity', 'GO:0015432 ABC-type bile acid transporter activity', 'GO:0015431 ABC-type glutathione S-conjugate transporter activity', 'GO:0140359 ABC-type transporter activity', 'GO:0008559 ABC-type xenobiotic transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0015562 efflux transmembrane transporter activity', 'GO:0034634 glutathione transmembrane transporter activity', 'GO:0001409 guanine nucleotide transmembrane transporter activity', 'GO:0015132 prostaglandin transmembrane transporter activity', 'GO:0015216 purine nucleotide transmembrane transporter activity', 'GO:0015143 urate transmembrane transporter activity', 'GO:0042910 xenobiotic transmembrane transporter activity']
|
['GO:0015721 bile acid and bile salt transport', 'GO:0070730 cAMP transport', 'GO:0060271 cilium assembly', 'GO:0140115 export across plasma membrane', 'GO:0034275 kynurenic acid metabolic process', 'GO:0006568 L-tryptophan metabolic process', 'GO:0071716 leukotriene transport', 'GO:0002576 platelet degranulation', 'GO:0032310 prostaglandin secretion', 'GO:0015732 prostaglandin transport', 'GO:0055085 transmembrane transport', 'GO:0150104 transport across blood-brain barrier', 'GO:0015747 urate transport', 'GO:0006805 xenobiotic metabolic process', 'GO:0006855 xenobiotic transmembrane transport']
|
['GO:0016324 apical plasma membrane', 'GO:0016323 basolateral plasma membrane', 'GO:0098591 external side of apical plasma membrane', 'GO:0005794 Golgi apparatus', 'GO:0016020 membrane', 'GO:0005730 nucleolus', 'GO:0005886 plasma membrane', 'GO:0031088 platelet dense granule membrane']
|
[
"Basolateral cell membrane",
"Apical cell membrane"
] |
ABCC5
|
O15440
|
ATP-binding cassette sub-family C member 5
|
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro) (PubMed:10893247, PubMed:12637526, PubMed:12695538, PubMed:15899835, PubMed:17229149, PubMed:25964343). Also acts as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins (PubMed:26515061). Confers resistance to the antiviral agent PMEA (PubMed:12695538). Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated (PubMed:10840050, PubMed:12435799, PubMed:12695538, PubMed:15899835). Acts as a heme transporter required for the translocation of cytosolic heme to the secretory pathway (PubMed:24836561). May play a role in energy metabolism by regulating the glucagon-like peptide 1 (GLP-1) secretion from enteroendocrine cells (By similarity)
|
['- IPR050173: ATP-binding cassette transporter C-like (family) [103-1427]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [134-479]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [175-471]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [179-446]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [180-459]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [534-790]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [562-783]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [575-782]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [578-712]', '- IPR003593: AAA+ ATPase domain (domain) [587-760]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [685-699]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [822-1170]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [857-1167]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [860-1141]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [860-1155]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1176-1430]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1185-1422]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1193-1427]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1210-1358]', '- IPR003593: AAA+ ATPase domain (domain) [1219-1404]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [1330-1344]']
|
['Mitochondrial ribosomal protein S7.']
|
['GOBP_AMIDE_TRANSPORT' 'GOBP_AMINOGLYCAN_BIOSYNTHETIC_PROCESS'
'GOBP_AMINOGLYCAN_METABOLIC_PROCESS'
'GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS'
'GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS'
'GOBP_CARBOHYDRATE_DERIVATIVE_TRANSPORT'
'GOBP_CELLULAR_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_CIRCULATORY_SYSTEM_PROCESS' 'GOBP_CYCLIC_NUCLEOTIDE_TRANSPORT'
'GOBP_DETOXIFICATION' 'GOBP_DICARBOXYLIC_ACID_TRANSPORT'
'GOBP_EXPORT_ACROSS_PLASMA_MEMBRANE' 'GOBP_EXPORT_FROM_CELL'
'GOBP_FOLIC_ACID_TRANSPORT' 'GOBP_GLUTATHIONE_TRANSMEMBRANE_TRANSPORT'
'GOBP_GLUTATHIONE_TRANSPORT'
'GOBP_GLYCOSAMINOGLYCAN_BIOSYNTHETIC_PROCESS'
'GOBP_GLYCOSAMINOGLYCAN_METABOLIC_PROCESS'
'GOBP_GUANINE_NUCLEOTIDE_TRANSPORT' 'GOBP_HEME_TRANSPORT'
'GOBP_HYALURONAN_BIOSYNTHETIC_PROCESS'
'GOBP_HYALURONAN_METABOLIC_PROCESS'
'GOBP_IRON_COORDINATION_ENTITY_TRANSPORT'
'GOBP_IRON_ION_TRANSMEMBRANE_TRANSPORT' 'GOBP_IRON_ION_TRANSPORT'
'GOBP_METAL_ION_TRANSPORT' 'GOBP_MODIFIED_AMINO_ACID_TRANSPORT'
'GOBP_MONOATOMIC_ANION_TRANSPORT'
'GOBP_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORT'
'GOBP_MONOATOMIC_CATION_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSPORT' 'GOBP_NITROGEN_COMPOUND_TRANSPORT'
'GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT'
'GOBP_NUCLEOTIDE_TRANSPORT' 'GOBP_OLIGOPEPTIDE_TRANSPORT'
'GOBP_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT' 'GOBP_ORGANIC_ACID_TRANSPORT'
'GOBP_ORGANIC_ANION_TRANSPORT' 'GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT'
'GOBP_PEPTIDE_TRANSPORT' 'GOBP_PURINE_NUCLEOTIDE_TRANSPORT'
'GOBP_RESPONSE_TO_TOXIC_SUBSTANCE' 'GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_SULFUR_COMPOUND_TRANSPORT' 'GOBP_TRANSITION_METAL_ION_TRANSPORT'
'GOBP_TRANSMEMBRANE_TRANSPORT' 'GOBP_TRIPEPTIDE_TRANSMEMBRANE_TRANSPORT'
'GOBP_TRIPEPTIDE_TRANSPORT' 'GOBP_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM'
'GOBP_VASCULAR_TRANSPORT' 'GOBP_VITAMIN_TRANSMEMBRANE_TRANSPORT'
'GOBP_VITAMIN_TRANSPORT' 'GOBP_XENOBIOTIC_EXPORT_FROM_CELL'
'GOBP_XENOBIOTIC_METABOLIC_PROCESS'
'GOBP_XENOBIOTIC_TRANSMEMBRANE_TRANSPORT' 'GOBP_XENOBIOTIC_TRANSPORT'
'GOCC_APICAL_PART_OF_CELL' 'GOCC_BASAL_PART_OF_CELL'
'GOCC_BASOLATERAL_PLASMA_MEMBRANE' 'GOCC_ENDOSOME'
'GOCC_ENDOSOME_MEMBRANE' 'GOCC_GOLGI_APPARATUS' 'GOCC_GOLGI_LUMEN'
'GOCC_PLASMA_MEMBRANE_REGION' 'GOCC_VESICLE_MEMBRANE'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_AMIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_CARBOHYDRATE_DERIVATIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_EFFLUX_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_GLUTATHIONE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_HEME_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_MACROMOLECULE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_MODIFIED_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_OLIGOPEPTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANOPHOSPHATE_ESTER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PURINE_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY'
'GOMF_TRIPEPTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'HALLMARK_P53_PATHWAY' 'HALLMARK_PEROXISOME' 'KEGG_ABC_TRANSPORTERS'
'MEL18_DN.V1_UP' 'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_AZATHIOPRINE_ADME' 'REACTOME_DRUG_ADME'
'REACTOME_GLYCOSAMINOGLYCAN_METABOLISM'
'REACTOME_HYALURONAN_BIOSYNTHESIS_AND_EXPORT'
'REACTOME_HYALURONAN_METABOLISM'
'REACTOME_METABOLISM_OF_CARBOHYDRATES_AND_CARBOHYDRATE_DERIVATIVES'
'REACTOME_PARACETAMOL_ADME' 'REACTOME_TRANSPORT_OF_SMALL_MOLECULES'
'WP_FLUOROPYRIMIDINE_ACTIVITY' 'WP_NRF2_PATHWAY'
'WP_NUCLEAR_RECEPTORS_METAPATHWAY']
|
['GO:0140359 ABC-type transporter activity', 'GO:0008559 ABC-type xenobiotic transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:1901505 carbohydrate derivative transmembrane transporter activity', 'GO:0015562 efflux transmembrane transporter activity', 'GO:0034634 glutathione transmembrane transporter activity', 'GO:0015232 heme transmembrane transporter activity', 'GO:0022884 macromolecule transmembrane transporter activity', 'GO:0008514 organic anion transmembrane transporter activity', 'GO:0015216 purine nucleotide transmembrane transporter activity', 'GO:0042910 xenobiotic transmembrane transporter activity']
|
['GO:0070730 cAMP transport', 'GO:1901264 carbohydrate derivative transport', 'GO:0070731 cGMP transport', 'GO:0140115 export across plasma membrane', 'GO:0098838 folate transmembrane transport', 'GO:0034775 glutathione transmembrane transport', 'GO:0035351 heme transmembrane transport', 'GO:0030213 hyaluronan biosynthetic process', 'GO:0015865 purine nucleotide transport', 'GO:0055085 transmembrane transport', 'GO:0150104 transport across blood-brain barrier', 'GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane', 'GO:0006805 xenobiotic metabolic process', 'GO:0006855 xenobiotic transmembrane transport', 'GO:0042908 xenobiotic transport']
|
['GO:0016324 apical plasma membrane', 'GO:0016323 basolateral plasma membrane', 'GO:0010008 endosome membrane', 'GO:0005796 Golgi lumen', 'GO:0016020 membrane', 'GO:0005886 plasma membrane']
|
[
"Basolateral cell membrane",
"Golgi apparatus lumen",
"Endosome membrane",
"Cytoplasmic granule",
"Apical cell membrane"
] |
ABCC6
|
O95255
|
ATP-binding cassette sub-family C member 6
|
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123 (PubMed:11880368, PubMed:12414644). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Does not appear to actively transport drugs outside the cell. Confers low levels of cellular resistance to etoposide, teniposide, anthracyclines and cisplatin (PubMed:12414644)
|
['- IPR056227: ABC transporter, TMD0 domain (domain) [24-151]', '- IPR005292: Multi drug resistance-associated protein (family) [27-1502]', '- IPR050173: ATP-binding cassette transporter C-like (family) [208-1500]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [281-610]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [297-601]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [312-578]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [312-593]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [623-859]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [627-848]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [629-853]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [646-780]', '- IPR003593: AAA+ ATPase domain (domain) [655-845]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [753-767]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [923-1245]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [946-1251]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [948-1215]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [950-1228]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1251-1496]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1257-1498]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1265-1499]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1283-1430]', '- IPR003593: AAA+ ATPase domain (domain) [1291-1478]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [1402-1416]']
|
['Vitamin K-dependent gamma-carboxylase', 'Matrix Gla protein', 'Xylosyltransferase 1', 'Vitamin K epoxide reductase complex subunit 1', 'Mitochondrial ribosomal protein S7.', 'Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form', 'Alpha-2-HS-glycoprotein chain A', 'Nodal modulator 2', 'Xylosyltransferase 2']
|
['ESC_V6.5_UP_EARLY.V1_UP' 'GOBP_ATP_METABOLIC_PROCESS'
'GOBP_ATP_TRANSPORT' 'GOBP_CALCIUM_ION_HOMEOSTASIS'
'GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS'
'GOBP_CARBOHYDRATE_DERIVATIVE_TRANSPORT' 'GOBP_CELLULAR_HOMEOSTASIS'
'GOBP_CHEMICAL_HOMEOSTASIS' 'GOBP_HOMEOSTATIC_PROCESS'
'GOBP_ICOSANOID_TRANSPORT' 'GOBP_INORGANIC_ANION_TRANSPORT'
'GOBP_INORGANIC_ION_HOMEOSTASIS'
'GOBP_INTRACELLULAR_PHOSPHATE_ION_HOMEOSTASIS'
'GOBP_LEUKOTRIENE_TRANSPORT' 'GOBP_MONOATOMIC_ANION_TRANSPORT'
'GOBP_MONOATOMIC_ION_HOMEOSTASIS'
'GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSPORT'
'GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS'
'GOBP_NERVOUS_SYSTEM_PROCESS' 'GOBP_NITROGEN_COMPOUND_TRANSPORT'
'GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT'
'GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS'
'GOBP_NUCLEOTIDE_METABOLIC_PROCESS' 'GOBP_NUCLEOTIDE_TRANSPORT'
'GOBP_ORGANIC_ACID_TRANSPORT' 'GOBP_ORGANIC_ANION_TRANSPORT'
'GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT'
'GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS' 'GOBP_PHOSPHATE_ION_HOMEOSTASIS'
'GOBP_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_PURINE_NUCLEOTIDE_TRANSPORT' 'GOBP_RESPONSE_TO_MAGNESIUM_ION'
'GOBP_RESPONSE_TO_METAL_ION' 'GOBP_RESPONSE_TO_SALT'
'GOBP_RESPONSE_TO_SODIUM_PHOSPHATE'
'GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_RIBOSE_PHOSPHATE_METABOLIC_PROCESS' 'GOBP_SENSORY_PERCEPTION'
'GOBP_SENSORY_PERCEPTION_OF_LIGHT_STIMULUS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS' 'GOBP_TISSUE_HOMEOSTASIS'
'GOBP_TRANSMEMBRANE_TRANSPORT' 'GOCC_BASAL_PART_OF_CELL'
'GOCC_BASOLATERAL_PLASMA_MEMBRANE'
'GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK'
'GOCC_ORGANELLE_SUBCOMPARTMENT' 'GOCC_PLASMA_MEMBRANE_REGION'
'GOMF_ABC_TYPE_GLUTATHIONE_S_CONJUGATE_TRANSPORTER_ACTIVITY'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY' 'KEGG_ABC_TRANSPORTERS'
'KRAS.AMP.LUNG_UP.V1_UP'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTER_DISORDERS'
'REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES'
'WP_16P1311_COPY_NUMBER_VARIATION_SYNDROME'
'WP_PHOTODYNAMIC_THERAPYINDUCED_NFE2L2_NRF2_SURVIVAL_SIGNALING']
|
['GO:0015431 ABC-type glutathione S-conjugate transporter activity', 'GO:0140359 ABC-type transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity']
|
['GO:0046034 ATP metabolic process', 'GO:0015867 ATP transport', 'GO:0055074 calcium ion homeostasis', 'GO:0010467 gene expression', 'GO:0140928 inhibition of non-skeletal tissue mineralization', 'GO:0030505 inorganic diphosphate transport', 'GO:0030643 intracellular phosphate ion homeostasis', 'GO:0071716 leukotriene transport', 'GO:0055062 phosphate ion homeostasis', 'GO:0032026 response to magnesium ion', 'GO:1904383 response to sodium phosphate', 'GO:0009410 response to xenobiotic stimulus', 'GO:0055085 transmembrane transport', 'GO:0007601 visual perception']
|
['GO:0009925 basal plasma membrane', 'GO:0016323 basolateral plasma membrane', 'GO:0005789 endoplasmic reticulum membrane', 'GO:0005576 extracellular region', 'GO:0005654 nucleoplasm', 'GO:0005886 plasma membrane']
|
[
"Basal cell membrane",
"Basolateral cell membrane",
"Endoplasmic reticulum membrane"
] |
ABCC8
|
Q09428
|
ATP-binding cassette sub-family C member 8
|
Regulator subunit of pancreatic ATP-sensitive potassium channel (KATP), playing a major role in the regulation of insulin release. In pancreatic cells, it forms KATP channels with KCNJ11; KCNJ11 forms the channel pore while ABCC8 is required for activation and regulation
|
['- IPR000844: ATP-binding cassette subfamily C member 8 (family) [9-19]', '- IPR000388: ATP-binding cassette sub-family C member 8/9 (family) [25-52]', '- IPR000388: ATP-binding cassette sub-family C member 8/9 (family) [65-79]', '- IPR000388: ATP-binding cassette sub-family C member 8/9 (family) [122-136]', '- IPR000388: ATP-binding cassette sub-family C member 8/9 (family) [204-227]', '- IPR050173: ATP-binding cassette transporter C-like (family) [222-1577]', '- IPR000844: ATP-binding cassette subfamily C member 8 (family) [269-277]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [275-618]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [293-621]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [300-602]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [304-590]', '- IPR000388: ATP-binding cassette sub-family C member 8/9 (family) [357-379]', '- IPR000844: ATP-binding cassette subfamily C member 8 (family) [617-629]', '- IPR000844: ATP-binding cassette subfamily C member 8 (family) [638-654]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [671-951]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [679-929]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [680-925]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [696-856]', '- IPR003593: AAA+ ATPase domain (domain) [705-913]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [829-843]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [982-1324]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [1010-1323]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [1014-1292]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [1014-1306]', '- IPR000844: ATP-binding cassette subfamily C member 8 (family) [1046-1056]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1331-1579]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1337-1575]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1344-1578]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1361-1509]', '- IPR003593: AAA+ ATPase domain (domain) [1370-1563]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [1481-1495]']
|
['ATP-sensitive inward rectifier potassium channel 8', 'ATP-sensitive inward rectifier potassium channel 11', 'Transient receptor potential cation channel subfamily M member 4', 'Rap guanine nucleotide exchange factor 4', 'Hexokinase-4', 'cAMP-dependent protein kinase catalytic subunit beta', 'cAMP-dependent protein kinase catalytic subunit alpha', 'cAMP-dependent protein kinase catalytic subunit gamma', 'Insulin A chain', 'ATP-binding cassette sub-family C member 9']
|
['GOBP_ACIDIC_AMINO_ACID_TRANSPORT' 'GOBP_ACTION_POTENTIAL'
'GOBP_AMIDE_TRANSPORT' 'GOBP_AMINO_ACID_TRANSPORT'
'GOBP_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS'
'GOBP_ASSOCIATIVE_LEARNING' 'GOBP_BEHAVIOR'
'GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS'
'GOBP_BLOOD_VESSEL_MORPHOGENESIS' 'GOBP_CARBOHYDRATE_HOMEOSTASIS'
'GOBP_CELLULAR_COMPONENT_DISASSEMBLY' 'GOBP_CELLULAR_HOMEOSTASIS'
'GOBP_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_NUTRIENT_LEVELS'
'GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND'
'GOBP_CELL_CELL_JUNCTION_DISASSEMBLY'
'GOBP_CELL_CELL_JUNCTION_ORGANIZATION' 'GOBP_CELL_CELL_SIGNALING'
'GOBP_CELL_JUNCTION_DISASSEMBLY' 'GOBP_CELL_JUNCTION_ORGANIZATION'
'GOBP_CELL_MOTILITY' 'GOBP_CHEMICAL_HOMEOSTASIS'
'GOBP_CIRCULATORY_SYSTEM_DEVELOPMENT' 'GOBP_CIRCULATORY_SYSTEM_PROCESS'
'GOBP_COGNITION' 'GOBP_CYTOKINE_PRODUCTION'
'GOBP_DICARBOXYLIC_ACID_TRANSPORT'
'GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION' 'GOBP_EXPORT_FROM_CELL'
'GOBP_GLIAL_CELL_PROLIFERATION' 'GOBP_GLIOGENESIS'
'GOBP_GLUTAMATE_SECRETION' 'GOBP_GLUTAMATE_SECRETION_NEUROTRANSMISSION'
'GOBP_HOMEOSTATIC_PROCESS' 'GOBP_HORMONE_TRANSPORT'
'GOBP_IMPORT_ACROSS_PLASMA_MEMBRANE' 'GOBP_IMPORT_INTO_CELL'
'GOBP_INORGANIC_ION_IMPORT_ACROSS_PLASMA_MEMBRANE'
'GOBP_INSULIN_SECRETION'
'GOBP_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS'
'GOBP_INTRACELLULAR_GLUCOSE_HOMEOSTASIS' 'GOBP_LEARNING'
'GOBP_LOCOMOTION' 'GOBP_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE'
'GOBP_L_AMINO_ACID_TRANSPORT' 'GOBP_L_GLUTAMATE_IMPORT'
'GOBP_MAINTENANCE_OF_BLOOD_BRAIN_BARRIER' 'GOBP_MEMORY'
'GOBP_METAL_ION_TRANSPORT'
'GOBP_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORT'
'GOBP_MONOATOMIC_CATION_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSPORT'
'GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS'
'GOBP_MULTI_MULTICELLULAR_ORGANISM_PROCESS' 'GOBP_MUSCLE_SYSTEM_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_CELL_DEVELOPMENT'
'GOBP_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION'
'GOBP_NEGATIVE_REGULATION_OF_CELL_POPULATION_PROLIFERATION'
'GOBP_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION'
'GOBP_NEGATIVE_REGULATION_OF_GLIAL_CELL_PROLIFERATION'
'GOBP_NEGATIVE_REGULATION_OF_GLIOGENESIS'
'GOBP_NEGATIVE_REGULATION_OF_HORMONE_SECRETION'
'GOBP_NEGATIVE_REGULATION_OF_LIPOPROTEIN_PARTICLE_CLEARANCE'
'GOBP_NEGATIVE_REGULATION_OF_LOCOMOTION'
'GOBP_NEGATIVE_REGULATION_OF_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE'
'GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT'
'GOBP_NEGATIVE_REGULATION_OF_PEPTIDE_SECRETION'
'GOBP_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION'
'GOBP_NEGATIVE_REGULATION_OF_PROTEIN_SECRETION'
'GOBP_NEGATIVE_REGULATION_OF_SECRETION'
'GOBP_NEGATIVE_REGULATION_OF_SIGNALING'
'GOBP_NEGATIVE_REGULATION_OF_TRANSPORT'
'GOBP_NEGATIVE_REGULATION_OF_VASCULAR_PERMEABILITY'
'GOBP_NEGATIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT'
'GOBP_NERVOUS_SYSTEM_PROCESS' 'GOBP_NEUROBLAST_MIGRATION'
'GOBP_NEUROGENESIS' 'GOBP_NEUROMUSCULAR_PROCESS'
'GOBP_NEUROTRANSMITTER_SECRETION' 'GOBP_NEUROTRANSMITTER_TRANSPORT'
'GOBP_NITROGEN_COMPOUND_TRANSPORT' 'GOBP_ORGANIC_ACID_TRANSPORT'
'GOBP_ORGANIC_ANION_TRANSPORT' 'GOBP_PEPTIDE_TRANSPORT'
'GOBP_PLASMA_LIPOPROTEIN_PARTICLE_CLEARANCE'
'GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION'
'GOBP_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION'
'GOBP_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_GENE_EXPRESSION'
'GOBP_POSITIVE_REGULATION_OF_HORMONE_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_INSULIN_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS'
'GOBP_POSITIVE_REGULATION_OF_MONOATOMIC_ION_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_PEPTIDE_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_SIGNALING'
'GOBP_POSITIVE_REGULATION_OF_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION'
'GOBP_POTASSIUM_ION_IMPORT_ACROSS_PLASMA_MEMBRANE'
'GOBP_POTASSIUM_ION_TRANSPORT'
'GOBP_PROTEIN_LOCALIZATION_TO_EXTRACELLULAR_REGION'
'GOBP_PROTEIN_TRANSPORT'
'GOBP_REGULATION_OF_ANATOMICAL_STRUCTURE_MORPHOGENESIS'
'GOBP_REGULATION_OF_BLOOD_BRAIN_BARRIER_PERMEABILITY'
'GOBP_REGULATION_OF_CELLULAR_LOCALIZATION'
'GOBP_REGULATION_OF_CELL_DEVELOPMENT'
'GOBP_REGULATION_OF_CELL_DIFFERENTIATION'
'GOBP_REGULATION_OF_CELL_POPULATION_PROLIFERATION'
'GOBP_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION'
'GOBP_REGULATION_OF_GLIAL_CELL_PROLIFERATION'
'GOBP_REGULATION_OF_GLIOGENESIS' 'GOBP_REGULATION_OF_HORMONE_LEVELS'
'GOBP_REGULATION_OF_HORMONE_SECRETION'
'GOBP_REGULATION_OF_INSULIN_SECRETION'
'GOBP_REGULATION_OF_LIPOPROTEIN_PARTICLE_CLEARANCE'
'GOBP_REGULATION_OF_LOCOMOTION'
'GOBP_REGULATION_OF_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE'
'GOBP_REGULATION_OF_MEMBRANE_POTENTIAL'
'GOBP_REGULATION_OF_MONOATOMIC_ION_TRANSPORT'
'GOBP_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT'
'GOBP_REGULATION_OF_MUSCLE_SYSTEM_PROCESS'
'GOBP_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT'
'GOBP_REGULATION_OF_NEUROGENESIS' 'GOBP_REGULATION_OF_PEPTIDE_TRANSPORT'
'GOBP_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS'
'GOBP_REGULATION_OF_POTASSIUM_ION_TRANSPORT'
'GOBP_REGULATION_OF_PROTEIN_SECRETION'
'GOBP_REGULATION_OF_PROTEIN_TRANSPORT'
'GOBP_REGULATION_OF_RELAXATION_OF_MUSCLE' 'GOBP_REGULATION_OF_SECRETION'
'GOBP_REGULATION_OF_SYSTEM_PROCESS'
'GOBP_REGULATION_OF_TIGHT_JUNCTION_DISASSEMBLY'
'GOBP_REGULATION_OF_TRANSPORT' 'GOBP_REGULATION_OF_VASCULAR_PERMEABILITY'
'GOBP_REGULATION_OF_VASCULATURE_DEVELOPMENT' 'GOBP_RELAXATION_OF_MUSCLE'
'GOBP_RELAXATION_OF_SMOOTH_MUSCLE' 'GOBP_REPRODUCTIVE_PROCESS'
'GOBP_RESPONSE_TO_ABIOTIC_STIMULUS' 'GOBP_RESPONSE_TO_BACTERIUM'
'GOBP_RESPONSE_TO_CARBOHYDRATE' 'GOBP_RESPONSE_TO_ENDOGENOUS_STIMULUS'
'GOBP_RESPONSE_TO_HORMONE' 'GOBP_RESPONSE_TO_INSULIN'
'GOBP_RESPONSE_TO_LIGHT_STIMULUS' 'GOBP_RESPONSE_TO_LIPID'
'GOBP_RESPONSE_TO_METAL_ION'
'GOBP_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN'
'GOBP_RESPONSE_TO_NITROGEN_COMPOUND' 'GOBP_RESPONSE_TO_NUTRIENT_LEVELS'
'GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND'
'GOBP_RESPONSE_TO_PEPTIDE_HORMONE' 'GOBP_RESPONSE_TO_PH'
'GOBP_RESPONSE_TO_RADIATION' 'GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_RESPONSE_TO_ZINC_ION' 'GOBP_SECRETION' 'GOBP_SIGNAL_RELEASE'
'GOBP_SYNAPTIC_SIGNALING' 'GOBP_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC'
'GOBP_TIGHT_JUNCTION_ORGANIZATION' 'GOBP_TISSUE_HOMEOSTASIS'
'GOBP_TRANSMEMBRANE_TRANSPORT' 'GOBP_TUBE_DEVELOPMENT'
'GOBP_TUBE_MORPHOGENESIS'
'GOBP_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION'
'GOBP_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM'
'GOBP_VASCULATURE_DEVELOPMENT' 'GOBP_VISUAL_BEHAVIOR'
'GOCC_ATPASE_DEPENDENT_TRANSMEMBRANE_TRANSPORT_COMPLEX'
'GOCC_CATION_CHANNEL_COMPLEX' 'GOCC_EXOCYTIC_VESICLE'
'GOCC_MEMBRANE_PROTEIN_COMPLEX' 'GOCC_MONOATOMIC_ION_CHANNEL_COMPLEX'
'GOCC_PLASMA_MEMBRANE_PROTEIN_COMPLEX' 'GOCC_PLASMA_MEMBRANE_REGION'
'GOCC_POTASSIUM_CHANNEL_COMPLEX' 'GOCC_PRESYNAPSE'
'GOCC_PRESYNAPTIC_MEMBRANE' 'GOCC_SARCOLEMMA' 'GOCC_SECRETORY_VESICLE'
'GOCC_SYNAPSE' 'GOCC_SYNAPTIC_MEMBRANE' 'GOCC_SYNAPTIC_VESICLE_MEMBRANE'
'GOCC_TRANSPORTER_COMPLEX' 'GOCC_TRANSPORT_VESICLE'
'GOCC_TRANSPORT_VESICLE_MEMBRANE' 'GOCC_VESICLE_MEMBRANE'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING' 'GOMF_ADP_BINDING'
'GOMF_ATPASE_COUPLED_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_ACTIVATED_INWARD_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_GATED_CHANNEL_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_INWARD_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY'
'GOMF_LIGAND_GATED_CHANNEL_ACTIVITY'
'GOMF_LIGAND_GATED_MONOATOMIC_CATION_CHANNEL_ACTIVITY'
'GOMF_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_MONOATOMIC_CATION_CHANNEL_ACTIVITY'
'GOMF_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PASSIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_POTASSIUM_CHANNEL_ACTIVITY'
'GOMF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY'
'GOMF_TRANSMEMBRANE_TRANSPORTER_BINDING' 'GOMF_TRANSPORTER_ACTIVITY'
'GOMF_VOLTAGE_GATED_CHANNEL_ACTIVITY'
'GOMF_VOLTAGE_GATED_MONOATOMIC_CATION_CHANNEL_ACTIVITY'
'GOMF_VOLTAGE_GATED_POTASSIUM_CHANNEL_ACTIVITY'
'HALLMARK_PANCREAS_BETA_CELLS' 'HALLMARK_PEROXISOME' 'IL21_UP.V1_UP'
'KEGG_ABC_TRANSPORTERS' 'KEGG_TYPE_II_DIABETES_MELLITUS'
'PID_HNF3B_PATHWAY' 'REACTOME_ABC_TRANSPORTER_DISORDERS'
'REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS'
'REACTOME_INTEGRATION_OF_ENERGY_METABOLISM'
'REACTOME_INWARDLY_RECTIFYING_K_CHANNELS' 'REACTOME_NEURONAL_SYSTEM'
'REACTOME_POTASSIUM_CHANNELS' 'REACTOME_REGULATION_OF_INSULIN_SECRETION']
|
['GO:0140359 ABC-type transporter activity', 'GO:0043531 ADP binding', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0015272 ATP-activated inward rectifier potassium channel activity', 'GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity', 'GO:0046872 metal ion binding', 'GO:0005267 potassium channel activity', 'GO:0008281 sulfonylurea receptor activity', 'GO:0044325 transmembrane transporter binding']
