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Feb 6

Student Answer Forecasting: Transformer-Driven Answer Choice Prediction for Language Learning

Intelligent Tutoring Systems (ITS) enhance personalized learning by predicting student answers to provide immediate and customized instruction. However, recent research has primarily focused on the correctness of the answer rather than the student's performance on specific answer choices, limiting insights into students' thought processes and potential misconceptions. To address this gap, we present MCQStudentBert, an answer forecasting model that leverages the capabilities of Large Language Models (LLMs) to integrate contextual understanding of students' answering history along with the text of the questions and answers. By predicting the specific answer choices students are likely to make, practitioners can easily extend the model to new answer choices or remove answer choices for the same multiple-choice question (MCQ) without retraining the model. In particular, we compare MLP, LSTM, BERT, and Mistral 7B architectures to generate embeddings from students' past interactions, which are then incorporated into a finetuned BERT's answer-forecasting mechanism. We apply our pipeline to a dataset of language learning MCQ, gathered from an ITS with over 10,000 students to explore the predictive accuracy of MCQStudentBert, which incorporates student interaction patterns, in comparison to correct answer prediction and traditional mastery-learning feature-based approaches. This work opens the door to more personalized content, modularization, and granular support.

  • 7 authors
·
May 30, 2024

Spike-driven Transformer V2: Meta Spiking Neural Network Architecture Inspiring the Design of Next-generation Neuromorphic Chips

Neuromorphic computing, which exploits Spiking Neural Networks (SNNs) on neuromorphic chips, is a promising energy-efficient alternative to traditional AI. CNN-based SNNs are the current mainstream of neuromorphic computing. By contrast, no neuromorphic chips are designed especially for Transformer-based SNNs, which have just emerged, and their performance is only on par with CNN-based SNNs, offering no distinct advantage. In this work, we propose a general Transformer-based SNN architecture, termed as ``Meta-SpikeFormer", whose goals are: 1) Lower-power, supports the spike-driven paradigm that there is only sparse addition in the network; 2) Versatility, handles various vision tasks; 3) High-performance, shows overwhelming performance advantages over CNN-based SNNs; 4) Meta-architecture, provides inspiration for future next-generation Transformer-based neuromorphic chip designs. Specifically, we extend the Spike-driven Transformer in yao2023spike into a meta architecture, and explore the impact of structure, spike-driven self-attention, and skip connection on its performance. On ImageNet-1K, Meta-SpikeFormer achieves 80.0\% top-1 accuracy (55M), surpassing the current state-of-the-art (SOTA) SNN baselines (66M) by 3.7\%. This is the first direct training SNN backbone that can simultaneously supports classification, detection, and segmentation, obtaining SOTA results in SNNs. Finally, we discuss the inspiration of the meta SNN architecture for neuromorphic chip design. Source code and models are available at https://github.com/BICLab/Spike-Driven-Transformer-V2.

  • 8 authors
·
Feb 15, 2024

Quantized Spike-driven Transformer

Spiking neural networks are emerging as a promising energy-efficient alternative to traditional artificial neural networks due to their spike-driven paradigm. However, recent research in the SNN domain has mainly focused on enhancing accuracy by designing large-scale Transformer structures, which typically rely on substantial computational resources, limiting their deployment on resource-constrained devices. To overcome this challenge, we propose a quantized spike-driven Transformer baseline (QSD-Transformer), which achieves reduced resource demands by utilizing a low bit-width parameter. Regrettably, the QSD-Transformer often suffers from severe performance degradation. In this paper, we first conduct empirical analysis and find that the bimodal distribution of quantized spike-driven self-attention (Q-SDSA) leads to spike information distortion (SID) during quantization, causing significant performance degradation. To mitigate this issue, we take inspiration from mutual information entropy and propose a bi-level optimization strategy to rectify the information distribution in Q-SDSA. Specifically, at the lower level, we introduce an information-enhanced LIF to rectify the information distribution in Q-SDSA. At the upper level, we propose a fine-grained distillation scheme for the QSD-Transformer to align the distribution in Q-SDSA with that in the counterpart ANN. By integrating the bi-level optimization strategy, the QSD-Transformer can attain enhanced energy efficiency without sacrificing its high-performance advantage.For instance, when compared to the prior SNN benchmark on ImageNet, the QSD-Transformer achieves 80.3% top-1 accuracy, accompanied by significant reductions of 6.0times and 8.1times in power consumption and model size, respectively. Code is available at https://github.com/bollossom/QSD-Transformer.

  • 10 authors
·
Jan 23, 2025

Neuromorphic Camera Denoising using Graph Neural Network-driven Transformers

Neuromorphic vision is a bio-inspired technology that has triggered a paradigm shift in the computer-vision community and is serving as a key-enabler for a multitude of applications. This technology has offered significant advantages including reduced power consumption, reduced processing needs, and communication speed-ups. However, neuromorphic cameras suffer from significant amounts of measurement noise. This noise deteriorates the performance of neuromorphic event-based perception and navigation algorithms. In this paper, we propose a novel noise filtration algorithm to eliminate events which do not represent real log-intensity variations in the observed scene. We employ a Graph Neural Network (GNN)-driven transformer algorithm, called GNN-Transformer, to classify every active event pixel in the raw stream into real-log intensity variation or noise. Within the GNN, a message-passing framework, called EventConv, is carried out to reflect the spatiotemporal correlation among the events, while preserving their asynchronous nature. We also introduce the Known-object Ground-Truth Labeling (KoGTL) approach for generating approximate ground truth labels of event streams under various illumination conditions. KoGTL is used to generate labeled datasets, from experiments recorded in chalenging lighting conditions. These datasets are used to train and extensively test our proposed algorithm. When tested on unseen datasets, the proposed algorithm outperforms existing methods by 8.8% in terms of filtration accuracy. Additional tests are also conducted on publicly available datasets to demonstrate the generalization capabilities of the proposed algorithm in the presence of illumination variations and different motion dynamics. Compared to existing solutions, qualitative results verified the superior capability of the proposed algorithm to eliminate noise while preserving meaningful scene events.

  • 6 authors
·
Dec 17, 2021

STORM: Spatio-Temporal Reconstruction Model for Large-Scale Outdoor Scenes

We present STORM, a spatio-temporal reconstruction model designed for reconstructing dynamic outdoor scenes from sparse observations. Existing dynamic reconstruction methods often rely on per-scene optimization, dense observations across space and time, and strong motion supervision, resulting in lengthy optimization times, limited generalization to novel views or scenes, and degenerated quality caused by noisy pseudo-labels for dynamics. To address these challenges, STORM leverages a data-driven Transformer architecture that directly infers dynamic 3D scene representations--parameterized by 3D Gaussians and their velocities--in a single forward pass. Our key design is to aggregate 3D Gaussians from all frames using self-supervised scene flows, transforming them to the target timestep to enable complete (i.e., "amodal") reconstructions from arbitrary viewpoints at any moment in time. As an emergent property, STORM automatically captures dynamic instances and generates high-quality masks using only reconstruction losses. Extensive experiments on public datasets show that STORM achieves precise dynamic scene reconstruction, surpassing state-of-the-art per-scene optimization methods (+4.3 to 6.6 PSNR) and existing feed-forward approaches (+2.1 to 4.7 PSNR) in dynamic regions. STORM reconstructs large-scale outdoor scenes in 200ms, supports real-time rendering, and outperforms competitors in scene flow estimation, improving 3D EPE by 0.422m and Acc5 by 28.02%. Beyond reconstruction, we showcase four additional applications of our model, illustrating the potential of self-supervised learning for broader dynamic scene understanding.

  • 13 authors
·
Dec 31, 2024

DTT: An Example-Driven Tabular Transformer for Joinability by Leveraging Large Language Models

Many organizations rely on data from government and third-party sources, and those sources rarely follow the same data formatting. This introduces challenges in integrating data from multiple sources or aligning external sources with internal databases. Commercial database systems do not offer adequate support for integrating data from heterogeneous sources, and manual integration is both time-consuming and inefficient. State-of-the-art data integration approaches that rely on similarity functions and textual transformations often fail to handle challenging cases where multiple mappings are required, or the mappings go beyond simple textual transformations. In this paper, we study the potentials of deep neural models for transforming tables for joinability. In particular, we cast the problem as a prediction task and develop a framework that leverages large deep-learning language models to transform tabular data from a source formatting to a desired target representation. Our framework can efficiently learn the patterns for mapping a source formatting into an expected target using just a few examples, which can then be used for tasks such as table joining, filling in missing values, and error detection. Compared to state-of-the-art mapping and joining approaches, our framework delivers noticeably more accurate and scalable performance on both real-world and synthetic datasets. Our experimental evaluation also shows that the performance of the proposed framework using our fine-tuned model is at par or better than large language models such as GPT-3, despite the significant difference in size, and that using large language models within our framework improves their performance.

  • 2 authors
·
Mar 12, 2023

3MDiT: Unified Tri-Modal Diffusion Transformer for Text-Driven Synchronized Audio-Video Generation

Text-to-video (T2V) diffusion models have recently achieved impressive visual quality, yet most systems still generate silent clips and treat audio as a secondary concern. Existing audio-video generation pipelines typically decompose the task into cascaded stages, which accumulate errors across modalities and are trained under separate objectives. Recent joint audio-video generators alleviate this issue but often rely on dual-tower architectures with ad-hoc cross-modal bridges and static, single-shot text conditioning, making it difficult to both reuse T2V backbones and to reason about how audio, video and language interact over time. To address these challenges, we propose 3MDiT, a unified tri-modal diffusion transformer for text-driven synchronized audio-video generation. Our framework models video, audio and text as jointly evolving streams: an isomorphic audio branch mirrors a T2V backbone, tri-modal omni-blocks perform feature-level fusion across the three modalities, and an optional dynamic text conditioning mechanism updates the text representation as audio and video evidence co-evolve. The design supports two regimes: training from scratch on audio-video data, and orthogonally adapting a pretrained T2V model without modifying its backbone. Experiments show that our approach generates high-quality videos and realistic audio while consistently improving audio-video synchronization and tri-modal alignment across a range of quantitative metrics.