|
['GO:0001508 action potential', 'GO:0031669 cellular response to nutrient levels', 'GO:0007565 female pregnancy', 'GO:0061535 glutamate secretion, neurotransmission', 'GO:0098662 inorganic cation transmembrane transport', 'GO:0001678 intracellular glucose homeostasis', 'GO:0007613 memory', 'GO:0016525 negative regulation of angiogenesis', 'GO:1905604 negative regulation of blood-brain barrier permeability', 'GO:0060253 negative regulation of glial cell proliferation', 'GO:0046676 negative regulation of insulin secretion', 'GO:0010989 negative regulation of low-density lipoprotein particle clearance', 'GO:0061855 negative regulation of neuroblast migration', 'GO:0050905 neuromuscular process', 'GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus', 'GO:0043268 positive regulation of potassium ion transport', 'GO:1905075 positive regulation of tight junction disassembly', 'GO:0032760 positive regulation of tumor necrosis factor production', 'GO:1900721 positive regulation of uterine smooth muscle relaxation', 'GO:1990573 potassium ion import across plasma membrane', 'GO:0071805 potassium ion transmembrane transport', 'GO:0006813 potassium ion transport', 'GO:0050796 regulation of insulin secretion', 'GO:0032868 response to insulin', 'GO:0032496 response to lipopolysaccharide', 'GO:0009268 response to pH', 'GO:0009410 response to xenobiotic stimulus', 'GO:0010043 response to zinc ion', 'GO:0055085 transmembrane transport', 'GO:0008542 visual learning']
|
['GO:0008282 inward rectifying potassium channel', 'GO:0005886 plasma membrane', 'GO:0031004 potassium ion-transporting ATPase complex', 'GO:0042734 presynaptic membrane', 'GO:0042383 sarcolemma', 'GO:0030672 synaptic vesicle membrane']
|
[
"Cell membrane"
] |
ABCC9
|
O60706
|
ATP-binding cassette sub-family C member 9
|
Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (PubMed:9831708). Can form a sulfonylurea-sensitive but ATP-insensitive potassium channel with KCNJ8 (By similarity)
|
['- IPR001475: ATP-binding cassette subfamily C member 9 (family) [8-16]', '- IPR000388: ATP-binding cassette sub-family C member 8/9 (family) [23-50]', '- IPR000388: ATP-binding cassette sub-family C member 8/9 (family) [63-77]', '- IPR000388: ATP-binding cassette sub-family C member 8/9 (family) [120-134]', '- IPR000388: ATP-binding cassette sub-family C member 8/9 (family) [202-225]', '- IPR050173: ATP-binding cassette transporter C-like (family) [220-1546]', '- IPR001475: ATP-binding cassette subfamily C member 9 (family) [262-270]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [263-613]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [286-609]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [302-585]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [306-597]', '- IPR000388: ATP-binding cassette sub-family C member 8/9 (family) [353-375]', '- IPR001475: ATP-binding cassette subfamily C member 9 (family) [557-570]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [648-940]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [667-911]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [672-912]', '- IPR047080: ATP-binding cassette sub-family C member 9, ATP-binding cassette domain 1 (domain) [672-889]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [688-839]', '- IPR003593: AAA+ ATPase domain (domain) [697-905]', '- IPR001475: ATP-binding cassette subfamily C member 9 (family) [733-751]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [812-826]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [957-1292]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [982-1291]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [994-1255]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [995-1273]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1296-1548]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1302-1544]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1312-1546]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [1329-1477]', '- IPR003593: AAA+ ATPase domain (domain) [1338-1531]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [1449-1463]']
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['ATP-sensitive inward rectifier potassium channel 8', 'ATP-sensitive inward rectifier potassium channel 11', 'ATP-binding cassette sub-family C member 8', 'RNA-binding protein 20', 'Sodium channel protein type 5 subunit alpha', 'Myosin-binding protein C, cardiac-type', 'Cysteine and glycine-rich protein 3', 'Lamina-associated polypeptide 2, isoform alpha', 'Eyes absent homolog 4', 'Desmoglein-2']
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['CRX_NRL_DN.V1_DN' 'GOBP_ACTIN_FILAMENT_BASED_MOVEMENT'
'GOBP_ACTIN_FILAMENT_BASED_PROCESS'
'GOBP_ACTIN_MEDIATED_CELL_CONTRACTION' 'GOBP_ACTION_POTENTIAL'
'GOBP_ANIMAL_ORGAN_MORPHOGENESIS' 'GOBP_APOPTOTIC_PROCESS'
'GOBP_ATP_METABOLIC_PROCESS'
'GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS'
'GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS'
'GOBP_CARDIAC_CONDUCTION' 'GOBP_CARDIAC_MUSCLE_CELL_CONTRACTION'
'GOBP_CARDIAC_MUSCLE_CONTRACTION' 'GOBP_CELLULAR_RESPIRATION'
'GOBP_CELLULAR_RESPONSE_TO_ATP' 'GOBP_CELLULAR_RESPONSE_TO_CALCIUM_ION'
'GOBP_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS'
'GOBP_CELLULAR_RESPONSE_TO_METAL_ION'
'GOBP_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND'
'GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND'
'GOBP_CELLULAR_RESPONSE_TO_POTASSIUM_ION'
'GOBP_CELLULAR_RESPONSE_TO_STRESS'
'GOBP_CELLULAR_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_CIRCULATORY_SYSTEM_DEVELOPMENT' 'GOBP_CIRCULATORY_SYSTEM_PROCESS'
'GOBP_CORONARY_VASCULATURE_DEVELOPMENT'
'GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM'
'GOBP_DEFENSE_RESPONSE_TO_VIRUS'
'GOBP_ENERGY_DERIVATION_BY_OXIDATION_OF_ORGANIC_COMPOUNDS'
'GOBP_FATTY_ACID_METABOLIC_PROCESS' 'GOBP_FIBROBLAST_PROLIFERATION'
'GOBP_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY'
'GOBP_HEART_DEVELOPMENT' 'GOBP_HEART_MORPHOGENESIS' 'GOBP_HEART_PROCESS'
'GOBP_IMPORT_ACROSS_PLASMA_MEMBRANE' 'GOBP_IMPORT_INTO_CELL'
'GOBP_INORGANIC_ION_IMPORT_ACROSS_PLASMA_MEMBRANE'
'GOBP_LIPID_METABOLIC_PROCESS' 'GOBP_LIPID_MODIFICATION'
'GOBP_LIPID_OXIDATION' 'GOBP_MAPK_CASCADE' 'GOBP_METAL_ION_TRANSPORT'
'GOBP_MITOCHONDRION_ORGANIZATION' 'GOBP_MONOATOMIC_ANION_TRANSPORT'
'GOBP_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORT'
'GOBP_MONOATOMIC_CATION_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSPORT'
'GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS' 'GOBP_MUSCLE_CONTRACTION'
'GOBP_MUSCLE_ORGAN_DEVELOPMENT' 'GOBP_MUSCLE_STRUCTURE_DEVELOPMENT'
'GOBP_MUSCLE_SYSTEM_PROCESS' 'GOBP_MUSCLE_TISSUE_DEVELOPMENT'
'GOBP_NEGATIVE_REGULATION_OF_BLOOD_PRESSURE'
'GOBP_NEGATIVE_REGULATION_OF_PROGRAMMED_CELL_DEATH'
'GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS'
'GOBP_NUCLEOTIDE_METABOLIC_PROCESS' 'GOBP_ORGANIC_ACID_METABOLIC_PROCESS'
'GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS' 'GOBP_OXYGEN_METABOLIC_PROCESS'
'GOBP_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_POTASSIUM_ION_IMPORT_ACROSS_PLASMA_MEMBRANE'
'GOBP_POTASSIUM_ION_TRANSPORT'
'GOBP_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS'
'GOBP_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_ANATOMICAL_STRUCTURE_SIZE'
'GOBP_REGULATION_OF_BLOOD_CIRCULATION'
'GOBP_REGULATION_OF_BLOOD_PRESSURE'
'GOBP_REGULATION_OF_HEART_CONTRACTION'
'GOBP_REGULATION_OF_MEMBRANE_POTENTIAL'
'GOBP_REGULATION_OF_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT'
'GOBP_REGULATION_OF_MONOATOMIC_ION_TRANSPORT'
'GOBP_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT'
'GOBP_REGULATION_OF_POTASSIUM_ION_TRANSPORT'
'GOBP_REGULATION_OF_PROGRAMMED_CELL_DEATH'
'GOBP_REGULATION_OF_SYSTEM_PROCESS'
'GOBP_REGULATION_OF_TRANSMEMBRANE_TRANSPORT'
'GOBP_REGULATION_OF_TRANSPORT' 'GOBP_REGULATION_OF_TUBE_SIZE'
'GOBP_RESPONSE_TO_ABIOTIC_STIMULUS' 'GOBP_RESPONSE_TO_ACTIVITY'
'GOBP_RESPONSE_TO_ATP' 'GOBP_RESPONSE_TO_CALCIUM_ION'
'GOBP_RESPONSE_TO_ENDOGENOUS_STIMULUS' 'GOBP_RESPONSE_TO_ESTROGEN'
'GOBP_RESPONSE_TO_HORMONE' 'GOBP_RESPONSE_TO_HYDROGEN_PEROXIDE'
'GOBP_RESPONSE_TO_METAL_ION' 'GOBP_RESPONSE_TO_NITROGEN_COMPOUND'
'GOBP_RESPONSE_TO_ORGANOPHOSPHORUS' 'GOBP_RESPONSE_TO_OXIDATIVE_STRESS'
'GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND'
'GOBP_RESPONSE_TO_OXYGEN_LEVELS' 'GOBP_RESPONSE_TO_PEPTIDE'
'GOBP_RESPONSE_TO_POTASSIUM_ION'
'GOBP_RESPONSE_TO_PURINE_CONTAINING_COMPOUND'
'GOBP_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES' 'GOBP_RESPONSE_TO_VIRUS'
'GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_RIBOSE_PHOSPHATE_METABOLIC_PROCESS'
'GOBP_SKELETAL_MUSCLE_ORGAN_DEVELOPMENT'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_STRIATED_MUSCLE_CONTRACTION' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM' 'GOBP_VASCULAR_TRANSPORT'
'GOBP_VASCULATURE_DEVELOPMENT' 'GOBP_VASODILATION'
'GOCC_ATPASE_DEPENDENT_TRANSMEMBRANE_TRANSPORT_COMPLEX'
'GOCC_CATION_CHANNEL_COMPLEX' 'GOCC_CONTRACTILE_MUSCLE_FIBER'
'GOCC_MEMBRANE_PROTEIN_COMPLEX' 'GOCC_MITOCHONDRION'
'GOCC_MONOATOMIC_ION_CHANNEL_COMPLEX'
'GOCC_PLASMA_MEMBRANE_PROTEIN_COMPLEX' 'GOCC_POTASSIUM_CHANNEL_COMPLEX'
'GOCC_SARCOLEMMA' 'GOCC_SUPRAMOLECULAR_COMPLEX'
'GOCC_SUPRAMOLECULAR_POLYMER' 'GOCC_TRANSPORTER_COMPLEX'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_ACTIVATED_INWARD_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_CHANNEL_ACTIVATOR_ACTIVITY' 'GOMF_GATED_CHANNEL_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_INWARD_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY'
'GOMF_LIGAND_GATED_CHANNEL_ACTIVITY'
'GOMF_LIGAND_GATED_MONOATOMIC_CATION_CHANNEL_ACTIVITY'
'GOMF_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_MOLECULAR_FUNCTION_ACTIVATOR_ACTIVITY'
'GOMF_MONOATOMIC_CATION_CHANNEL_ACTIVITY'
'GOMF_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PASSIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_POTASSIUM_CHANNEL_ACTIVATOR_ACTIVITY'
'GOMF_POTASSIUM_CHANNEL_ACTIVITY'
'GOMF_POTASSIUM_CHANNEL_REGULATOR_ACTIVITY'
'GOMF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PROTEIN_CONTAINING_COMPLEX_BINDING'
'GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY'
'GOMF_TRANSMEMBRANE_TRANSPORTER_BINDING'
'GOMF_TRANSPORTER_ACTIVATOR_ACTIVITY' 'GOMF_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_REGULATOR_ACTIVITY'
'GOMF_VOLTAGE_GATED_CHANNEL_ACTIVITY'
'GOMF_VOLTAGE_GATED_MONOATOMIC_CATION_CHANNEL_ACTIVITY'
'GOMF_VOLTAGE_GATED_POTASSIUM_CHANNEL_ACTIVITY' 'KEGG_ABC_TRANSPORTERS'
'NRL_DN.V1_DN' 'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTER_DISORDERS' 'REACTOME_CARDIAC_CONDUCTION'
'REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS'
'REACTOME_INWARDLY_RECTIFYING_K_CHANNELS' 'REACTOME_ION_HOMEOSTASIS'
'REACTOME_MUSCLE_CONTRACTION' 'REACTOME_NEURONAL_SYSTEM'
'REACTOME_POTASSIUM_CHANNELS' 'REACTOME_TRANSPORT_OF_SMALL_MOLECULES']
|
['GO:0140359 ABC-type transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity', 'GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0099104 potassium channel activator activity', 'GO:0005267 potassium channel activity', 'GO:0015459 potassium channel regulator activity', 'GO:0044877 protein-containing complex binding', 'GO:0008281 sulfonylurea receptor activity', 'GO:0044325 transmembrane transporter binding']
|
['GO:0001508 action potential', 'GO:0046034 ATP metabolic process', 'GO:0061337 cardiac conduction', 'GO:0086003 cardiac muscle cell contraction', 'GO:0045333 cellular respiration', 'GO:0071318 cellular response to ATP', 'GO:0071277 cellular response to calcium ion', 'GO:0062197 cellular response to chemical stress', 'GO:0035865 cellular response to potassium ion', 'GO:0071466 cellular response to xenobiotic stimulus', 'GO:0060976 coronary vasculature development', 'GO:0051607 defense response to virus', 'GO:0019395 fatty acid oxidation', 'GO:0048144 fibroblast proliferation', 'GO:0010467 gene expression', 'GO:0003007 heart morphogenesis', 'GO:0098662 inorganic cation transmembrane transport', 'GO:0000165 MAPK cascade', 'GO:0007005 mitochondrion organization', 'GO:0098655 monoatomic cation transmembrane transport', 'GO:0043066 negative regulation of apoptotic process', 'GO:0045776 negative regulation of blood pressure', 'GO:0072592 oxygen metabolic process', 'GO:1990573 potassium ion import across plasma membrane', 'GO:0071805 potassium ion transmembrane transport', 'GO:1903409 reactive oxygen species biosynthetic process', 'GO:1901379 regulation of potassium ion transmembrane transport', 'GO:0006357 regulation of transcription by RNA polymerase II', 'GO:0014823 response to activity', 'GO:0033198 response to ATP', 'GO:0043627 response to estrogen', 'GO:0042542 response to hydrogen peroxide', 'GO:1904880 response to hydrogen sulfide', 'GO:0001666 response to hypoxia', 'GO:1901652 response to peptide', 'GO:0007519 skeletal muscle tissue development', 'GO:0055085 transmembrane transport', 'GO:0150104 transport across blood-brain barrier', 'GO:0042311 vasodilation']
|
['GO:0008282 inward rectifying potassium channel', 'GO:0005739 mitochondrion', 'GO:0005886 plasma membrane', 'GO:0031004 potassium ion-transporting ATPase complex', 'GO:0042383 sarcolemma', 'GO:0030017 sarcomere']
|
[
"Membrane"
] |
ABCD1
|
P33897
|
ATP-binding cassette sub-family D member 1
|
ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen (PubMed:11248239, PubMed:15682271, PubMed:16946495, PubMed:18757502, PubMed:21145416, PubMed:23671276, PubMed:29397936, PubMed:33500543). Coupled to the ATP-dependent transporter activity also has a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process (PubMed:29397936, PubMed:33500543). Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation (PubMed:21145416, PubMed:23671276). Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance. Also controls the cellular response to oxidative stress by regulating mitochondrial functions such as mitochondrial oxidative phosphorylation and depolarization. And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs (By similarity)
|
['- IPR005283: Peroxysomal long chain fatty acyl transporter (family) [1-681]', '- IPR050835: ATP-binding cassette sub-family D (family) [58-686]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [78-352]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [88-340]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [99-335]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [463-710]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [473-675]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [474-700]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [492-633]', '- IPR003593: AAA+ ATPase domain (domain) [499-703]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [605-619]']
|
['ATP-binding cassette sub-family D member 3', 'ATP-binding cassette sub-family D member 2', 'Peroxisomal biogenesis factor 19', 'Very long-chain acyl-CoA synthetase', 'Peroxisomal biogenesis factor 3', 'Long-chain-fatty-acid--CoA ligase ACSBG1', 'Spastin', 'Peroxisomal membrane protein PEX13', 'B-cell receptor-associated protein 31', 'Peroxisomal membrane protein 11B']
|
['ATM_DN.V1_DN' 'GOBP_ACYL_COA_METABOLIC_PROCESS'
'GOBP_AEROBIC_RESPIRATION' 'GOBP_ALPHA_LINOLENIC_ACID_METABOLIC_PROCESS'
'GOBP_AMIDE_METABOLIC_PROCESS' 'GOBP_AMIDE_TRANSPORT'
'GOBP_CELLULAR_RESPIRATION' 'GOBP_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS'
'GOBP_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS'
'GOBP_CELLULAR_RESPONSE_TO_STRESS' 'GOBP_CELL_PROJECTION_ORGANIZATION'
'GOBP_CHEMICAL_HOMEOSTASIS' 'GOBP_CYTOKINE_PRODUCTION'
'GOBP_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE'
'GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION'
'GOBP_ENERGY_DERIVATION_BY_OXIDATION_OF_ORGANIC_COMPOUNDS'
'GOBP_ENSHEATHMENT_OF_NEURONS' 'GOBP_FATTY_ACID_BETA_OXIDATION'
'GOBP_FATTY_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_FATTY_ACID_CATABOLIC_PROCESS'
'GOBP_FATTY_ACID_DERIVATIVE_BIOSYNTHETIC_PROCESS'
'GOBP_FATTY_ACID_DERIVATIVE_CATABOLIC_PROCESS'
'GOBP_FATTY_ACID_DERIVATIVE_METABOLIC_PROCESS'
'GOBP_FATTY_ACID_ELONGATION' 'GOBP_FATTY_ACID_HOMEOSTASIS'
'GOBP_FATTY_ACID_METABOLIC_PROCESS'
'GOBP_FATTY_ACID_TRANSMEMBRANE_TRANSPORT' 'GOBP_FATTY_ACID_TRANSPORT'
'GOBP_FATTY_ACYL_COA_CATABOLIC_PROCESS'
'GOBP_FATTY_ACYL_COA_METABOLIC_PROCESS'
'GOBP_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY'
'GOBP_HOMEOSTATIC_PROCESS' 'GOBP_INFLAMMATORY_RESPONSE'
'GOBP_INTRACELLULAR_LIPID_TRANSPORT' 'GOBP_INTRACELLULAR_TRANSPORT'
'GOBP_KETONE_METABOLIC_PROCESS' 'GOBP_LINOLEIC_ACID_METABOLIC_PROCESS'
'GOBP_LIPID_BIOSYNTHETIC_PROCESS' 'GOBP_LIPID_CATABOLIC_PROCESS'
'GOBP_LIPID_HOMEOSTASIS' 'GOBP_LIPID_LOCALIZATION'
'GOBP_LIPID_METABOLIC_PROCESS' 'GOBP_LIPID_MODIFICATION'
'GOBP_LIPID_OXIDATION' 'GOBP_LONG_CHAIN_FATTY_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_LONG_CHAIN_FATTY_ACID_CATABOLIC_PROCESS'
'GOBP_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS'
'GOBP_LONG_CHAIN_FATTY_ACID_TRANSPORT' 'GOBP_MEMBRANE_DEPOLARIZATION'
'GOBP_MEMBRANE_ORGANIZATION' 'GOBP_MITOCHONDRIAL_DEPOLARIZATION'
'GOBP_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_TRANSPORT' 'GOBP_MYELIN_MAINTENANCE'
'GOBP_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION'
'GOBP_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE'
'GOBP_NEGATIVE_REGULATION_OF_GENE_EXPRESSION'
'GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS'
'GOBP_NEURON_PROJECTION_MAINTENANCE'
'GOBP_NEURON_PROJECTION_ORGANIZATION' 'GOBP_NITROGEN_COMPOUND_TRANSPORT'
'GOBP_NUCLEOBASE_CONTAINING_COMPOUND_CATABOLIC_PROCESS'
'GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT'
'GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_NUCLEOSIDE_PHOSPHATE_CATABOLIC_PROCESS'
'GOBP_OLEFINIC_COMPOUND_METABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_ORGANIC_ACID_CATABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_METABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT' 'GOBP_ORGANIC_ACID_TRANSPORT'
'GOBP_ORGANIC_ANION_TRANSPORT' 'GOBP_ORGANOPHOSPHATE_CATABOLIC_PROCESS'
'GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT'
'GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS' 'GOBP_OXIDATIVE_PHOSPHORYLATION'
'GOBP_PEROXISOMAL_TRANSPORT' 'GOBP_PEROXISOME_ORGANIZATION'
'GOBP_PHOSPHORUS_METABOLIC_PROCESS' 'GOBP_PLASMA_MEMBRANE_ORGANIZATION'
'GOBP_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_FATTY_ACID_BETA_OXIDATION'
'GOBP_POSITIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_FATTY_ACID_OXIDATION'
'GOBP_POSITIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_PRODUCTION_OF_MOLECULAR_MEDIATOR_INVOLVED_IN_INFLAMMATORY_RESPONSE'
'GOBP_PURINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS'
'GOBP_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS'
'GOBP_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_AEROBIC_RESPIRATION'
'GOBP_REGULATION_OF_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_CELLULAR_RESPIRATION'
'GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS'
'GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_STRESS'
'GOBP_REGULATION_OF_FATTY_ACID_BETA_OXIDATION'
'GOBP_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_FATTY_ACID_OXIDATION'
'GOBP_REGULATION_OF_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY'
'GOBP_REGULATION_OF_KETONE_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_MEMBRANE_DEPOLARIZATION'
'GOBP_REGULATION_OF_MEMBRANE_POTENTIAL'
'GOBP_REGULATION_OF_MITOCHONDRIAL_DEPOLARIZATION'
'GOBP_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_POTENTIAL'
'GOBP_REGULATION_OF_OXIDATIVE_PHOSPHORYLATION'
'GOBP_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS'
'GOBP_REGULATION_OF_RESPONSE_TO_STRESS'
'GOBP_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_RESPONSE_TO_OXIDATIVE_STRESS'
'GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS'
'GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS' 'GOBP_STEROL_HOMEOSTASIS'
'GOBP_SULFUR_COMPOUND_CATABOLIC_PROCESS'
'GOBP_SULFUR_COMPOUND_METABOLIC_PROCESS' 'GOBP_SULFUR_COMPOUND_TRANSPORT'
'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_UNSATURATED_FATTY_ACID_METABOLIC_PROCESS'
'GOBP_VERY_LONG_CHAIN_FATTY_ACID_CATABOLIC_PROCESS'
'GOBP_VERY_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS' 'GOCC_MICROBODY'
'GOCC_MICROBODY_MEMBRANE' 'GOCC_MITOCHONDRIAL_ENVELOPE'
'GOCC_MITOCHONDRION'
'GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK'
'GOCC_ORGANELLE_ENVELOPE' 'GOCC_ORGANELLE_SUBCOMPARTMENT'
'GOCC_PERINUCLEAR_REGION_OF_CYTOPLASM' 'GOCC_VACUOLAR_MEMBRANE'
'GOCC_VACUOLE' 'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ACYL_COA_HYDROLASE_ACTIVITY' 'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ADP_BINDING' 'GOMF_AMIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_DEACYLASE_ACTIVITY'
'GOMF_FATTY_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS'
'GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_LONG_CHAIN_FATTY_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANOPHOSPHATE_ESTER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PROTEIN_DIMERIZATION_ACTIVITY'
'GOMF_PROTEIN_HOMODIMERIZATION_ACTIVITY'
'GOMF_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_THIOLESTER_HYDROLASE_ACTIVITY' 'GOMF_TRANSPORTER_ACTIVITY'
'HALLMARK_BILE_ACID_METABOLISM' 'HALLMARK_PEROXISOME' 'JNK_DN.V1_UP'
'KEGG_ABC_TRANSPORTERS' 'KEGG_PEROXISOME' 'KRAS.AMP.LUNG_UP.V1_DN'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS'
'REACTOME_ABC_TRANSPORTER_DISORDERS'
'REACTOME_ALPHA_LINOLENIC_OMEGA3_AND_LINOLEIC_OMEGA6_ACID_METABOLISM'
'REACTOME_BETA_OXIDATION_OF_VERY_LONG_CHAIN_FATTY_ACIDS'
'REACTOME_CLASS_I_PEROXISOMAL_MEMBRANE_PROTEIN_IMPORT'
'REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS'
'REACTOME_FATTY_ACID_METABOLISM' 'REACTOME_LINOLEIC_ACID_LA_METABOLISM'
'REACTOME_METABOLISM_OF_LIPIDS' 'REACTOME_PEROXISOMAL_LIPID_METABOLISM'
'REACTOME_PROTEIN_LOCALIZATION' 'REACTOME_TRANSPORT_OF_SMALL_MOLECULES'
'WP_FATTY_ACID_AND_LIPOPROTEIN_TRANSPORT_IN_HEPATOCYTES'
'WP_VITAMIN_D_RECEPTOR_PATHWAY']
|
['GO:0015607 ABC-type fatty-acyl-CoA transporter activity', 'GO:0043531 ADP binding', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0019899 enzyme binding', 'GO:0047617 fatty acyl-CoA hydrolase activity', 'GO:0042802 identical protein binding', 'GO:0005324 long-chain fatty acid transmembrane transporter activity', 'GO:0042803 protein homodimerization activity', 'GO:0052817 very long-chain fatty acyl-CoA hydrolase activity']
|
['GO:0036109 alpha-linolenic acid metabolic process', 'GO:0006635 fatty acid beta-oxidation', 'GO:1901570 fatty acid derivative biosynthetic process', 'GO:0030497 fatty acid elongation', 'GO:0055089 fatty acid homeostasis', 'GO:0043651 linoleic acid metabolic process', 'GO:0042759 long-chain fatty acid biosynthetic process', 'GO:0042758 long-chain fatty acid catabolic process', 'GO:0015910 long-chain fatty acid import into peroxisome', 'GO:0043217 myelin maintenance', 'GO:1900016 negative regulation of cytokine production involved in inflammatory response', 'GO:1903427 negative regulation of reactive oxygen species biosynthetic process', 'GO:1990535 neuron projection maintenance', 'GO:0015919 peroxisomal membrane transport', 'GO:0007031 peroxisome organization', 'GO:0032000 positive regulation of fatty acid beta-oxidation', 'GO:2001280 positive regulation of unsaturated fatty acid biosynthetic process', 'GO:1900407 regulation of cellular response to oxidative stress', 'GO:0031998 regulation of fatty acid beta-oxidation', 'GO:0051900 regulation of mitochondrial depolarization', 'GO:0002082 regulation of oxidative phosphorylation', 'GO:0055092 sterol homeostasis', 'GO:0006636 unsaturated fatty acid biosynthetic process', 'GO:0042760 very long-chain fatty acid catabolic process', 'GO:0000038 very long-chain fatty acid metabolic process', 'GO:0036113 very long-chain fatty-acyl-CoA catabolic process']
|
['GO:0005737 cytoplasm', 'GO:0005829 cytosol', 'GO:0005789 endoplasmic reticulum membrane', 'GO:0005765 lysosomal membrane', 'GO:0016020 membrane', 'GO:0031966 mitochondrial membrane', 'GO:0048471 perinuclear region of cytoplasm', 'GO:0005778 peroxisomal membrane', 'GO:0005777 peroxisome']
|
[
"Peroxisome membrane",
"Mitochondrion membrane",
"Lysosome membrane",
"Endoplasmic reticulum membrane"
] |
ABCD2
|
Q9UBJ2
|
ATP-binding cassette sub-family D member 2
|
ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen (PubMed:21145416, PubMed:29397936). Like ABCD1 seems to have fatty acyl-CoA thioesterase (ACOT) and ATPase activities, according to this model, VLCFA-CoA as free VLCFA is transpoted in an ATP-dependent manner into peroxisomes after the hydrolysis of VLCFA-CoA mediated by the ACOT activity of ABCD2 (Probable) (PubMed:29397936). Shows overlapping substrate specificities with ABCD1 toward saturated fatty acids (FA) and monounsaturated FA (MUFA) but has a distinct substrate preference for shorter VLCFA (C22:0) and polyunsaturated fatty acid (PUFA) such as C22:6-CoA and C24:6-CoA (in vitro) (PubMed:21145416). Thus, may play a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed:21145416)
|
['- IPR050835: ATP-binding cassette sub-family D (family) [26-690]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [91-365]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [95-427]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [98-351]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [112-348]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [467-709]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [475-679]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [478-704]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [496-637]', '- IPR003593: AAA+ ATPase domain (domain) [503-689]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [609-623]']
|
['ATP-binding cassette sub-family D member 1', 'ATP-binding cassette sub-family D member 3', 'Peroxisomal biogenesis factor 19', 'Long-chain-fatty-acid--CoA ligase ACSBG1', 'Very long-chain acyl-CoA synthetase', 'Peroxisomal membrane protein PEX13', 'Peroxisomal membrane protein 11B', 'Peroxisomal membrane protein 4.']
|
['ATF2_S_UP.V1_UP' 'BIOCARTA_NUCLEARRS_PATHWAY' 'CAHOY_ASTROCYTIC'
'GOBP_ALPHA_LINOLENIC_ACID_METABOLIC_PROCESS' 'GOBP_AMIDE_TRANSPORT'
'GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS'
'GOBP_CELL_PROJECTION_ORGANIZATION' 'GOBP_CYTOKINE_PRODUCTION'
'GOBP_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE'
'GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION' 'GOBP_ENSHEATHMENT_OF_NEURONS'
'GOBP_FATTY_ACID_BETA_OXIDATION' 'GOBP_FATTY_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_FATTY_ACID_CATABOLIC_PROCESS'
'GOBP_FATTY_ACID_DERIVATIVE_BIOSYNTHETIC_PROCESS'
'GOBP_FATTY_ACID_DERIVATIVE_METABOLIC_PROCESS'
'GOBP_FATTY_ACID_METABOLIC_PROCESS'
'GOBP_FATTY_ACID_TRANSMEMBRANE_TRANSPORT' 'GOBP_FATTY_ACID_TRANSPORT'
'GOBP_INFLAMMATORY_RESPONSE' 'GOBP_INTRACELLULAR_LIPID_TRANSPORT'
'GOBP_INTRACELLULAR_TRANSPORT' 'GOBP_KETONE_METABOLIC_PROCESS'
'GOBP_LINOLEIC_ACID_METABOLIC_PROCESS' 'GOBP_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_LIPID_CATABOLIC_PROCESS' 'GOBP_LIPID_LOCALIZATION'
'GOBP_LIPID_METABOLIC_PROCESS' 'GOBP_LIPID_MODIFICATION'
'GOBP_LIPID_OXIDATION' 'GOBP_LONG_CHAIN_FATTY_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS'
'GOBP_LONG_CHAIN_FATTY_ACID_TRANSPORT' 'GOBP_MEMBRANE_ORGANIZATION'
'GOBP_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_TRANSPORT' 'GOBP_MYELIN_MAINTENANCE'
'GOBP_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION'
'GOBP_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE'
'GOBP_NEGATIVE_REGULATION_OF_GENE_EXPRESSION'
'GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS'
'GOBP_NEURON_PROJECTION_MAINTENANCE'
'GOBP_NEURON_PROJECTION_ORGANIZATION' 'GOBP_NITROGEN_COMPOUND_TRANSPORT'
'GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT'
'GOBP_OLEFINIC_COMPOUND_METABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_ORGANIC_ACID_CATABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_METABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT' 'GOBP_ORGANIC_ACID_TRANSPORT'
'GOBP_ORGANIC_ANION_TRANSPORT' 'GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT'
'GOBP_PEROXISOMAL_TRANSPORT' 'GOBP_PEROXISOME_ORGANIZATION'
'GOBP_PLASMA_MEMBRANE_ORGANIZATION'
'GOBP_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_FATTY_ACID_BETA_OXIDATION'
'GOBP_POSITIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_FATTY_ACID_OXIDATION'
'GOBP_POSITIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_PRODUCTION_OF_MOLECULAR_MEDIATOR_INVOLVED_IN_INFLAMMATORY_RESPONSE'
'GOBP_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS'
'GOBP_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_FATTY_ACID_BETA_OXIDATION'
'GOBP_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_FATTY_ACID_OXIDATION'
'GOBP_REGULATION_OF_KETONE_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_RESPONSE_TO_BACTERIUM' 'GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS'
'GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_UNSATURATED_FATTY_ACID_METABOLIC_PROCESS'
'GOBP_VERY_LONG_CHAIN_FATTY_ACID_CATABOLIC_PROCESS'
'GOBP_VERY_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS' 'GOCC_MICROBODY'
'GOCC_MICROBODY_MEMBRANE' 'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ACYL_COA_HYDROLASE_ACTIVITY' 'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_AMIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_DEACYLASE_ACTIVITY'
'GOMF_FATTY_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS'
'GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_LONG_CHAIN_FATTY_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANOPHOSPHATE_ESTER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PROTEIN_DIMERIZATION_ACTIVITY'
'GOMF_PROTEIN_HETERODIMERIZATION_ACTIVITY'
'GOMF_PROTEIN_HOMODIMERIZATION_ACTIVITY'
'GOMF_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_THIOLESTER_HYDROLASE_ACTIVITY' 'GOMF_TRANSPORTER_ACTIVITY'
'HALLMARK_BILE_ACID_METABOLISM' 'HALLMARK_PEROXISOME'
'HALLMARK_XENOBIOTIC_METABOLISM' 'IL15_UP.V1_DN' 'IL2_UP.V1_DN'
'KEGG_ABC_TRANSPORTERS' 'KEGG_PEROXISOME'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS'
'REACTOME_CLASS_I_PEROXISOMAL_MEMBRANE_PROTEIN_IMPORT'
'REACTOME_PROTEIN_LOCALIZATION' 'REACTOME_TRANSPORT_OF_SMALL_MOLECULES'
'WP_FATTY_ACID_AND_LIPOPROTEIN_TRANSPORT_IN_HEPATOCYTES'
'WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY']
|
['GO:0140359 ABC-type transporter activity', 'GO:0042887 amide transmembrane transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0047617 fatty acyl-CoA hydrolase activity', 'GO:0005324 long-chain fatty acid transmembrane transporter activity', 'GO:0015932 nucleobase-containing compound transmembrane transporter activity', 'GO:0015605 organophosphate ester transmembrane transporter activity', 'GO:0046982 protein heterodimerization activity', 'GO:0042803 protein homodimerization activity', 'GO:1901682 sulfur compound transmembrane transporter activity']
|
['GO:0036109 alpha-linolenic acid metabolic process', 'GO:0006635 fatty acid beta-oxidation', 'GO:1901570 fatty acid derivative biosynthetic process', 'GO:0043651 linoleic acid metabolic process', 'GO:0042759 long-chain fatty acid biosynthetic process', 'GO:0015910 long-chain fatty acid import into peroxisome', 'GO:0043217 myelin maintenance', 'GO:1900016 negative regulation of cytokine production involved in inflammatory response', 'GO:1903427 negative regulation of reactive oxygen species biosynthetic process', 'GO:1990535 neuron projection maintenance', 'GO:0007031 peroxisome organization', 'GO:0032000 positive regulation of fatty acid beta-oxidation', 'GO:2001280 positive regulation of unsaturated fatty acid biosynthetic process', 'GO:0009617 response to bacterium', 'GO:0006636 unsaturated fatty acid biosynthetic process', 'GO:0042760 very long-chain fatty acid catabolic process', 'GO:0000038 very long-chain fatty acid metabolic process']
|
['GO:0005829 cytosol', 'GO:0005778 peroxisomal membrane', 'GO:0005777 peroxisome']
|
[
"Peroxisome membrane"
] |
ABCD3
|
P28288
|
ATP-binding cassette sub-family D member 3
|
Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long-chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched-chain fatty acids-CoA and bile acids from the cytosol to the peroxisome lumen for beta-oxydation (PubMed:11248239, PubMed:24333844, PubMed:25168382, PubMed:29397936). Has fatty acyl-CoA thioesterase and ATPase activities (PubMed:29397936). Probably hydrolyzes fatty acyl-CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes (By similarity). Thus, play a role in regulation of LCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed:24333844, PubMed:25944712)
|
['- IPR005283: Peroxysomal long chain fatty acyl transporter (family) [7-647]', '- IPR050835: ATP-binding cassette sub-family D (family) [44-652]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [45-397]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [70-338]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [87-333]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [107-321]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [434-646]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [434-656]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [440-659]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [457-599]', '- IPR003593: AAA+ ATPase domain (domain) [465-640]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [571-585]']
|
['Peroxisomal biogenesis factor 19', 'ATP-binding cassette sub-family D member 1', 'DNA repair protein RAD51 homolog 1', 'Peroxisomal biogenesis factor 3', 'Peroxisomal membrane protein PEX16', 'ATP-binding cassette sub-family D member 2', 'Peroxisome biogenesis factor 2', 'Peroxisomal targeting signal 1 receptor', 'Peroxisomal membrane protein PEX14', 'Peroxisomal membrane protein PEX13']
|
['BIOCARTA_NUCLEARRS_PATHWAY' 'GOBP_BILE_ACID_AND_BILE_SALT_TRANSPORT'
'GOBP_BILE_ACID_BIOSYNTHETIC_PROCESS' 'GOBP_BILE_ACID_METABOLIC_PROCESS'
'GOBP_FATTY_ACID_BETA_OXIDATION' 'GOBP_FATTY_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_FATTY_ACID_CATABOLIC_PROCESS' 'GOBP_FATTY_ACID_METABOLIC_PROCESS'
'GOBP_FATTY_ACID_TRANSMEMBRANE_TRANSPORT' 'GOBP_FATTY_ACID_TRANSPORT'
'GOBP_INTRACELLULAR_LIPID_TRANSPORT' 'GOBP_INTRACELLULAR_TRANSPORT'
'GOBP_LIPID_BIOSYNTHETIC_PROCESS' 'GOBP_LIPID_CATABOLIC_PROCESS'
'GOBP_LIPID_LOCALIZATION' 'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_LIPID_MODIFICATION' 'GOBP_LIPID_OXIDATION'
'GOBP_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS'
'GOBP_LONG_CHAIN_FATTY_ACID_TRANSPORT'
'GOBP_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_TRANSPORT'
'GOBP_ORGANIC_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_ORGANIC_ACID_CATABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_METABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT' 'GOBP_ORGANIC_ACID_TRANSPORT'
'GOBP_ORGANIC_ANION_TRANSPORT' 'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_PEROXISOMAL_TRANSPORT' 'GOBP_PEROXISOME_ORGANIZATION'
'GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS'
'GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS' 'GOBP_STEROID_METABOLIC_PROCESS'
'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_VERY_LONG_CHAIN_FATTY_ACID_CATABOLIC_PROCESS'
'GOBP_VERY_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS' 'GOCC_MICROBODY'
'GOCC_MICROBODY_LUMEN' 'GOCC_MICROBODY_MEMBRANE' 'GOCC_MITOCHONDRION'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ACYL_COA_HYDROLASE_ACTIVITY' 'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_DEACYLASE_ACTIVITY'
'GOMF_FATTY_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS'
'GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_LONG_CHAIN_FATTY_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PROTEIN_DIMERIZATION_ACTIVITY'
'GOMF_PROTEIN_HOMODIMERIZATION_ACTIVITY'
'GOMF_THIOLESTER_HYDROLASE_ACTIVITY' 'GOMF_TRANSPORTER_ACTIVITY'
'HALLMARK_BILE_ACID_METABOLISM' 'HALLMARK_PEROXISOME'
'KEGG_ABC_TRANSPORTERS' 'KEGG_PEROXISOME'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS'
'REACTOME_CLASS_I_PEROXISOMAL_MEMBRANE_PROTEIN_IMPORT'
'REACTOME_PROTEIN_LOCALIZATION' 'REACTOME_RHOA_GTPASE_CYCLE'
'REACTOME_RHOC_GTPASE_CYCLE' 'REACTOME_RHO_GTPASE_CYCLE'
'REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES'
'WP_CHOLESTEROL_BIOSYNTHESIS_PATHWAY_IN_HEPATOCYTES'
'WP_DISORDERS_OF_BILE_ACID_SYNTHESIS_AND_BILIARY_TRANSPORT'
'WP_FATTY_ACID_AND_LIPOPROTEIN_TRANSPORT_IN_HEPATOCYTES'
'WP_FRAGILE_X_SYNDROME'
'WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY']
|
['GO:0140359 ABC-type transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0047617 fatty acyl-CoA hydrolase activity', 'GO:0005324 long-chain fatty acid transmembrane transporter activity', 'GO:0042803 protein homodimerization activity']
|
['GO:0015721 bile acid and bile salt transport', 'GO:0006699 bile acid biosynthetic process', 'GO:0006635 fatty acid beta-oxidation', 'GO:0006633 fatty acid biosynthetic process', 'GO:0015910 long-chain fatty acid import into peroxisome', 'GO:0007031 peroxisome organization', 'GO:1903512 phytanic acid metabolic process', 'GO:0009410 response to xenobiotic stimulus', 'GO:0042760 very long-chain fatty acid catabolic process', 'GO:0000038 very long-chain fatty acid metabolic process']
|
['GO:0005829 cytosol', 'GO:0016020 membrane', 'GO:0005739 mitochondrion', 'GO:0005782 peroxisomal matrix', 'GO:0005778 peroxisomal membrane', 'GO:0005777 peroxisome']
|
[
"Peroxisome membrane"
] |
ABCD4
|
O14678
|
Lysosomal cobalamin transporter ABCD4
|
Lysosomal membrane protein that transports cobalamin (Vitamin B12) from the lysosomal lumen to the cytosol in an ATP-dependent manner (PubMed:22922874, PubMed:28572511, PubMed:31467407, PubMed:33845046). Targeted by LMBRD1 lysosomal chaperone from the endoplasmic reticulum to the lysosomal membrane (PubMed:27456980). Then forms a complex with lysosomal chaperone LMBRD1 and cytosolic MMACHC to transport cobalamin across the lysosomal membrane (PubMed:25535791)
|
['- IPR050835: ATP-binding cassette sub-family D (family) [12-604]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [23-350]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [27-294]', '- IPR011527: ABC transporter type 1, transmembrane domain (domain) [40-311]', '- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [40-337]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [379-597]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [379-598]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [389-603]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [405-552]', '- IPR003593: AAA+ ATPase domain (domain) [413-604]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [524-538]']
|
['Probable lysosomal cobalamin transporter', 'ATP-binding cassette sub-family A member 2', 'ATP-binding cassette sub-family B member 6, mitochondrial', 'ATP-binding cassette sub-family G member 5', 'ATP-binding cassette sub-family G member 8', 'DNA repair protein RAD51 homolog 1', 'Long-chain-fatty-acid--CoA ligase ACSBG1', 'Mitochondrial potassium channel ATP-binding subunit', 'Very long-chain acyl-CoA synthetase', 'Methylmalonic aciduria and homocystinuria type C protein']
|
['GOBP_COBALAMIN_METABOLIC_PROCESS' 'GOBP_COBALAMIN_TRANSPORT'
'GOBP_FATTY_ACID_BETA_OXIDATION' 'GOBP_FATTY_ACID_CATABOLIC_PROCESS'
'GOBP_FATTY_ACID_METABOLIC_PROCESS'
'GOBP_FATTY_ACID_TRANSMEMBRANE_TRANSPORT' 'GOBP_FATTY_ACID_TRANSPORT'
'GOBP_INTRACELLULAR_LIPID_TRANSPORT' 'GOBP_INTRACELLULAR_TRANSPORT'
'GOBP_LIPID_CATABOLIC_PROCESS' 'GOBP_LIPID_LOCALIZATION'
'GOBP_LIPID_METABOLIC_PROCESS' 'GOBP_LIPID_MODIFICATION'
'GOBP_LIPID_OXIDATION' 'GOBP_LONG_CHAIN_FATTY_ACID_TRANSPORT'
'GOBP_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_TRANSPORT' 'GOBP_NITROGEN_COMPOUND_TRANSPORT'
'GOBP_ORGANIC_ACID_CATABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_METABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT' 'GOBP_ORGANIC_ACID_TRANSPORT'
'GOBP_ORGANIC_ANION_TRANSPORT' 'GOBP_PEROXISOMAL_TRANSPORT'
'GOBP_PEROXISOME_ORGANIZATION'
'GOBP_RESPONSE_TO_LEUKEMIA_INHIBITORY_FACTOR' 'GOBP_RESPONSE_TO_PEPTIDE'
'GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_TETRAPYRROLE_METABOLIC_PROCESS' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_VERY_LONG_CHAIN_FATTY_ACID_CATABOLIC_PROCESS'
'GOBP_VERY_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS'
'GOBP_VITAMIN_METABOLIC_PROCESS' 'GOBP_VITAMIN_TRANSPORT'
'GOBP_WATER_SOLUBLE_VITAMIN_METABOLIC_PROCESS'
'GOCC_ATPASE_DEPENDENT_TRANSMEMBRANE_TRANSPORT_COMPLEX'
'GOCC_ATP_BINDING_CASSETTE_ABC_TRANSPORTER_COMPLEX'
'GOCC_MEMBRANE_PROTEIN_COMPLEX' 'GOCC_MICROBODY'
'GOCC_MICROBODY_MEMBRANE'
'GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK'
'GOCC_ORGANELLE_SUBCOMPARTMENT' 'GOCC_PLASMA_MEMBRANE_PROTEIN_COMPLEX'
'GOCC_TRANSPORTER_COMPLEX' 'GOCC_VACUOLAR_MEMBRANE' 'GOCC_VACUOLE'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_FATTY_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_LONG_CHAIN_FATTY_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY'
'GOMF_VITAMIN_TRANSMEMBRANE_TRANSPORTER_ACTIVITY' 'KEGG_ABC_TRANSPORTERS'
'KEGG_PEROXISOME' 'REACTOME_ABC_TRANSPORTER_DISORDERS'
'REACTOME_COBALAMIN_CBL_VITAMIN_B12_TRANSPORT_AND_METABOLISM'
'REACTOME_DEFECTS_IN_COBALAMIN_B12_METABOLISM'
'REACTOME_DEFECTS_IN_VITAMIN_AND_COFACTOR_METABOLISM'
'REACTOME_DISEASES_OF_METABOLISM'
'REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS'
'REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS'
'REACTOME_METABOLISM_OF_WATER_SOLUBLE_VITAMINS_AND_COFACTORS'
'REACTOME_TRANSPORT_OF_RCBL_WITHIN_THE_BODY'
'REACTOME_UPTAKE_OF_DIETARY_COBALAMINS_INTO_ENTEROCYTES'
'WP_ADHD_AND_AUTISM_ASD_PATHWAYS'
'WP_FATTY_ACID_AND_LIPOPROTEIN_TRANSPORT_IN_HEPATOCYTES'
'WP_PATHWAYS_INTO_METHIONINE_AND_FOLATE_CYCLES']
|
['GO:0015420 ABC-type vitamin B12 transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0042802 identical protein binding', 'GO:0005324 long-chain fatty acid transmembrane transporter activity']
|
['GO:1990830 cellular response to leukemia inhibitory factor', 'GO:0009235 cobalamin metabolic process', 'GO:0015889 cobalamin transport', 'GO:0006635 fatty acid beta-oxidation', 'GO:0015910 long-chain fatty acid import into peroxisome', 'GO:0007031 peroxisome organization', 'GO:0055085 transmembrane transport', 'GO:0042760 very long-chain fatty acid catabolic process']
|
['GO:0043190 ATP-binding cassette (ABC) transporter complex', 'GO:0005789 endoplasmic reticulum membrane', 'GO:0005765 lysosomal membrane', 'GO:0016020 membrane', 'GO:0005778 peroxisomal membrane', 'GO:0005777 peroxisome']
|
[
"Endoplasmic reticulum membrane",
"Lysosome membrane"
] |
ABCE1
|
P61221
|
ATP-binding cassette sub-family E member 1
|
Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly (PubMed:20122402, PubMed:21448132). Able to hydrolyze ATP, GTP, UTP and CTP (PubMed:20122402). Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits (PubMed:20122402, PubMed:21448132). Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota) (PubMed:20122402, PubMed:21448132). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132). Also plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391). As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy (PubMed:29861391). RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL (PubMed:9660177). Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway (PubMed:11585831, PubMed:9660177, PubMed:9847332)
|
['- IPR013283: RLI1 (family) [1-599]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1-332]', '- IPR007209: RNase L inhibitor RLI-like, possible metal-binding domain (domain) [6-36]', '- IPR013283: RLI1 (family) [24-39]', '- IPR017896: 4Fe-4S ferredoxin-type, iron-sulphur binding domain (domain) [46-75]', '- IPR017896: 4Fe-4S ferredoxin-type, iron-sulphur binding domain (domain) [49-70]', '- IPR013283: RLI1 (family) [52-76]', '- IPR017900: 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (conserved_site) [55-66]', '- IPR034348: RLI, domain 1 (domain) [78-332]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [79-315]', '- IPR013283: RLI1 (family) [79-99]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [101-244]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [101-291]', '- IPR003593: AAA+ ATPase domain (domain) [102-293]', '- IPR013283: RLI1 (family) [107-132]', '- IPR013283: RLI1 (family) [140-156]', '- IPR013283: RLI1 (family) [156-182]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [333-597]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [342-562]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [368-489]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [368-535]', '- IPR003593: AAA+ ATPase domain (domain) [371-539]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [462-476]']
|
['Eukaryotic peptide chain release factor subunit 1', 'Eukaryotic translation initiation factor 3 subunit J', 'Eukaryotic translation initiation factor 3 subunit A', 'Eukaryotic translation initiation factor 3 subunit B', '40S ribosomal protein S23', '2-5A-dependent ribonuclease', 'Ubiquitin-like protein FUBI', '60S acidic ribosomal protein P0', '40S ribosomal protein S3', '40S ribosomal protein S6']
|
['GCNP_SHH_UP_LATE.V1_UP' 'GOBP_CELLULAR_COMPONENT_DISASSEMBLY'
'GOBP_NEGATIVE_REGULATION_OF_CATALYTIC_ACTIVITY'
'GOBP_NEGATIVE_REGULATION_OF_HYDROLASE_ACTIVITY'
'GOBP_NEGATIVE_REGULATION_OF_MOLECULAR_FUNCTION'
'GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_ORGANELLE_DISASSEMBLY'
'GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION'
'GOBP_PROTEIN_CONTAINING_COMPLEX_DISASSEMBLY'
'GOBP_PROTEIN_CONTAINING_COMPLEX_ORGANIZATION'
'GOBP_REGULATION_OF_CATALYTIC_ACTIVITY'
'GOBP_REGULATION_OF_HYDROLASE_ACTIVITY'
'GOBP_REGULATION_OF_MOLECULAR_FUNCTION'
'GOBP_REGULATION_OF_PROTEIN_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_RIBONUCLEASE_ACTIVITY'
'GOBP_REGULATION_OF_TRANSLATION' 'GOBP_RESCUE_OF_STALLED_RIBOSOME'
'GOBP_RIBOSOME_DISASSEMBLY' 'GOBP_TRANSLATION'
'GOBP_TRANSLATIONAL_ELONGATION' 'GOBP_TRANSLATIONAL_INITIATION'
'GOBP_TRANSLATIONAL_TERMINATION' 'GOCC_CYTOSOLIC_RIBOSOME'
'GOCC_MITOCHONDRIAL_MATRIX' 'GOCC_MITOCHONDRION' 'GOCC_RIBOSOME'
'GOMF_4_IRON_4_SULFUR_CLUSTER_BINDING' 'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_CATALYTIC_ACTIVITY_ACTING_ON_A_NUCLEIC_ACID'
'GOMF_CATALYTIC_ACTIVITY_ACTING_ON_RNA' 'GOMF_CTPASE_ACTIVITY'
'GOMF_ENDONUCLEASE_ACTIVITY' 'GOMF_ENZYME_INHIBITOR_ACTIVITY'
'GOMF_ENZYME_REGULATOR_ACTIVITY' 'GOMF_GTPASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS' 'GOMF_IRON_ION_BINDING'
'GOMF_METAL_CLUSTER_BINDING' 'GOMF_MOLECULAR_FUNCTION_INHIBITOR_ACTIVITY'
'GOMF_NUCLEASE_ACTIVITY' 'GOMF_NUCLEASE_INHIBITOR_ACTIVITY'
'GOMF_PROTEIN_CONTAINING_COMPLEX_BINDING'
'GOMF_RIBONUCLEASE_INHIBITOR_ACTIVITY'
'GOMF_RIBONUCLEOPROTEIN_COMPLEX_BINDING'
'GOMF_RIBOSOMAL_SMALL_SUBUNIT_BINDING' 'GOMF_RIBOSOME_BINDING'
'GOMF_RNA_ENDONUCLEASE_ACTIVITY' 'GOMF_RNA_NUCLEASE_ACTIVITY'
'HALLMARK_ALLOGRAFT_REJECTION' 'HALLMARK_MYC_TARGETS_V1' 'PGF_UP.V1_UP'
'REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES'
'REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM'
'REACTOME_INTERFERON_ALPHA_BETA_SIGNALING'
'REACTOME_INTERFERON_SIGNALING' 'REACTOME_OAS_ANTIVIRAL_RESPONSE'
'SNF5_DN.V1_UP']
|
['GO:0051539 4 iron, 4 sulfur cluster binding', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0043273 CTPase activity', 'GO:0060698 endoribonuclease inhibitor activity', 'GO:0003924 GTPase activity', 'GO:0005506 iron ion binding', 'GO:0017111 ribonucleoside triphosphate phosphatase activity', 'GO:0043024 ribosomal small subunit binding']
|
['GO:0060702 negative regulation of endoribonuclease activity', 'GO:0006417 regulation of translation', 'GO:0072344 rescue of stalled ribosome', 'GO:0032790 ribosome disassembly', 'GO:0006413 translational initiation', 'GO:0006415 translational termination']
|
['GO:0005737 cytoplasm', 'GO:0005829 cytosol', 'GO:0022626 cytosolic ribosome', 'GO:0016020 membrane', 'GO:0005759 mitochondrial matrix', 'GO:0005739 mitochondrion']
|
[
"Cytoplasm",
"Mitochondrion"
] |
ABCF1
|
Q8NE71
|
ATP-binding cassette sub-family F member 1
|
Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis
|
['- IPR050611: ABCF protein (family) [249-834]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [265-562]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [302-555]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [304-548]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [321-480]', '- IPR003593: AAA+ ATPase domain (domain) [328-532]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [452-466]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [568-841]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [604-822]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [625-840]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [641-771]', '- IPR003593: AAA+ ATPase domain (domain) [650-815]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [743-757]']
|
['60S ribosomal protein L11', '40S ribosomal protein S23', '60S ribosomal protein L10a', 'Ribosomal protein S29.', '60S ribosomal protein L8', 'Ribosomal protein L19', 'Ribosomal protein S28', '60S ribosomal protein L18', 'Ribosomal protein L38', 'Ribosomal protein S21']
|
['GOBP_INFLAMMATORY_RESPONSE'
'GOBP_POSITIVE_REGULATION_OF_GENE_EXPRESSION'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_TRANSLATION'
'GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION'
'GOBP_REGULATION_OF_PROTEIN_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_TRANSLATION'
'GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS' 'GOBP_RIBOSOME_BIOGENESIS'
'GOBP_TRANSLATION' 'GOBP_TRANSLATIONAL_INITIATION'
'GOCC_NUCLEAR_ENVELOPE' 'GOCC_ORGANELLE_ENVELOPE'
'GOMF_ADENYL_NUCLEOTIDE_BINDING' 'GOMF_ATP_DEPENDENT_ACTIVITY'
'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_PROTEIN_CONTAINING_COMPLEX_BINDING'
'GOMF_RIBONUCLEOPROTEIN_COMPLEX_BINDING' 'GOMF_RIBOSOME_BINDING'
'GOMF_TRANSLATION_ACTIVATOR_ACTIVITY' 'GOMF_TRANSLATION_FACTOR_ACTIVITY'
'GOMF_TRANSLATION_FACTOR_ACTIVITY_RNA_BINDING'
'GOMF_TRANSLATION_REGULATOR_ACTIVITY'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES' 'TBK1.DN.48HRS_DN'
'WP_IL18_SIGNALING']
|
['GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0043022 ribosome binding', 'GO:0003723 RNA binding', 'GO:0008494 translation activator activity', 'GO:0008135 translation factor activity, RNA binding']
|
['GO:0006954 inflammatory response', 'GO:0045727 positive regulation of translation', 'GO:0006412 translation', 'GO:0006413 translational initiation']
|
['GO:0005737 cytoplasm', 'GO:0005829 cytosol', 'GO:0016020 membrane', 'GO:0005635 nuclear envelope', 'GO:0005654 nucleoplasm']
|
[
"Cytoplasm",
"Nucleus, nucleoplasm",
"Nucleus envelope"
] |
ABCF2
|
Q9UG63
|
ATP-binding cassette sub-family F member 2
| null |
['- IPR050611: ABCF protein (family) [28-608]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [78-324]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [84-349]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [86-325]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [101-257]', '- IPR003593: AAA+ ATPase domain (domain) [110-303]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [229-243]', '- IPR032781: ABC-transporter extension domain (domain) [296-368]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [356-622]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [377-592]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [396-613]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [414-545]', '- IPR003593: AAA+ ATPase domain (domain) [422-590]']
|
['ATP-binding cassette sub-family E member 1', 'Mitochondrial ribosomal protein L20.', 'ATP-dependent translocase ABCB1', 'Mitochondrial ribosomal protein L27.', '60S ribosomal protein L35', '60S ribosomal protein L23a', 'Mitochondrial ribosomal protein L21.', '60S ribosomal protein L11', 'Mitochondrial ribosomal protein L33.', '40S ribosomal protein S18']
|
['GOMF_ADENYL_NUCLEOTIDE_BINDING' 'GOMF_ATP_DEPENDENT_ACTIVITY'
'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'HALLMARK_MTORC1_SIGNALING' 'REACTOME_CELLULAR_RESPONSES_TO_STIMULI'
'REACTOME_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS'
'REACTOME_KEAP1_NFE2L2_PATHWAY'
'REACTOME_NFE2L2_REGULATING_MDR_ASSOCIATED_ENZYMES'
'REACTOME_NUCLEAR_EVENTS_MEDIATED_BY_NFE2L2'
'WP_MIRTARGETED_GENES_IN_LYMPHOCYTES' 'WP_VEGFAVEGFR2_SIGNALING']
|
['GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity']
|
[]
|
['GO:0016020 membrane', 'GO:0005886 plasma membrane']
|
[] |
ABCF3
|
Q9NUQ8
|
ATP-binding cassette sub-family F member 3
|
Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B
|
['- IPR058770: ABCF3, PWI-like helical bundle domain (domain) [1-73]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [118-437]', '- IPR050611: ABCF protein (family) [120-702]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [175-420]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [178-424]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [195-356]', '- IPR003593: AAA+ ATPase domain (domain) [202-401]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [328-342]', '- IPR032781: ABC-transporter extension domain (domain) [395-474]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [454-707]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [492-707]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [505-685]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [510-639]', '- IPR003593: AAA+ ATPase domain (domain) [517-683]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [611-625]']
|
['eIF-2-alpha kinase activator GCN1', 'Mitochondrial ribosomal protein L20.', 'Mitochondrial ribosomal protein L27.', '60S ribosomal protein L35', '60S ribosomal protein L11', '60S ribosomal protein L23a', '40S ribosomal protein S18', 'Mitochondrial ribosomal protein L21.', '60S ribosomal protein L5', 'Mitochondrial ribosomal protein L33.']