  • 11 authors
·
Nov 26, 2025

SEA: Sparse Linear Attention with Estimated Attention Mask

The transformer architecture has driven breakthroughs in recent years on tasks which require modeling pairwise relationships between sequential elements, as is the case in natural language understanding. However, long seqeuences pose a problem due to the quadratic complexity of the attention operation. Previous research has aimed to lower the complexity by sparsifying or linearly approximating the attention matrix. Yet, these approaches cannot straightforwardly distill knowledge from a teacher's attention matrix and often require complete retraining from scratch. Furthermore, previous sparse and linear approaches lose interpretability if they cannot produce full attention matrices. To address these challenges, we propose SEA: Sparse linear attention with an Estimated Attention mask. SEA estimates the attention matrix with linear complexity via kernel-based linear attention, then subsequently creates a sparse attention matrix with a top-k selection to perform a sparse attention operation. For language modeling tasks (Wikitext2), previous linear and sparse attention methods show roughly two-fold worse perplexity scores over the quadratic OPT-1.3B baseline, while SEA achieves better perplexity than OPT-1.3B, using roughly half the memory of OPT-1.3B, providing interpretable attention matrix. We believe that our work will have a large practical impact, as it opens the possibility of running large transformers on resource-limited devices with less memory.

  • 4 authors
·
Oct 2, 2023

Video Adverse-Weather-Component Suppression Network via Weather Messenger and Adversarial Backpropagation

Although convolutional neural networks (CNNs) have been proposed to remove adverse weather conditions in single images using a single set of pre-trained weights, they fail to restore weather videos due to the absence of temporal information. Furthermore, existing methods for removing adverse weather conditions (e.g., rain, fog, and snow) from videos can only handle one type of adverse weather. In this work, we propose the first framework for restoring videos from all adverse weather conditions by developing a video adverse-weather-component suppression network (ViWS-Net). To achieve this, we first devise a weather-agnostic video transformer encoder with multiple transformer stages. Moreover, we design a long short-term temporal modeling mechanism for weather messenger to early fuse input adjacent video frames and learn weather-specific information. We further introduce a weather discriminator with gradient reversion, to maintain the weather-invariant common information and suppress the weather-specific information in pixel features, by adversarially predicting weather types. Finally, we develop a messenger-driven video transformer decoder to retrieve the residual weather-specific feature, which is spatiotemporally aggregated with hierarchical pixel features and refined to predict the clean target frame of input videos. Experimental results, on benchmark datasets and real-world weather videos, demonstrate that our ViWS-Net outperforms current state-of-the-art methods in terms of restoring videos degraded by any weather condition.

  • 6 authors
·
Sep 24, 2023

Dense Object Grounding in 3D Scenes

Localizing objects in 3D scenes according to the semantics of a given natural language is a fundamental yet important task in the field of multimedia understanding, which benefits various real-world applications such as robotics and autonomous driving. However, the majority of existing 3D object grounding methods are restricted to a single-sentence input describing an individual object, which cannot comprehend and reason more contextualized descriptions of multiple objects in more practical 3D cases. To this end, we introduce a new challenging task, called 3D Dense Object Grounding (3D DOG), to jointly localize multiple objects described in a more complicated paragraph rather than a single sentence. Instead of naively localizing each sentence-guided object independently, we found that dense objects described in the same paragraph are often semantically related and spatially located in a focused region of the 3D scene. To explore such semantic and spatial relationships of densely referred objects for more accurate localization, we propose a novel Stacked Transformer based framework for 3D DOG, named 3DOGSFormer. Specifically, we first devise a contextual query-driven local transformer decoder to generate initial grounding proposals for each target object. Then, we employ a proposal-guided global transformer decoder that exploits the local object features to learn their correlation for further refining initial grounding proposals. Extensive experiments on three challenging benchmarks (Nr3D, Sr3D, and ScanRefer) show that our proposed 3DOGSFormer outperforms state-of-the-art 3D single-object grounding methods and their dense-object variants by significant margins.

  • 3 authors
·
Sep 5, 2023

AIS Data-Driven Maritime Monitoring Based on Transformer: A Comprehensive Review

With the increasing demands for safety, efficiency, and sustainability in global shipping, Automatic Identification System (AIS) data plays an increasingly important role in maritime monitoring. AIS data contains spatial-temporal variation patterns of vessels that hold significant research value in the marine domain. However, due to its massive scale, the full potential of AIS data has long remained untapped. With its powerful sequence modeling capabilities, particularly its ability to capture long-range dependencies and complex temporal dynamics, the Transformer model has emerged as an effective tool for processing AIS data. Therefore, this paper reviews the research on Transformer-based AIS data-driven maritime monitoring, providing a comprehensive overview of the current applications of Transformer models in the marine field. The focus is on Transformer-based trajectory prediction methods, behavior detection, and prediction techniques. Additionally, this paper collects and organizes publicly available AIS datasets from the reviewed papers, performing data filtering, cleaning, and statistical analysis. The statistical results reveal the operational characteristics of different vessel types, providing data support for further research on maritime monitoring tasks. Finally, we offer valuable suggestions for future research, identifying two promising research directions. Datasets are available at https://github.com/eyesofworld/Maritime-Monitoring.

  • 5 authors
·
May 12, 2025

Reactive Transformer (RxT) -- Stateful Real-Time Processing for Event-Driven Reactive Language Models

The Transformer architecture has become the de facto standard for Large Language Models (LLMs), demonstrating remarkable capabilities in language understanding and generation. However, its application in conversational AI is fundamentally constrained by its stateless nature and the quadratic computational complexity (O(L^2)) with respect to sequence length L. Current models emulate memory by reprocessing an ever-expanding conversation history with each turn, leading to prohibitive costs and latency in long dialogues. This paper introduces the Reactive Transformer (RxT), a novel architecture designed to overcome these limitations by shifting from a data-driven to an event-driven paradigm. RxT processes each conversational turn as a discrete event in real-time, maintaining context in an integrated, fixed-size Short-Term Memory (STM) system. The architecture features a distinct operational cycle where a generator-decoder produces a response based on the current query and the previous memory state, after which a memory-encoder and a dedicated Memory Attention network asynchronously update the STM with a representation of the complete interaction. This design fundamentally alters the scaling dynamics, reducing the total user-facing cost of a conversation from quadratic (O(N^2 cdot T)) to linear (O(N cdot T)) with respect to the number of interactions N. By decoupling response generation from memory updates, RxT achieves low latency, enabling truly real-time, stateful, and economically viable long-form conversations. We validated our architecture with a series of proof-of-concept experiments on synthetic data, demonstrating superior performance and constant-time inference latency compared to a baseline stateless model of comparable size.

ReactiveAI Reactive AI
·
Oct 3, 2025 2

A Unified View of Attention and Residual Sinks: Outlier-Driven Rescaling is Essential for Transformer Training

We investigate the functional role of emergent outliers in large language models, specifically attention sinks (a few tokens that consistently receive large attention logits) and residual sinks (a few fixed dimensions with persistently large activations across most tokens). We hypothesize that these outliers, in conjunction with the corresponding normalizations (e.g., softmax attention and RMSNorm), effectively rescale other non-outlier components. We term this phenomenon outlier-driven rescaling and validate this hypothesis across different model architectures and training token counts. This view unifies the origin and mitigation of both sink types. Our main conclusions and observations include: (1) Outliers function jointly with normalization: removing normalization eliminates the corresponding outliers but degrades training stability and performance; directly clipping outliers while retaining normalization leads to degradation, indicating that outlier-driven rescaling contributes to training stability. (2) Outliers serve more as rescale factors rather than contributors, as the final contributions of attention and residual sinks are significantly smaller than those of non-outliers. (3) Outliers can be absorbed into learnable parameters or mitigated via explicit gated rescaling, leading to improved training performance (average gain of 2 points) and enhanced quantization robustness (1.2 points degradation under W4A4 quantization).

  • 19 authors
·
Jan 30

Short-Range Dependency Effects on Transformer Instability and a Decomposed Attention Solution

Transformer language models have driven significant progress across various fields, including natural language processing and computer vision. A central component of these models is the self-attention (SA) mechanism, which learns rich vector representations of tokens by modeling their relationships with others in a sequence. However, despite extensive research, transformers continue to suffer from training instability -- often manifesting as spikes or divergence in the training loss during a run. In this work, we identify one source of this instability: SA's limited ability to capture short-range dependencies, especially in tasks like language modeling, where almost every token heavily relies on its nearby neighbors. This limitation causes the pre-softmax logits of SA to grow rapidly, destabilizing training. To address this, we propose decomposing the SA into local (short-range) and global (long-range) attention heads. This decomposed attention, referred to as Long Short-attention (LS-attention), mitigates logit explosion and results in more stable training compared to an equivalent multi-head self-attention (MHSA). Empirical comparisons with two alternative training stabilization methods show that LS-attention reduces the validation perplexity to nearly 2/5 of that achieved by one method and reaches a similar perplexity as the other method using only 1/20 of the GPU hours. Additionally, our experiments demonstrate that LS-attention reduces inference latency by up to 36% compared to a state-of-the-art implementation of equivalent MHSA.