|
['GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS'
'GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM'
'GOBP_DEFENSE_RESPONSE_TO_VIRUS' 'GOBP_RESPONSE_TO_VIRUS'
'GOMF_ADENYL_NUCLEOTIDE_BINDING' 'GOMF_ATP_DEPENDENT_ACTIVITY'
'GOMF_ATP_HYDROLYSIS_ACTIVITY' 'GOMF_CADHERIN_BINDING'
'GOMF_CELL_ADHESION_MOLECULE_BINDING'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES']
|
['GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0045296 cadherin binding']
|
['GO:0051607 defense response to virus']
|
['GO:0016020 membrane']
|
[] |
ABCG1
|
P45844
|
ATP-binding cassette sub-family G member 1
|
Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrolysis of ATP (PubMed:17408620, PubMed:24576892). The lipid efflux is ALB-dependent (PubMed:16702602). Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol (PubMed:17408620)
|
['- IPR050352: ATP-binding cassette subfamily G transporters (family) [55-666]', '- IPR005284: Pigment precursor permease/Protein ATP-binding cassette sub-family G (family) [61-677]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [74-340]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [77-317]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [77-309]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [101-245]', '- IPR003593: AAA+ ATPase domain (domain) [110-293]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [217-231]', '- IPR043926: ABC transporter family G domain (domain) [274-332]', '- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [403-612]']
|
['Truncated apolipoprotein A-I', 'Oxysterols receptor LXR-alpha', 'Apolipoprotein E', 'Oxysterols receptor LXR-beta', 'Processed sterol regulatory element-binding protein 2', 'Xenotropic and polytropic retrovirus receptor 1', 'Scavenger receptor class B member 1', 'Processed sterol regulatory element-binding protein 1', 'Cytochrome P450 7A1', 'Retinoic acid receptor RXR-alpha']
|
['BIOCARTA_NUCLEARRS_PATHWAY' 'ERBB2_UP.V1_UP' 'ESC_J1_UP_EARLY.V1_UP'
'GOBP_ALCOHOL_BIOSYNTHETIC_PROCESS' 'GOBP_ALCOHOL_METABOLIC_PROCESS'
'GOBP_AMIDE_METABOLIC_PROCESS' 'GOBP_AMYLOID_BETA_FORMATION'
'GOBP_AMYLOID_BETA_METABOLIC_PROCESS'
'GOBP_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS'
'GOBP_AMYLOID_PRECURSOR_PROTEIN_METABOLIC_PROCESS'
'GOBP_CARBOHYDRATE_DERIVATIVE_TRANSPORT'
'GOBP_CELLULAR_RESPONSE_TO_LIPOPROTEIN_PARTICLE_STIMULUS'
'GOBP_CHEMICAL_HOMEOSTASIS' 'GOBP_CHOLESTEROL_EFFLUX'
'GOBP_CHOLESTEROL_STORAGE' 'GOBP_DETOXIFICATION'
'GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION'
'GOBP_EXPORT_ACROSS_PLASMA_MEMBRANE' 'GOBP_EXPORT_FROM_CELL'
'GOBP_FOAM_CELL_DIFFERENTIATION'
'GOBP_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING'
'GOBP_HOMEOSTATIC_PROCESS' 'GOBP_INTRACELLULAR_LIPID_TRANSPORT'
'GOBP_INTRACELLULAR_STEROL_TRANSPORT' 'GOBP_INTRACELLULAR_TRANSPORT'
'GOBP_LIPID_BIOSYNTHETIC_PROCESS' 'GOBP_LIPID_HOMEOSTASIS'
'GOBP_LIPID_LOCALIZATION' 'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_LOW_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING'
'GOBP_MEMBRANE_ORGANIZATION'
'GOBP_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION'
'GOBP_NEGATIVE_REGULATION_OF_CHOLESTEROL_STORAGE'
'GOBP_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_NEGATIVE_REGULATION_OF_LIPID_STORAGE'
'GOBP_NEGATIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION'
'GOBP_NITROGEN_COMPOUND_TRANSPORT' 'GOBP_NUTRIENT_STORAGE'
'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT' 'GOBP_PHOSPHOLIPID_EFFLUX'
'GOBP_PHOSPHOLIPID_HOMEOSTASIS' 'GOBP_PHOSPHOLIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_AMIDE_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_AMYLOID_BETA_FORMATION'
'GOBP_POSITIVE_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX'
'GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_TRANSPORT'
'GOBP_PROTEIN_CONTAINING_COMPLEX_ORGANIZATION'
'GOBP_PROTEIN_CONTAINING_COMPLEX_REMODELING'
'GOBP_PROTEIN_LIPID_COMPLEX_ORGANIZATION'
'GOBP_PROTEIN_LOCALIZATION_TO_EXTRACELLULAR_REGION'
'GOBP_PROTEIN_TRANSPORT'
'GOBP_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_AMIDE_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_CELLULAR_LOCALIZATION'
'GOBP_REGULATION_OF_CELL_DIFFERENTIATION'
'GOBP_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_CHOLESTEROL_EFFLUX'
'GOBP_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_CHOLESTEROL_STORAGE'
'GOBP_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION'
'GOBP_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_STORAGE' 'GOBP_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION'
'GOBP_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS'
'GOBP_REGULATION_OF_PROTEIN_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_PROTEIN_SECRETION'
'GOBP_REGULATION_OF_PROTEIN_TRANSPORT' 'GOBP_REGULATION_OF_SECRETION'
'GOBP_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_STEROID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_STEROL_TRANSPORT' 'GOBP_REGULATION_OF_TRANSPORT'
'GOBP_RESPONSE_TO_LIPID' 'GOBP_RESPONSE_TO_TOXIC_SUBSTANCE'
'GOBP_REVERSE_CHOLESTEROL_TRANSPORT'
'GOBP_SECONDARY_ALCOHOL_METABOLIC_PROCESS' 'GOBP_SECRETION'
'GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_STEROID_BIOSYNTHETIC_PROCESS' 'GOBP_STEROID_METABOLIC_PROCESS'
'GOBP_STEROL_BIOSYNTHETIC_PROCESS' 'GOBP_STEROL_HOMEOSTASIS'
'GOBP_STEROL_TRANSPORT' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_XENOBIOTIC_EXPORT_FROM_CELL' 'GOBP_XENOBIOTIC_TRANSPORT'
'GOCC_CELL_SURFACE' 'GOCC_ENDOSOME'
'GOCC_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE' 'GOCC_GOLGI_APPARATUS'
'GOCC_GOLGI_MEMBRANE' 'GOCC_MITOCHONDRION'
'GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK'
'GOCC_ORGANELLE_SUBCOMPARTMENT' 'GOCC_RECYCLING_ENDOSOME'
'GOCC_SIDE_OF_MEMBRANE' 'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING' 'GOMF_ADP_BINDING'
'GOMF_ALCOHOL_BINDING'
'GOMF_ATPASE_COUPLED_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_CHOLESTEROL_BINDING' 'GOMF_CHOLESTEROL_TRANSFER_ACTIVITY'
'GOMF_FLOPPASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY' 'GOMF_LIPID_BINDING'
'GOMF_LIPID_TRANSFER_ACTIVITY'
'GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_PHOSPHATIDYLCHOLINE_FLOPPASE_ACTIVITY'
'GOMF_PHOSPHATIDYLCHOLINE_TRANSPORTER_ACTIVITY'
'GOMF_PHOSPHOLIPID_BINDING' 'GOMF_PHOSPHOLIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PROTEIN_DIMERIZATION_ACTIVITY'
'GOMF_PROTEIN_HETERODIMERIZATION_ACTIVITY'
'GOMF_PROTEIN_HOMODIMERIZATION_ACTIVITY' 'GOMF_STEROID_BINDING'
'GOMF_STEROL_BINDING' 'GOMF_STEROL_TRANSFER_ACTIVITY'
'GOMF_TOXIN_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY' 'KEGG_ABC_TRANSPORTERS'
'KEGG_MEDICUS_REFERENCE_ACTIVATION_OF_PRC2' 'MEK_UP.V1_UP'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS'
'REACTOME_HDL_REMODELING' 'REACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING'
'REACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX'
'REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY_REMODELING_AND_CLEARANCE'
'REACTOME_PLASMA_LIPOPROTEIN_REMODELING'
'REACTOME_SIGNALING_BY_NUCLEAR_RECEPTORS'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES' 'TGFB_UP.V1_UP'
'WP_CHOLESTEROL_BIOSYNTHESIS_PATHWAY_IN_HEPATOCYTES'
'WP_CHOLESTEROL_METABOLISM_WITH_BLOCH_AND_KANDUTSCHRUSSELL_PATHWAYS'
'WP_EFFECT_OF_OMEGA3_PUFA_ON_HUNTINGTONS_DISEASE_PATHWAYS'
'WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY']
|
['GO:0034041 ABC-type sterol transporter activity', 'GO:0043531 ADP binding', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0015485 cholesterol binding', 'GO:0120020 cholesterol transfer activity', 'GO:0140328 floppase activity', 'GO:0090554 phosphatidylcholine floppase activity', 'GO:0005543 phospholipid binding', 'GO:0046982 protein heterodimerization activity', 'GO:0042803 protein homodimerization activity', 'GO:0019534 toxin transmembrane transporter activity']
|
['GO:0042987 amyloid precursor protein catabolic process', 'GO:0071403 cellular response to high density lipoprotein particle stimulus', 'GO:0033344 cholesterol efflux', 'GO:0042632 cholesterol homeostasis', 'GO:0008203 cholesterol metabolic process', 'GO:0034436 glycoprotein transport', 'GO:0034375 high-density lipoprotein particle remodeling', 'GO:0032367 intracellular cholesterol transport', 'GO:0034374 low-density lipoprotein particle remodeling', 'GO:0010887 negative regulation of cholesterol storage', 'GO:0010745 negative regulation of macrophage derived foam cell differentiation', 'GO:0033700 phospholipid efflux', 'GO:0055091 phospholipid homeostasis', 'GO:1902004 positive regulation of amyloid-beta formation', 'GO:0045542 positive regulation of cholesterol biosynthetic process', 'GO:0010875 positive regulation of cholesterol efflux', 'GO:0050714 positive regulation of protein secretion', 'GO:0090181 regulation of cholesterol metabolic process', 'GO:0033993 response to lipid', 'GO:0043691 reverse cholesterol transport', 'GO:0055085 transmembrane transport', 'GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane']
|
['GO:0005789 endoplasmic reticulum membrane', 'GO:0005768 endosome', 'GO:0009897 external side of plasma membrane', 'GO:0005794 Golgi apparatus', 'GO:0000139 Golgi membrane', 'GO:0005739 mitochondrion', 'GO:0005654 nucleoplasm', 'GO:0005886 plasma membrane', 'GO:0055037 recycling endosome']
|
[
"Endoplasmic reticulum membrane",
"Golgi apparatus membrane",
"Cell membrane"
] |
ABCG2
|
Q9UNQ0
|
Broad substrate specificity ATP-binding cassette transporter ABCG2
|
Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells (PubMed:11306452, PubMed:12958161, PubMed:19506252, PubMed:20705604, PubMed:28554189, PubMed:30405239, PubMed:31003562). Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme (PubMed:20705604, PubMed:23189181). Also mediates the efflux of sphingosine-1-P from cells (PubMed:20110355). Acts as a urate exporter functioning in both renal and extrarenal urate excretion (PubMed:19506252, PubMed:20368174, PubMed:22132962, PubMed:31003562, PubMed:36749388). In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (By similarity). Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates (PubMed:12682043, PubMed:28554189, PubMed:30405239). Mediates the secretion of the vitamins riboflavin and biotin into milk (By similarity). Involved in the excretion of the riboflavin-derived compound lumichrome into the intestinal lumen and in its secretion into milk (PubMed:39337371). Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (By similarity). Plays an important role in the exclusion of xenobiotics from the brain (Probable). It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux (PubMed:11306452, PubMed:12477054, PubMed:15670731, PubMed:18056989, PubMed:31254042). In placenta, it limits the penetration of drugs from the maternal plasma into the fetus (By similarity). May play a role in early stem cell self-renewal by blocking differentiation (By similarity). In inflammatory macrophages, exports itaconate from the cytosol to the extracellular compartment and limits the activation of TFEB-dependent lysosome biogenesis involved in antibacterial innate immune response
|
['- IPR050352: ATP-binding cassette subfamily G transporters (family) [29-644]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [37-286]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [37-281]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [61-285]', '- IPR003593: AAA+ ATPase domain (domain) [72-270]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [75-214]', '- IPR043926: ABC transporter family G domain (domain) [243-301]', '- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [376-586]']
|
['Canalicular multispecific organic anion transporter 1', 'Multidrug resistance-associated protein 1', 'Solute carrier organic anion transporter family member 1B1', 'Solute carrier family 2, facilitated glucose transporter member 9', 'Solute carrier family 22 member 12', 'Basigin', 'Mitochondrial ribosomal protein S7.', 'Solute carrier family 22 member 1', 'Solute carrier family 22 member 8', 'Serum albumin']
|
['E2F3_UP.V1_UP' 'GOBP_AMIDE_TRANSPORT'
'GOBP_CELLULAR_RESPONSE_TO_TOXIC_SUBSTANCE'
'GOBP_CIRCULATORY_SYSTEM_PROCESS' 'GOBP_DETOXIFICATION' 'GOBP_EXCRETION'
'GOBP_EXPORT_ACROSS_PLASMA_MEMBRANE' 'GOBP_EXPORT_FROM_CELL'
'GOBP_LIPID_BIOSYNTHETIC_PROCESS' 'GOBP_LIPID_LOCALIZATION'
'GOBP_LIPID_METABOLIC_PROCESS' 'GOBP_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_MEMBRANE_LIPID_METABOLIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_TRANSPORT' 'GOBP_NITROGEN_COMPOUND_TRANSPORT'
'GOBP_ORGANIC_ACID_TRANSPORT' 'GOBP_ORGANIC_ANION_TRANSPORT'
'GOBP_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_RENAL_SYSTEM_PROCESS' 'GOBP_RENAL_TUBULAR_SECRETION'
'GOBP_RESPONSE_TO_TOXIC_SUBSTANCE' 'GOBP_RIBOFLAVIN_TRANSPORT'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_SPHINGOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_SPHINGOLIPID_METABOLIC_PROCESS' 'GOBP_SULFUR_COMPOUND_TRANSPORT'
'GOBP_TRANSEPITHELIAL_TRANSPORT' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_URATE_METABOLIC_PROCESS' 'GOBP_URATE_TRANSPORT'
'GOBP_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM' 'GOBP_VASCULAR_TRANSPORT'
'GOBP_VITAMIN_TRANSPORT' 'GOBP_XENOBIOTIC_TRANSPORT'
'GOBP_XENOBIOTIC_TRANSPORT_ACROSS_BLOOD_BRAIN_BARRIER'
'GOCC_APICAL_PART_OF_CELL' 'GOCC_BRUSH_BORDER'
'GOCC_BRUSH_BORDER_MEMBRANE' 'GOCC_CELL_PROJECTION_MEMBRANE'
'GOCC_CELL_SURFACE' 'GOCC_CLUSTER_OF_ACTIN_BASED_CELL_PROJECTIONS'
'GOCC_EXTERNAL_SIDE_OF_APICAL_PLASMA_MEMBRANE'
'GOCC_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE' 'GOCC_MEMBRANE_MICRODOMAIN'
'GOCC_MITOCHONDRIAL_ENVELOPE' 'GOCC_MITOCHONDRION'
'GOCC_ORGANELLE_ENVELOPE' 'GOCC_PLASMA_MEMBRANE_REGION'
'GOCC_SIDE_OF_MEMBRANE' 'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_AMIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_EFFLUX_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PROTEIN_DIMERIZATION_ACTIVITY'
'GOMF_PROTEIN_HOMODIMERIZATION_ACTIVITY'
'GOMF_RIBOFLAVIN_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_SALT_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_SPHINGOLIPID_TRANSPORTER_ACTIVITY'
'GOMF_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY'
'GOMF_VITAMIN_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'HALLMARK_HEME_METABOLISM' 'KEGG_ABC_TRANSPORTERS' 'LTE2_UP.V1_UP'
'PID_HIF1_TFPATHWAY' 'PID_HIF2PATHWAY' 'RB_P130_DN.V1_DN'
'REACTOME_ABACAVIR_ADME' 'REACTOME_ABACAVIR_TRANSMEMBRANE_TRANSPORT'
'REACTOME_CELLULAR_RESPONSES_TO_STIMULI'
'REACTOME_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS'
'REACTOME_CIPROFLOXACIN_ADME' 'REACTOME_DEVELOPMENTAL_CELL_LINEAGES'
'REACTOME_DIFFERENTIATION_OF_KERATINOCYTES_IN_INTERFOLLICULAR_EPIDERMIS_IN_MAMMALIAN_SKIN'
'REACTOME_DRUG_ADME' 'REACTOME_HEME_BIOSYNTHESIS'
'REACTOME_HEME_DEGRADATION' 'REACTOME_IRON_UPTAKE_AND_TRANSPORT'
'REACTOME_KEAP1_NFE2L2_PATHWAY' 'REACTOME_METABOLISM_OF_LIPIDS'
'REACTOME_METABOLISM_OF_PORPHYRINS'
'REACTOME_NFE2L2_REGULATING_MDR_ASSOCIATED_ENZYMES'
'REACTOME_NUCLEAR_EVENTS_MEDIATED_BY_NFE2L2' 'REACTOME_PARACETAMOL_ADME'
'REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS'
'REACTOME_SPHINGOLIPID_METABOLISM'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES' 'WP_FLUOROPYRIMIDINE_ACTIVITY'
'WP_IMATINIB_AND_CHRONIC_MYELOID_LEUKEMIA' 'WP_IRINOTECAN_PATHWAY'
'WP_MIRTARGETED_GENES_IN_LYMPHOCYTES'
'WP_MIRTARGETED_GENES_IN_MUSCLE_CELL'
'WP_PHOTODYNAMIC_THERAPYINDUCED_NFE2L2_NRF2_SURVIVAL_SIGNALING'
'WP_PROXIMAL_TUBULE_TRANSPORT']
|
['GO:0008559 ABC-type xenobiotic transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0015225 biotin transmembrane transporter activity', 'GO:0015562 efflux transmembrane transporter activity', 'GO:0042802 identical protein binding', 'GO:0008514 organic anion transmembrane transporter activity', 'GO:0042803 protein homodimerization activity', 'GO:0032217 riboflavin transmembrane transporter activity', 'GO:0046624 sphingolipid transporter activity', 'GO:0015143 urate transmembrane transporter activity', 'GO:0042910 xenobiotic transmembrane transporter activity']
|
['GO:0015878 biotin transport', 'GO:1990748 cellular detoxification', 'GO:0140115 export across plasma membrane', 'GO:0015711 organic anion transport', 'GO:0097744 renal urate salt excretion', 'GO:0032218 riboflavin transport', 'GO:0030148 sphingolipid biosynthetic process', 'GO:0070633 transepithelial transport', 'GO:0055085 transmembrane transport', 'GO:0150104 transport across blood-brain barrier', 'GO:0046415 urate metabolic process', 'GO:1990962 xenobiotic transport across blood-brain barrier']
|
['GO:0016324 apical plasma membrane', 'GO:0031526 brush border membrane', 'GO:0098591 external side of apical plasma membrane', 'GO:0045121 membrane raft', 'GO:0031966 mitochondrial membrane', 'GO:0005654 nucleoplasm', 'GO:0005886 plasma membrane']
|
[
"Cell membrane",
"Apical cell membrane",
"Mitochondrion membrane"
] |
ABCG4
|
Q9H172
|
ATP-binding cassette sub-family G member 4
|
ATP-dependent transporter of the ATP-binding cassette (ABC) family that may be involved in the cellular efflux of sterols, in particular cholesterol and desmosterol (a cholesterol precursor), to high-density lipoprotein (HDL) (PubMed:15240127, PubMed:33141061). May play an important role in the removal of amyloid-beta peptides from brain, in a process that can be antagonized by desmosterol. However it is unclear whether ABCG4 can directly transport amyloid-beta peptides or whether peptide export may be facilitated due to changes in the membrane lipid environment (By similarity). Induces apoptosis in various cells (PubMed:27228027)
|
['- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [51-293]', '- IPR050352: ATP-binding cassette subfamily G transporters (family) [51-635]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [61-301]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [80-299]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [86-229]', '- IPR003593: AAA+ ATPase domain (domain) [94-285]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [201-215]', '- IPR043926: ABC transporter family G domain (domain) [258-315]', '- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [372-581]']
|
['Truncated apolipoprotein A-I']
|
['CRX_NRL_DN.V1_UP' 'GOBP_ALCOHOL_BIOSYNTHETIC_PROCESS'
'GOBP_ALCOHOL_METABOLIC_PROCESS'
'GOBP_CELLULAR_RESPONSE_TO_LIPOPROTEIN_PARTICLE_STIMULUS'
'GOBP_CHEMICAL_HOMEOSTASIS' 'GOBP_CHOLESTEROL_EFFLUX'
'GOBP_HOMEOSTATIC_PROCESS' 'GOBP_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_LIPID_HOMEOSTASIS' 'GOBP_LIPID_LOCALIZATION'
'GOBP_LIPID_METABOLIC_PROCESS' 'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX'
'GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_TRANSPORT'
'GOBP_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_CHOLESTEROL_EFFLUX'
'GOBP_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_STEROID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_STEROL_TRANSPORT' 'GOBP_REGULATION_OF_TRANSPORT'
'GOBP_RESPONSE_TO_LEUKEMIA_INHIBITORY_FACTOR' 'GOBP_RESPONSE_TO_PEPTIDE'
'GOBP_SECONDARY_ALCOHOL_METABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_STEROID_BIOSYNTHETIC_PROCESS' 'GOBP_STEROID_METABOLIC_PROCESS'
'GOBP_STEROL_BIOSYNTHETIC_PROCESS' 'GOBP_STEROL_HOMEOSTASIS'
'GOBP_STEROL_TRANSPORT' 'GOBP_TRANSMEMBRANE_TRANSPORT' 'GOCC_ENDOSOME'
'GOCC_ENDOSOME_MEMBRANE' 'GOCC_VESICLE_MEMBRANE'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PROTEIN_DIMERIZATION_ACTIVITY'
'GOMF_PROTEIN_HETERODIMERIZATION_ACTIVITY'
'GOMF_PROTEIN_HOMODIMERIZATION_ACTIVITY' 'GOMF_TRANSPORTER_ACTIVITY'
'HALLMARK_BILE_ACID_METABOLISM' 'HALLMARK_KRAS_SIGNALING_DN'
'KEGG_ABC_TRANSPORTERS' 'KRAS.600_UP.V1_DN' 'KRAS.PROSTATE_UP.V1_DN'
'RB_P130_DN.V1_UP' 'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES'
'WP_EFFECT_OF_OMEGA3_PUFA_ON_HUNTINGTONS_DISEASE_PATHWAYS']
|
['GO:0034041 ABC-type sterol transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042802 identical protein binding', 'GO:0046982 protein heterodimerization activity', 'GO:0042803 protein homodimerization activity']
|
['GO:0071403 cellular response to high density lipoprotein particle stimulus', 'GO:1990830 cellular response to leukemia inhibitory factor', 'GO:0033344 cholesterol efflux', 'GO:0042632 cholesterol homeostasis', 'GO:0045542 positive regulation of cholesterol biosynthetic process', 'GO:0010875 positive regulation of cholesterol efflux', 'GO:0006355 regulation of DNA-templated transcription', 'GO:0055085 transmembrane transport']
|
['GO:0031410 cytoplasmic vesicle', 'GO:0010008 endosome membrane', 'GO:0005886 plasma membrane']
|
[
"Cell membrane",
"Cytoplasmic vesicle membrane",
"Endosome membrane"
] |
ABCG5
|
Q9H222
|
ATP-binding cassette sub-family G member 5
|
ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane (PubMed:27144356). Plays an essential role in the selective transport of dietary plant sterols and cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:11099417, PubMed:11138003, PubMed:15054092, PubMed:27144356). Required for normal sterol homeostasis (PubMed:11099417, PubMed:11138003, PubMed:15054092). The heterodimer with ABCG8 has ATPase activity (PubMed:16893193, PubMed:20210363, PubMed:27144356)
|
['- IPR050352: ATP-binding cassette subfamily G transporters (family) [42-625]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [52-293]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [58-340]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [66-293]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [69-221]', '- IPR003593: AAA+ ATPase domain (domain) [78-270]', '- IPR043926: ABC transporter family G domain (domain) [250-329]', '- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [368-580]']
|