  • 1 authors
·
May 21, 2025

AxFormer: Accuracy-driven Approximation of Transformers for Faster, Smaller and more Accurate NLP Models

Transformers have greatly advanced the state-of-the-art in Natural Language Processing (NLP) in recent years, but present very large computation and storage requirements. We observe that the design process of Transformers (pre-train a foundation model on a large dataset in a self-supervised manner, and subsequently fine-tune it for different downstream tasks) leads to task-specific models that are highly over-parameterized, adversely impacting both accuracy and inference efficiency. We propose AxFormer, a systematic framework that applies accuracy-driven approximations to create optimized transformer models for a given downstream task. AxFormer combines two key optimizations -- accuracy-driven pruning and selective hard attention. Accuracy-driven pruning identifies and removes parts of the fine-tuned transformer that hinder performance on the given downstream task. Sparse hard-attention optimizes attention blocks in selected layers by eliminating irrelevant word aggregations, thereby helping the model focus only on the relevant parts of the input. In effect, AxFormer leads to models that are more accurate, while also being faster and smaller. Our experiments on GLUE and SQUAD tasks show that AxFormer models are up to 4.5% more accurate, while also being up to 2.5X faster and up to 3.2X smaller than conventional fine-tuned models. In addition, we demonstrate that AxFormer can be combined with previous efforts such as distillation or quantization to achieve further efficiency gains.

  • 4 authors
·
Oct 7, 2020

Beyond Uniform Query Distribution: Key-Driven Grouped Query Attention

The Transformer architecture has revolutionized deep learning through its Self-Attention mechanism, which effectively captures contextual information. However, the memory footprint of Self-Attention presents significant challenges for long-sequence tasks. Grouped Query Attention (GQA) addresses this issue by grouping queries and mean-pooling the corresponding key-value heads - reducing the number of overall parameters and memory requirements in a flexible manner without adversely compromising model accuracy. In this work, we introduce enhancements to GQA, focusing on two novel approaches that deviate from the static nature of grouping: Key-Distributed GQA (KDGQA) and Dynamic Key-Distributed GQA (DGQA), which leverage information from the norms of the key heads to inform query allocation. Specifically, KDGQA looks at the ratios of the norms of the key heads during each forward pass, while DGQA examines the ratios of the norms as they evolve through training. Additionally, we present Perturbed GQA (PGQA) as a case-study, which introduces variability in (static) group formation via subtracting noise from the attention maps. Our experiments with up-trained Vision Transformers, for Image Classification on datasets such as CIFAR-10, CIFAR-100, Food101, and Tiny ImageNet, demonstrate the promise of these variants in improving upon the original GQA through more informed and adaptive grouping mechanisms: specifically ViT-L experiences accuracy gains of up to 8% when utilizing DGQA in comparison to GQA and other variants. We further analyze the impact of the number of Key-Value Heads on performance, underscoring the importance of utilizing query-key affinities. Code is available on GitHub.

  • 5 authors
·
Aug 15, 2024

Invariant Graph Transformer

Rationale discovery is defined as finding a subset of the input data that maximally supports the prediction of downstream tasks. In graph machine learning context, graph rationale is defined to locate the critical subgraph in the given graph topology, which fundamentally determines the prediction results. In contrast to the rationale subgraph, the remaining subgraph is named the environment subgraph. Graph rationalization can enhance the model performance as the mapping between the graph rationale and prediction label is viewed as invariant, by assumption. To ensure the discriminative power of the extracted rationale subgraphs, a key technique named "intervention" is applied. The core idea of intervention is that given any changing environment subgraphs, the semantics from the rationale subgraph is invariant, which guarantees the correct prediction result. However, most, if not all, of the existing rationalization works on graph data develop their intervention strategies on the graph level, which is coarse-grained. In this paper, we propose well-tailored intervention strategies on graph data. Our idea is driven by the development of Transformer models, whose self-attention module provides rich interactions between input nodes. Based on the self-attention module, our proposed invariant graph Transformer (IGT) can achieve fine-grained, more specifically, node-level and virtual node-level intervention. Our comprehensive experiments involve 7 real-world datasets, and the proposed IGT shows significant performance advantages compared to 13 baseline methods.

  • 7 authors
·
Dec 12, 2023

A Space-Time Transformer for Precipitation Forecasting

Meteorological agencies around the world rely on real-time flood guidance to issue live-saving advisories and warnings. For decades traditional numerical weather prediction (NWP) models have been state-of-the-art for precipitation forecasting. However, physically-parameterized models suffer from a few core limitations: first, solving PDEs to resolve atmospheric dynamics is computationally demanding, and second, these methods degrade in performance at nowcasting timescales (i.e., 0-4 hour lead-times). Motivated by these shortcomings, recent work proposes AI-weather prediction (AI-WP) alternatives that learn to emulate analysis data with neural networks. While these data-driven approaches have enjoyed enormous success across diverse spatial and temporal resolutions, applications of video-understanding architectures for weather forecasting remain underexplored. To address these gaps, we propose SaTformer: a video transformer built on full space-time attention that skillfully forecasts extreme precipitation from satellite radiances. Along with our novel architecture, we introduce techniques to tame long-tailed precipitation datasets. Namely, we reformulate precipitation regression into a classification problem, and employ a class-weighted loss to address label imbalances. Our model scored first place on the NeurIPS Weather4Cast 2025 Cumulative Rainfall challenge. Code and model weights are available: https://github.com/leharris3/satformer

  • 2 authors
·
Nov 14, 2025

Hi-End-MAE: Hierarchical encoder-driven masked autoencoders are stronger vision learners for medical image segmentation

Medical image segmentation remains a formidable challenge due to the label scarcity. Pre-training Vision Transformer (ViT) through masked image modeling (MIM) on large-scale unlabeled medical datasets presents a promising solution, providing both computational efficiency and model generalization for various downstream tasks. However, current ViT-based MIM pre-training frameworks predominantly emphasize local aggregation representations in output layers and fail to exploit the rich representations across different ViT layers that better capture fine-grained semantic information needed for more precise medical downstream tasks. To fill the above gap, we hereby present Hierarchical Encoder-driven MAE (Hi-End-MAE), a simple yet effective ViT-based pre-training solution, which centers on two key innovations: (1) Encoder-driven reconstruction, which encourages the encoder to learn more informative features to guide the reconstruction of masked patches; and (2) Hierarchical dense decoding, which implements a hierarchical decoding structure to capture rich representations across different layers. We pre-train Hi-End-MAE on a large-scale dataset of 10K CT scans and evaluated its performance across seven public medical image segmentation benchmarks. Extensive experiments demonstrate that Hi-End-MAE achieves superior transfer learning capabilities across various downstream tasks, revealing the potential of ViT in medical imaging applications. The code is available at: https://github.com/FengheTan9/Hi-End-MAE

  • 6 authors
·
Feb 12, 2025

Exploring a Physics-Informed Decision Transformer for Distribution System Restoration: Methodology and Performance Analysis

Driven by advancements in sensing and computing, deep reinforcement learning (DRL)-based methods have demonstrated significant potential in effectively tackling distribution system restoration (DSR) challenges under uncertain operational scenarios. However, the data-intensive nature of DRL poses obstacles in achieving satisfactory DSR solutions for large-scale, complex distribution systems. Inspired by the transformative impact of emerging foundation models, including large language models (LLMs), across various domains, this paper explores an innovative approach harnessing LLMs' powerful computing capabilities to address scalability challenges inherent in conventional DRL methods for solving DSR. To our knowledge, this study represents the first exploration of foundation models, including LLMs, in revolutionizing conventional DRL applications in power system operations. Our contributions are twofold: 1) introducing a novel LLM-powered Physics-Informed Decision Transformer (PIDT) framework that leverages LLMs to transform conventional DRL methods for DSR operations, and 2) conducting comparative studies to assess the performance of the proposed LLM-powered PIDT framework at its initial development stage for solving DSR problems. While our primary focus in this paper is on DSR operations, the proposed PIDT framework can be generalized to optimize sequential decision-making across various power system operations.

  • 4 authors
·
Jun 30, 2024

Regression Transformer: Concurrent sequence regression and generation for molecular language modeling

Despite significant progress of generative models in the natural sciences, their controllability remains challenging. One fundamentally missing aspect of molecular or protein generative models is an inductive bias that can reflect continuous properties of interest. To that end, we propose the Regression Transformer (RT), a novel method that abstracts regression as a conditional sequence modeling problem. This introduces a new paradigm of multitask language models which seamlessly bridge sequence regression and conditional sequence generation. We thoroughly demonstrate that, despite using a nominal-scale training objective, the RT matches or surpasses the performance of conventional regression models in property prediction tasks of small molecules, proteins and chemical reactions. Critically, priming the same model with continuous properties yields a highly competitive conditional generative model that outperforms specialized approaches in a substructure-constrained, property-driven molecule generation benchmark. Our dichotomous approach is facilitated by a novel, alternating training scheme that enables the model to decorate seed sequences by desired properties, e.g., to optimize reaction yield. In sum, the RT is the first report of a multitask model that concurrently excels at predictive and generative tasks in biochemistry. This finds particular application in property-driven, local exploration of the chemical or protein space and could pave the road toward foundation models in material design. The code to reproduce all experiments of the paper is available at: https://github.com/IBM/regression-transformer

  • 2 authors
·
Feb 1, 2022

OmniTalker: Real-Time Text-Driven Talking Head Generation with In-Context Audio-Visual Style Replication

Recent years have witnessed remarkable advances in talking head generation, owing to its potential to revolutionize the human-AI interaction from text interfaces into realistic video chats. However, research on text-driven talking heads remains underexplored, with existing methods predominantly adopting a cascaded pipeline that combines TTS systems with audio-driven talking head models. This conventional pipeline not only introduces system complexity and latency overhead but also fundamentally suffers from asynchronous audiovisual output and stylistic discrepancies between generated speech and visual expressions. To address these limitations, we introduce OmniTalker, an end-to-end unified framework that simultaneously generates synchronized speech and talking head videos from text and reference video in real-time zero-shot scenarios, while preserving both speech style and facial styles. The framework employs a dual-branch diffusion transformer architecture: the audio branch synthesizes mel-spectrograms from text, while the visual branch predicts fine-grained head poses and facial dynamics. To bridge modalities, we introduce a novel audio-visual fusion module that integrates cross-modal information to ensure temporal synchronization and stylistic coherence between audio and visual outputs. Furthermore, our in-context reference learning module effectively captures both speech and facial style characteristics from a single reference video without introducing an extra style extracting module. To the best of our knowledge, OmniTalker presents the first unified framework that jointly models speech style and facial style in a zero-shot setting, achieving real-time inference speed of 25 FPS. Extensive experiments demonstrate that our method surpasses existing approaches in generation quality, particularly excelling in style preservation and audio-video synchronization.