['ATP-binding cassette sub-family G member 8', 'ATP-binding cassette sub-family D member 4', 'ATP-binding cassette sub-family B member 6, mitochondrial', 'ATP-binding cassette sub-family A member 2', 'Processed sterol regulatory element-binding protein 2', 'Xenotropic and polytropic retrovirus receptor 1', 'Oxysterols receptor LXR-alpha', 'Cytochrome P450 7A1', 'NPC1-like intracellular cholesterol transporter 1', 'Oxysterols receptor LXR-beta']
|
['ATM_DN.V1_UP' 'BIOCARTA_NUCLEARRS_PATHWAY'
'GOBP_ACYLGLYCEROL_HOMEOSTASIS' 'GOBP_CHEMICAL_HOMEOSTASIS'
'GOBP_CHOLESTEROL_EFFLUX' 'GOBP_DIGESTION'
'GOBP_DIGESTIVE_SYSTEM_PROCESS' 'GOBP_HOMEOSTATIC_PROCESS'
'GOBP_INTESTINAL_ABSORPTION' 'GOBP_INTESTINAL_CHOLESTEROL_ABSORPTION'
'GOBP_INTESTINAL_LIPID_ABSORPTION' 'GOBP_LIPID_DIGESTION'
'GOBP_LIPID_HOMEOSTASIS' 'GOBP_LIPID_LOCALIZATION'
'GOBP_NEGATIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS'
'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS'
'GOBP_REGULATION_OF_INTESTINAL_ABSORPTION'
'GOBP_REGULATION_OF_INTESTINAL_CHOLESTEROL_ABSORPTION'
'GOBP_REGULATION_OF_INTESTINAL_LIPID_ABSORPTION'
'GOBP_REGULATION_OF_SYSTEM_PROCESS' 'GOBP_RESPONSE_TO_ABIOTIC_STIMULUS'
'GOBP_RESPONSE_TO_ACTIVITY' 'GOBP_RESPONSE_TO_IONIZING_RADIATION'
'GOBP_RESPONSE_TO_MUSCLE_ACTIVITY' 'GOBP_RESPONSE_TO_NUTRIENT'
'GOBP_RESPONSE_TO_NUTRIENT_LEVELS' 'GOBP_RESPONSE_TO_RADIATION'
'GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS' 'GOBP_STEROL_HOMEOSTASIS'
'GOBP_STEROL_TRANSPORT' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOCC_APICAL_PART_OF_CELL'
'GOCC_ATPASE_DEPENDENT_TRANSMEMBRANE_TRANSPORT_COMPLEX'
'GOCC_ATP_BINDING_CASSETTE_ABC_TRANSPORTER_COMPLEX'
'GOCC_MEMBRANE_PROTEIN_COMPLEX' 'GOCC_PLASMA_MEMBRANE_PROTEIN_COMPLEX'
'GOCC_PLASMA_MEMBRANE_REGION' 'GOCC_RECEPTOR_COMPLEX'
'GOCC_TRANSPORTER_COMPLEX' 'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_CHOLESTEROL_TRANSFER_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_LIPID_TRANSFER_ACTIVITY' 'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PROTEIN_DIMERIZATION_ACTIVITY'
'GOMF_PROTEIN_HETERODIMERIZATION_ACTIVITY'
'GOMF_STEROL_TRANSFER_ACTIVITY' 'GOMF_TRANSPORTER_ACTIVITY'
'KEGG_ABC_TRANSPORTERS' 'KRAS.AMP.LUNG_UP.V1_UP' 'P53_DN.V2_DN'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS'
'REACTOME_ABC_TRANSPORTER_DISORDERS'
'REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS'
'REACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING'
'REACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX'
'REACTOME_SIGNALING_BY_NUCLEAR_RECEPTORS'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES'
'WP_ANGIOPOIETINLIKE_PROTEIN_8_REGULATORY_PATHWAY'
'WP_BILE_ACID_SYNTHESIS_AND_ENTEROHEPATIC_CIRCULATION' 'WP_CHOLESTASIS'
'WP_CHOLESTEROL_METABOLISM' 'WP_ENTEROCYTE_CHOLESTEROL_METABOLISM'
'WP_LIVER_X_RECEPTOR_PATHWAY'
'WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY'
'WP_NUCLEAR_RECEPTORS_METAPATHWAY'
'WP_STATIN_INHIBITION_OF_CHOLESTEROL_PRODUCTION'
'WP_VITAMIN_A_AND_CAROTENOID_METABOLISM']
|
['GO:0140359 ABC-type transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0120020 cholesterol transfer activity', 'GO:0046872 metal ion binding', 'GO:0046982 protein heterodimerization activity']
|
['GO:0033344 cholesterol efflux', 'GO:0042632 cholesterol homeostasis', 'GO:0030299 intestinal cholesterol absorption', 'GO:0045796 negative regulation of intestinal cholesterol absorption', 'GO:0010949 negative regulation of intestinal phytosterol absorption', 'GO:0010212 response to ionizing radiation', 'GO:0014850 response to muscle activity', 'GO:0007584 response to nutrient', 'GO:0009410 response to xenobiotic stimulus', 'GO:0015918 sterol transport', 'GO:0055085 transmembrane transport', 'GO:0070328 triglyceride homeostasis']
|
['GO:0016324 apical plasma membrane', 'GO:0043190 ATP-binding cassette (ABC) transporter complex', 'GO:0005886 plasma membrane', 'GO:0043235 receptor complex']
|
[
"Cell membrane",
"Apical cell membrane"
] |
ABCG8
|
Q9H221
|
ATP-binding cassette sub-family G member 8
|
ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:11099417, PubMed:11452359, PubMed:15054092, PubMed:27144356). Required for normal sterol homeostasis (PubMed:11099417, PubMed:11452359, PubMed:15054092). The heterodimer with ABCG5 has ATPase activity (PubMed:16893193, PubMed:20210363, PubMed:27144356)
|
['- IPR050352: ATP-binding cassette subfamily G transporters (family) [38-627]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [47-313]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [84-307]', '- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [88-312]', '- IPR003439: ABC transporter-like, ATP-binding domain (domain) [89-241]', '- IPR017871: ABC transporter-like, conserved site (conserved_site) [213-227]', '- IPR043926: ABC transporter family G domain (domain) [270-327]', '- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [397-608]']
|
['ATP-binding cassette sub-family G member 5', 'ATP-binding cassette sub-family D member 4', 'ATP-binding cassette sub-family B member 6, mitochondrial', 'ATP-binding cassette sub-family A member 2', 'Processed sterol regulatory element-binding protein 2', 'Oxysterols receptor LXR-alpha', 'Xenotropic and polytropic retrovirus receptor 1', 'NPC1-like intracellular cholesterol transporter 1', 'Oxysterols receptor LXR-beta', 'Cytochrome P450 7A1']
|
['GOBP_ACYLGLYCEROL_HOMEOSTASIS' 'GOBP_CHEMICAL_HOMEOSTASIS'
'GOBP_CHOLESTEROL_EFFLUX' 'GOBP_DIGESTION'
'GOBP_DIGESTIVE_SYSTEM_PROCESS' 'GOBP_HOMEOSTATIC_PROCESS'
'GOBP_INTESTINAL_ABSORPTION' 'GOBP_INTESTINAL_CHOLESTEROL_ABSORPTION'
'GOBP_INTESTINAL_LIPID_ABSORPTION' 'GOBP_LIPID_DIGESTION'
'GOBP_LIPID_HOMEOSTASIS' 'GOBP_LIPID_LOCALIZATION'
'GOBP_NEGATIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS'
'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT' 'GOBP_PHOSPHOLIPID_TRANSPORT'
'GOBP_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS'
'GOBP_REGULATION_OF_INTESTINAL_ABSORPTION'
'GOBP_REGULATION_OF_INTESTINAL_CHOLESTEROL_ABSORPTION'
'GOBP_REGULATION_OF_INTESTINAL_LIPID_ABSORPTION'
'GOBP_REGULATION_OF_SYSTEM_PROCESS' 'GOBP_RESPONSE_TO_ACTIVITY'
'GOBP_RESPONSE_TO_MUSCLE_ACTIVITY' 'GOBP_RESPONSE_TO_NUTRIENT'
'GOBP_RESPONSE_TO_NUTRIENT_LEVELS' 'GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_STEROL_HOMEOSTASIS' 'GOBP_STEROL_TRANSPORT'
'GOBP_TRANSMEMBRANE_TRANSPORT' 'GOCC_APICAL_PART_OF_CELL'
'GOCC_ATPASE_DEPENDENT_TRANSMEMBRANE_TRANSPORT_COMPLEX'
'GOCC_ATP_BINDING_CASSETTE_ABC_TRANSPORTER_COMPLEX'
'GOCC_MEMBRANE_PROTEIN_COMPLEX' 'GOCC_PLASMA_MEMBRANE_PROTEIN_COMPLEX'
'GOCC_PLASMA_MEMBRANE_REGION' 'GOCC_RECEPTOR_COMPLEX'
'GOCC_TRANSPORTER_COMPLEX' 'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_CHOLESTEROL_TRANSFER_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_LIPID_TRANSFER_ACTIVITY' 'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PROTEIN_DIMERIZATION_ACTIVITY'
'GOMF_PROTEIN_HETERODIMERIZATION_ACTIVITY'
'GOMF_STEROL_TRANSFER_ACTIVITY' 'GOMF_TRANSPORTER_ACTIVITY'
'HALLMARK_BILE_ACID_METABOLISM' 'KEGG_ABC_TRANSPORTERS'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS'
'REACTOME_ABC_TRANSPORTER_DISORDERS'
'REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS'
'REACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING'
'REACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX'
'REACTOME_SIGNALING_BY_NUCLEAR_RECEPTORS'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES'
'WP_ANGIOPOIETINLIKE_PROTEIN_8_REGULATORY_PATHWAY'
'WP_BILE_ACID_SYNTHESIS_AND_ENTEROHEPATIC_CIRCULATION' 'WP_CHOLESTASIS'
'WP_CHOLESTEROL_METABOLISM' 'WP_ENTEROCYTE_CHOLESTEROL_METABOLISM'
'WP_LIVER_X_RECEPTOR_PATHWAY' 'WP_NUCLEAR_RECEPTORS_METAPATHWAY'
'WP_STATIN_INHIBITION_OF_CHOLESTEROL_PRODUCTION'
'WP_VITAMIN_A_AND_CAROTENOID_METABOLISM']
|
['GO:0140359 ABC-type transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0120020 cholesterol transfer activity', 'GO:0046872 metal ion binding', 'GO:0046982 protein heterodimerization activity']
|
['GO:0033344 cholesterol efflux', 'GO:0042632 cholesterol homeostasis', 'GO:0030299 intestinal cholesterol absorption', 'GO:0045796 negative regulation of intestinal cholesterol absorption', 'GO:0010949 negative regulation of intestinal phytosterol absorption', 'GO:0015914 phospholipid transport', 'GO:0014850 response to muscle activity', 'GO:0007584 response to nutrient', 'GO:0009410 response to xenobiotic stimulus', 'GO:0015918 sterol transport', 'GO:0055085 transmembrane transport', 'GO:0070328 triglyceride homeostasis']
|
['GO:0016324 apical plasma membrane', 'GO:0043190 ATP-binding cassette (ABC) transporter complex', 'GO:0005886 plasma membrane', 'GO:0043235 receptor complex']
|
[
"Cell membrane",
"Apical cell membrane"
] |
ABHD1
|
Q96SE0
|
Protein ABHD1
| null |
['- IPR012020: AB hydrolase 4 family (family) [16-387]', '- IPR050960: AB hydrolase superfamily, subfamily 4 (family) [38-386]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [82-362]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [97-365]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [123-364]', '- IPR000952: AB hydrolase 4, conserved site (conserved_site) [288-329]']
|
['Prolactin regulatory element-binding protein']
|
['CAHOY_ASTROCYTIC' 'GOBP_FATTY_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_FATTY_ACID_CATABOLIC_PROCESS' 'GOBP_FATTY_ACID_METABOLIC_PROCESS'
'GOBP_LIPID_BIOSYNTHETIC_PROCESS' 'GOBP_LIPID_CATABOLIC_PROCESS'
'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_MEDIUM_CHAIN_FATTY_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_MEDIUM_CHAIN_FATTY_ACID_CATABOLIC_PROCESS'
'GOBP_MEDIUM_CHAIN_FATTY_ACID_METABOLIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_ORGANIC_ACID_CATABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_METABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS'
'GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS' 'GOMF_ACETYLESTERASE_ACTIVITY'
'GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS' 'GOMF_LIPASE_ACTIVITY'
'GOMF_MONOACYLGLYCEROL_LIPASE_ACTIVITY'
'GOMF_SHORT_CHAIN_CARBOXYLESTERASE_ACTIVITY']
|
['GO:0008126 acetylesterase activity', 'GO:0047372 monoacylglycerol lipase activity']
|
['GO:0051792 medium-chain fatty acid biosynthetic process', 'GO:0051793 medium-chain fatty acid catabolic process']
|
['GO:0016020 membrane']
|
[
"Membrane"
] |
ABHD10
|
Q9NUJ1
|
Palmitoyl-protein thioesterase ABHD10, mitochondrial
|
Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins (PubMed:31740833). Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability (PubMed:31740833). Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate (PubMed:22294686)
|
['- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [10-298]', '- IPR052382: Mitochondrial ABHD10 acyl-protein thioesterase (family) [10-306]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [62-301]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [78-180]']
|
[]
|
['GOBP_CELLULAR_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_LIPOPROTEIN_CATABOLIC_PROCESS' 'GOBP_LIPOPROTEIN_METABOLIC_PROCESS'
'GOBP_MACROMOLECULE_CATABOLIC_PROCESS' 'GOBP_MACROMOLECULE_DEACYLATION'
'GOBP_MACROMOLECULE_DEPALMITOYLATION' 'GOBP_PROTEIN_CATABOLIC_PROCESS'
'GOBP_PROTEIN_DEACYLATION' 'GOBP_PROTEIN_DEPALMITOYLATION'
'GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_XENOBIOTIC_METABOLIC_PROCESS' 'GOCC_MITOCHONDRIAL_MATRIX'
'GOCC_MITOCHONDRION' 'GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_GLYCOSYL_BONDS'
'GOMF_HYDROLASE_ACTIVITY_HYDROLYZING_O_GLYCOSYL_COMPOUNDS'
'GOMF_PALMITOYL_PROTEIN_HYDROLASE_ACTIVITY'
'GOMF_THIOLESTER_HYDROLASE_ACTIVITY' 'KRAS.DF.V1_UP'
'REACTOME_BIOLOGICAL_OXIDATIONS' 'REACTOME_GLUCURONIDATION'
'REACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS'
'WP_MIRTARGETED_GENES_IN_LYMPHOCYTES'
'WP_MIRTARGETED_GENES_IN_MUSCLE_CELL']
|
['GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds', 'GO:0102390 mycophenolic acid acyl-glucuronide esterase activity', 'GO:0008474 palmitoyl-(protein) hydrolase activity']
|
['GO:0019585 glucuronate metabolic process', 'GO:0002084 protein depalmitoylation', 'GO:0006805 xenobiotic metabolic process']
|
['GO:0005829 cytosol', 'GO:0005759 mitochondrial matrix', 'GO:0005739 mitochondrion']
|
[
"Mitochondrion"
] |
ABHD11
|
Q8NFV4
|
sn-1-specific diacylglycerol lipase ABHD11
|
Catalyzes the hydrolysis of diacylglycerol in vitro and may function as a key regulator in lipid metabolism, namely by regulating the intracellular levels of diacylglycerol (PubMed:32579589). 1,2-diacyl-sn-glycerols are the preferred substrate over 1,3-diacyl-sn-glycerols (By similarity). The enzyme hydrolyzes stearate in preference to palmitate from the sn-1 position of 1,2-diacyl-sn-glycerols (By similarity). Maintains the functional lipoylation of the 2-oxoglutarate dehydrogenase complex (OGDHc) through its interaction with the OGDHc by preventing the formation of lipoyl adducts (PubMed:32792488). In addition, is also required for the expansion and differentiation of embryonic stem cells (ESCs) (By similarity)
|
['- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [46-305]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [51-305]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [58-294]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [85-100]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [128-141]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [142-155]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [251-265]']
|
[]
|
['GOBP_LIPID_METABOLIC_PROCESS'
'GOCC_ALPHA_KETOACID_DEHYDROGENASE_COMPLEX' 'GOCC_CATALYTIC_COMPLEX'
'GOCC_MITOCHONDRIAL_MATRIX' 'GOCC_MITOCHONDRION'
'GOCC_OXIDOREDUCTASE_COMPLEX' 'GOCC_OXOGLUTARATE_DEHYDROGENASE_COMPLEX'
'GOCC_TRICARBOXYLIC_ACID_CYCLE_HETEROMERIC_ENZYME_COMPLEX'
'GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS' 'GOMF_LIPASE_ACTIVITY'
'WP_7Q1123_COPY_NUMBER_VARIATION_SYNDROME'
'WP_MIRTARGETED_GENES_IN_LYMPHOCYTES']
|
['GO:0052689 carboxylic ester hydrolase activity', 'GO:0016298 lipase activity']
|
['GO:0006629 lipid metabolic process']
|
['GO:0005759 mitochondrial matrix', 'GO:0005739 mitochondrion', 'GO:0045252 oxoglutarate dehydrogenase complex']
|
[
"Mitochondrion",
"Mitochondrion matrix"
] |
ABHD12
|
Q8N2K0
|
Lysophosphatidylserine lipase ABHD12
|
Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (PubMed:25290914, PubMed:30237167, PubMed:30420694, PubMed:30643283, PubMed:30720278). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal (PubMed:30643283). Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways (PubMed:22969151, PubMed:24027063). Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (PubMed:30237167)
|
['- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [143-391]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [154-389]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [169-274]']
|
['Monoacylglycerol lipase ABHD6', 'Phosphatidylserine lipase ABHD16A', 'Monoglyceride lipase', 'Fatty-acid amide hydrolase 1', 'N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D', 'Sn1-specific diacylglycerol lipase alpha', '(Lyso)-N-acylphosphatidylethanolamine lipase', 'Sn1-specific diacylglycerol lipase beta']
|
['GOBP_ADULT_BEHAVIOR' 'GOBP_ADULT_LOCOMOTORY_BEHAVIOR'
'GOBP_ARACHIDONATE_METABOLIC_PROCESS' 'GOBP_BEHAVIOR'
'GOBP_FATTY_ACID_METABOLIC_PROCESS' 'GOBP_GLYCEROLIPID_CATABOLIC_PROCESS'
'GOBP_GLYCEROLIPID_METABOLIC_PROCESS'
'GOBP_GLYCEROPHOSPHOLIPID_CATABOLIC_PROCESS'
'GOBP_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS'
'GOBP_ICOSANOID_METABOLIC_PROCESS' 'GOBP_INFLAMMATORY_RESPONSE'
'GOBP_LIPID_CATABOLIC_PROCESS' 'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_LOCOMOTORY_BEHAVIOR' 'GOBP_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS'
'GOBP_MACROMOLECULE_DEACYLATION' 'GOBP_MACROMOLECULE_DEPALMITOYLATION'
'GOBP_MODIFIED_AMINO_ACID_CATABOLIC_PROCESS'
'GOBP_MODIFIED_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_MONOACYLGLYCEROL_CATABOLIC_PROCESS'
'GOBP_MONOACYLGLYCEROL_METABOLIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS'
'GOBP_NEUTRAL_LIPID_CATABOLIC_PROCESS'
'GOBP_NEUTRAL_LIPID_METABOLIC_PROCESS'
'GOBP_OLEFINIC_COMPOUND_METABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_METABOLIC_PROCESS'
'GOBP_ORGANOPHOSPHATE_CATABOLIC_PROCESS'
'GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS'
'GOBP_PHOSPHATIDYLSERINE_METABOLIC_PROCESS'
'GOBP_PHOSPHOLIPID_CATABOLIC_PROCESS'
'GOBP_PHOSPHOLIPID_METABOLIC_PROCESS' 'GOBP_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_DEFENSE_RESPONSE'
'GOBP_REGULATION_OF_INFLAMMATORY_RESPONSE'
'GOBP_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS'
'GOBP_REGULATION_OF_RESPONSE_TO_STRESS'
'GOBP_RESPONSE_TO_ABIOTIC_STIMULUS' 'GOBP_RESPONSE_TO_AUDITORY_STIMULUS'
'GOBP_RESPONSE_TO_MECHANICAL_STIMULUS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_UNSATURATED_FATTY_ACID_METABOLIC_PROCESS' 'GOBP_WALKING_BEHAVIOR'
'GOCC_AMPA_GLUTAMATE_RECEPTOR_COMPLEX' 'GOCC_CYTOPLASMIC_REGION'
'GOCC_DENDRITE_CYTOPLASM' 'GOCC_DENDRITIC_TREE'
'GOCC_IONOTROPIC_GLUTAMATE_RECEPTOR_COMPLEX'
'GOCC_MEMBRANE_PROTEIN_COMPLEX' 'GOCC_MONOATOMIC_ION_CHANNEL_COMPLEX'
'GOCC_NEURON_PROJECTION' 'GOCC_NEURON_PROJECTION_CYTOPLASM'
'GOCC_NEUROTRANSMITTER_RECEPTOR_COMPLEX'
'GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK'
'GOCC_ORGANELLE_SUBCOMPARTMENT' 'GOCC_PLASMA_MEMBRANE_PROTEIN_COMPLEX'
'GOCC_PLASMA_MEMBRANE_SIGNALING_RECEPTOR_COMPLEX' 'GOCC_RECEPTOR_COMPLEX'
'GOCC_SOMATODENDRITIC_COMPARTMENT' 'GOCC_TRANSPORTER_COMPLEX'
'GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS' 'GOMF_LIPASE_ACTIVITY'
'GOMF_LYSOPHOSPHOLIPASE_ACTIVITY' 'GOMF_MONOACYLGLYCEROL_LIPASE_ACTIVITY'
'GOMF_PALMITOYL_PROTEIN_HYDROLASE_ACTIVITY' 'GOMF_PHOSPHOLIPASE_ACTIVITY'
'GOMF_THIOLESTER_HYDROLASE_ACTIVITY'
'REACTOME_ARACHIDONATE_PRODUCTION_FROM_DAG'
'REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS'
'REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS' 'REACTOME_HEMOSTASIS'
'REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION'
'REACTOME_SIGNALING_BY_GPCR']
|
['GO:0047372 monoacylglycerol lipase activity', 'GO:0008474 palmitoyl-(protein) hydrolase activity', 'GO:0004622 phosphatidylcholine lysophospholipase activity', 'GO:0120560 phosphatidylserine lysophospholipase activity', 'GO:0004620 phospholipase activity']
|
['GO:0046464 acylglycerol catabolic process', 'GO:0007628 adult walking behavior', 'GO:0019369 arachidonate metabolic process', 'GO:0046475 glycerophospholipid catabolic process', 'GO:0052651 monoacylglycerol catabolic process', 'GO:0006660 phosphatidylserine catabolic process', 'GO:0009395 phospholipid catabolic process', 'GO:0050727 regulation of inflammatory response', 'GO:0010996 response to auditory stimulus']
|
['GO:0032281 AMPA glutamate receptor complex', 'GO:0032839 dendrite cytoplasm', 'GO:0005789 endoplasmic reticulum membrane', 'GO:0016020 membrane', 'GO:0005886 plasma membrane']
|
[
"Endoplasmic reticulum membrane"
] |
ABHD12B
|
Q7Z5M8
|
Protein ABHD12B
| null |
['- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [49-360]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [126-360]', '- IPR022742: Alpha/beta hydrolase domain-containing protein 17C-like (domain) [141-258]']
|
[]
|
['GOBP_GLYCEROLIPID_CATABOLIC_PROCESS'
'GOBP_GLYCEROLIPID_METABOLIC_PROCESS'
'GOBP_GLYCEROPHOSPHOLIPID_CATABOLIC_PROCESS'
'GOBP_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS'
'GOBP_LIPID_CATABOLIC_PROCESS' 'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_MODIFIED_AMINO_ACID_CATABOLIC_PROCESS'
'GOBP_MODIFIED_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_MONOACYLGLYCEROL_CATABOLIC_PROCESS'
'GOBP_MONOACYLGLYCEROL_METABOLIC_PROCESS'
'GOBP_NEUTRAL_LIPID_CATABOLIC_PROCESS'
'GOBP_NEUTRAL_LIPID_METABOLIC_PROCESS'
'GOBP_ORGANOPHOSPHATE_CATABOLIC_PROCESS'
'GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS'
'GOBP_PHOSPHATIDYLSERINE_METABOLIC_PROCESS'
'GOBP_PHOSPHOLIPID_CATABOLIC_PROCESS'
'GOBP_PHOSPHOLIPID_METABOLIC_PROCESS' 'GOBP_PHOSPHORUS_METABOLIC_PROCESS'
'GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK'
'GOCC_ORGANELLE_SUBCOMPARTMENT'
'GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS' 'GOMF_LIPASE_ACTIVITY'
'GOMF_LYSOPHOSPHOLIPASE_ACTIVITY' 'GOMF_MONOACYLGLYCEROL_LIPASE_ACTIVITY'
'GOMF_PHOSPHOLIPASE_ACTIVITY']
|
['GO:0047372 monoacylglycerol lipase activity', 'GO:0004622 phosphatidylcholine lysophospholipase activity']
|
['GO:0052651 monoacylglycerol catabolic process', 'GO:0006660 phosphatidylserine catabolic process']
|
['GO:0005789 endoplasmic reticulum membrane']
|
[] |
ABHD13
|
Q7L211
|
Protein ABHD13
| null |
['- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [35-321]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [70-310]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [115-231]']
|
[]
|
['GOBP_MACROMOLECULE_DEACYLATION' 'GOBP_MACROMOLECULE_DEPALMITOYLATION'
'GOCC_CYTOPLASMIC_REGION' 'GOCC_DENDRITE_CYTOPLASM' 'GOCC_DENDRITIC_TREE'
'GOCC_NEURON_PROJECTION' 'GOCC_NEURON_PROJECTION_CYTOPLASM'
'GOCC_SOMATODENDRITIC_COMPARTMENT'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS'
'GOMF_PALMITOYL_PROTEIN_HYDROLASE_ACTIVITY'
'GOMF_THIOLESTER_HYDROLASE_ACTIVITY']
|
['GO:0008474 palmitoyl-(protein) hydrolase activity']
|
[]
|
['GO:0032839 dendrite cytoplasm', 'GO:0016020 membrane']
|
[
"Membrane"
] |
ABHD14A
|
Q9BUJ0
|
Protein ABHD14A
|
Possible role in granule neuron development
|
['- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [74-271]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [77-269]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [97-195]']
|
[]
|
['AKT_UP_MTOR_DN.V1_DN' 'CRX_NRL_DN.V1_UP' 'SNF5_DN.V1_UP']
|
['GO:0016787 hydrolase activity']
|
[]
|
['GO:0005737 cytoplasm', 'GO:0016020 membrane']
|
[
"Cytoplasm",
"Membrane"
] |
ABHD14B
|
Q96IU4
|
Putative protein-lysine deacylase ABHD14B
|