  • 6 authors
·
Apr 3, 2025 1

OmniVCus: Feedforward Subject-driven Video Customization with Multimodal Control Conditions

Existing feedforward subject-driven video customization methods mainly study single-subject scenarios due to the difficulty of constructing multi-subject training data pairs. Another challenging problem that how to use the signals such as depth, mask, camera, and text prompts to control and edit the subject in the customized video is still less explored. In this paper, we first propose a data construction pipeline, VideoCus-Factory, to produce training data pairs for multi-subject customization from raw videos without labels and control signals such as depth-to-video and mask-to-video pairs. Based on our constructed data, we develop an Image-Video Transfer Mixed (IVTM) training with image editing data to enable instructive editing for the subject in the customized video. Then we propose a diffusion Transformer framework, OmniVCus, with two embedding mechanisms, Lottery Embedding (LE) and Temporally Aligned Embedding (TAE). LE enables inference with more subjects by using the training subjects to activate more frame embeddings. TAE encourages the generation process to extract guidance from temporally aligned control signals by assigning the same frame embeddings to the control and noise tokens. Experiments demonstrate that our method significantly surpasses state-of-the-art methods in both quantitative and qualitative evaluations. Video demos are at our project page: https://caiyuanhao1998.github.io/project/OmniVCus/. Our code will be released at https://github.com/caiyuanhao1998/Open-OmniVCus

  • 14 authors
·
Jun 29, 2025

Scaling transformer neural networks for skillful and reliable medium-range weather forecasting

Weather forecasting is a fundamental problem for anticipating and mitigating the impacts of climate change. Recently, data-driven approaches for weather forecasting based on deep learning have shown great promise, achieving accuracies that are competitive with operational systems. However, those methods often employ complex, customized architectures without sufficient ablation analysis, making it difficult to understand what truly contributes to their success. Here we introduce Stormer, a simple transformer model that achieves state-of-the-art performance on weather forecasting with minimal changes to the standard transformer backbone. We identify the key components of Stormer through careful empirical analyses, including weather-specific embedding, randomized dynamics forecast, and pressure-weighted loss. At the core of Stormer is a randomized forecasting objective that trains the model to forecast the weather dynamics over varying time intervals. During inference, this allows us to produce multiple forecasts for a target lead time and combine them to obtain better forecast accuracy. On WeatherBench 2, Stormer performs competitively at short to medium-range forecasts and outperforms current methods beyond 7 days, while requiring orders-of-magnitude less training data and compute. Additionally, we demonstrate Stormer's favorable scaling properties, showing consistent improvements in forecast accuracy with increases in model size and training tokens. Code and checkpoints are available at https://github.com/tung-nd/stormer.

  • 9 authors
·
Dec 6, 2023

DBConformer: Dual-Branch Convolutional Transformer for EEG Decoding

Electroencephalography (EEG)-based brain-computer interfaces (BCIs) transform spontaneous/evoked neural activity into control commands for external communication. While convolutional neural networks (CNNs) remain the mainstream backbone for EEG decoding, their inherently short receptive field makes it difficult to capture long-range temporal dependencies and global inter-channel relationships. Recent CNN-Transformer (Conformers) hybrids partially address this issue, but most adopt a serial design, resulting in suboptimal integration of local and global features, and often overlook explicit channel-wise modeling. To address these limitations, we propose DBConformer, a dual-branch convolutional Transformer network tailored for EEG decoding. It integrates a temporal Conformer to model long-range temporal dependencies and a spatial Conformer to extract inter-channel interactions, capturing both temporal dynamics and spatial patterns in EEG signals. A lightweight channel attention module further refines spatial representations by assigning data-driven importance to EEG channels. Extensive experiments on five motor imagery (MI) datasets and two seizure detection datasets under three evaluation settings demonstrate that DBConformer consistently outperforms 10 competitive baseline models, with over eight times fewer parameters than the high-capacity EEG Conformer baseline. Further, the visualization results confirm that the features extracted by DBConformer are physiologically interpretable and aligned with sensorimotor priors in MI. The superior performance and interpretability of DBConformer make it reliable for robust and explainable EEG decoding. Code is publicized at https://github.com/wzwvv/DBConformer.

  • 6 authors
·
Jun 26, 2025

Free-Editor: Zero-shot Text-driven 3D Scene Editing

Text-to-Image (T2I) diffusion models have recently gained traction for their versatility and user-friendliness in 2D content generation and editing. However, training a diffusion model specifically for 3D scene editing is challenging due to the scarcity of large-scale datasets. Currently, editing 3D scenes necessitates either retraining the model to accommodate various 3D edits or developing specific methods tailored to each unique editing type. Moreover, state-of-the-art (SOTA) techniques require multiple synchronized edited images from the same scene to enable effective scene editing. Given the current limitations of T2I models, achieving consistent editing effects across multiple images remains difficult, leading to multi-view inconsistency in editing. This inconsistency undermines the performance of 3D scene editing when these images are utilized. In this study, we introduce a novel, training-free 3D scene editing technique called Free-Editor, which enables users to edit 3D scenes without the need for model retraining during the testing phase. Our method effectively addresses the issue of multi-view style inconsistency found in state-of-the-art (SOTA) methods through the implementation of a single-view editing scheme. Specifically, we demonstrate that editing a particular 3D scene can be achieved by modifying only a single view. To facilitate this, we present an Edit Transformer that ensures intra-view consistency and inter-view style transfer using self-view and cross-view attention mechanisms, respectively. By eliminating the need for model retraining and multi-view editing, our approach significantly reduces editing time and memory resource requirements, achieving runtimes approximately 20 times faster than SOTA methods. We have performed extensive experiments on various benchmark datasets, showcasing the diverse editing capabilities of our proposed technique.

  • 5 authors
·
Dec 21, 2023

TM2D: Bimodality Driven 3D Dance Generation via Music-Text Integration

We propose a novel task for generating 3D dance movements that simultaneously incorporate both text and music modalities. Unlike existing works that generate dance movements using a single modality such as music, our goal is to produce richer dance movements guided by the instructive information provided by the text. However, the lack of paired motion data with both music and text modalities limits the ability to generate dance movements that integrate both. To alleviate this challenge, we propose to utilize a 3D human motion VQ-VAE to project the motions of the two datasets into a latent space consisting of quantized vectors, which effectively mix the motion tokens from the two datasets with different distributions for training. Additionally, we propose a cross-modal transformer to integrate text instructions into motion generation architecture for generating 3D dance movements without degrading the performance of music-conditioned dance generation. To better evaluate the quality of the generated motion, we introduce two novel metrics, namely Motion Prediction Distance (MPD) and Freezing Score, to measure the coherence and freezing percentage of the generated motion. Extensive experiments show that our approach can generate realistic and coherent dance movements conditioned on both text and music while maintaining comparable performance with the two single modalities. Code will be available at: https://garfield-kh.github.io/TM2D/.

  • 7 authors
·
Apr 5, 2023

UniFormer: Unified Transformer for Efficient Spatiotemporal Representation Learning

It is a challenging task to learn rich and multi-scale spatiotemporal semantics from high-dimensional videos, due to large local redundancy and complex global dependency between video frames. The recent advances in this research have been mainly driven by 3D convolutional neural networks and vision transformers. Although 3D convolution can efficiently aggregate local context to suppress local redundancy from a small 3D neighborhood, it lacks the capability to capture global dependency because of the limited receptive field. Alternatively, vision transformers can effectively capture long-range dependency by self-attention mechanism, while having the limitation on reducing local redundancy with blind similarity comparison among all the tokens in each layer. Based on these observations, we propose a novel Unified transFormer (UniFormer) which seamlessly integrates merits of 3D convolution and spatiotemporal self-attention in a concise transformer format, and achieves a preferable balance between computation and accuracy. Different from traditional transformers, our relation aggregator can tackle both spatiotemporal redundancy and dependency, by learning local and global token affinity respectively in shallow and deep layers. We conduct extensive experiments on the popular video benchmarks, e.g., Kinetics-400, Kinetics-600, and Something-Something V1&V2. With only ImageNet-1K pretraining, our UniFormer achieves 82.9%/84.8% top-1 accuracy on Kinetics-400/Kinetics-600, while requiring 10x fewer GFLOPs than other state-of-the-art methods. For Something-Something V1 and V2, our UniFormer achieves new state-of-the-art performances of 60.9% and 71.2% top-1 accuracy respectively. Code is available at https://github.com/Sense-X/UniFormer.

  • 7 authors
·
Jan 12, 2022

StableAvatar: Infinite-Length Audio-Driven Avatar Video Generation

Current diffusion models for audio-driven avatar video generation struggle to synthesize long videos with natural audio synchronization and identity consistency. This paper presents StableAvatar, the first end-to-end video diffusion transformer that synthesizes infinite-length high-quality videos without post-processing. Conditioned on a reference image and audio, StableAvatar integrates tailored training and inference modules to enable infinite-length video generation. We observe that the main reason preventing existing models from generating long videos lies in their audio modeling. They typically rely on third-party off-the-shelf extractors to obtain audio embeddings, which are then directly injected into the diffusion model via cross-attention. Since current diffusion backbones lack any audio-related priors, this approach causes severe latent distribution error accumulation across video clips, leading the latent distribution of subsequent segments to drift away from the optimal distribution gradually. To address this, StableAvatar introduces a novel Time-step-aware Audio Adapter that prevents error accumulation via time-step-aware modulation. During inference, we propose a novel Audio Native Guidance Mechanism to further enhance the audio synchronization by leveraging the diffusion's own evolving joint audio-latent prediction as a dynamic guidance signal. To enhance the smoothness of the infinite-length videos, we introduce a Dynamic Weighted Sliding-window Strategy that fuses latent over time. Experiments on benchmarks show the effectiveness of StableAvatar both qualitatively and quantitatively.

  • 9 authors
·
Aug 11, 2025 2

Neural-Driven Image Editing

Traditional image editing typically relies on manual prompting, making it labor-intensive and inaccessible to individuals with limited motor control or language abilities. Leveraging recent advances in brain-computer interfaces (BCIs) and generative models, we propose LoongX, a hands-free image editing approach driven by multimodal neurophysiological signals. LoongX utilizes state-of-the-art diffusion models trained on a comprehensive dataset of 23,928 image editing pairs, each paired with synchronized electroencephalography (EEG), functional near-infrared spectroscopy (fNIRS), photoplethysmography (PPG), and head motion signals that capture user intent. To effectively address the heterogeneity of these signals, LoongX integrates two key modules. The cross-scale state space (CS3) module encodes informative modality-specific features. The dynamic gated fusion (DGF) module further aggregates these features into a unified latent space, which is then aligned with edit semantics via fine-tuning on a diffusion transformer (DiT). Additionally, we pre-train the encoders using contrastive learning to align cognitive states with semantic intentions from embedded natural language. Extensive experiments demonstrate that LoongX achieves performance comparable to text-driven methods (CLIP-I: 0.6605 vs. 0.6558; DINO: 0.4812 vs. 0.4636) and outperforms them when neural signals are combined with speech (CLIP-T: 0.2588 vs. 0.2549). These results highlight the promise of neural-driven generative models in enabling accessible, intuitive image editing and open new directions for cognitive-driven creative technologies. Datasets and code will be released to support future work and foster progress in this emerging area.

  • 17 authors
·
Jul 7, 2025 1

RealTalk: Real-time and Realistic Audio-driven Face Generation with 3D Facial Prior-guided Identity Alignment Network

Person-generic audio-driven face generation is a challenging task in computer vision. Previous methods have achieved remarkable progress in audio-visual synchronization, but there is still a significant gap between current results and practical applications. The challenges are two-fold: 1) Preserving unique individual traits for achieving high-precision lip synchronization. 2) Generating high-quality facial renderings in real-time performance. In this paper, we propose a novel generalized audio-driven framework RealTalk, which consists of an audio-to-expression transformer and a high-fidelity expression-to-face renderer. In the first component, we consider both identity and intra-personal variation features related to speaking lip movements. By incorporating cross-modal attention on the enriched facial priors, we can effectively align lip movements with audio, thus attaining greater precision in expression prediction. In the second component, we design a lightweight facial identity alignment (FIA) module which includes a lip-shape control structure and a face texture reference structure. This novel design allows us to generate fine details in real-time, without depending on sophisticated and inefficient feature alignment modules. Our experimental results, both quantitative and qualitative, on public datasets demonstrate the clear advantages of our method in terms of lip-speech synchronization and generation quality. Furthermore, our method is efficient and requires fewer computational resources, making it well-suited to meet the needs of practical applications.

  • 10 authors
·
Jun 26, 2024 2

CustomVideoX: 3D Reference Attention Driven Dynamic Adaptation for Zero-Shot Customized Video Diffusion Transformers

Customized generation has achieved significant progress in image synthesis, yet personalized video generation remains challenging due to temporal inconsistencies and quality degradation. In this paper, we introduce CustomVideoX, an innovative framework leveraging the video diffusion transformer for personalized video generation from a reference image. CustomVideoX capitalizes on pre-trained video networks by exclusively training the LoRA parameters to extract reference features, ensuring both efficiency and adaptability. To facilitate seamless interaction between the reference image and video content, we propose 3D Reference Attention, which enables direct and simultaneous engagement of reference image features with all video frames across spatial and temporal dimensions. To mitigate the excessive influence of reference image features and textual guidance on generated video content during inference, we implement the Time-Aware Reference Attention Bias (TAB) strategy, dynamically modulating reference bias over different time steps. Additionally, we introduce the Entity Region-Aware Enhancement (ERAE) module, aligning highly activated regions of key entity tokens with reference feature injection by adjusting attention bias. To thoroughly evaluate personalized video generation, we establish a new benchmark, VideoBench, comprising over 50 objects and 100 prompts for extensive assessment. Experimental results show that CustomVideoX significantly outperforms existing methods in terms of video consistency and quality.

  • 12 authors
·
Feb 10, 2025 2

VFX Creator: Animated Visual Effect Generation with Controllable Diffusion Transformer

Crafting magic and illusions is one of the most thrilling aspects of filmmaking, with visual effects (VFX) serving as the powerhouse behind unforgettable cinematic experiences. While recent advances in generative artificial intelligence have driven progress in generic image and video synthesis, the domain of controllable VFX generation remains relatively underexplored. In this work, we propose a novel paradigm for animated VFX generation as image animation, where dynamic effects are generated from user-friendly textual descriptions and static reference images. Our work makes two primary contributions: (i) Open-VFX, the first high-quality VFX video dataset spanning 15 diverse effect categories, annotated with textual descriptions, instance segmentation masks for spatial conditioning, and start-end timestamps for temporal control. (ii) VFX Creator, a simple yet effective controllable VFX generation framework based on a Video Diffusion Transformer. The model incorporates a spatial and temporal controllable LoRA adapter, requiring minimal training videos. Specifically, a plug-and-play mask control module enables instance-level spatial manipulation, while tokenized start-end motion timestamps embedded in the diffusion process, alongside the text encoder, allow precise temporal control over effect timing and pace. Extensive experiments on the Open-VFX test set demonstrate the superiority of the proposed system in generating realistic and dynamic effects, achieving state-of-the-art performance and generalization ability in both spatial and temporal controllability. Furthermore, we introduce a specialized metric to evaluate the precision of temporal control. By bridging traditional VFX techniques with generative approaches, VFX Creator unlocks new possibilities for efficient and high-quality video effect generation, making advanced VFX accessible to a broader audience.

  • 7 authors
·
Feb 9, 2025 2

The devil is in the details: Enhancing Video Virtual Try-On via Keyframe-Driven Details Injection

Although diffusion transformer (DiT)-based video virtual try-on (VVT) has made significant progress in synthesizing realistic videos, existing methods still struggle to capture fine-grained garment dynamics and preserve background integrity across video frames. They also incur high computational costs due to additional interaction modules introduced into DiTs, while the limited scale and quality of existing public datasets also restrict model generalization and effective training. To address these challenges, we propose a novel framework, KeyTailor, along with a large-scale, high-definition dataset, ViT-HD. The core idea of KeyTailor is a keyframe-driven details injection strategy, motivated by the fact that keyframes inherently contain both foreground dynamics and background consistency. Specifically, KeyTailor adopts an instruction-guided keyframe sampling strategy to filter informative frames from the input video. Subsequently,two tailored keyframe-driven modules, the garment details enhancement module and the collaborative background optimization module, are employed to distill garment dynamics into garment-related latents and to optimize the integrity of background latents, both guided by keyframes.These enriched details are then injected into standard DiT blocks together with pose, mask, and noise latents, enabling efficient and realistic try-on video synthesis. This design ensures consistency without explicitly modifying the DiT architecture, while simultaneously avoiding additional complexity. In addition, our dataset ViT-HD comprises 15, 070 high-quality video samples at a resolution of 810*1080, covering diverse garments. Extensive experiments demonstrate that KeyTailor outperforms state-of-the-art baselines in terms of garment fidelity and background integrity across both dynamic and static scenarios.

  • 10 authors
·
Dec 23, 2025

CADmium: Fine-Tuning Code Language Models for Text-Driven Sequential CAD Design

Computer-aided design (CAD) is the digital construction of 2D and 3D objects, and is central to a wide range of engineering and manufacturing applications like automobile and aviation. Despite its importance, CAD modeling remains largely a time-intensive, manual task. Recent works have attempted to automate this process with small transformer-based models and handcrafted CAD sequence representations. However, there has been little effort to leverage the potential of large language models (LLMs) for sequential CAD design. In this work, we introduce a new large-scale dataset of more than 170k CAD models annotated with high-quality, human-like descriptions generated with our pipeline based on GPT-4.1. Using this dataset, we fine-tune powerful code-LLMs to generate CAD sequences represented in a JSON-based format from natural language descriptions, demonstrating the viability and effectiveness of this approach for text-conditioned CAD generation. Because simple metrics often fail to reflect the quality of generated objects, we introduce geometric and topological metrics based on sphericity, mean curvature, and Euler characteristic to provide richer structural insights. Our experiments and ablation studies on both synthetic and human-annotated data demonstrate that CADmium is able to automate CAD design, drastically speeding up the design of new objects. The dataset, code, and fine-tuned models are available online.