Acts as an atypical protein-lysine deacetylase in vitro (PubMed:31478652). Catalyzes the deacetylation of lysine residues using CoA as substrate, generating acetyl-CoA and the free amine of protein-lysine residues (PubMed:31478652). Additional experiments are however required to confirm the protein-lysine deacetylase activity in vivo (Probable). Has hydrolase activity towards various surrogate p-nitrophenyl (pNp) substrates, such as pNp-butyrate, pNp-acetate and pNp-octanoate in vitro, with a strong preference for pNp-acetate (PubMed:14672934, PubMed:31478652). May activate transcription (PubMed:14672934)
|
['- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [1-210]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [5-208]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [35-118]']
|
[]
|
['GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS'
'GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_NUCLEOTIDE_METABOLIC_PROCESS' 'GOBP_ORGANIC_ACID_METABOLIC_PROCESS'
'GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS'
'GOBP_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_RNA_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II'
'GOBP_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_PURINE_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS'
'GOBP_RIBOSE_PHOSPHATE_METABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_SULFUR_COMPOUND_METABOLIC_PROCESS' 'GOCC_NUCLEOLUS'
'GOMF_ACETYLTRANSFERASE_ACTIVITY' 'GOMF_ACYLTRANSFERASE_ACTIVITY'
'GOMF_ACYLTRANSFERASE_ACTIVITY_TRANSFERRING_GROUPS_OTHER_THAN_AMINO_ACYL_GROUPS'
'GOMF_N_ACETYLTRANSFERASE_ACTIVITY' 'GOMF_N_ACYLTRANSFERASE_ACTIVITY'
'GOMF_PROTEIN_N_ACETYLTRANSFERASE_ACTIVITY'
'KEGG_MEDICUS_REFERENCE_ACTIVATION_OF_PRC2'
'REACTOME_BIOLOGICAL_OXIDATIONS'
'REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES'
'REACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS' 'STK33_DN' 'STK33_NOMO_DN'
'STK33_SKM_DN']
|
['GO:0016787 hydrolase activity', 'GO:0061733 protein-lysine-acetyltransferase activity']
|
["GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process", 'GO:0045944 positive regulation of transcription by RNA polymerase II']
|
['GO:0005737 cytoplasm', 'GO:0005829 cytosol', 'GO:0070062 extracellular exosome', 'GO:0005730 nucleolus', 'GO:0005654 nucleoplasm', 'GO:0005634 nucleus']
|
[
"Cytoplasm",
"Nucleus"
] |
ABHD15
|
Q6UXT9
|
Protein ABHD15
|
May regulate adipocyte lipolysis and liver lipid accumulation
|
['- IPR050960: AB hydrolase superfamily, subfamily 4 (family) [71-419]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [124-413]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [144-422]']
|
["cGMP-inhibited 3',5'-cyclic phosphodiesterase B"]
|
['E2F3_UP.V1_UP' 'GOBP_ADIPOSE_TISSUE_DEVELOPMENT'
'GOBP_CONNECTIVE_TISSUE_DEVELOPMENT' 'GOBP_LIPID_CATABOLIC_PROCESS'
'GOBP_LIPID_METABOLIC_PROCESS' 'GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS' 'GOMF_LIPASE_ACTIVITY'
'GOMF_MONOACYLGLYCEROL_LIPASE_ACTIVITY'
'GOMF_SHORT_CHAIN_CARBOXYLESTERASE_ACTIVITY']
|
['GO:0047372 monoacylglycerol lipase activity', 'GO:0034338 short-chain carboxylesterase activity']
|
['GO:0060612 adipose tissue development', 'GO:0016042 lipid catabolic process', 'GO:0006629 lipid metabolic process']
|
['GO:0005576 extracellular region', 'GO:0016020 membrane']
|
[
"Secreted"
] |
ABHD16A
|
O95870
|
Phosphatidylserine lipase ABHD16A
|
Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (PubMed:25290914). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G) (PubMed:25290914)
|
['- IPR054518: Phosphatidylserine Lipase ABHD16, N-terminal domain (domain) [3-152]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [259-477]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [272-474]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [281-408]']
|
['Lysophosphatidylserine lipase ABHD12', 'Zinc finger and BTB domain-containing protein 12', 'E3 ubiquitin-protein ligase RNF5', 'Leukocyte-specific transcript 1 protein', 'Protein PRRC2A', 'Minor histocompatibility antigen H13']
|
['GOBP_FATTY_ACID_DERIVATIVE_CATABOLIC_PROCESS'
'GOBP_FATTY_ACID_DERIVATIVE_METABOLIC_PROCESS'
'GOBP_GLYCEROLIPID_CATABOLIC_PROCESS'
'GOBP_GLYCEROLIPID_METABOLIC_PROCESS'
'GOBP_GLYCEROPHOSPHOLIPID_CATABOLIC_PROCESS'
'GOBP_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS'
'GOBP_ICOSANOID_CATABOLIC_PROCESS' 'GOBP_LIPID_CATABOLIC_PROCESS'
'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_MODIFIED_AMINO_ACID_CATABOLIC_PROCESS'
'GOBP_MODIFIED_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_MONOACYLGLYCEROL_CATABOLIC_PROCESS'
'GOBP_MONOACYLGLYCEROL_METABOLIC_PROCESS'
'GOBP_NEUTRAL_LIPID_CATABOLIC_PROCESS'
'GOBP_NEUTRAL_LIPID_METABOLIC_PROCESS'
'GOBP_ORGANOPHOSPHATE_CATABOLIC_PROCESS'
'GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS'
'GOBP_PHOSPHATIDYLSERINE_METABOLIC_PROCESS'
'GOBP_PHOSPHOLIPID_CATABOLIC_PROCESS'
'GOBP_PHOSPHOLIPID_METABOLIC_PROCESS' 'GOBP_PHOSPHORUS_METABOLIC_PROCESS'
'GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS' 'GOMF_LIPASE_ACTIVITY'
'GOMF_LYSOPHOSPHOLIPASE_ACTIVITY' 'GOMF_MONOACYLGLYCEROL_LIPASE_ACTIVITY'
'GOMF_PHOSPHOLIPASE_ACTIVITY' 'WP_IL18_SIGNALING']
|
['GO:0047372 monoacylglycerol lipase activity', 'GO:0004620 phospholipase activity']
|
['GO:0052651 monoacylglycerol catabolic process', 'GO:0006660 phosphatidylserine catabolic process', 'GO:1905344 prostaglandin catabolic process']
|
['GO:0016020 membrane']
|
[
"Membrane"
] |
ABHD16B
|
Q9H3Z7
|
ABHD16B
|
Hydrolyzes the sn-1 position of glycerophospholipids with high specificity towards phosphatidylserine (PS), PS-PLA1 enzyme (PubMed:36841071). Also hydrolyzes the acyl chain of glycerolipids with a preference for the monoacylglycerol (MAG) 1-acylglycerol, MAG lipase (PubMed:36841071). Plays a regulatory role in cellular lipid homeostasis by modulating genes involved in neutral lipid degradation and in phospholipid synthesis and composition (PubMed:37944658)
|
['- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [141-332]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [159-328]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [173-305]']
|
[]
|
['GOBP_GLYCEROLIPID_CATABOLIC_PROCESS'
'GOBP_GLYCEROLIPID_METABOLIC_PROCESS'
'GOBP_GLYCEROPHOSPHOLIPID_CATABOLIC_PROCESS'
'GOBP_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS'
'GOBP_LIPID_CATABOLIC_PROCESS' 'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_MODIFIED_AMINO_ACID_CATABOLIC_PROCESS'
'GOBP_MODIFIED_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_MONOACYLGLYCEROL_CATABOLIC_PROCESS'
'GOBP_MONOACYLGLYCEROL_METABOLIC_PROCESS'
'GOBP_NEUTRAL_LIPID_CATABOLIC_PROCESS'
'GOBP_NEUTRAL_LIPID_METABOLIC_PROCESS'
'GOBP_ORGANOPHOSPHATE_CATABOLIC_PROCESS'
'GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS'
'GOBP_PHOSPHATIDYLSERINE_METABOLIC_PROCESS'
'GOBP_PHOSPHOLIPID_CATABOLIC_PROCESS'
'GOBP_PHOSPHOLIPID_METABOLIC_PROCESS' 'GOBP_PHOSPHORUS_METABOLIC_PROCESS'
'GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS' 'GOMF_LIPASE_ACTIVITY'
'GOMF_MONOACYLGLYCEROL_LIPASE_ACTIVITY' 'GOMF_PHOSPHOLIPASE_ACTIVITY']
|
['GO:0047372 monoacylglycerol lipase activity', 'GO:0004620 phospholipase activity']
|
['GO:0052651 monoacylglycerol catabolic process', 'GO:0006660 phosphatidylserine catabolic process']
|
['GO:0005654 nucleoplasm']
|
[] |
ABHD17A
|
Q96GS6
|
Alpha/beta hydrolase domain-containing protein 17A
|
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:26701913). Has depalmitoylating activity towards NRAS (PubMed:26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:26701913). May have depalmitoylating activity towards MAP6 (By similarity)
|
['- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [68-305]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [96-306]', '- IPR022742: Alpha/beta hydrolase domain-containing protein 17C-like (domain) [111-216]']
|
['Acyl-protein thioesterase 1']
|
['GOBP_ACTIVATION_OF_IMMUNE_RESPONSE'
'GOBP_ACTIVATION_OF_INNATE_IMMUNE_RESPONSE'
'GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS'
'GOBP_CELL_JUNCTION_ORGANIZATION'
'GOBP_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM'
'GOBP_DEFENSE_RESPONSE_TO_SYMBIONT'
'GOBP_IMMUNE_RESPONSE_REGULATING_SIGNALING_PATHWAY'
'GOBP_INFLAMMASOME_MEDIATED_SIGNALING_PATHWAY'
'GOBP_INFLAMMATORY_RESPONSE'
'GOBP_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_LIPOPROTEIN_CATABOLIC_PROCESS' 'GOBP_LIPOPROTEIN_METABOLIC_PROCESS'
'GOBP_LOCALIZATION_WITHIN_MEMBRANE'
'GOBP_MACROMOLECULE_CATABOLIC_PROCESS' 'GOBP_MACROMOLECULE_DEACYLATION'
'GOBP_MACROMOLECULE_DEPALMITOYLATION'
'GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION'
'GOBP_NEGATIVE_REGULATION_OF_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_NEGATIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_INFLAMMASOME_MEDIATED_SIGNALING_PATHWAY'
'GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION'
'GOBP_NEGATIVE_REGULATION_OF_NLRP3_INFLAMMASOME_COMPLEX_ASSEMBLY'
'GOBP_NEGATIVE_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY'
'GOBP_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION'
'GOBP_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_MICROTUBULE'
'GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS'
'GOBP_NEGATIVE_REGULATION_OF_SIGNALING'
'GOBP_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE'
'GOBP_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE'
'GOBP_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS'
'GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS'
'GOBP_POSTSYNAPSE_ORGANIZATION' 'GOBP_PROTEIN_CATABOLIC_PROCESS'
'GOBP_PROTEIN_CONTAINING_COMPLEX_ORGANIZATION' 'GOBP_PROTEIN_DEACYLATION'
'GOBP_PROTEIN_DEPALMITOYLATION'
'GOBP_PROTEIN_LOCALIZATION_TO_CYTOSKELETON'
'GOBP_PROTEIN_LOCALIZATION_TO_ENDOSOME'
'GOBP_PROTEIN_LOCALIZATION_TO_MICROTUBULE'
'GOBP_PROTEIN_LOCALIZATION_TO_ORGANELLE'
'GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS'
'GOBP_REGULATION_OF_CELLULAR_LOCALIZATION'
'GOBP_REGULATION_OF_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_REGULATION_OF_DEFENSE_RESPONSE'
'GOBP_REGULATION_OF_IMMUNE_RESPONSE'
'GOBP_REGULATION_OF_IMMUNE_SYSTEM_PROCESS'
'GOBP_REGULATION_OF_INFLAMMASOME_MEDIATED_SIGNALING_PATHWAY'
'GOBP_REGULATION_OF_INNATE_IMMUNE_RESPONSE'
'GOBP_REGULATION_OF_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_REGULATION_OF_POSTSYNAPSE_ORGANIZATION'
'GOBP_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY'
'GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_ENDOSOME'
'GOBP_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS'
'GOBP_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS'
'GOBP_REGULATION_OF_RESPONSE_TO_STRESS'
'GOBP_REGULATION_OF_SYNAPSE_STRUCTURE_OR_ACTIVITY'
'GOBP_SYNAPSE_ORGANIZATION' 'GOCC_DENDRITIC_TREE' 'GOCC_ENDOSOME'
'GOCC_ENDOSOME_MEMBRANE' 'GOCC_GLUTAMATERGIC_SYNAPSE'
'GOCC_NEURON_PROJECTION' 'GOCC_NEURON_SPINE'
'GOCC_NEURON_TO_NEURON_SYNAPSE' 'GOCC_NUCLEAR_BODY' 'GOCC_NUCLEAR_SPECK'
'GOCC_PLASMA_MEMBRANE_REGION' 'GOCC_POSTSYNAPSE'
'GOCC_POSTSYNAPTIC_DENSITY_MEMBRANE' 'GOCC_POSTSYNAPTIC_ENDOSOME'
'GOCC_POSTSYNAPTIC_ENDOSOME_MEMBRANE' 'GOCC_POSTSYNAPTIC_MEMBRANE'
'GOCC_POSTSYNAPTIC_RECYCLING_ENDOSOME'
'GOCC_POSTSYNAPTIC_RECYCLING_ENDOSOME_MEMBRANE'
'GOCC_POSTSYNAPTIC_SPECIALIZATION'
'GOCC_POSTSYNAPTIC_SPECIALIZATION_MEMBRANE' 'GOCC_RECYCLING_ENDOSOME'
'GOCC_RECYCLING_ENDOSOME_MEMBRANE' 'GOCC_SOMATODENDRITIC_COMPARTMENT'
'GOCC_SYNAPSE' 'GOCC_SYNAPTIC_MEMBRANE' 'GOCC_VESICLE_MEMBRANE'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS'
'GOMF_PALMITOYL_PROTEIN_HYDROLASE_ACTIVITY'
'GOMF_THIOLESTER_HYDROLASE_ACTIVITY' 'REACTOME_MAPK1_MAPK3_SIGNALING'
'REACTOME_MAPK_FAMILY_SIGNALING_CASCADES' 'REACTOME_RAS_PROCESSING']
|
['GO:0008474 palmitoyl-(protein) hydrolase activity']
|
['GO:1900226 negative regulation of NLRP3 inflammasome complex assembly', 'GO:1902817 negative regulation of protein localization to microtubule', 'GO:1905668 positive regulation of protein localization to endosome', 'GO:0002084 protein depalmitoylation', 'GO:0072657 protein localization to membrane', 'GO:0099175 regulation of postsynapse organization']
|
['GO:0043197 dendritic spine', 'GO:0010008 endosome membrane', 'GO:0098978 glutamatergic synapse', 'GO:0016020 membrane', 'GO:0016607 nuclear speck', 'GO:0005886 plasma membrane', 'GO:0098839 postsynaptic density membrane', 'GO:0098944 postsynaptic recycling endosome membrane', 'GO:0055038 recycling endosome membrane']
|
[
"Cell membrane",
"Endosome membrane",
"Cell projection, dendritic spine",
"Postsynaptic density membrane"
] |
ABHD17B
|
Q5VST6
|
Alpha/beta hydrolase domain-containing protein 17B
|
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:26701913). Has depalmitoylating activity towards GAP43 (By similarity). Has depalmitoylating activity towards MAP6 (By similarity). Has depalmitoylating activity towards NRAS (PubMed:26701913)
|
['- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [40-283]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [68-285]', '- IPR022742: Alpha/beta hydrolase domain-containing protein 17C-like (domain) [90-196]']
|
[]
|
['GOBP_CELLULAR_COMPONENT_MAINTENANCE' 'GOBP_CELL_JUNCTION_ORGANIZATION'
'GOBP_CELL_PROJECTION_ORGANIZATION' 'GOBP_DENDRITIC_SPINE_MAINTENANCE'
'GOBP_LIPOPROTEIN_CATABOLIC_PROCESS' 'GOBP_LIPOPROTEIN_METABOLIC_PROCESS'
'GOBP_MACROMOLECULE_CATABOLIC_PROCESS' 'GOBP_MACROMOLECULE_DEACYLATION'
'GOBP_MACROMOLECULE_DEPALMITOYLATION'
'GOBP_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION'
'GOBP_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_MICROTUBULE'
'GOBP_NEURON_PROJECTION_ORGANIZATION'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION'
'GOBP_POSTSYNAPSE_ORGANIZATION' 'GOBP_PROTEIN_CATABOLIC_PROCESS'
'GOBP_PROTEIN_DEACYLATION' 'GOBP_PROTEIN_DEPALMITOYLATION'
'GOBP_PROTEIN_LOCALIZATION_TO_CELL_JUNCTION'
'GOBP_PROTEIN_LOCALIZATION_TO_CYTOSKELETON'
'GOBP_PROTEIN_LOCALIZATION_TO_ENDOSOME'
'GOBP_PROTEIN_LOCALIZATION_TO_MICROTUBULE'
'GOBP_PROTEIN_LOCALIZATION_TO_ORGANELLE'
'GOBP_PROTEIN_LOCALIZATION_TO_SYNAPSE'
'GOBP_REGULATION_OF_CELLULAR_LOCALIZATION'
'GOBP_REGULATION_OF_CELL_PROJECTION_ORGANIZATION'
'GOBP_REGULATION_OF_DENDRITIC_SPINE_MAINTENANCE'
'GOBP_REGULATION_OF_POSTSYNAPSE_ORGANIZATION'
'GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_ENDOSOME'
'GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_SYNAPSE'
'GOBP_REGULATION_OF_SYNAPSE_STRUCTURE_OR_ACTIVITY'
'GOBP_SYNAPSE_ORGANIZATION' 'GOCC_DENDRITIC_TREE' 'GOCC_ENDOSOME'
'GOCC_ENDOSOME_MEMBRANE' 'GOCC_GLUTAMATERGIC_SYNAPSE'
'GOCC_NEURON_PROJECTION' 'GOCC_NEURON_SPINE'
'GOCC_NEURON_TO_NEURON_SYNAPSE' 'GOCC_PLASMA_MEMBRANE_REGION'
'GOCC_POSTSYNAPSE' 'GOCC_POSTSYNAPTIC_DENSITY_MEMBRANE'
'GOCC_POSTSYNAPTIC_ENDOSOME' 'GOCC_POSTSYNAPTIC_ENDOSOME_MEMBRANE'
'GOCC_POSTSYNAPTIC_MEMBRANE' 'GOCC_POSTSYNAPTIC_RECYCLING_ENDOSOME'
'GOCC_POSTSYNAPTIC_RECYCLING_ENDOSOME_MEMBRANE'
'GOCC_POSTSYNAPTIC_SPECIALIZATION'
'GOCC_POSTSYNAPTIC_SPECIALIZATION_MEMBRANE' 'GOCC_RECYCLING_ENDOSOME'
'GOCC_RECYCLING_ENDOSOME_MEMBRANE' 'GOCC_SOMATODENDRITIC_COMPARTMENT'
'GOCC_SYNAPSE' 'GOCC_SYNAPTIC_MEMBRANE' 'GOCC_VESICLE_MEMBRANE'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS'
'GOMF_PALMITOYL_PROTEIN_HYDROLASE_ACTIVITY'
'GOMF_THIOLESTER_HYDROLASE_ACTIVITY' 'REACTOME_MAPK1_MAPK3_SIGNALING'
'REACTOME_MAPK_FAMILY_SIGNALING_CASCADES' 'REACTOME_RAS_PROCESSING']
|
['GO:0008474 palmitoyl-(protein) hydrolase activity']
|
['GO:1902817 negative regulation of protein localization to microtubule', 'GO:1905668 positive regulation of protein localization to endosome', 'GO:0002084 protein depalmitoylation', 'GO:1902950 regulation of dendritic spine maintenance', 'GO:0099175 regulation of postsynapse organization', 'GO:1902473 regulation of protein localization to synapse']
|
['GO:0043197 dendritic spine', 'GO:0010008 endosome membrane', 'GO:0098978 glutamatergic synapse', 'GO:0016020 membrane', 'GO:0005886 plasma membrane', 'GO:0098839 postsynaptic density membrane', 'GO:0098944 postsynaptic recycling endosome membrane', 'GO:0055038 recycling endosome membrane']
|
[
"Cell membrane",
"Recycling endosome membrane",
"Cell projection, dendritic spine",
"Postsynaptic density membrane"
] |
ABHD17C
|
Q6PCB6
|
Alpha/beta hydrolase domain-containing protein 17C
|
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS and DLG4/PSD95
|
['- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [100-326]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [116-326]', '- IPR022742: Alpha/beta hydrolase domain-containing protein 17C-like (domain) [132-237]']
|
[]
|
['GOBP_CELL_JUNCTION_ORGANIZATION' 'GOBP_LIPOPROTEIN_CATABOLIC_PROCESS'
'GOBP_LIPOPROTEIN_METABOLIC_PROCESS'
'GOBP_MACROMOLECULE_CATABOLIC_PROCESS' 'GOBP_MACROMOLECULE_DEACYLATION'
'GOBP_MACROMOLECULE_DEPALMITOYLATION'
'GOBP_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION'
'GOBP_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_MICROTUBULE'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION'
'GOBP_POSTSYNAPSE_ORGANIZATION' 'GOBP_PROTEIN_CATABOLIC_PROCESS'
'GOBP_PROTEIN_DEACYLATION' 'GOBP_PROTEIN_DEPALMITOYLATION'
'GOBP_PROTEIN_LOCALIZATION_TO_CYTOSKELETON'
'GOBP_PROTEIN_LOCALIZATION_TO_ENDOSOME'
'GOBP_PROTEIN_LOCALIZATION_TO_MICROTUBULE'
'GOBP_PROTEIN_LOCALIZATION_TO_ORGANELLE'
'GOBP_REGULATION_OF_CELLULAR_LOCALIZATION'
'GOBP_REGULATION_OF_POSTSYNAPSE_ORGANIZATION'
'GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_ENDOSOME'
'GOBP_REGULATION_OF_SYNAPSE_STRUCTURE_OR_ACTIVITY'
'GOBP_SYNAPSE_ORGANIZATION' 'GOCC_DENDRITIC_TREE' 'GOCC_ENDOSOME'
'GOCC_ENDOSOME_MEMBRANE' 'GOCC_GLUTAMATERGIC_SYNAPSE'
'GOCC_NEURON_PROJECTION' 'GOCC_NEURON_SPINE'
'GOCC_NEURON_TO_NEURON_SYNAPSE' 'GOCC_PLASMA_MEMBRANE_REGION'
'GOCC_POSTSYNAPSE' 'GOCC_POSTSYNAPTIC_DENSITY_MEMBRANE'
'GOCC_POSTSYNAPTIC_MEMBRANE' 'GOCC_POSTSYNAPTIC_SPECIALIZATION'
'GOCC_POSTSYNAPTIC_SPECIALIZATION_MEMBRANE' 'GOCC_RECYCLING_ENDOSOME'
'GOCC_RECYCLING_ENDOSOME_MEMBRANE' 'GOCC_SOMATODENDRITIC_COMPARTMENT'
'GOCC_SYNAPSE' 'GOCC_SYNAPTIC_MEMBRANE' 'GOCC_VESICLE_MEMBRANE'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS'
'GOMF_PALMITOYL_PROTEIN_HYDROLASE_ACTIVITY'
'GOMF_THIOLESTER_HYDROLASE_ACTIVITY' 'REACTOME_MAPK1_MAPK3_SIGNALING'
'REACTOME_MAPK_FAMILY_SIGNALING_CASCADES' 'REACTOME_RAS_PROCESSING']
|
['GO:0008474 palmitoyl-(protein) hydrolase activity']
|
['GO:1902817 negative regulation of protein localization to microtubule', 'GO:1905668 positive regulation of protein localization to endosome', 'GO:0002084 protein depalmitoylation', 'GO:0099175 regulation of postsynapse organization']
|
['GO:0043197 dendritic spine', 'GO:0010008 endosome membrane', 'GO:0098978 glutamatergic synapse', 'GO:0005886 plasma membrane', 'GO:0098839 postsynaptic density membrane', 'GO:0055038 recycling endosome membrane']
|
[
"Recycling endosome membrane",
"Cell projection, dendritic spine",
"Postsynaptic density membrane"
] |
ABHD18
|
Q0P651
|
Protein ABHD18
| null |
['- IPR019149: Alpha/beta hydrolase domain-containing protein 18 (family) [16-414]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [92-409]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [94-406]']
|
[]
|
['GOCC_MITOCHONDRION' 'JAK2_DN.V1_DN']
|
[]
|
[]
|
['GO:0005576 extracellular region', 'GO:0005739 mitochondrion']
|
[
"Secreted"
] |
ABHD2
|
P08910
|
Monoacylglycerol lipase ABHD2
|
Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester (PubMed:27247428). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199). May also play a role in smooth muscle cells migration (By similarity)
|
['- IPR012020: AB hydrolase 4 family (family) [13-423]', '- IPR050960: AB hydrolase superfamily, subfamily 4 (family) [31-406]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [89-382]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [98-407]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [127-382]', '- IPR000952: AB hydrolase 4, conserved site (conserved_site) [304-345]']
|
['Sperm surface protein Sp17']
|
['GOBP_ACROSOME_REACTION' 'GOBP_ANATOMICAL_STRUCTURE_MATURATION'
'GOBP_CELLULAR_PROCESS_INVOLVED_IN_REPRODUCTION_IN_MULTICELLULAR_ORGANISM'
'GOBP_CELLULAR_RESPONSE_TO_ENDOGENOUS_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_LIPID'
'GOBP_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS'
'GOBP_CELL_MATURATION' 'GOBP_CELL_MOTILITY'
'GOBP_DEVELOPMENTAL_MATURATION'
'GOBP_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION'
'GOBP_FATTY_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_FATTY_ACID_CATABOLIC_PROCESS' 'GOBP_FATTY_ACID_METABOLIC_PROCESS'
'GOBP_FERTILIZATION' 'GOBP_GAMETE_GENERATION'
'GOBP_GLYCEROLIPID_CATABOLIC_PROCESS'
'GOBP_GLYCEROLIPID_METABOLIC_PROCESS'
'GOBP_HORMONE_MEDIATED_SIGNALING_PATHWAY'
'GOBP_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_LIPID_BIOSYNTHETIC_PROCESS' 'GOBP_LIPID_CATABOLIC_PROCESS'
'GOBP_LIPID_METABOLIC_PROCESS' 'GOBP_LOCOMOTION'
'GOBP_MALE_GAMETE_GENERATION'
'GOBP_MEDIUM_CHAIN_FATTY_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_MEDIUM_CHAIN_FATTY_ACID_CATABOLIC_PROCESS'
'GOBP_MEDIUM_CHAIN_FATTY_ACID_METABOLIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS'
'GOBP_MULTICELLULAR_ORGANISMAL_REPRODUCTIVE_PROCESS'
'GOBP_MUSCLE_CELL_MIGRATION' 'GOBP_NEGATIVE_REGULATION_OF_LOCOMOTION'
'GOBP_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION'
'GOBP_NEUTRAL_LIPID_CATABOLIC_PROCESS'
'GOBP_NEUTRAL_LIPID_METABOLIC_PROCESS'
'GOBP_NUCLEAR_RECEPTOR_MEDIATED_SIGNALING_PATHWAY'
'GOBP_ORGANIC_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_ORGANIC_ACID_CATABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_METABOLIC_PROCESS' 'GOBP_REGULATION_OF_LOCOMOTION'
'GOBP_REPRODUCTIVE_PROCESS' 'GOBP_RESPONSE_TO_ENDOGENOUS_STIMULUS'
'GOBP_RESPONSE_TO_HORMONE' 'GOBP_RESPONSE_TO_KETONE'
'GOBP_RESPONSE_TO_LIPID' 'GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND'
'GOBP_RESPONSE_TO_PROGESTERONE' 'GOBP_RESPONSE_TO_STEROID_HORMONE'
'GOBP_RESPONSE_TO_WOUNDING' 'GOBP_SEXUAL_REPRODUCTION'
'GOBP_SINGLE_FERTILIZATION' 'GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS'
'GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_SMOOTH_MUSCLE_CELL_MIGRATION' 'GOBP_SPERMATID_DIFFERENTIATION'
'GOBP_SPERM_CAPACITATION'
'GOBP_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY'
'GOCC_9PLUS2_MOTILE_CILIUM' 'GOCC_ACROSOMAL_VESICLE' 'GOCC_CILIUM'
'GOCC_MOTILE_CILIUM' 'GOCC_SECRETORY_GRANULE' 'GOCC_SECRETORY_VESICLE'
'GOCC_SPERM_PLASMA_MEMBRANE' 'GOMF_ACETYLESTERASE_ACTIVITY'
'GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY'
'GOMF_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY' 'GOMF_HORMONE_BINDING'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS'
'GOMF_LIGAND_MODULATED_TRANSCRIPTION_FACTOR_ACTIVITY'
'GOMF_LIPASE_ACTIVITY' 'GOMF_MONOACYLGLYCEROL_LIPASE_ACTIVITY'
'GOMF_NUCLEAR_STEROID_RECEPTOR_ACTIVITY'
'GOMF_SHORT_CHAIN_CARBOXYLESTERASE_ACTIVITY'
'GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY'
'GOMF_TRIACYLGLYCEROL_LIPASE_ACTIVITY' 'HALLMARK_ANDROGEN_RESPONSE'
'HALLMARK_ESTROGEN_RESPONSE_EARLY' 'HALLMARK_ESTROGEN_RESPONSE_LATE'
'JNK_DN.V1_DN' 'STK33_NOMO_UP' 'STK33_UP'
'WP_GLUCOCORTICOID_RECEPTOR_PATHWAY' 'WP_NUCLEAR_RECEPTORS_METAPATHWAY']
|
['GO:0008126 acetylesterase activity', 'GO:0120516 diacylglycerol lipase activity', 'GO:0042562 hormone binding', 'GO:0047372 monoacylglycerol lipase activity', 'GO:0003707 nuclear steroid receptor activity', 'GO:0004806 triacylglycerol lipase activity']
|
['GO:0007340 acrosome reaction', 'GO:0046464 acylglycerol catabolic process', 'GO:0051792 medium-chain fatty acid biosynthetic process', 'GO:0051793 medium-chain fatty acid catabolic process', 'GO:0014912 negative regulation of smooth muscle cell migration', 'GO:0032570 response to progesterone', 'GO:0009611 response to wounding', 'GO:0014909 smooth muscle cell migration', 'GO:0048240 sperm capacitation', 'GO:0043401 steroid hormone receptor signaling pathway']
|
['GO:0001669 acrosomal vesicle', 'GO:0036126 sperm flagellum', 'GO:0097524 sperm plasma membrane']
|
[
"Cell projection, cilium, flagellum membrane",
"Cell membrane"
] |
ABHD3
|
Q8WU67
|
Phospholipase ABHD3
|
Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids
|
['- IPR012020: AB hydrolase 4 family (family) [2-403]', '- IPR050960: AB hydrolase superfamily, subfamily 4 (family) [49-403]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [95-379]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [101-404]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [140-381]', '- IPR000952: AB hydrolase 4, conserved site (conserved_site) [305-346]']
|
[]
|
['GOBP_FATTY_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_FATTY_ACID_CATABOLIC_PROCESS' 'GOBP_FATTY_ACID_METABOLIC_PROCESS'
'GOBP_GLYCEROLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_GLYCEROLIPID_METABOLIC_PROCESS'
'GOBP_GLYCEROPHOSPHOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS'
'GOBP_LIPID_BIOSYNTHETIC_PROCESS' 'GOBP_LIPID_CATABOLIC_PROCESS'
'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_MEDIUM_CHAIN_FATTY_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_MEDIUM_CHAIN_FATTY_ACID_CATABOLIC_PROCESS'
'GOBP_MEDIUM_CHAIN_FATTY_ACID_METABOLIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_ORGANIC_ACID_CATABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_METABOLIC_PROCESS'
'GOBP_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS'
'GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS'
'GOBP_PHOSPHATIDYLCHOLINE_BIOSYNTHETIC_PROCESS'
'GOBP_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS'
'GOBP_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_PHOSPHOLIPID_METABOLIC_PROCESS' 'GOBP_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS'
'GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS' 'GOMF_ACETYLESTERASE_ACTIVITY'
'GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS' 'GOMF_LIPASE_ACTIVITY'
'GOMF_MONOACYLGLYCEROL_LIPASE_ACTIVITY' 'GOMF_PHOSPHOLIPASE_A1_ACTIVITY'
'GOMF_PHOSPHOLIPASE_A2_ACTIVITY' 'GOMF_PHOSPHOLIPASE_ACTIVITY'
'GOMF_SHORT_CHAIN_CARBOXYLESTERASE_ACTIVITY' 'MYC_UP.V1_DN'
'NRL_DN.V1_DN' 'REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS'
'REACTOME_METABOLISM_OF_LIPIDS' 'REACTOME_PHOSPHOLIPID_METABOLISM'
'REACTOME_SYNTHESIS_OF_PC' 'SRC_UP.V1_DN' 'VEGF_A_UP.V1_UP']
|
['GO:0008126 acetylesterase activity', 'GO:0047372 monoacylglycerol lipase activity', 'GO:0008970 phospholipase A1 activity', 'GO:0004623 phospholipase A2 activity']
|
['GO:0051792 medium-chain fatty acid biosynthetic process', 'GO:0051793 medium-chain fatty acid catabolic process', 'GO:0006656 phosphatidylcholine biosynthetic process', 'GO:0046470 phosphatidylcholine metabolic process']
|
['GO:0005886 plasma membrane']
|
[
"Membrane"
] |
ABHD4
|
Q8TB40
|
(Lyso)-N-acylphosphatidylethanolamine lipase
|
Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine
|
['- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [29-338]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [41-340]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [70-324]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [94-109]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [142-155]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [156-169]']
|
['Glycerophosphodiester phosphodiesterase 1', 'N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D', 'Lysophosphatidylserine lipase ABHD12', 'Monoglyceride lipase', 'Monoacylglycerol lipase ABHD6', 'Fatty-acid amide hydrolase 1', 'Sn1-specific diacylglycerol lipase alpha']
|
['GOBP_AMIDE_METABOLIC_PROCESS' 'GOBP_CHEMICAL_HOMEOSTASIS'
'GOBP_GLYCEROLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_GLYCEROLIPID_METABOLIC_PROCESS'
'GOBP_GLYCEROPHOSPHOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS' 'GOBP_HOMEOSTATIC_PROCESS'
'GOBP_LIPID_BIOSYNTHETIC_PROCESS' 'GOBP_LIPID_CATABOLIC_PROCESS'
'GOBP_LIPID_HOMEOSTASIS' 'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_N_ACYLPHOSPHATIDYLETHANOLAMINE_METABOLIC_PROCESS'
'GOBP_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS'
'GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS'
'GOBP_PHOSPHATIDIC_ACID_METABOLIC_PROCESS'
'GOBP_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS'
'GOBP_PHOSPHATIDYLETHANOLAMINE_ACYL_CHAIN_REMODELING'
'GOBP_PHOSPHATIDYLETHANOLAMINE_METABOLIC_PROCESS'
'GOBP_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_PHOSPHOLIPID_METABOLIC_PROCESS' 'GOBP_PHOSPHORUS_METABOLIC_PROCESS'
'GOCC_LIPID_DROPLET' 'GOCC_MITOCHONDRION'
'GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK'
'GOCC_ORGANELLE_SUBCOMPARTMENT' 'GOMF_ACYLTRANSFERASE_ACTIVITY'
'GOMF_ACYLTRANSFERASE_ACTIVITY_TRANSFERRING_GROUPS_OTHER_THAN_AMINO_ACYL_GROUPS'
'GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS' 'GOMF_LIPASE_ACTIVITY'
'GOMF_LYSOPHOSPHOLIPASE_ACTIVITY'
'GOMF_LYSOPHOSPHOLIPID_ACYLTRANSFERASE_ACTIVITY'
'GOMF_PHOSPHOLIPASE_ACTIVITY' 'HALLMARK_P53_PATHWAY' 'NFE2L2.V2'
'REACTOME_ACYL_CHAIN_REMODELLING_OF_PE'
'REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS'
'REACTOME_METABOLISM_OF_LIPIDS' 'REACTOME_PHOSPHOLIPID_METABOLISM']
|
['GO:0016787 hydrolase activity', 'GO:0042171 lysophosphatidic acid acyltransferase activity', 'GO:0004622 phosphatidylcholine lysophospholipase activity']
|
['GO:0016042 lipid catabolic process', 'GO:0055088 lipid homeostasis', 'GO:0070292 N-acylphosphatidylethanolamine metabolic process', 'GO:0006654 phosphatidic acid biosynthetic process', 'GO:0036152 phosphatidylethanolamine acyl-chain remodeling']
|
['GO:0005789 endoplasmic reticulum membrane', 'GO:0005811 lipid droplet']
|
[] |
ABHD5
|
Q8WTS1
|
1-acylglycerol-3-phosphate O-acyltransferase ABHD5
|
Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfer of an acyl group on a lysophosphatidic acid (PubMed:18606822). Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors (By similarity). Functions in phosphatidic acid biosynthesis (PubMed:18606822). May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2 (PubMed:16679289). Involved in keratinocyte differentiation (PubMed:18832586). Regulates lipid droplet fusion (By similarity)
|
['- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [35-347]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [55-346]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [77-332]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [101-116]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [149-162]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [163-176]']
|
['Perilipin-1', 'Patatin-like phospholipase domain-containing protein 2', 'Perilipin-5', 'Hormone-sensitive lipase', 'Perilipin-2', '1-acylglycerol-3-phosphate O-acyltransferase PNPLA3', 'Hydroperoxide isomerase ALOXE3', 'Arachidonate 12-lipoxygenase, 12R-type', 'Patatin-like phospholipase domain-containing protein 1', 'Patatin-like phospholipase domain-containing protein 4']
|
['ESC_J1_UP_LATE.V1_UP' 'GOBP_CHEMICAL_HOMEOSTASIS'
'GOBP_FATTY_ACID_METABOLIC_PROCESS'
'GOBP_GLYCEROLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_GLYCEROLIPID_CATABOLIC_PROCESS'
'GOBP_GLYCEROLIPID_METABOLIC_PROCESS'
'GOBP_GLYCEROPHOSPHOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS' 'GOBP_HOMEOSTATIC_PROCESS'
'GOBP_LIPID_BIOSYNTHETIC_PROCESS' 'GOBP_LIPID_CATABOLIC_PROCESS'
'GOBP_LIPID_HOMEOSTASIS' 'GOBP_LIPID_LOCALIZATION'
'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_NEGATIVE_REGULATION_OF_LIPID_STORAGE'
'GOBP_NEUTRAL_LIPID_CATABOLIC_PROCESS'
'GOBP_NEUTRAL_LIPID_METABOLIC_PROCESS' 'GOBP_NUTRIENT_STORAGE'
'GOBP_ORGANIC_ACID_METABOLIC_PROCESS'
'GOBP_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS'
'GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS'
'GOBP_PHOSPHATIDIC_ACID_METABOLIC_PROCESS'
'GOBP_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_PHOSPHOLIPID_METABOLIC_PROCESS' 'GOBP_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_TRIGLYCERIDE_CATABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_STORAGE'
'GOBP_REGULATION_OF_TRIGLYCERIDE_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_TRIGLYCERIDE_CATABOLIC_PROCESS'
'GOBP_TRIGLYCERIDE_METABOLIC_PROCESS' 'GOBP_TRIGLYCERIDE_STORAGE'
'GOCC_LIPID_DROPLET' 'GOCC_MITOCHONDRION'
'GOMF_ACYLGLYCEROL_O_ACYLTRANSFERASE_ACTIVITY'
'GOMF_ACYLTRANSFERASE_ACTIVITY'
'GOMF_ACYLTRANSFERASE_ACTIVITY_TRANSFERRING_GROUPS_OTHER_THAN_AMINO_ACYL_GROUPS'
'GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY'
'GOMF_ENZYME_ACTIVATOR_ACTIVITY' 'GOMF_ENZYME_REGULATOR_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS'
'GOMF_LIPASE_ACTIVATOR_ACTIVITY' 'GOMF_LIPASE_ACTIVITY'
'GOMF_LYSOPHOSPHOLIPID_ACYLTRANSFERASE_ACTIVITY'
'GOMF_MOLECULAR_FUNCTION_ACTIVATOR_ACTIVITY'
'GOMF_O_ACYLTRANSFERASE_ACTIVITY' 'GOMF_TRIACYLGLYCEROL_LIPASE_ACTIVITY'
'REACTOME_METABOLISM_OF_LIPIDS' 'REACTOME_TRIGLYCERIDE_CATABOLISM'
'REACTOME_TRIGLYCERIDE_METABOLISM' 'WP_5Q35_COPY_NUMBER_VARIATION'
'WP_LIPID_METABOLISM_PATHWAY']
|
['GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity', 'GO:0052689 carboxylic ester hydrolase activity', 'GO:0060229 lipase activator activity', 'GO:0042171 lysophosphatidic acid acyltransferase activity']
|
['GO:0030154 cell differentiation', 'GO:0006631 fatty acid metabolic process', 'GO:0055088 lipid homeostasis', 'GO:0010891 negative regulation of triglyceride storage', 'GO:0006654 phosphatidic acid biosynthetic process', 'GO:0010898 positive regulation of triglyceride catabolic process']
|
['GO:0005829 cytosol', 'GO:0005811 lipid droplet', 'GO:0005654 nucleoplasm']
|
[
"Cytoplasm",
"Lipid droplet",
"Cytoplasm, cytosol"
] |
ABHD6
|
Q9BV23
|
Monoacylglycerol lipase ABHD6
|
Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (By similarity). Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism (PubMed:26491015). BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (PubMed:26491015)
|
['- IPR050266: AB hydrolase superfamily (family) [15-332]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [41-336]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [50-324]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [72-313]', '- IPR000639: Epoxide hydrolase-like (family) [78-96]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [97-112]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [144-157]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [158-171]', '- IPR000639: Epoxide hydrolase-like (family) [158-171]', '- IPR000639: Epoxide hydrolase-like (family) [268-284]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [270-284]', '- IPR000639: Epoxide hydrolase-like (family) [301-323]']
|
['Lysophosphatidylserine lipase ABHD12', 'Monoglyceride lipase', 'Fatty-acid amide hydrolase 1', 'Sn1-specific diacylglycerol lipase alpha', 'N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D', 'Sn1-specific diacylglycerol lipase beta', '(Lyso)-N-acylphosphatidylethanolamine lipase', 'G-protein coupled receptor 55']
|
['GOBP_ADAPTIVE_THERMOGENESIS' 'GOBP_ALDITOL_PHOSPHATE_METABOLIC_PROCESS'
'GOBP_ARACHIDONATE_METABOLIC_PROCESS'
'GOBP_CANNABINOID_SIGNALING_PATHWAY'
'GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS'
'GOBP_CELL_CELL_SIGNALING' 'GOBP_CELL_MOTILITY'
'GOBP_FATTY_ACID_METABOLIC_PROCESS' 'GOBP_GLYCEROLIPID_CATABOLIC_PROCESS'
'GOBP_GLYCEROLIPID_METABOLIC_PROCESS'
'GOBP_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS'
'GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_HOMEOSTATIC_PROCESS' 'GOBP_ICOSANOID_METABOLIC_PROCESS'
'GOBP_LIPID_BIOSYNTHETIC_PROCESS' 'GOBP_LIPID_CATABOLIC_PROCESS'
'GOBP_LIPID_METABOLIC_PROCESS' 'GOBP_LOCOMOTION'
'GOBP_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS'
'GOBP_LONG_TERM_SYNAPTIC_DEPRESSION'
'GOBP_MONOACYLGLYCEROL_CATABOLIC_PROCESS'
'GOBP_MONOACYLGLYCEROL_METABOLIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS'
'GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS'
'GOBP_NEGATIVE_REGULATION_OF_COLD_INDUCED_THERMOGENESIS'
'GOBP_NEGATIVE_REGULATION_OF_LOCOMOTION'
'GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_SIGNALING'
'GOBP_NEGATIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION'
'GOBP_NEUTRAL_LIPID_CATABOLIC_PROCESS'
'GOBP_NEUTRAL_LIPID_METABOLIC_PROCESS'
'GOBP_OLEFINIC_COMPOUND_METABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_METABOLIC_PROCESS'
'GOBP_ORGANOPHOSPHATE_CATABOLIC_PROCESS'
'GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS'
'GOBP_PHOSPHOLIPID_CATABOLIC_PROCESS'
'GOBP_PHOSPHOLIPID_METABOLIC_PROCESS' 'GOBP_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_LOCOMOTION' 'GOBP_REGULATION_OF_SYNAPTIC_PLASTICITY'
'GOBP_REGULATION_OF_TRANS_SYNAPTIC_SIGNALING'
'GOBP_RETROGRADE_TRANS_SYNAPTIC_SIGNALING'
'GOBP_RETROGRADE_TRANS_SYNAPTIC_SIGNALING_BY_LIPID'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS' 'GOBP_SYNAPTIC_SIGNALING'
'GOBP_TEMPERATURE_HOMEOSTASIS' 'GOBP_TRANS_SYNAPTIC_SIGNALING_BY_LIPID'
'GOBP_UNSATURATED_FATTY_ACID_METABOLIC_PROCESS'
'GOCC_AMPA_GLUTAMATE_RECEPTOR_COMPLEX' 'GOCC_ENDOSOME'
'GOCC_ENDOSOME_MEMBRANE' 'GOCC_GABA_ERGIC_SYNAPSE'
'GOCC_GLUTAMATERGIC_SYNAPSE' 'GOCC_IONOTROPIC_GLUTAMATE_RECEPTOR_COMPLEX'
'GOCC_LATE_ENDOSOME' 'GOCC_LATE_ENDOSOME_MEMBRANE'
'GOCC_MEMBRANE_PROTEIN_COMPLEX' 'GOCC_MITOCHONDRIAL_ENVELOPE'
'GOCC_MITOCHONDRION' 'GOCC_MONOATOMIC_ION_CHANNEL_COMPLEX'
'GOCC_NEUROTRANSMITTER_RECEPTOR_COMPLEX' 'GOCC_ORGANELLE_ENVELOPE'
'GOCC_PLASMA_MEMBRANE_PROTEIN_COMPLEX' 'GOCC_PLASMA_MEMBRANE_REGION'
'GOCC_PLASMA_MEMBRANE_SIGNALING_RECEPTOR_COMPLEX' 'GOCC_POSTSYNAPSE'
'GOCC_POSTSYNAPTIC_MEMBRANE' 'GOCC_RECEPTOR_COMPLEX' 'GOCC_SYNAPSE'
'GOCC_SYNAPTIC_MEMBRANE' 'GOCC_TRANSPORTER_COMPLEX'
'GOCC_VACUOLAR_MEMBRANE' 'GOCC_VACUOLE' 'GOCC_VESICLE_MEMBRANE'
'GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS' 'GOMF_LIPASE_ACTIVITY'
'GOMF_MONOACYLGLYCEROL_LIPASE_ACTIVITY' 'GOMF_PHOSPHOLIPASE_ACTIVITY'
'HALLMARK_XENOBIOTIC_METABOLISM' 'MTOR_UP.N4.V1_UP' 'RAF_UP.V1_UP'
'REACTOME_ARACHIDONATE_PRODUCTION_FROM_DAG'
'REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS'
'REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS' 'REACTOME_HEMOSTASIS'
'REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION'
'REACTOME_SIGNALING_BY_GPCR']
|
['GO:0047372 monoacylglycerol lipase activity', 'GO:0004620 phospholipase activity']
|
['GO:0046464 acylglycerol catabolic process', 'GO:0019369 arachidonate metabolic process', 'GO:0060292 long-term synaptic depression', 'GO:2001311 lysobisphosphatidic acid metabolic process', 'GO:0052651 monoacylglycerol catabolic process', 'GO:0030336 negative regulation of cell migration', 'GO:0120163 negative regulation of cold-induced thermogenesis', 'GO:0009395 phospholipid catabolic process', 'GO:0046889 positive regulation of lipid biosynthetic process', 'GO:2000124 regulation of endocannabinoid signaling pathway', 'GO:0099178 regulation of retrograde trans-synaptic signaling by endocanabinoid']
|
['GO:0032281 AMPA glutamate receptor complex', 'GO:0098982 GABA-ergic synapse', 'GO:0098978 glutamatergic synapse', 'GO:0031902 late endosome membrane', 'GO:0005765 lysosomal membrane', 'GO:0016020 membrane', 'GO:0031966 mitochondrial membrane', 'GO:0005886 plasma membrane', 'GO:0045211 postsynaptic membrane']
|
[
"Late endosome membrane",
"Lysosome membrane",
"Mitochondrion membrane"
] |
ABHD8
|
Q96I13
|
Protein ABHD8
|
Negatively regulates NLRP3-driven inflammation (PubMed:39225180). Promotes NLRP3 degradation through the chaperone-mediated autophagy (CMA) pathway, hence attenuating inflammasome activation and IL1B secretion. Acts by recruiting palmitoyltransferase ZDHHC12 to NLRP3, facilitating NLRP3 palmitoylation and subsequent degradation (PubMed:39225180)
|
['- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [148-417]', '- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [174-416]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [177-277]', '- IPR000639: Epoxide hydrolase-like (family) [182-200]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [202-217]', '- IPR000639: Epoxide hydrolase-like (family) [202-217]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [248-261]', '- IPR000639: Epoxide hydrolase-like (family) [248-261]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [262-275]', '- IPR000073: Alpha/beta hydrolase fold-1 (domain) [362-376]', '- IPR000639: Epoxide hydrolase-like (family) [393-415]']
|
['Ankyrin repeat and LEM domain-containing protein 1']
|
['ALK_DN.V1_DN' 'ATF2_S_UP.V1_DN' 'BMI1_DN.V1_DN' 'CAHOY_OLIGODENDROCUTIC'
'GOBP_ACTIVATION_OF_IMMUNE_RESPONSE'
'GOBP_ACTIVATION_OF_INNATE_IMMUNE_RESPONSE'
'GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS'
'GOBP_CHEMICAL_HOMEOSTASIS'
'GOBP_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM'
'GOBP_DEFENSE_RESPONSE_TO_SYMBIONT'
'GOBP_GLYCEROLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_GLYCEROLIPID_METABOLIC_PROCESS'
'GOBP_GLYCEROPHOSPHOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS' 'GOBP_HOMEOSTATIC_PROCESS'
'GOBP_IMMUNE_RESPONSE_REGULATING_SIGNALING_PATHWAY'
'GOBP_INFLAMMASOME_MEDIATED_SIGNALING_PATHWAY'
'GOBP_INFLAMMATORY_RESPONSE'
'GOBP_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_LIPID_BIOSYNTHETIC_PROCESS' 'GOBP_LIPID_HOMEOSTASIS'
'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION'
'GOBP_NEGATIVE_REGULATION_OF_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_NEGATIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_INFLAMMASOME_MEDIATED_SIGNALING_PATHWAY'
'GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION'
'GOBP_NEGATIVE_REGULATION_OF_NLRP3_INFLAMMASOME_COMPLEX_ASSEMBLY'
'GOBP_NEGATIVE_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY'
'GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS'
'GOBP_NEGATIVE_REGULATION_OF_SIGNALING'
'GOBP_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS'
'GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS'
'GOBP_PHOSPHATIDIC_ACID_METABOLIC_PROCESS'
'GOBP_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_PHOSPHOLIPID_METABOLIC_PROCESS' 'GOBP_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE'
'GOBP_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE'
'GOBP_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS'
'GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS'
'GOBP_PROTEIN_CONTAINING_COMPLEX_ORGANIZATION'
'GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS'
'GOBP_REGULATION_OF_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_REGULATION_OF_DEFENSE_RESPONSE'
'GOBP_REGULATION_OF_IMMUNE_RESPONSE'
'GOBP_REGULATION_OF_IMMUNE_SYSTEM_PROCESS'
'GOBP_REGULATION_OF_INFLAMMASOME_MEDIATED_SIGNALING_PATHWAY'
'GOBP_REGULATION_OF_INNATE_IMMUNE_RESPONSE'
'GOBP_REGULATION_OF_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY'
'GOBP_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS'
'GOBP_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS'
'GOBP_REGULATION_OF_RESPONSE_TO_STRESS' 'GOCC_MITOCHONDRION'
'GOMF_ACYLTRANSFERASE_ACTIVITY'
'GOMF_ACYLTRANSFERASE_ACTIVITY_TRANSFERRING_GROUPS_OTHER_THAN_AMINO_ACYL_GROUPS'
'GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS'
'GOMF_LYSOPHOSPHOLIPID_ACYLTRANSFERASE_ACTIVITY' 'KRAS.PROSTATE_UP.V1_UP']
|
['GO:0052689 carboxylic ester hydrolase activity', 'GO:0042171 lysophosphatidic acid acyltransferase activity']
|
['GO:0006954 inflammatory response', 'GO:0055088 lipid homeostasis', 'GO:1900226 negative regulation of NLRP3 inflammasome complex assembly', 'GO:0006654 phosphatidic acid biosynthetic process']
|
['GO:0005737 cytoplasm', 'GO:0070062 extracellular exosome']
|
[
"Cytoplasm"
] |
ABI1
|
Q8IZP0
|
Abl interactor 1
|
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons
|
['- IPR028457: ABI family (family) [1-461]', '- IPR000727: Target SNARE coiled-coil homology domain (domain) [45-107]', '- IPR012849: Abl-interactor, homeo-domain homologous domain (domain) [93-170]', '- IPR036028: SH3-like domain superfamily (homologous_superfamily) [442-502]', '- IPR001452: SH3 domain (domain) [446-505]', '- IPR001452: SH3 domain (domain) [449-459]', '- IPR001452: SH3 domain (domain) [449-504]', '- IPR035725: Abl Interactor 1, SH3 domain (domain) [450-508]', '- IPR001452: SH3 domain (domain) [452-496]', '- IPR001452: SH3 domain (domain) [463-478]', '- IPR001452: SH3 domain (domain) [480-489]', '- IPR001452: SH3 domain (domain) [491-503]']