  • 5 authors
·
Jul 13, 2025

Text2Human: Text-Driven Controllable Human Image Generation

Generating high-quality and diverse human images is an important yet challenging task in vision and graphics. However, existing generative models often fall short under the high diversity of clothing shapes and textures. Furthermore, the generation process is even desired to be intuitively controllable for layman users. In this work, we present a text-driven controllable framework, Text2Human, for a high-quality and diverse human generation. We synthesize full-body human images starting from a given human pose with two dedicated steps. 1) With some texts describing the shapes of clothes, the given human pose is first translated to a human parsing map. 2) The final human image is then generated by providing the system with more attributes about the textures of clothes. Specifically, to model the diversity of clothing textures, we build a hierarchical texture-aware codebook that stores multi-scale neural representations for each type of texture. The codebook at the coarse level includes the structural representations of textures, while the codebook at the fine level focuses on the details of textures. To make use of the learned hierarchical codebook to synthesize desired images, a diffusion-based transformer sampler with mixture of experts is firstly employed to sample indices from the coarsest level of the codebook, which then is used to predict the indices of the codebook at finer levels. The predicted indices at different levels are translated to human images by the decoder learned accompanied with hierarchical codebooks. The use of mixture-of-experts allows for the generated image conditioned on the fine-grained text input. The prediction for finer level indices refines the quality of clothing textures. Extensive quantitative and qualitative evaluations demonstrate that our proposed framework can generate more diverse and realistic human images compared to state-of-the-art methods.

  • 6 authors
·
May 31, 2022

Self-Supervised Graph Transformer on Large-Scale Molecular Data

How to obtain informative representations of molecules is a crucial prerequisite in AI-driven drug design and discovery. Recent researches abstract molecules as graphs and employ Graph Neural Networks (GNNs) for molecular representation learning. Nevertheless, two issues impede the usage of GNNs in real scenarios: (1) insufficient labeled molecules for supervised training; (2) poor generalization capability to new-synthesized molecules. To address them both, we propose a novel framework, GROVER, which stands for Graph Representation frOm self-superVised mEssage passing tRansformer. With carefully designed self-supervised tasks in node-, edge- and graph-level, GROVER can learn rich structural and semantic information of molecules from enormous unlabelled molecular data. Rather, to encode such complex information, GROVER integrates Message Passing Networks into the Transformer-style architecture to deliver a class of more expressive encoders of molecules. The flexibility of GROVER allows it to be trained efficiently on large-scale molecular dataset without requiring any supervision, thus being immunized to the two issues mentioned above. We pre-train GROVER with 100 million parameters on 10 million unlabelled molecules -- the biggest GNN and the largest training dataset in molecular representation learning. We then leverage the pre-trained GROVER for molecular property prediction followed by task-specific fine-tuning, where we observe a huge improvement (more than 6% on average) from current state-of-the-art methods on 11 challenging benchmarks. The insights we gained are that well-designed self-supervision losses and largely-expressive pre-trained models enjoy the significant potential on performance boosting.

  • 7 authors
·
Jun 18, 2020

Teller: Real-Time Streaming Audio-Driven Portrait Animation with Autoregressive Motion Generation

In this work, we introduce the first autoregressive framework for real-time, audio-driven portrait animation, a.k.a, talking head. Beyond the challenge of lengthy animation times, a critical challenge in realistic talking head generation lies in preserving the natural movement of diverse body parts. To this end, we propose Teller, the first streaming audio-driven protrait animation framework with autoregressive motion generation. Specifically, Teller first decomposes facial and body detail animation into two components: Facial Motion Latent Generation (FMLG) based on an autoregressive transfromer, and movement authenticity refinement using a Efficient Temporal Module (ETM).Concretely, FMLG employs a Residual VQ model to map the facial motion latent from the implicit keypoint-based model into discrete motion tokens, which are then temporally sliced with audio embeddings. This enables the AR tranformer to learn real-time, stream-based mappings from audio to motion. Furthermore, Teller incorporate ETM to capture finer motion details. This module ensures the physical consistency of body parts and accessories, such as neck muscles and earrings, improving the realism of these movements. Teller is designed to be efficient, surpassing the inference speed of diffusion-based models (Hallo 20.93s vs. Teller 0.92s for one second video generation), and achieves a real-time streaming performance of up to 25 FPS. Extensive experiments demonstrate that our method outperforms recent audio-driven portrait animation models, especially in small movements, as validated by human evaluations with a significant margin in quality and realism.

  • 8 authors
·
Mar 24, 2025

CreatiDesign: A Unified Multi-Conditional Diffusion Transformer for Creative Graphic Design

Graphic design plays a vital role in visual communication across advertising, marketing, and multimedia entertainment. Prior work has explored automated graphic design generation using diffusion models, aiming to streamline creative workflows and democratize design capabilities. However, complex graphic design scenarios require accurately adhering to design intent specified by multiple heterogeneous user-provided elements (\eg images, layouts, and texts), which pose multi-condition control challenges for existing methods. Specifically, previous single-condition control models demonstrate effectiveness only within their specialized domains but fail to generalize to other conditions, while existing multi-condition methods often lack fine-grained control over each sub-condition and compromise overall compositional harmony. To address these limitations, we introduce CreatiDesign, a systematic solution for automated graphic design covering both model architecture and dataset construction. First, we design a unified multi-condition driven architecture that enables flexible and precise integration of heterogeneous design elements with minimal architectural modifications to the base diffusion model. Furthermore, to ensure that each condition precisely controls its designated image region and to avoid interference between conditions, we propose a multimodal attention mask mechanism. Additionally, we develop a fully automated pipeline for constructing graphic design datasets, and introduce a new dataset with 400K samples featuring multi-condition annotations, along with a comprehensive benchmark. Experimental results show that CreatiDesign outperforms existing models by a clear margin in faithfully adhering to user intent.

  • 9 authors
·
May 25, 2025

MEG-GPT: A transformer-based foundation model for magnetoencephalography data

Modelling the complex spatiotemporal patterns of large-scale brain dynamics is crucial for neuroscience, but traditional methods fail to capture the rich structure in modalities such as magnetoencephalography (MEG). Recent advances in deep learning have enabled significant progress in other domains, such as language and vision, by using foundation models at scale. Here, we introduce MEG-GPT, a transformer based foundation model that uses time-attention and next time-point prediction. To facilitate this, we also introduce a novel data-driven tokeniser for continuous MEG data, which preserves the high temporal resolution of continuous MEG signals without lossy transformations. We trained MEG-GPT on tokenised brain region time-courses extracted from a large-scale MEG dataset (N=612, eyes-closed rest, Cam-CAN data), and show that the learnt model can generate data with realistic spatio-spectral properties, including transient events and population variability. Critically, it performs well in downstream decoding tasks, improving downstream supervised prediction task, showing improved zero-shot generalisation across sessions (improving accuracy from 0.54 to 0.59) and subjects (improving accuracy from 0.41 to 0.49) compared to a baseline methods. Furthermore, we show the model can be efficiently fine-tuned on a smaller labelled dataset to boost performance in cross-subject decoding scenarios. This work establishes a powerful foundation model for electrophysiological data, paving the way for applications in computational neuroscience and neural decoding.

  • 5 authors
·
Oct 20, 2025

CRA5: Extreme Compression of ERA5 for Portable Global Climate and Weather Research via an Efficient Variational Transformer

The advent of data-driven weather forecasting models, which learn from hundreds of terabytes (TB) of reanalysis data, has significantly advanced forecasting capabilities. However, the substantial costs associated with data storage and transmission present a major challenge for data providers and users, affecting resource-constrained researchers and limiting their accessibility to participate in AI-based meteorological research. To mitigate this issue, we introduce an efficient neural codec, the Variational Autoencoder Transformer (VAEformer), for extreme compression of climate data to significantly reduce data storage cost, making AI-based meteorological research portable to researchers. Our approach diverges from recent complex neural codecs by utilizing a low-complexity Auto-Encoder transformer. This encoder produces a quantized latent representation through variance inference, which reparameterizes the latent space as a Gaussian distribution. This method improves the estimation of distributions for cross-entropy coding. Extensive experiments demonstrate that our VAEformer outperforms existing state-of-the-art compression methods in the context of climate data. By applying our VAEformer, we compressed the most popular ERA5 climate dataset (226 TB) into a new dataset, CRA5 (0.7 TB). This translates to a compression ratio of over 300 while retaining the dataset's utility for accurate scientific analysis. Further, downstream experiments show that global weather forecasting models trained on the compact CRA5 dataset achieve forecasting accuracy comparable to the model trained on the original dataset. Code, the CRA5 dataset, and the pre-trained model are available at https://github.com/taohan10200/CRA5.

  • 5 authors
·
May 6, 2024

YingVideo-MV: Music-Driven Multi-Stage Video Generation

While diffusion model for audio-driven avatar video generation have achieved notable process in synthesizing long sequences with natural audio-visual synchronization and identity consistency, the generation of music-performance videos with camera motions remains largely unexplored. We present YingVideo-MV, the first cascaded framework for music-driven long-video generation. Our approach integrates audio semantic analysis, an interpretable shot planning module (MV-Director), temporal-aware diffusion Transformer architectures, and long-sequence consistency modeling to enable automatic synthesis of high-quality music performance videos from audio signals. We construct a large-scale Music-in-the-Wild Dataset by collecting web data to support the achievement of diverse, high-quality results. Observing that existing long-video generation methods lack explicit camera motion control, we introduce a camera adapter module that embeds camera poses into latent noise. To enhance continulity between clips during long-sequence inference, we further propose a time-aware dynamic window range strategy that adaptively adjust denoising ranges based on audio embedding. Comprehensive benchmark tests demonstrate that YingVideo-MV achieves outstanding performance in generating coherent and expressive music videos, and enables precise music-motion-camera synchronization. More videos are available in our project page: https://giantailab.github.io/YingVideo-MV/ .

  • 6 authors
·
Dec 2, 2025 2

HunyuanVideo-Avatar: High-Fidelity Audio-Driven Human Animation for Multiple Characters

Recent years have witnessed significant progress in audio-driven human animation. However, critical challenges remain in (i) generating highly dynamic videos while preserving character consistency, (ii) achieving precise emotion alignment between characters and audio, and (iii) enabling multi-character audio-driven animation. To address these challenges, we propose HunyuanVideo-Avatar, a multimodal diffusion transformer (MM-DiT)-based model capable of simultaneously generating dynamic, emotion-controllable, and multi-character dialogue videos. Concretely, HunyuanVideo-Avatar introduces three key innovations: (i) A character image injection module is designed to replace the conventional addition-based character conditioning scheme, eliminating the inherent condition mismatch between training and inference. This ensures the dynamic motion and strong character consistency; (ii) An Audio Emotion Module (AEM) is introduced to extract and transfer the emotional cues from an emotion reference image to the target generated video, enabling fine-grained and accurate emotion style control; (iii) A Face-Aware Audio Adapter (FAA) is proposed to isolate the audio-driven character with latent-level face mask, enabling independent audio injection via cross-attention for multi-character scenarios. These innovations empower HunyuanVideo-Avatar to surpass state-of-the-art methods on benchmark datasets and a newly proposed wild dataset, generating realistic avatars in dynamic, immersive scenarios.

  • 9 authors
·
May 26, 2025 1

EgoReAct: Egocentric Video-Driven 3D Human Reaction Generation

Humans exhibit adaptive, context-sensitive responses to egocentric visual input. However, faithfully modeling such reactions from egocentric video remains challenging due to the dual requirements of strictly causal generation and precise 3D spatial alignment. To tackle this problem, we first construct the Human Reaction Dataset (HRD) to address data scarcity and misalignment by building a spatially aligned egocentric video-reaction dataset, as existing datasets (e.g., ViMo) suffer from significant spatial inconsistency between the egocentric video and reaction motion, e.g., dynamically moving motions are always paired with fixed-camera videos. Leveraging HRD, we present EgoReAct, the first autoregressive framework that generates 3D-aligned human reaction motions from egocentric video streams in real-time. We first compress the reaction motion into a compact yet expressive latent space via a Vector Quantised-Variational AutoEncoder and then train a Generative Pre-trained Transformer for reaction generation from the visual input. EgoReAct incorporates 3D dynamic features, i.e., metric depth, and head dynamics during the generation, which effectively enhance spatial grounding. Extensive experiments demonstrate that EgoReAct achieves remarkably higher realism, spatial consistency, and generation efficiency compared with prior methods, while maintaining strict causality during generation. We will release code, models, and data upon acceptance.

  • 13 authors
·
Dec 28, 2025

SWiT-4D: Sliding-Window Transformer for Lossless and Parameter-Free Temporal 4D Generation

Despite significant progress in 4D content generation, the conversion of monocular videos into high-quality animated 3D assets with explicit 4D meshes remains considerably challenging. The scarcity of large-scale, naturally captured 4D mesh datasets further limits the ability to train generalizable video-to-4D models from scratch in a purely data-driven manner. Meanwhile, advances in image-to-3D generation, supported by extensive datasets, offer powerful prior models that can be leveraged. To better utilize these priors while minimizing reliance on 4D supervision, we introduce SWiT-4D, a Sliding-Window Transformer for lossless, parameter-free temporal 4D mesh generation. SWiT-4D integrates seamlessly with any Diffusion Transformer (DiT)-based image-to-3D generator, adding spatial-temporal modeling across video frames while preserving the original single-image forward process, enabling 4D mesh reconstruction from videos of arbitrary length. To recover global translation, we further introduce an optimization-based trajectory module tailored for static-camera monocular videos. SWiT-4D demonstrates strong data efficiency: with only a single short (<10s) video for fine-tuning, it achieves high-fidelity geometry and stable temporal consistency, indicating practical deployability under extremely limited 4D supervision. Comprehensive experiments on both in-domain zoo-test sets and challenging out-of-domain benchmarks (C4D, Objaverse, and in-the-wild videos) show that SWiT-4D consistently outperforms existing baselines in temporal smoothness. Project page: https://animotionlab.github.io/SWIT4D/

  • 12 authors
·
Dec 11, 2025

SplatFormer: Point Transformer for Robust 3D Gaussian Splatting

3D Gaussian Splatting (3DGS) has recently transformed photorealistic reconstruction, achieving high visual fidelity and real-time performance. However, rendering quality significantly deteriorates when test views deviate from the camera angles used during training, posing a major challenge for applications in immersive free-viewpoint rendering and navigation. In this work, we conduct a comprehensive evaluation of 3DGS and related novel view synthesis methods under out-of-distribution (OOD) test camera scenarios. By creating diverse test cases with synthetic and real-world datasets, we demonstrate that most existing methods, including those incorporating various regularization techniques and data-driven priors, struggle to generalize effectively to OOD views. To address this limitation, we introduce SplatFormer, the first point transformer model specifically designed to operate on Gaussian splats. SplatFormer takes as input an initial 3DGS set optimized under limited training views and refines it in a single forward pass, effectively removing potential artifacts in OOD test views. To our knowledge, this is the first successful application of point transformers directly on 3DGS sets, surpassing the limitations of previous multi-scene training methods, which could handle only a restricted number of input views during inference. Our model significantly improves rendering quality under extreme novel views, achieving state-of-the-art performance in these challenging scenarios and outperforming various 3DGS regularization techniques, multi-scene models tailored for sparse view synthesis, and diffusion-based frameworks.

  • 6 authors
·
Nov 10, 2024

BiPFT: Binary Pre-trained Foundation Transformer with Low-rank Estimation of Binarization Residual Polynomials

Pretrained foundation models offer substantial benefits for a wide range of downstream tasks, which can be one of the most potential techniques to access artificial general intelligence. However, scaling up foundation transformers for maximal task-agnostic knowledge has brought about computational challenges, especially on resource-limited devices such as mobiles. This work proposes the first Binary Pretrained Foundation Transformer (BiPFT) for natural language understanding (NLU) tasks, which remarkably saves 56 times operations and 28 times memory. In contrast to previous task-specific binary transformers, BiPFT exhibits a substantial enhancement in the learning capabilities of binary neural networks (BNNs), promoting BNNs into the era of pre-training. Benefiting from extensive pretraining data, we further propose a data-driven binarization method. Specifically, we first analyze the binarization error in self-attention operations and derive the polynomials of binarization error. To simulate full-precision self-attention, we define binarization error as binarization residual polynomials, and then introduce low-rank estimators to model these polynomials. Extensive experiments validate the effectiveness of BiPFTs, surpassing task-specific baseline by 15.4% average performance on the GLUE benchmark. BiPFT also demonstrates improved robustness to hyperparameter changes, improved optimization efficiency, and reduced reliance on downstream distillation, which consequently generalize on various NLU tasks and simplify the downstream pipeline of BNNs. Our code and pretrained models are publicly available at https://github.com/Xingrun-Xing/BiPFT.

  • 7 authors
·
Dec 14, 2023

Life of PII -- A PII Obfuscation Transformer

Protecting sensitive information is crucial in today's world of Large Language Models (LLMs) and data-driven services. One common method used to preserve privacy is by using data perturbation techniques to reduce overreaching utility of (sensitive) Personal Identifiable Information (PII) data while maintaining its statistical and semantic properties. Data perturbation methods often result in significant information loss, making them impractical for use. In this paper, we propose 'Life of PII', a novel Obfuscation Transformer framework for transforming PII into faux-PII while preserving the original information, intent, and context as much as possible. Our approach includes an API to interface with the given document, a configuration-based obfuscator, and a model based on the Transformer architecture, which has shown high context preservation and performance in natural language processing tasks and LLMs. Our Transformer-based approach learns mapping between the original PII and its transformed faux-PII representation, which we call "obfuscated" data. Our experiments demonstrate that our method, called Life of PII, outperforms traditional data perturbation techniques in terms of both utility preservation and privacy protection. We show that our approach can effectively reduce utility loss while preserving the original information, offering greater flexibility in the trade-off between privacy protection and data utility. Our work provides a solution for protecting PII in various real-world applications.

  • 3 authors
·
May 16, 2023

ThinK: Thinner Key Cache by Query-Driven Pruning

Large Language Models (LLMs) have revolutionized the field of natural language processing, achieving unprecedented performance across a variety of applications by leveraging increased model sizes and sequence lengths. However, the associated rise in computational and memory costs poses significant challenges, particularly in managing long sequences due to the quadratic complexity of the transformer attention mechanism. This paper focuses on the long-context scenario, addressing the inefficiencies in KV cache memory consumption during inference. Unlike existing approaches that optimize the memory based on the sequence lengths, we uncover that the channel dimension of the KV cache exhibits significant redundancy, characterized by unbalanced magnitude distribution and low-rank structure in attention weights. Based on these observations, we propose ThinK, a novel query-dependent KV cache pruning method designed to minimize attention weight loss while selectively pruning the least significant channels. Our approach not only maintains or enhances model accuracy but also achieves a reduction in memory costs by over 20% compared with vanilla KV cache eviction methods. Extensive evaluations on the LLaMA3 and Mistral models across various long-sequence datasets confirm the efficacy of ThinK, setting a new precedent for efficient LLM deployment without compromising performance. We also outline the potential of extending our method to value cache pruning, demonstrating ThinK's versatility and broad applicability in reducing both memory and computational overheads.