|
['Wiskott-Aldrich syndrome protein family member 2', 'Protein BRICK1', 'Nck-associated protein 1', 'Nck-associated protein 1-like', 'Epidermal growth factor receptor kinase substrate 8', 'Cytoplasmic FMR1-interacting protein 2', 'Wiskott-Aldrich syndrome protein family member 1', 'Cytoplasmic FMR1-interacting protein 1', 'Tyrosine-protein kinase ABL1', 'Son of sevenless homolog 1']
|
['GOBP_ACTIN_FILAMENT_BASED_PROCESS' 'GOBP_ACTIN_FILAMENT_ORGANIZATION'
'GOBP_ACTIN_POLYMERIZATION_OR_DEPOLYMERIZATION'
'GOBP_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS'
'GOBP_ANTERIOR_POSTERIOR_PATTERN_SPECIFICATION' 'GOBP_CELL_MORPHOGENESIS'
'GOBP_CELL_MORPHOGENESIS_INVOLVED_IN_NEURON_DIFFERENTIATION'
'GOBP_CELL_MOTILITY' 'GOBP_CELL_PROJECTION_MORPHOGENESIS'
'GOBP_CELL_PROJECTION_ORGANIZATION'
'GOBP_CELL_SURFACE_RECEPTOR_PROTEIN_TYROSINE_KINASE_SIGNALING_PATHWAY'
'GOBP_CYTOSKELETON_ORGANIZATION' 'GOBP_DENDRITE_DEVELOPMENT'
'GOBP_DENDRITE_MORPHOGENESIS' 'GOBP_EMBRYO_DEVELOPMENT'
'GOBP_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING'
'GOBP_ENZYME_LINKED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY'
'GOBP_EPITHELIUM_DEVELOPMENT' 'GOBP_GENERATION_OF_NEURONS'
'GOBP_HEMOPOIESIS' 'GOBP_LAMELLIPODIUM_MORPHOGENESIS'
'GOBP_LAMELLIPODIUM_ORGANIZATION' 'GOBP_MEGAKARYOCYTE_DEVELOPMENT'
'GOBP_MEGAKARYOCYTE_DIFFERENTIATION' 'GOBP_MYELOID_CELL_DEVELOPMENT'
'GOBP_MYELOID_CELL_DIFFERENTIATION'
'GOBP_NEGATIVE_REGULATION_OF_CELL_POPULATION_PROLIFERATION'
'GOBP_NEUROGENESIS' 'GOBP_NEURON_DEVELOPMENT' 'GOBP_NEURON_MIGRATION'
'GOBP_PATTERN_SPECIFICATION_PROCESS'
'GOBP_PEPTIDYL_AMINO_ACID_MODIFICATION'
'GOBP_PEPTIDYL_TYROSINE_MODIFICATION' 'GOBP_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_PHOSPHORYLATION' 'GOBP_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY'
'GOBP_POSITIVE_REGULATION_OF_KINASE_ACTIVITY'
'GOBP_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION'
'GOBP_POSITIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION'
'GOBP_POSITIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_PHOSPHORYLATION'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY'
'GOBP_POSITIVE_REGULATION_OF_TRANSFERASE_ACTIVITY'
'GOBP_REGULATION_OF_CATALYTIC_ACTIVITY'
'GOBP_REGULATION_OF_CELL_POPULATION_PROLIFERATION'
'GOBP_REGULATION_OF_KINASE_ACTIVITY'
'GOBP_REGULATION_OF_MOLECULAR_FUNCTION'
'GOBP_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION'
'GOBP_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_PHOSPHORYLATION'
'GOBP_REGULATION_OF_PROTEIN_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS'
'GOBP_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY'
'GOBP_REGULATION_OF_TRANSFERASE_ACTIVITY' 'GOBP_SEGMENTATION'
'GOBP_SOMITE_DEVELOPMENT' 'GOBP_SOMITOGENESIS'
'GOBP_SUPRAMOLECULAR_FIBER_ORGANIZATION'
'GOCC_ACTIN_BASED_CELL_PROJECTION' 'GOCC_AXON' 'GOCC_CELL_LEADING_EDGE'
'GOCC_DISTAL_AXON' 'GOCC_FILOPODIUM' 'GOCC_FILOPODIUM_TIP'
'GOCC_LAMELLIPODIUM' 'GOCC_NEURON_PROJECTION'
'GOCC_NEURON_TO_NEURON_SYNAPSE' 'GOCC_POSTSYNAPSE'
'GOCC_POSTSYNAPTIC_SPECIALIZATION' 'GOCC_SCAR_COMPLEX'
'GOCC_SITE_OF_POLARIZED_GROWTH' 'GOCC_SYNAPSE' 'GOMF_CADHERIN_BINDING'
'GOMF_CELL_ADHESION_MOLECULE_BINDING' 'GOMF_CYTOSKELETAL_PROTEIN_BINDING'
'GOMF_ENZYME_ACTIVATOR_ACTIVITY' 'GOMF_ENZYME_REGULATOR_ACTIVITY'
'GOMF_KINASE_ACTIVATOR_ACTIVITY' 'GOMF_KINASE_ACTIVITY'
'GOMF_KINASE_REGULATOR_ACTIVITY' 'GOMF_MOLECULAR_ADAPTOR_ACTIVITY'
'GOMF_MOLECULAR_FUNCTION_ACTIVATOR_ACTIVITY'
'GOMF_PROTEIN_DOMAIN_SPECIFIC_BINDING' 'GOMF_PROTEIN_KINASE_ACTIVITY'
'GOMF_PROTEIN_TYROSINE_KINASE_ACTIVATOR_ACTIVITY'
'GOMF_PROTEIN_TYROSINE_KINASE_ACTIVITY' 'GOMF_SH3_DOMAIN_BINDING'
'GOMF_SIGNALING_ADAPTOR_ACTIVITY'
'GOMF_TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS'
'HALLMARK_ALLOGRAFT_REJECTION' 'HALLMARK_INFLAMMATORY_RESPONSE'
'HALLMARK_MITOTIC_SPINDLE'
'KEGG_MEDICUS_PATHOGEN_ESCHERICHIA_ESPT_TO_RAC_SIGNALING_PATHWAY'
'KEGG_MEDICUS_PATHOGEN_SALMONELLA_SOPB_TO_ARNO_ARF_ACTB_G_SIGNALING_PATHWAY'
'KEGG_MEDICUS_PATHOGEN_SALMONELLA_SOPE_TO_RAC_SIGNALING_PATHWAY'
'KEGG_MEDICUS_PATHOGEN_SHIGELLA_IPGD_TO_ARNO_ARF_ACTB_G_SIGNALING_PATHWAY'
'KEGG_MEDICUS_REFERENCE_ARNO_ARF_ACTB_G_SIGNALING_PATHWAY'
'PID_ECADHERIN_NASCENT_AJ_PATHWAY' 'PID_ECADHERIN_STABILIZATION_PATHWAY'
'PID_ERBB1_DOWNSTREAM_PATHWAY' 'PID_INTEGRIN_A4B1_PATHWAY'
'PID_PDGFRB_PATHWAY' 'PID_RAC1_PATHWAY' 'PID_RAC1_REG_PATHWAY'
'REACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS'
'REACTOME_INFECTIOUS_DISEASE' 'REACTOME_INNATE_IMMUNE_SYSTEM'
'REACTOME_LEISHMANIA_INFECTION' 'REACTOME_PARASITE_INFECTION'
'REACTOME_RAC1_GTPASE_CYCLE' 'REACTOME_RAC2_GTPASE_CYCLE'
'REACTOME_RAC3_GTPASE_CYCLE'
'REACTOME_RHO_GTPASES_ACTIVATE_WASPS_AND_WAVES'
'REACTOME_RHO_GTPASE_CYCLE' 'REACTOME_RHO_GTPASE_EFFECTORS'
'REACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES'
'REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3'
'REACTOME_SIGNALING_BY_VEGF' 'WP_EGFEGFR_SIGNALING']
|
['GO:0045296 cadherin binding', 'GO:0008092 cytoskeletal protein binding', 'GO:0030296 protein tyrosine kinase activator activity', 'GO:0017124 SH3 domain binding', 'GO:0035591 signaling adaptor activity']
|
['GO:0008154 actin polymerization or depolymerization', 'GO:0048858 cell projection morphogenesis', 'GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway', 'GO:0048813 dendrite morphogenesis', 'GO:0072673 lamellipodium morphogenesis', 'GO:0035855 megakaryocyte development', 'GO:0008285 negative regulation of cell population proliferation', 'GO:0001764 neuron migration', 'GO:0061098 positive regulation of protein tyrosine kinase activity', 'GO:0001756 somitogenesis']
|
['GO:0098858 actin-based cell projection', 'GO:0005856 cytoskeleton', 'GO:0005829 cytosol', 'GO:0005783 endoplasmic reticulum', 'GO:0070062 extracellular exosome', 'GO:0032433 filopodium tip', 'GO:0030426 growth cone', 'GO:0030027 lamellipodium', 'GO:0005634 nucleus', 'GO:0014069 postsynaptic density', 'GO:0031209 SCAR complex']
|
[
"Cytoplasm",
"Nucleus",
"Cell projection, lamellipodium",
"Cell projection, filopodium",
"Cell projection, growth cone",
"Postsynaptic density",
"Cytoplasm, cytoskeleton"
] |
ABI2
|
Q9NYB9
|
Abl interactor 2
|
Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692)
|
['- IPR028457: ABI family (family) [1-466]', '- IPR000727: Target SNARE coiled-coil homology domain (domain) [45-107]', '- IPR012849: Abl-interactor, homeo-domain homologous domain (domain) [93-164]', '- IPR036028: SH3-like domain superfamily (homologous_superfamily) [445-507]', '- IPR001452: SH3 domain (domain) [451-510]', '- IPR035726: Abl interactor 2, SH3 domain (domain) [452-512]', '- IPR001452: SH3 domain (domain) [454-464]', '- IPR001452: SH3 domain (domain) [454-509]', '- IPR001452: SH3 domain (domain) [457-501]', '- IPR001452: SH3 domain (domain) [468-483]', '- IPR001452: SH3 domain (domain) [485-494]', '- IPR001452: SH3 domain (domain) [496-508]']
|
['Cytoplasmic FMR1-interacting protein 2', 'Wiskott-Aldrich syndrome protein family member 1', 'Cytoplasmic FMR1-interacting protein 1', 'Wiskott-Aldrich syndrome protein family member 2', 'Protein BRICK1', 'Nck-associated protein 1', 'Nck-associated protein 1-like', 'Abl interactor 1', 'Wiskott-Aldrich syndrome protein family member 3', 'Tyrosine-protein kinase ABL1']
|
['BIOCARTA_ACTINY_PATHWAY' 'GOBP_ACTIN_FILAMENT_BASED_PROCESS'
'GOBP_ACTIN_FILAMENT_ORGANIZATION' 'GOBP_ACTIN_NUCLEATION'
'GOBP_ACTIN_POLYMERIZATION_OR_DEPOLYMERIZATION'
'GOBP_ADHERENS_JUNCTION_ASSEMBLY' 'GOBP_ADHERENS_JUNCTION_ORGANIZATION'
'GOBP_ANIMAL_ORGAN_MORPHOGENESIS' 'GOBP_APICAL_JUNCTION_ASSEMBLY'
'GOBP_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION'
'GOBP_AUTOPHAGY_OF_MITOCHONDRION' 'GOBP_CAMERA_TYPE_EYE_MORPHOGENESIS'
'GOBP_CELL_CELL_JUNCTION_ASSEMBLY' 'GOBP_CELL_CELL_JUNCTION_ORGANIZATION'
'GOBP_CELL_JUNCTION_ASSEMBLY' 'GOBP_CELL_JUNCTION_ORGANIZATION'
'GOBP_CELL_MORPHOGENESIS'
'GOBP_CELL_MORPHOGENESIS_INVOLVED_IN_NEURON_DIFFERENTIATION'
'GOBP_CELL_MOTILITY' 'GOBP_CELL_PROJECTION_ASSEMBLY'
'GOBP_CELL_PROJECTION_MORPHOGENESIS' 'GOBP_CELL_PROJECTION_ORGANIZATION'
'GOBP_CYTOSKELETON_ORGANIZATION' 'GOBP_DENDRITE_DEVELOPMENT'
'GOBP_DENDRITE_MORPHOGENESIS' 'GOBP_DENDRITIC_SPINE_DEVELOPMENT'
'GOBP_DENDRITIC_SPINE_MORPHOGENESIS' 'GOBP_EPITHELIAL_CELL_DEVELOPMENT'
'GOBP_EPITHELIAL_CELL_DIFFERENTIATION' 'GOBP_EPITHELIUM_DEVELOPMENT'
'GOBP_EYE_MORPHOGENESIS' 'GOBP_GENERATION_OF_NEURONS'
'GOBP_LAMELLIPODIUM_ASSEMBLY' 'GOBP_LAMELLIPODIUM_ORGANIZATION'
'GOBP_LENS_DEVELOPMENT_IN_CAMERA_TYPE_EYE'
'GOBP_LENS_FIBER_CELL_DEVELOPMENT' 'GOBP_LENS_FIBER_CELL_DIFFERENTIATION'
'GOBP_LENS_FIBER_CELL_MORPHOGENESIS'
'GOBP_LENS_MORPHOGENESIS_IN_CAMERA_TYPE_EYE' 'GOBP_MACROAUTOPHAGY'
'GOBP_MITOPHAGY' 'GOBP_NEUROGENESIS' 'GOBP_NEURON_DEVELOPMENT'
'GOBP_NEURON_MIGRATION' 'GOBP_NEURON_PROJECTION_ORGANIZATION'
'GOBP_PEPTIDYL_AMINO_ACID_MODIFICATION'
'GOBP_PEPTIDYL_TYROSINE_MODIFICATION' 'GOBP_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_PHOSPHORYLATION' 'GOBP_POSITIVE_REGULATION_OF_ACTIN_NUCLEATION'
'GOBP_POSITIVE_REGULATION_OF_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION'
'GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS'
'GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION'
'GOBP_POSITIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION'
'GOBP_POSITIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION'
'GOBP_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY'
'GOBP_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION'
'GOBP_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION'
'GOBP_POSITIVE_REGULATION_OF_PLASMA_MEMBRANE_BOUNDED_CELL_PROJECTION_ASSEMBLY'
'GOBP_POSITIVE_REGULATION_OF_SUPRAMOLECULAR_FIBER_ORGANIZATION'
'GOBP_POSTSYNAPSE_ORGANIZATION'
'GOBP_PROCESS_UTILIZING_AUTOPHAGIC_MECHANISM'
'GOBP_RAC_PROTEIN_SIGNAL_TRANSDUCTION'
'GOBP_REGULATION_OF_ACTIN_FILAMENT_BASED_PROCESS'
'GOBP_REGULATION_OF_ACTIN_FILAMENT_ORGANIZATION'
'GOBP_REGULATION_OF_ACTIN_NUCLEATION'
'GOBP_REGULATION_OF_ANATOMICAL_STRUCTURE_MORPHOGENESIS'
'GOBP_REGULATION_OF_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION'
'GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS'
'GOBP_REGULATION_OF_CELL_PROJECTION_ASSEMBLY'
'GOBP_REGULATION_OF_CELL_PROJECTION_ORGANIZATION'
'GOBP_REGULATION_OF_CYTOSKELETON_ORGANIZATION'
'GOBP_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS'
'GOBP_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY'
'GOBP_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION'
'GOBP_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT'
'GOBP_REGULATION_OF_ORGANELLE_ORGANIZATION'
'GOBP_REGULATION_OF_POSTSYNAPSE_ORGANIZATION'
'GOBP_REGULATION_OF_SUPRAMOLECULAR_FIBER_ORGANIZATION'
'GOBP_REGULATION_OF_SYNAPSE_STRUCTURE_OR_ACTIVITY'
'GOBP_SENSORY_ORGAN_DEVELOPMENT' 'GOBP_SENSORY_ORGAN_MORPHOGENESIS'
'GOBP_SENSORY_SYSTEM_DEVELOPMENT'
'GOBP_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION'
'GOBP_SUPRAMOLECULAR_FIBER_ORGANIZATION' 'GOBP_SYNAPSE_ORGANIZATION'
'GOCC_ACTIN_BASED_CELL_PROJECTION' 'GOCC_ACTIN_CYTOSKELETON'
'GOCC_ACTIN_FILAMENT' 'GOCC_ADHERENS_JUNCTION' 'GOCC_ANCHORING_JUNCTION'
'GOCC_CELL_CELL_JUNCTION' 'GOCC_CELL_LEADING_EDGE' 'GOCC_DENDRITIC_TREE'
'GOCC_FILOPODIUM' 'GOCC_FILOPODIUM_TIP' 'GOCC_LAMELLIPODIUM'
'GOCC_NEURON_PROJECTION' 'GOCC_NEURON_SPINE'
'GOCC_POLYMERIC_CYTOSKELETAL_FIBER' 'GOCC_POSTSYNAPSE'
'GOCC_SCAR_COMPLEX' 'GOCC_SOMATODENDRITIC_COMPARTMENT'
'GOCC_SUPRAMOLECULAR_COMPLEX' 'GOCC_SUPRAMOLECULAR_POLYMER'
'GOCC_SYNAPSE' 'GOMF_CYTOSKELETAL_ANCHOR_ACTIVITY' 'GOMF_GTPASE_BINDING'
'GOMF_KINASE_BINDING' 'GOMF_MOLECULAR_ADAPTOR_ACTIVITY'
'GOMF_PROLINE_RICH_REGION_BINDING' 'GOMF_PROTEIN_DOMAIN_SPECIFIC_BINDING'
'GOMF_SH3_DOMAIN_BINDING' 'GOMF_SIGNALING_ADAPTOR_ACTIVITY'
'GOMF_UBIQUITIN_LIKE_PROTEIN_LIGASE_BINDING'
'KEGG_REGULATION_OF_ACTIN_CYTOSKELETON' 'PID_RAC1_PATHWAY'
'REACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS'
'REACTOME_INFECTIOUS_DISEASE' 'REACTOME_INNATE_IMMUNE_SYSTEM'
'REACTOME_LEISHMANIA_INFECTION' 'REACTOME_PARASITE_INFECTION'
'REACTOME_RAC1_GTPASE_CYCLE' 'REACTOME_RAC2_GTPASE_CYCLE'
'REACTOME_RAC3_GTPASE_CYCLE'
'REACTOME_RHO_GTPASES_ACTIVATE_WASPS_AND_WAVES'
'REACTOME_RHO_GTPASE_CYCLE' 'REACTOME_RHO_GTPASE_EFFECTORS'
'REACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES'
'REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3'
'REACTOME_SIGNALING_BY_VEGF' 'WP_REGULATION_OF_ACTIN_CYTOSKELETON']
|
['GO:0008093 cytoskeletal anchor activity', 'GO:0042802 identical protein binding', 'GO:0019900 kinase binding', 'GO:0017124 SH3 domain binding', 'GO:0035591 signaling adaptor activity', 'GO:0031625 ubiquitin protein ligase binding']
|
['GO:0008154 actin polymerization or depolymerization', 'GO:0016477 cell migration', 'GO:0048858 cell projection morphogenesis', 'GO:0007010 cytoskeleton organization', 'GO:0070309 lens fiber cell morphogenesis', 'GO:0000423 mitophagy', 'GO:0001764 neuron migration', 'GO:0018108 peptidyl-tyrosine phosphorylation', 'GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation', 'GO:0010592 positive regulation of lamellipodium assembly', 'GO:0016601 Rac protein signal transduction', 'GO:0061001 regulation of dendritic spine morphogenesis', 'GO:0045186 zonula adherens assembly']
|
['GO:0098858 actin-based cell projection', 'GO:0005912 adherens junction', 'GO:0005737 cytoplasm', 'GO:0005856 cytoskeleton', 'GO:0005829 cytosol', 'GO:0043197 dendritic spine', 'GO:0032433 filopodium tip', 'GO:0030027 lamellipodium', 'GO:0005634 nucleus', 'GO:0031209 SCAR complex']
|
[
"Cytoplasm",
"Nucleus",
"Cell projection, lamellipodium",
"Cell projection, filopodium",
"Cytoplasm, cytoskeleton",
"Cell junction, adherens junction"
] |
ABI3
|
Q9P2A4
|
ABI gene family member 3
|
May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility
|
['- IPR028457: ABI family (family) [1-323]', '- IPR012849: Abl-interactor, homeo-domain homologous domain (domain) [94-165]', '- IPR036028: SH3-like domain superfamily (homologous_superfamily) [299-364]', '- IPR001452: SH3 domain (domain) [308-366]', '- IPR001452: SH3 domain (domain) [311-321]', '- IPR001452: SH3 domain (domain) [311-366]', '- IPR028455: ABI gene family member 3, SH3 domain (domain) [312-363]', '- IPR001452: SH3 domain (domain) [316-363]', '- IPR001452: SH3 domain (domain) [325-340]', '- IPR001452: SH3 domain (domain) [353-365]']
|
['Target of Nesh-SH3', 'Cytoplasmic FMR1-interacting protein 1', 'Nck-associated protein 1', 'Nck-associated protein 1-like', 'Protein BRICK1', 'Wiskott-Aldrich syndrome protein family member 2', 'Wiskott-Aldrich syndrome protein family member 1', 'Cytoplasmic FMR1-interacting protein 2', 'Wiskott-Aldrich syndrome protein family member 3', 'Abl interactor 2']
|
['GOBP_ACTIN_FILAMENT_BASED_PROCESS' 'GOBP_CELLULAR_RESPONSE_TO_STRESS'
'GOBP_CELLULAR_SENESCENCE' 'GOBP_CELL_JUNCTION_ASSEMBLY'
'GOBP_CELL_JUNCTION_ORGANIZATION' 'GOBP_CELL_MORPHOGENESIS'
'GOBP_CELL_MORPHOGENESIS_INVOLVED_IN_NEURON_DIFFERENTIATION'
'GOBP_CELL_MOTILITY' 'GOBP_CELL_PROJECTION_ASSEMBLY'
'GOBP_CELL_PROJECTION_MORPHOGENESIS' 'GOBP_CELL_PROJECTION_ORGANIZATION'
'GOBP_CYTOSKELETON_ORGANIZATION' 'GOBP_DEFENSE_RESPONSE_TO_TUMOR_CELL'
'GOBP_DENDRITE_DEVELOPMENT' 'GOBP_DENDRITE_MORPHOGENESIS'
'GOBP_DENDRITIC_SPINE_DEVELOPMENT' 'GOBP_DENDRITIC_SPINE_MORPHOGENESIS'
'GOBP_EXCITATORY_SYNAPSE_ASSEMBLY' 'GOBP_GENERATION_OF_NEURONS'
'GOBP_LAMELLIPODIUM_ASSEMBLY' 'GOBP_LAMELLIPODIUM_ORGANIZATION'
'GOBP_LOCALIZATION_WITHIN_MEMBRANE' 'GOBP_LOCOMOTION'
'GOBP_MODIFICATION_OF_POSTSYNAPTIC_ACTIN_CYTOSKELETON'
'GOBP_MODIFICATION_OF_POSTSYNAPTIC_STRUCTURE'
'GOBP_MODIFICATION_OF_SYNAPTIC_STRUCTURE'
'GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION'
'GOBP_NEGATIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION'
'GOBP_NEGATIVE_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY'
'GOBP_NEGATIVE_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION'
'GOBP_NEGATIVE_REGULATION_OF_PLASMA_MEMBRANE_BOUNDED_CELL_PROJECTION_ASSEMBLY'
'GOBP_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION'
'GOBP_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY'
'GOBP_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE'
'GOBP_NEGATIVE_REGULATION_OF_RUFFLE_ASSEMBLY' 'GOBP_NEUROGENESIS'
'GOBP_NEURON_DEVELOPMENT' 'GOBP_NEURON_MIGRATION'
'GOBP_NEURON_PROJECTION_ORGANIZATION' 'GOBP_ORGANELLE_ASSEMBLY'
'GOBP_PEPTIDYL_AMINO_ACID_MODIFICATION'
'GOBP_PEPTIDYL_TYROSINE_MODIFICATION' 'GOBP_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_PHOSPHORYLATION' 'GOBP_POSITIVE_REGULATION_OF_CELLULAR_SENESCENCE'
'GOBP_POSTSYNAPSE_ASSEMBLY' 'GOBP_POSTSYNAPSE_ORGANIZATION'
'GOBP_POSTSYNAPTIC_DENSITY_ASSEMBLY'
'GOBP_POSTSYNAPTIC_DENSITY_ORGANIZATION'
'GOBP_POSTSYNAPTIC_SPECIALIZATION_ASSEMBLY'
'GOBP_POSTSYNAPTIC_SPECIALIZATION_ORGANIZATION'
'GOBP_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY'
'GOBP_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE'
'GOBP_REGULATION_OF_ANATOMICAL_STRUCTURE_MORPHOGENESIS'
'GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS'
'GOBP_REGULATION_OF_CELLULAR_LOCALIZATION'
'GOBP_REGULATION_OF_CELLULAR_SENESCENCE'
'GOBP_REGULATION_OF_CELL_JUNCTION_ASSEMBLY'
'GOBP_REGULATION_OF_CELL_PROJECTION_ASSEMBLY'
'GOBP_REGULATION_OF_CELL_PROJECTION_ORGANIZATION'
'GOBP_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS'
'GOBP_REGULATION_OF_EXCITATORY_SYNAPSE_ASSEMBLY'
'GOBP_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY'
'GOBP_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION'
'GOBP_REGULATION_OF_LOCOMOTION'
'GOBP_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT'
'GOBP_REGULATION_OF_ORGANELLE_ASSEMBLY'
'GOBP_REGULATION_OF_ORGANELLE_ORGANIZATION'
'GOBP_REGULATION_OF_POSTSYNAPSE_ORGANIZATION'
'GOBP_REGULATION_OF_POSTSYNAPTIC_DENSITY_ASSEMBLY'
'GOBP_REGULATION_OF_POSTSYNAPTIC_DENSITY_ORGANIZATION'
'GOBP_REGULATION_OF_POSTSYNAPTIC_SPECIALIZATION_ASSEMBLY'
'GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY'
'GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE'
'GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE'
'GOBP_REGULATION_OF_RUFFLE_ASSEMBLY'
'GOBP_REGULATION_OF_SYNAPSE_ASSEMBLY'
'GOBP_REGULATION_OF_SYNAPSE_STRUCTURE_OR_ACTIVITY'
'GOBP_RESPONSE_TO_TUMOR_CELL' 'GOBP_RUFFLE_ASSEMBLY'
'GOBP_RUFFLE_ORGANIZATION' 'GOBP_SYNAPSE_ASSEMBLY'
'GOBP_SYNAPSE_ORGANIZATION' 'GOCC_ACTIN_BASED_CELL_PROJECTION'
'GOCC_CELL_LEADING_EDGE' 'GOCC_DENDRITIC_SHAFT' 'GOCC_DENDRITIC_TREE'
'GOCC_GLUTAMATERGIC_SYNAPSE' 'GOCC_LAMELLIPODIUM'
'GOCC_NEURON_PROJECTION' 'GOCC_NEURON_SPINE'
'GOCC_NEURON_TO_NEURON_SYNAPSE' 'GOCC_POSTSYNAPSE'
'GOCC_POSTSYNAPTIC_SPECIALIZATION' 'GOCC_SCAR_COMPLEX'
'GOCC_SOMATODENDRITIC_COMPARTMENT' 'GOCC_SYNAPSE' 'GOMF_ACTIN_BINDING'
'GOMF_ACTIN_FILAMENT_BINDING' 'GOMF_CYTOSKELETAL_PROTEIN_BINDING'
'GOMF_MOLECULAR_ADAPTOR_ACTIVITY'
'GOMF_PROTEIN_CONTAINING_COMPLEX_BINDING'
'GOMF_SIGNALING_ADAPTOR_ACTIVITY']
|
['GO:0051015 actin filament binding', 'GO:0042802 identical protein binding', 'GO:0035591 signaling adaptor activity']
|
['GO:0030036 actin cytoskeleton organization', 'GO:0048858 cell projection morphogenesis', 'GO:0002357 defense response to tumor cell', 'GO:0098885 modification of postsynaptic actin cytoskeleton', 'GO:0010593 negative regulation of lamellipodium assembly', 'GO:1903077 negative regulation of protein localization to plasma membrane', 'GO:1900028 negative regulation of ruffle assembly', 'GO:0001764 neuron migration', 'GO:2000774 positive regulation of cellular senescence', 'GO:0030334 regulation of cell migration', 'GO:0061001 regulation of dendritic spine morphogenesis', 'GO:0099151 regulation of postsynaptic density assembly']
|
['GO:0098858 actin-based cell projection', 'GO:0005737 cytoplasm', 'GO:0043198 dendritic shaft', 'GO:0043197 dendritic spine', 'GO:0098978 glutamatergic synapse', 'GO:0030027 lamellipodium', 'GO:0016020 membrane', 'GO:0014069 postsynaptic density', 'GO:0031209 SCAR complex']
|
[
"Cytoplasm"
] |
ABI3BP
|
Q7Z7G0
|
Target of Nesh-SH3
| null |
['- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [110-213]', '- IPR003961: Fibronectin type III (domain) [114-203]', '- IPR003961: Fibronectin type III (domain) [116-195]', '- IPR003961: Fibronectin type III (domain) [116-214]', '- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [116-213]', '- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [825-930]', '- IPR003961: Fibronectin type III (domain) [830-913]', '- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [831-925]', '- IPR003961: Fibronectin type III (domain) [832-923]', '- IPR003961: Fibronectin type III (domain) [833-920]', '- IPR003961: Fibronectin type III (domain) [833-926]', '- IPR049109: Target of Nesh-SH3/FNDC1, C-terminal domain (domain) [942-1065]']
|
['ABI gene family member 3']
|
['CTIP_DN.V1_DN' 'GOBP_CELL_ADHESION' 'GOBP_CELL_SUBSTRATE_ADHESION'
'GOBP_EXTERNAL_ENCAPSULATING_STRUCTURE_ORGANIZATION'
'GOBP_POSITIVE_REGULATION_OF_CELL_ADHESION'
'GOBP_POSITIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION'
'GOBP_REGULATION_OF_CELL_ADHESION'
'GOBP_REGULATION_OF_CELL_SUBSTRATE_ADHESION'
'GOCC_COLLAGEN_CONTAINING_EXTRACELLULAR_MATRIX'
'GOCC_EXTERNAL_ENCAPSULATING_STRUCTURE'
'GOMF_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT'
'GOMF_STRUCTURAL_MOLECULE_ACTIVITY'
'HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION' 'PKCA_DN.V1_DN'
'SNF5_DN.V1_UP']
|
[]
|
['GO:0030198 extracellular matrix organization', 'GO:0010811 positive regulation of cell-substrate adhesion']
|
['GO:0031012 extracellular matrix', 'GO:0005576 extracellular region', 'GO:0005615 extracellular space']
|
[
"Secreted"
] |
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