  • 9 authors
·
Jul 30, 2024 2

PA-CFL: Privacy-Adaptive Clustered Federated Learning for Transformer-Based Sales Forecasting on Heterogeneous Retail Data

Federated learning (FL) enables retailers to share model parameters for demand forecasting while maintaining privacy. However, heterogeneous data across diverse regions, driven by factors such as varying consumer behavior, poses challenges to the effectiveness of federated learning. To tackle this challenge, we propose Privacy-Adaptive Clustered Federated Learning (PA-CFL) tailored for demand forecasting on heterogeneous retail data. By leveraging differential privacy and feature importance distribution, PA-CFL groups retailers into distinct ``bubbles'', each forming its own federated learning system to effectively isolate data heterogeneity. Within each bubble, Transformer models are designed to predict local sales for each client. Our experiments demonstrate that PA-CFL significantly surpasses FedAvg and outperforms local learning in demand forecasting performance across all participating clients. Compared to local learning, PA-CFL achieves a 5.4% improvement in R^2, a 69% reduction in RMSE, and a 45% decrease in MAE. Our approach enables effective FL through adaptive adjustments to diverse noise levels and the range of clients participating in each bubble. By grouping participants and proactively filtering out high-risk clients, PA-CFL mitigates potential threats to the FL system. The findings demonstrate PA-CFL's ability to enhance federated learning in time series prediction tasks with heterogeneous data, achieving a balance between forecasting accuracy and privacy preservation in retail applications. Additionally, PA-CFL's capability to detect and neutralize poisoned data from clients enhances the system's robustness and reliability.

  • 4 authors
·
Mar 15, 2025 1

JoyVASA: Portrait and Animal Image Animation with Diffusion-Based Audio-Driven Facial Dynamics and Head Motion Generation

Audio-driven portrait animation has made significant advances with diffusion-based models, improving video quality and lipsync accuracy. However, the increasing complexity of these models has led to inefficiencies in training and inference, as well as constraints on video length and inter-frame continuity. In this paper, we propose JoyVASA, a diffusion-based method for generating facial dynamics and head motion in audio-driven facial animation. Specifically, in the first stage, we introduce a decoupled facial representation framework that separates dynamic facial expressions from static 3D facial representations. This decoupling allows the system to generate longer videos by combining any static 3D facial representation with dynamic motion sequences. Then, in the second stage, a diffusion transformer is trained to generate motion sequences directly from audio cues, independent of character identity. Finally, a generator trained in the first stage uses the 3D facial representation and the generated motion sequences as inputs to render high-quality animations. With the decoupled facial representation and the identity-independent motion generation process, JoyVASA extends beyond human portraits to animate animal faces seamlessly. The model is trained on a hybrid dataset of private Chinese and public English data, enabling multilingual support. Experimental results validate the effectiveness of our approach. Future work will focus on improving real-time performance and refining expression control, further expanding the applications in portrait animation. The code is available at: https://github.com/jdh-algo/JoyVASA.

  • 7 authors
·
Nov 14, 2024

InstantCharacter: Personalize Any Characters with a Scalable Diffusion Transformer Framework

Current learning-based subject customization approaches, predominantly relying on U-Net architectures, suffer from limited generalization ability and compromised image quality. Meanwhile, optimization-based methods require subject-specific fine-tuning, which inevitably degrades textual controllability. To address these challenges, we propose InstantCharacter, a scalable framework for character customization built upon a foundation diffusion transformer. InstantCharacter demonstrates three fundamental advantages: first, it achieves open-domain personalization across diverse character appearances, poses, and styles while maintaining high-fidelity results. Second, the framework introduces a scalable adapter with stacked transformer encoders, which effectively processes open-domain character features and seamlessly interacts with the latent space of modern diffusion transformers. Third, to effectively train the framework, we construct a large-scale character dataset containing 10-million-level samples. The dataset is systematically organized into paired (multi-view character) and unpaired (text-image combinations) subsets. This dual-data structure enables simultaneous optimization of identity consistency and textual editability through distinct learning pathways. Qualitative experiments demonstrate the advanced capabilities of InstantCharacter in generating high-fidelity, text-controllable, and character-consistent images, setting a new benchmark for character-driven image generation. Our source code is available at https://github.com/Tencent/InstantCharacter.

  • 12 authors
·
Apr 16, 2025 2

UNIC-Adapter: Unified Image-instruction Adapter with Multi-modal Transformer for Image Generation

Recently, text-to-image generation models have achieved remarkable advancements, particularly with diffusion models facilitating high-quality image synthesis from textual descriptions. However, these models often struggle with achieving precise control over pixel-level layouts, object appearances, and global styles when using text prompts alone. To mitigate this issue, previous works introduce conditional images as auxiliary inputs for image generation, enhancing control but typically necessitating specialized models tailored to different types of reference inputs. In this paper, we explore a new approach to unify controllable generation within a single framework. Specifically, we propose the unified image-instruction adapter (UNIC-Adapter) built on the Multi-Modal-Diffusion Transformer architecture, to enable flexible and controllable generation across diverse conditions without the need for multiple specialized models. Our UNIC-Adapter effectively extracts multi-modal instruction information by incorporating both conditional images and task instructions, injecting this information into the image generation process through a cross-attention mechanism enhanced by Rotary Position Embedding. Experimental results across a variety of tasks, including pixel-level spatial control, subject-driven image generation, and style-image-based image synthesis, demonstrate the effectiveness of our UNIC-Adapter in unified controllable image generation.

  • 10 authors
·
Dec 25, 2024

Image2Gcode: Image-to-G-code Generation for Additive Manufacturing Using Diffusion-Transformer Model

Mechanical design and manufacturing workflows conventionally begin with conceptual design, followed by the creation of a computer-aided design (CAD) model and fabrication through material-extrusion (MEX) printing. This process requires converting CAD geometry into machine-readable G-code through slicing and path planning. While each step is well established, dependence on CAD modeling remains a major bottleneck: constructing object-specific 3D geometry is slow and poorly suited to rapid prototyping. Even minor design variations typically necessitate manual updates in CAD software, making iteration time-consuming and difficult to scale. To address this limitation, we introduce Image2Gcode, an end-to-end data-driven framework that bypasses the CAD stage and generates printer-ready G-code directly from images and part drawings. Instead of relying on an explicit 3D model, a hand-drawn or captured 2D image serves as the sole input. The framework first extracts slice-wise structural cues from the image and then employs a denoising diffusion probabilistic model (DDPM) over G-code sequences. Through iterative denoising, the model transforms Gaussian noise into executable print-move trajectories with corresponding extrusion parameters, establishing a direct mapping from visual input to native toolpaths. By producing structured G-code directly from 2D imagery, Image2Gcode eliminates the need for CAD or STL intermediates, lowering the entry barrier for additive manufacturing and accelerating the design-to-fabrication cycle. This approach supports on-demand prototyping from simple sketches or visual references and integrates with upstream 2D-to-3D reconstruction modules to enable an automated pipeline from concept to physical artifact. The result is a flexible, computationally efficient framework that advances accessibility in design iteration, repair workflows, and distributed manufacturing.

  • 4 authors
·
Nov 25, 2025

Hallo3: Highly Dynamic and Realistic Portrait Image Animation with Diffusion Transformer Networks

Existing methodologies for animating portrait images face significant challenges, particularly in handling non-frontal perspectives, rendering dynamic objects around the portrait, and generating immersive, realistic backgrounds. In this paper, we introduce the first application of a pretrained transformer-based video generative model that demonstrates strong generalization capabilities and generates highly dynamic, realistic videos for portrait animation, effectively addressing these challenges. The adoption of a new video backbone model makes previous U-Net-based methods for identity maintenance, audio conditioning, and video extrapolation inapplicable. To address this limitation, we design an identity reference network consisting of a causal 3D VAE combined with a stacked series of transformer layers, ensuring consistent facial identity across video sequences. Additionally, we investigate various speech audio conditioning and motion frame mechanisms to enable the generation of continuous video driven by speech audio. Our method is validated through experiments on benchmark and newly proposed wild datasets, demonstrating substantial improvements over prior methods in generating realistic portraits characterized by diverse orientations within dynamic and immersive scenes. Further visualizations and the source code are available at: https://fudan-generative-vision.github.io/hallo3/.

  • 10 authors
·
Dec 1, 2024

Large-Scale Multi-omic Biosequence Transformers for Modeling Peptide-Nucleotide Interactions

The transformer architecture has revolutionized bioinformatics and driven progress in the understanding and prediction of the properties of biomolecules. Almost all research on large-scale biosequence transformers has focused on one domain at a time (single-omic), usually nucleotides or peptides. These models have seen incredible success in downstream tasks in each domain and have achieved particularly noteworthy breakthroughs in sequences of peptides and structural modeling. However, these single-omic models are naturally incapable of modeling multi-omic tasks, one of the most biologically critical being nucleotide-peptide interactions. We present our work training the first multi-omic nucleotide-peptide foundation models. We show that these multi-omic models (MOMs) can learn joint representations between various single-omic distributions that are emergently consistent with the Central Dogma of molecular biology, despite only being trained on unlabeled biosequences. We further demonstrate that MOMs can be fine-tuned to achieve state-of-the-art results on peptide-nucleotide interaction tasks, namely predicting the change in Gibbs free energy ({\Delta}G) of the binding interaction between a given oligonucleotide and peptide, as well as the effect on this binding interaction due to mutations in the oligonucleotide sequence ({\Delta}{\Delta}G). Remarkably, we show that multi-omic biosequence transformers emergently learn useful structural information without any prior structural training, allowing us to predict which peptide residues are most involved in the peptide-nucleotide binding interaction. Lastly, we provide evidence that multi-omic biosequence models are non-inferior to foundation models trained on single-omics distributions, suggesting a more generalized or foundational approach to building these models.

  • 5 authors
·
Aug 28, 2024 1